{"id":"https://openalex.org/W7202097644","doi":"https://doi.org/10.1152/ajprenal.00106.2026","title":"Dysregulated ferritin and iron homeostasis in autosomal dominant polycystic kidney disease","display_name":"Dysregulated ferritin and iron homeostasis in autosomal dominant polycystic kidney disease","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202097644","doi":"https://doi.org/10.1152/ajprenal.00106.2026","pmid":"https://pubmed.ncbi.nlm.nih.gov/42572368","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13654193"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00106.2026","doi":"https://doi.org/10.1152/ajprenal.00106.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajprenal.00106.2026","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1152/ajprenal.00106.2026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nicole Sommer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole Sommer","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120108966","display_name":"Sagine Placide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sagine Placide","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074477679","display_name":"Elizabeth Weatherly","orcid":"https://orcid.org/0009-0009-7084-7550","observed_orcids":["https://orcid.org/0009-0009-7084-7550"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Weatherly","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":"https://orcid.org/0009-0009-7084-7550","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148454222","display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124818385","display_name":"Rahima Begum","orcid":"https://orcid.org/0000-0003-1510-5748","observed_orcids":["https://orcid.org/0000-0003-1510-5748"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahima Begum","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139331645","display_name":"Mackenzie Dunfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mackenzie Dunfield","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104124534","display_name":"Siraj Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siraj Singh","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher J. Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Ward","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060712546","display_name":"Pamela Vivian Tran","orcid":"https://orcid.org/0000-0003-4619-4376","observed_orcids":["https://orcid.org/0000-0003-4619-4376"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela V. Tran","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-4619-4376","affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013395253","display_name":"Subhashini Bolisetty","orcid":"https://orcid.org/0000-0002-4650-3151","observed_orcids":["https://orcid.org/0000-0002-4650-3151"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subhashini Bolisetty","raw_affiliation_strings":["University of Alabama at Birmingham"],"raw_orcid":"https://orcid.org/0000-0002-4650-3151","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007219151","display_name":"Darren P. Wallace","orcid":"https://orcid.org/0000-0003-4616-7669","observed_orcids":["https://orcid.org/0000-0003-4616-7669"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren P. Wallace","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-4616-7669","affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089031028","display_name":"Madhulika Sharma","orcid":"https://orcid.org/0000-0001-7488-5444","observed_orcids":["https://orcid.org/0000-0001-7488-5444"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Madhulika Sharma","raw_affiliation_strings":["University of Kansas Medical Center"],"raw_orcid":"https://orcid.org/0000-0001-7488-5444","affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089031028","https://openalex.org/A5120108966"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"331","issue":"3","first_page":"F463","last_page":"F476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ferritin-light-chain","display_name":"ferritin light chain","score":0.8840000033378601},{"id":"https://openalex.org/keywords/fth1","display_name":"FTH1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.876800000667572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6624000072479248},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.5426999926567078},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5407000184059143},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.5116999745368958},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4767000079154968},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.45410001277923584},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4334000051021576},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43140000104904175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41100001335144043},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3822999894618988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3707999885082245},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.3643999993801117},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3463999927043915},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.336899995803833},{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3125},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.3118000030517578},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2556999921798706},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.25440001487731934},{"id":"https://openalex.org/C2779730776","wikidata":"https://www.wikidata.org/wiki/Q5631153","display_name":"HMOX1","level":5,"score":0.25}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001052","descriptor_name":"Apoferritins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001052","descriptor_name":"Apoferritins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.00106.2026","doi":"https://doi.org/10.1152/ajprenal.00106.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajprenal.00106.2026","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:42572368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42572368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13654193","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13654193/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13654193/pdf/nihms-2204883.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1152/ajprenal.00106.2026","doi":"https://doi.org/10.1152/ajprenal.00106.2026","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajprenal.00106.2026","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2931106538","display_name":null,"funder_award_id":"PR230752","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4012805929","display_name":null,"funder_award_id":"U54 DK126126","funder_id":"https://openalex.org/F4320306478","funder_display_name":"PKD Foundation"},{"id":"https://openalex.org/G6390080615","display_name":null,"funder_award_id":"905894","funder_id":"https://openalex.org/F4320306478","funder_display_name":"PKD Foundation"},{"id":"https://openalex.org/G8630316905","display_name":null,"funder_award_id":"R01DK122986","funder_id":"https://openalex.org/F4320338422","funder_display_name":"Division of Diabetes, Endocrinology, and Metabolic Diseases"},{"id":"https://openalex.org/G884660033","display_name":"Molecular Regulation of Cell Development and Differentiation Phase III COBRE","funder_award_id":"P30GM122731","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000862843","display_name":"Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury","funder_award_id":"R01DK122986","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000892737","display_name":"Kansas PKD Research and Translation Core Center","funder_award_id":"U54DK126126","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306478","display_name":"PKD Foundation","ror":"https://ror.org/05g0xkn45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338422","display_name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202097644.pdf","grobid_xml":"https://content.openalex.org/works/W7202097644.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1551862901","https://openalex.org/W1783360620","https://openalex.org/W1969296748","https://openalex.org/W1981137206","https://openalex.org/W1981388447","https://openalex.org/W1995594551","https://openalex.org/W1996152690","https://openalex.org/W1997977268","https://openalex.org/W2005934545","https://openalex.org/W2012095736","https://openalex.org/W2042135279","https://openalex.org/W2049958250","https://openalex.org/W2054054959","https://openalex.org/W2055560694","https://openalex.org/W2073637975","https://openalex.org/W2074787669","https://openalex.org/W2075302528","https://openalex.org/W2079837262","https://openalex.org/W2085346322","https://openalex.org/W2136428555","https://openalex.org/W2142227033","https://openalex.org/W2143108257","https://openalex.org/W2149409718","https://openalex.org/W2152653845","https://openalex.org/W2154921342","https://openalex.org/W2158115535","https://openalex.org/W2275201610","https://openalex.org/W2396587274","https://openalex.org/W2414659015","https://openalex.org/W2595532173","https://openalex.org/W2607216118","https://openalex.org/W2749918768","https://openalex.org/W2762281899","https://openalex.org/W2766936218","https://openalex.org/W2793689700","https://openalex.org/W2807176670","https://openalex.org/W2905675459","https://openalex.org/W2914517600","https://openalex.org/W2959431295","https://openalex.org/W2985482921","https://openalex.org/W3026178611","https://openalex.org/W3045395785","https://openalex.org/W3047457325","https://openalex.org/W3114491174","https://openalex.org/W3140708945","https://openalex.org/W3141374348","https://openalex.org/W3208250521","https://openalex.org/W4200428208","https://openalex.org/W4211149573","https://openalex.org/W4293105227","https://openalex.org/W4309245769","https://openalex.org/W4321242142","https://openalex.org/W4398321993","https://openalex.org/W4407183455","https://openalex.org/W4407229913","https://openalex.org/W4409690326"],"related_works":["https://openalex.org/W4397046544","https://openalex.org/W3208250521","https://openalex.org/W4403812208","https://openalex.org/W4396999595","https://openalex.org/W7171677803","https://openalex.org/W4397045254","https://openalex.org/W4403833233","https://openalex.org/W4397046630","https://openalex.org/W7165138226","https://openalex.org/W3023296981"],"abstract_inverted_index":{"Ferritin":[0],"dysregulation":[1,55],"in":[2,42,56],"autosomal":[3],"dominant":[4],"polycystic":[5,24],"kidney":[6,25],"disease":[7,12,26],"(ADPKD)":[8],"reveals":[9],"a":[10,65],"novel":[11],"mechanism.":[13],"Although":[14],"ferritin":[15,31,37,40,51],"heavy":[16],"chain":[17,33],"deletion":[18],"does":[19],"not":[20],"affect":[21],"cyst":[22],"growth,":[23],"(PKD)":[27],"kidneys":[28],"show":[29],"compensatory":[30],"light":[32],"upregulation":[34],"and":[35,48,53],"abnormal":[36],"trafficking.":[38],"Iron-loaded":[39],"accumulates":[41],"macrophage-rich":[43],"regions,":[44],"increasing":[45],"oxidative":[46],"stress":[47],"fibrosis.":[49],"Enhanced":[50],"uptake":[52],"receptor":[54],"cystic":[57],"epithelial":[58],"cells":[59],"highlight":[60],"disrupted":[61],"iron":[62],"homeostasis":[63],"as":[64],"previously":[66],"unrecognized":[67],"contributor":[68],"to":[69],"ADPKD":[70],"progression.":[71]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-10T00:00:00"}
