{"id":"https://openalex.org/W7202091916","doi":"https://doi.org/10.64898/2026.08.07.743303","title":"MYCN-induced lineage infidelity initiates SHH medulloblastoma-like tumors outside the canonical lineage of origin","display_name":"MYCN-induced lineage infidelity initiates SHH medulloblastoma-like tumors outside the canonical lineage of origin","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202091916","doi":"https://doi.org/10.64898/2026.08.07.743303"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.07.743303","doi":"https://doi.org/10.64898/2026.08.07.743303","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.07.743303","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.07.743303","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054496600","display_name":"Lauranne Bouteille","orcid":"https://orcid.org/0000-0003-3677-289X","observed_orcids":["https://orcid.org/0000-0003-3677-289X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lauranne Bouteille","raw_affiliation_strings":["Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0003-3677-289X","affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094222995","display_name":"William Fargues","orcid":"https://orcid.org/0009-0005-5291-0828","observed_orcids":["https://orcid.org/0009-0005-5291-0828"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"William Fargues","raw_affiliation_strings":["Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France"],"raw_orcid":"https://orcid.org/0009-0005-5291-0828","affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060660923","display_name":"Paul de Boissier","orcid":"https://orcid.org/0000-0003-2246-1580","observed_orcids":["https://orcid.org/0000-0003-2246-1580"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul de Boissier","raw_affiliation_strings":["Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0003-2246-1580","affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146922297","display_name":"Guillaume Girard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Girard","raw_affiliation_strings":["Universit\u00e9 Lyon 1, F-69100, Villeurbanne, France; Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, Service de Biostatistique et Bioinformatique, F-69003 ; Centre d\u2019excellence SouthROCK, Lyon, France; CNRS, UMR 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, F-69100, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Lyon 1, F-69100, Villeurbanne, France; Hospices Civils de Lyon, P\u00f4le Sant\u00e9 Publique, Service de Biostatistique et Bioinformatique, F-69003 ; Centre d\u2019excellence SouthROCK, Lyon, France; CNRS, UMR 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, \u00c9quipe Biostatistique-Sant\u00e9, F-69100, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210100596","https://openalex.org/I4210135640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037756044","display_name":"Mehdi Saadaoui","orcid":"https://orcid.org/0000-0001-9835-8489","observed_orcids":["https://orcid.org/0000-0001-9835-8489"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mehdi Saadaoui","raw_affiliation_strings":["Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-9835-8489","affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029566539","display_name":"C\u00e9dric Maurange","orcid":"https://orcid.org/0000-0001-8931-1419","observed_orcids":["https://orcid.org/0000-0001-8931-1419"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210120427","display_name":"Institut de Biologie du D\u00e9veloppement Marseille","ror":"https://ror.org/02me5cy06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210096427","https://openalex.org/I4210120427"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"C\u00e9dric Maurange","raw_affiliation_strings":["Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0001-8931-1419","affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9 & CNRS, IBDM\u2014UMR 7288, Equipe Labellis\u00e9e LIGUE 2025, Centre d\u2019excellence SouthROCK, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5029566539"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210120427"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.9819999933242798},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7760000228881836},{"id":"https://openalex.org/keywords/shh-medulloblastoma","display_name":"SHH medulloblastoma","score":0.9179999828338623},{"id":"https://openalex.org/keywords/lineage-infidelity","display_name":"lineage infidelity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/cerebellar-development","display_name":"cerebellar development","score":0.7250000238418579},{"id":"https://openalex.org/keywords/atoh1","display_name":"Atoh1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pax6","display_name":"Pax6","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neuronal-maturation","display_name":"neuronal maturation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/avian-embryo","display_name":"avian embryo","score":0.7229999899864197},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.804099977016449},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.6707000136375427},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5734000205993652},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.515999972820282},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49219998717308044},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.46299999952316284},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4187000095844269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41510000824928284},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.40959998965263367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40720000863075256},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.39809998869895935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3921999931335449},{"id":"https://openalex.org/C2777620950","wikidata":"https://www.wikidata.org/wiki/Q189105","display_name":"Cell lineage","level":4,"score":0.35589998960494995},{"id":"https://openalex.org/C2779310769","wikidata":"https://www.wikidata.org/wiki/Q6553374","display_name":"Lineage markers","level":4,"score":0.350600004196167},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.33090001344680786},{"id":"https://openalex.org/C2777302934","wikidata":"https://www.wikidata.org/wiki/Q18031655","display_name":"SOX10","level":4,"score":0.328900009393692},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C51816534","wikidata":"https://www.wikidata.org/wiki/Q14916213","display_name":"PAX6","level":4,"score":0.32339999079704285},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C2781246680","wikidata":"https://www.wikidata.org/wiki/Q1052970","display_name":"Cell of origin","level":3,"score":0.3199000060558319},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.29170000553131104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.2685000002384186},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.2662999927997589},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.26030001044273376},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.64898/2026.08.07.743303","doi":"https://doi.org/10.64898/2026.08.07.743303","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.07.743303","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:HAL:hal-05783810v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05783810","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2026","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.08.07.743303","doi":"https://doi.org/10.64898/2026.08.07.743303","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.07.743303","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6792575107","display_name":null,"funder_award_id":"INCa-Cancer_18695","funder_id":"https://openalex.org/F4320338030","funder_display_name":"Institute of Cancer Research"}],"funders":[{"id":"https://openalex.org/F4320338030","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1967337983","https://openalex.org/W1971139891","https://openalex.org/W1971412744","https://openalex.org/W1972207998","https://openalex.org/W1977779366","https://openalex.org/W1980812563","https://openalex.org/W1988126723","https://openalex.org/W1993000387","https://openalex.org/W1994794031","https://openalex.org/W1995541594","https://openalex.org/W2010470328","https://openalex.org/W2021536610","https://openalex.org/W2038444285","https://openalex.org/W2070855083","https://openalex.org/W2073302269","https://openalex.org/W2084478929","https://openalex.org/W2093640897","https://openalex.org/W2094252236","https://openalex.org/W2095680092","https://openalex.org/W2098776492","https://openalex.org/W2100826819","https://openalex.org/W2115599658","https://openalex.org/W2116481437","https://openalex.org/W2126735009","https://openalex.org/W2127643721","https://openalex.org/W2140213125","https://openalex.org/W2141078839","https://openalex.org/W2153016097","https://openalex.org/W2153398041","https://openalex.org/W2163870773","https://openalex.org/W2168957937","https://openalex.org/W2286322195","https://openalex.org/W2626440326","https://openalex.org/W2737542366","https://openalex.org/W2766437506","https://openalex.org/W2787308302","https://openalex.org/W2808584871","https://openalex.org/W2889859239","https://openalex.org/W2896789885","https://openalex.org/W2914707802","https://openalex.org/W2952200551","https://openalex.org/W2952481429","https://openalex.org/W2962905556","https://openalex.org/W2981304003","https://openalex.org/W2990909677","https://openalex.org/W2997022986","https://openalex.org/W3002301481","https://openalex.org/W3018947352","https://openalex.org/W3172218068","https://openalex.org/W4220957431","https://openalex.org/W4284968925","https://openalex.org/W4320482674","https://openalex.org/W4378212544","https://openalex.org/W4385502151","https://openalex.org/W4389132747","https://openalex.org/W4396577858","https://openalex.org/W4400448513","https://openalex.org/W4401331475","https://openalex.org/W4402223831","https://openalex.org/W4406155815","https://openalex.org/W4407569342","https://openalex.org/W4415051801","https://openalex.org/W7128907317"],"related_works":["https://openalex.org/W2078073947","https://openalex.org/W2153016097","https://openalex.org/W2317564642","https://openalex.org/W1973251215","https://openalex.org/W7132886710","https://openalex.org/W7064676232","https://openalex.org/W2052597256","https://openalex.org/W2023750739","https://openalex.org/W2308748041","https://openalex.org/W2011334551"],"abstract_inverted_index":{"Abstract":[0],"Amplification":[1],"and":[2,7,14,61,123],"high":[3],"expression":[4],"of":[5,12,37,84,112,141,148,177],"MYCN":[6,47,54,118],"MYC":[8],"are":[9,70],"recurrent":[10],"features":[11],"medulloblastoma":[13],"other":[15],"pediatric":[16],"cancers,":[17],"yet":[18],"how":[19,46],"these":[20,68,121],"proto-oncogenes":[21],"interact":[22],"with":[23,41],"developmental":[24],"programs":[25],"to":[26,44,72,80],"initiate":[27],"tumorigenesis":[28,140],"remains":[29],"unclear.":[30],"Here,":[31],"we":[32,65,115],"combine":[33],"the":[34,38,102,109,142,165,175],"experimental":[35],"accessibility":[36],"avian":[39],"embryo":[40],"single-cell":[42],"transcriptomics":[43],"investigate":[45],"overexpression":[48],"reshapes":[49],"cerebellar":[50],"lineage":[51,105,150,178],"trajectories.":[52],"While":[53],"broadly":[55],"promotes":[56],"transient":[57],"overproliferation,":[58],"enhanced":[59],"biosynthesis":[60],"delayed":[62],"neural":[63],"maturation,":[64],"find":[66],"that":[67,95,117,146,161],"effects":[69],"insufficient":[71],"drive":[73],"tumorigenesis.":[74],"Instead,":[75],"tumorigenic":[76],"competence":[77],"is":[78,152],"restricted":[79],"a":[81,128,169],"discrete":[82],"population":[83],"ATOH1":[85],"+":[86],"isthmic":[87],"progenitors,":[88],"which":[89],"reproducibly":[90],"expands":[91,120],"into":[92],"extracerebellar":[93],"tumors":[94],"transcriptionally":[96],"resemble":[97],"SHH":[98],"medulloblastoma,":[99],"partially":[100],"recapitulating":[101],"granule":[103,131],"cell":[104,132],"hierarchy.":[106],"By":[107],"reconstructing":[108],"earliest":[110],"stages":[111],"tumor":[113,156],"initiation,":[114],"show":[116],"first":[119],"progenitors":[122],"then":[124],"redirects":[125],"them":[126],"toward":[127],"hybrid":[129],"PAX6\u207a":[130],"progenitor-like":[133],"state.":[134],"Blocking":[135],"PAX6":[136],"transcriptional":[137],"activity":[138],"abolishes":[139],"reprogrammed":[143],"population,":[144],"demonstrating":[145],"cooption":[147],"this":[149],"program":[151],"functionally":[153],"required":[154],"for":[155],"growth.":[157],"Our":[158],"findings":[159],"reveal":[160],"MYCN-induced":[162],"oncogenicity":[163],"in":[164],"cerebellum":[166],"proceeds":[167],"through":[168],"three-step":[170],"temporal":[171],"sequence":[172],"driven":[173],"by":[174],"erosion":[176],"restrictions.":[179]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-10T00:00:00"}
