{"id":"https://openalex.org/W7202099496","doi":"https://doi.org/10.1039/d6md00266h","title":"Optimizing CRBN-ligands for optical targeted protein degradation","display_name":"Optimizing CRBN-ligands for optical targeted protein degradation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7202099496","doi":"https://doi.org/10.1039/d6md00266h","pmid":"https://pubmed.ncbi.nlm.nih.gov/42807851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13617755"},"language":"en","primary_location":{"id":"doi:10.1039/d6md00266h","doi":"https://doi.org/10.1039/d6md00266h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00266h","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1039/d6md00266h","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104858568","display_name":"Joseph A. Flores","orcid":"https://orcid.org/0000-0002-4597-4138","observed_orcids":["https://orcid.org/0000-0002-4597-4138"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Flores","raw_affiliation_strings":["Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4597-4138","affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090984969","display_name":"Ray G. DiNardi","orcid":"https://orcid.org/0000-0002-8864-5692","observed_orcids":["https://orcid.org/0000-0002-8864-5692"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray G. DiNardi","raw_affiliation_strings":["Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8864-5692","affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070112401","display_name":"George M. Burslem","orcid":"https://orcid.org/0000-0002-2812-983X","observed_orcids":["https://orcid.org/0000-0002-2812-983X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Burslem","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2812-983X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067076835","display_name":"Tianhao Cheng","orcid":"https://orcid.org/0000-0002-7737-4639","observed_orcids":["https://orcid.org/0000-0002-7737-4639","https://orcid.org/0009-0002-1221-5693","https://orcid.org/0009-0004-3024-5882"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianhao Cheng","raw_affiliation_strings":["Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0009-0002-1221-5693","affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5095690333","display_name":"Dirk Trauner","orcid":"https://orcid.org/0000-0002-6782-6056","observed_orcids":["https://orcid.org/0000-0002-6782-6056"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dirk H. Trauner","raw_affiliation_strings":["Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6782-6056","affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5095690333"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50142759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"10","first_page":"4828","last_page":"4837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9100000262260437},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/heterobifunctional-molecules","display_name":"heterobifunctional molecules","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ligand-optimization","display_name":"ligand optimization","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4426000118255615},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.4163999855518341},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.38179999589920044},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.37389999628067017},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23839999735355377},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2353000044822693},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.2290000021457672},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22460000216960907}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6md00266h","doi":"https://doi.org/10.1039/d6md00266h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00266h","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13617755","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13617755/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13617755/pdf/MD-OLF-D6MD00266H.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Med Chem","raw_type":"Text"},{"id":"pmid:42807851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42807851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6md00266h","doi":"https://doi.org/10.1039/d6md00266h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00266h","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000896686","display_name":"Structural biology and molecular biophysics training program","funder_award_id":"T32GM132039","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000912199","display_name":"Optical Control of the Actin Cytoskeleton","funder_award_id":"R01GM126228","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1512690422","https://openalex.org/W2227431445","https://openalex.org/W2463040786","https://openalex.org/W2767856718","https://openalex.org/W2814854939","https://openalex.org/W2974217727","https://openalex.org/W3000673710","https://openalex.org/W3008322752","https://openalex.org/W3011240628","https://openalex.org/W3198715393","https://openalex.org/W3208000383","https://openalex.org/W4282935215","https://openalex.org/W4286489333","https://openalex.org/W4294000265","https://openalex.org/W4386757974","https://openalex.org/W4388014175","https://openalex.org/W4390277658","https://openalex.org/W4391296390","https://openalex.org/W4392883115","https://openalex.org/W4396965309","https://openalex.org/W4406787795","https://openalex.org/W4408164615","https://openalex.org/W4408413789","https://openalex.org/W4410975308","https://openalex.org/W4414533087","https://openalex.org/W4414559084","https://openalex.org/W4415005291"],"related_works":["https://openalex.org/W3193572126","https://openalex.org/W3014659512","https://openalex.org/W2978960573","https://openalex.org/W4386337761","https://openalex.org/W7015212898","https://openalex.org/W4294000265","https://openalex.org/W3013856525","https://openalex.org/W7214951965","https://openalex.org/W3107754785","https://openalex.org/W4408413789"],"abstract_inverted_index":{",":[0],"the":[1],"first":[2],"nanomolar":[3],"photoswitchable":[4],"degrader":[5],"of":[6],"tumor-associated":[7],"protein":[8],"MTH1,":[9],"establishing":[10],"a":[11,33],"promising":[12],"synthetic":[13],"approach":[14],"for":[15],"future":[16],"PHOTAC":[17],"development.":[18],"Competitive":[19],"binding":[20],"studies":[21],"showed":[22],"that":[23],"irradiation":[24],"lowered":[25],"CRBN":[26],"affinity":[27,39],"even":[28],"as":[29],"degradation":[30],"increased,":[31],"revealing":[32],"decoupling":[34],"between":[35],"light-dependent":[36],"changes":[37],"in":[38],"and":[40],"efficacy.":[41]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-08-10T00:00:00"}
