{"id":"https://openalex.org/W7202096754","doi":"https://doi.org/10.1128/msystems.00779-26","title":"Profiling the aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile -specific N -acyl amino acids","display_name":"Profiling the aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile -specific N -acyl amino acids","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202096754","doi":"https://doi.org/10.1128/msystems.00779-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42573234","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13595955"},"language":"en","primary_location":{"id":"doi:10.1128/msystems.00779-26","doi":"https://doi.org/10.1128/msystems.00779-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00779-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/msystems.00779-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011806510","display_name":"David Chun-Cheng Hsieh","orcid":"https://orcid.org/0009-0003-0806-9555","observed_orcids":["https://orcid.org/0009-0003-0806-9555"]},"institutions":[{"id":"https://openalex.org/I4210100942","display_name":"Tri-Institutional PhD Program in Chemical Biology","ror":"https://ror.org/016twdg30","country_code":"US","type":"education","lineage":["https://openalex.org/I4210100942"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Chun-Cheng Hsieh","raw_affiliation_strings":["Laboratory of Genetically Encoded Small Molecules, The Rockefeller University","Tri-Institutional PhD Program in Chemical Biology, The Rockefeller University"],"raw_orcid":"https://orcid.org/0009-0003-0806-9555","affiliations":[{"raw_affiliation_string":"Laboratory of Genetically Encoded Small Molecules, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"Tri-Institutional PhD Program in Chemical Biology, The Rockefeller University","institution_ids":["https://openalex.org/I4210100942","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002773959","display_name":"Linhai Jiang","orcid":"https://orcid.org/0000-0002-9403-9170","observed_orcids":["https://orcid.org/0000-0002-9403-9170"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linhai Jiang","raw_affiliation_strings":["Laboratory of Genetically Encoded Small Molecules, The Rockefeller University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetically Encoded Small Molecules, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042300089","display_name":"Mengzhao Xue","orcid":"https://orcid.org/0000-0003-3752-0352","observed_orcids":["https://orcid.org/0000-0003-3752-0352"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengzhao Xue","raw_affiliation_strings":["Laboratory of Genetically Encoded Small Molecules, The Rockefeller University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetically Encoded Small Molecules, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049473553","display_name":"Niv Antonovsky","orcid":"https://orcid.org/0000-0002-2437-0159","observed_orcids":["https://orcid.org/0000-0002-2437-0159"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niv Antonovsky","raw_affiliation_strings":["Laboratory of Genetically Encoded Small Molecules, The Rockefeller University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genetically Encoded Small Molecules, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073186281","display_name":"Sean F. Brady","orcid":"https://orcid.org/0000-0001-5967-8586","observed_orcids":["https://orcid.org/0000-0001-5967-8586"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean F. Brady","raw_affiliation_strings":["Laboratory of Genetically Encoded Small Molecules, The Rockefeller University"],"raw_orcid":"https://orcid.org/0000-0001-5967-8586","affiliations":[{"raw_affiliation_string":"Laboratory of Genetically Encoded Small Molecules, The Rockefeller University","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073186281"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"9","first_page":"e0077926","last_page":"e0077926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.06780000030994415,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aromatic-amino-acids","display_name":"aromatic amino acids","score":0.7570000290870667},{"id":"https://openalex.org/keywords/n-acyl-amino-acids","display_name":"N-acyl amino acids","score":0.9430000185966492},{"id":"https://openalex.org/keywords/phenylacetic-acid","display_name":"phenylacetic acid","score":0.9440000057220459},{"id":"https://openalex.org/keywords/phenylpropionic-acid","display_name":"phenylpropionic acid","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bacterial-metabolites","display_name":"bacterial metabolites","score":0.6299999952316284},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.7979999780654907},{"id":"https://openalex.org/keywords/bacteroidetes","display_name":"Bacteroidetes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/proteobacteria","display_name":"Proteobacteria","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.9550999999046326},{"id":"https://openalex.org/C2778990612","wikidata":"https://www.wikidata.org/wiki/Q410842","display_name":"Phenylacetic acid","level":2,"score":0.7724000215530396},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7685999870300293},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7240999937057495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.670799970626831},{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.6665999889373779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6417999863624573},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6014000177383423},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3804999887943268},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.33090001344680786},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3301999866962433},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C199465337","wikidata":"https://www.wikidata.org/wiki/Q6823168","display_name":"Metaproteomics","level":4,"score":0.2930999994277954},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C2780677274","wikidata":"https://www.wikidata.org/wiki/Q420726","display_name":"Branched-chain amino acid","level":4,"score":0.2759999930858612},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26910001039505005}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024322","descriptor_name":"Amino Acids, Aromatic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D024322","descriptor_name":"Amino Acids, Aromatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/msystems.00779-26","doi":"https://doi.org/10.1128/msystems.00779-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00779-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13595955","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13595955/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13595955/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Text"},{"id":"pmid:42573234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42573234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:af2d642ccbbf4f219ba8d0c0bf64f928","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/af2d642ccbbf4f219ba8d0c0bf64f928","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSystems, Vol 11, Iss 9 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/msystems.00779-26","doi":"https://doi.org/10.1128/msystems.00779-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00779-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000871071","display_name":"Discovery of Antibiotics from Soil Microbiomes Using Metagenomics","funder_award_id":"R35GM122559","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320312920","display_name":"G. Harold and Leila Y. Mathers Foundation","ror":"https://ror.org/02a7hjv13"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202096754.pdf","grobid_xml":"https://content.openalex.org/works/W7202096754.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W157425433","https://openalex.org/W1564473377","https://openalex.org/W1611854178","https://openalex.org/W1897051525","https://openalex.org/W1989299822","https://openalex.org/W2063756270","https://openalex.org/W2097704313","https://openalex.org/W2107658072","https://openalex.org/W2141579920","https://openalex.org/W2149573313","https://openalex.org/W2150934173","https://openalex.org/W2169838204","https://openalex.org/W2474050011","https://openalex.org/W2504691963","https://openalex.org/W2744393374","https://openalex.org/W2753100975","https://openalex.org/W2769517706","https://openalex.org/W2789630263","https://openalex.org/W2807728333","https://openalex.org/W2888637453","https://openalex.org/W2911411449","https://openalex.org/W2940690307","https://openalex.org/W2967074377","https://openalex.org/W2970022405","https://openalex.org/W3007415664","https://openalex.org/W3009682272","https://openalex.org/W3015330164","https://openalex.org/W3023444868","https://openalex.org/W3063997159","https://openalex.org/W3080789666","https://openalex.org/W3127151710","https://openalex.org/W3155734097","https://openalex.org/W3156458251","https://openalex.org/W3178627242","https://openalex.org/W4282972916","https://openalex.org/W4312113467","https://openalex.org/W4315480674","https://openalex.org/W4387300991","https://openalex.org/W4390465682","https://openalex.org/W4401352958","https://openalex.org/W4411178803"],"related_works":["https://openalex.org/W7080625150","https://openalex.org/W2967929447","https://openalex.org/W2795050983","https://openalex.org/W2265314978","https://openalex.org/W4387045121","https://openalex.org/W7131668008","https://openalex.org/W4403939729","https://openalex.org/W2769517706","https://openalex.org/W7158257274","https://openalex.org/W2593280589"],"abstract_inverted_index":{"ABSTRACT":[0],"Owing":[1],"to":[2,68,140,193,215,249],"its":[3],"compositional":[4],"and":[5,35,56,62,115,121,148,188],"chemical":[6],"complexity,":[7],"much":[8],"of":[9,24,31,42,89,110,150,164,225,230,237,259,276,284],"the":[10,29,46,107,111,138,165,228,282],"gut":[11,78],"microbiota":[12,47],"metabolome":[13,159],"remains":[14],"poorly":[15],"characterized.":[16],"Aromatic":[17],"amino":[18,60,102,135,200,208,234],"acids":[19,61,136,201],"(AAAs)":[20],"have":[21,137,242],"a":[22,38,161,182,210],"history":[23],"being":[25],"privileged":[26],"substrates":[27],"for":[28,144],"biosynthesis":[30],"diverse":[32,76,132,216],"bioactive":[33,43],"metabolites":[34,71,261],"thus":[36],"represent":[37],"potentially":[39,176],"rich":[40],"source":[41],"molecules":[44,174],"within":[45],"metabolome.":[48],"In":[49],"this":[50,178],"study,":[51],"we":[52,82],"leveraged":[53],"13":[54],"C-":[55],"2":[57],"H-labeled":[58],"aromatic":[59],"untargeted":[63],"liquid":[64],"chromatography-mass":[65],"spectrometry":[66,191],"(LC-MS)":[67],"profile":[69],"AAA-derived":[70,112],"produced":[72,92,106,246,262],"by":[73,93,263],"80":[74],"phylogenetically":[75],"human":[77],"bacterial":[79,158],"isolates.":[80],"Collectively,":[81],"found":[83],"93":[84],"unique":[85],"LC-MS":[86],"features,":[87],"majority":[88],"which,":[90],"predominantly":[91],"Clostridioides":[94,196],"difficile":[95,105,128,146,152,197,221],",":[96],"were":[97],"identified":[98],"as":[99,142,273],"N":[100,206,232],"-acyl":[101,207,233],"acids.":[103],"C.":[104,127,145,151,220],"highest":[108],"levels":[109,224],"phenylacetic":[113,226,247],"acid":[114,248],"phenylpropionic":[116],"acid,":[117,227],"exceeding":[118],"all":[119],"Bacteroidetes":[120],"Proteobacteria":[122],"strains":[123],"in":[124,219],"our":[125],"panel.":[126],"\u2019":[129],"s":[130],"uniquely":[131,198],"N-":[133],"acyl":[134],"potential":[139],"serve":[141,272],"biomarkers":[143,275],"colonization":[147,277],"mediators":[149],"-specific":[153],"host":[154,169],"interaction.":[155],"IMPORTANCE":[156],"The":[157,257],"is":[160],"key":[162],"component":[163],"microbiota\u2019s":[166],"effect":[167],"on":[168],"physiology,":[170],"but":[171,278],"identifying":[172],"small":[173],"that":[175,195,270],"drive":[177],"interaction":[179],"has":[180],"remained":[181],"challenge.":[183],"This":[184],"study":[185],"uses":[186],"high-throughput":[187],"quantitative":[189],"mass":[190],"metabolomics":[192],"show":[194],"converts":[199],"into":[202],"at":[203],"least":[204],"28":[205],"acids,":[209,235],"metabolite":[211],"family":[212],"historically":[213],"linked":[214,244],"bioactivities.":[217],"Additionally,":[218],"cultures,":[222],"high":[223],"precursor":[229],"6":[231],"are":[236],"interest":[238],"because":[239],"previous":[240],"studies":[241],"mechanistically":[243],"microbially":[245],"cardiovascular":[250],"disease":[251],"via":[252],"\u03b22-adrenergic":[253],"receptor":[254],"(\u03b22AR)":[255],"signaling.":[256],"identification":[258],"species-specific":[260],"commensal":[264],"bacteria":[265],"provides":[266],"not":[267],"only":[268],"compounds":[269],"could":[271],"sensitive":[274],"also":[279],"helps":[280],"support":[281],"formulation":[283],"mechanistic":[285],"hypotheses":[286],"regarding":[287],"how":[288],"individual":[289],"species":[290],"influence":[291],"their":[292],"host.":[293]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-10T00:00:00"}
