{"id":"https://openalex.org/W7202087356","doi":"https://doi.org/10.1038/s43587-026-01197-w","title":"Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging","display_name":"Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202087356","doi":"https://doi.org/10.1038/s43587-026-01197-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42576025"},"language":"en","primary_location":{"id":"doi:10.1038/s43587-026-01197-w","doi":"https://doi.org/10.1038/s43587-026-01197-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s43587-026-01197-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210214063","display_name":"Nature Aging","issn_l":"2662-8465","issn":["2662-8465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-3","medline","norway-2","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Aging","raw_type":"journal-article"},"volume":null,"type":"other","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019495500","display_name":"Maziar Divangahi","orcid":"https://orcid.org/0000-0002-1254-6110","observed_orcids":["https://orcid.org/0000-0002-1254-6110"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Maziar Divangahi","raw_affiliation_strings":["Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada. Maziar.divangahi@mcgill.ca","McGill International TB Centre, McGill University Health Centre, Montreal, Quebec, Canada. Maziar.divangahi@mcgill.ca","Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada. Maziar.divangahi@mcgill.ca"],"raw_orcid":"https://orcid.org/0000-0002-1254-6110","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada. Maziar.divangahi@mcgill.ca","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"McGill International TB Centre, McGill University Health Centre, Montreal, Quebec, Canada. Maziar.divangahi@mcgill.ca","institution_ids":["https://openalex.org/I2801766832"]},{"raw_affiliation_string":"Meakins-Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada. Maziar.divangahi@mcgill.ca","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020638763","display_name":"Katherine Y. King","orcid":"https://orcid.org/0000-0002-5093-6005","observed_orcids":["https://orcid.org/0000-0002-5093-6005"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine Y. King","raw_affiliation_strings":["Division of Infectious Disease, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA. Katherine.king@bcm.edu","Stem Cells and Regenerative Medicine Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. Katherine.king@bcm.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Disease, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA. Katherine.king@bcm.edu","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"]},{"raw_affiliation_string":"Stem Cells and Regenerative Medicine Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. Katherine.king@bcm.edu","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019495500","https://openalex.org/A5020638763"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I2801766832","https://openalex.org/I4210147586","https://openalex.org/I5023651"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"9","first_page":"1747","last_page":"1749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trained-immunity","display_name":"trained immunity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sirt3","display_name":"SIRT3","score":0.847000002861023},{"id":"https://openalex.org/keywords/mitochondrial-deacetylase","display_name":"mitochondrial deacetylase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/age-related-physiological-decline","display_name":"age-related physiological decline","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6218000054359436},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6082000136375427},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5964999794960022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5795999765396118},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5590999722480774},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5519000291824341},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.536300003528595},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5333999991416931},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.42820000648498535},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33660000562667847},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3109000027179718},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.25440001487731934},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s43587-026-01197-w","doi":"https://doi.org/10.1038/s43587-026-01197-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s43587-026-01197-w","pdf_url":null,"source":{"id":"https://openalex.org/S4210214063","display_name":"Nature Aging","issn_l":"2662-8465","issn":["2662-8465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-3","medline","norway-2","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Aging","raw_type":"journal-article"},{"id":"pmid:42576025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42576025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2782649526","https://openalex.org/W2783329544","https://openalex.org/W2783711120","https://openalex.org/W2885738092","https://openalex.org/W3097788036","https://openalex.org/W3184907113","https://openalex.org/W4281715700","https://openalex.org/W4290069293","https://openalex.org/W4406179562","https://openalex.org/W4410859581","https://openalex.org/W4411556086","https://openalex.org/W4416649241","https://openalex.org/W7161133491","https://openalex.org/W7167223718","https://openalex.org/W7168608699"],"related_works":["https://openalex.org/W7168608699","https://openalex.org/W7128785127","https://openalex.org/W7167223718","https://openalex.org/W2913021614","https://openalex.org/W2898084205","https://openalex.org/W4414003125","https://openalex.org/W2062942017","https://openalex.org/W2230641108","https://openalex.org/W3198939037","https://openalex.org/W1977408830"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-08-10T00:00:00"}
