{"id":"https://openalex.org/W7202080065","doi":"https://doi.org/10.1177/10499091261474447","title":"Interventions for Xerostomia and Thirst in Adults Receiving Palliative and End-Of-Life Care: A Systematic Review With Synthesis Without Meta-Analysis","display_name":"Interventions for Xerostomia and Thirst in Adults Receiving Palliative and End-Of-Life Care: A Systematic Review With Synthesis Without Meta-Analysis","publication_year":2026,"publication_date":"2026-08-09","ids":{"openalex":"https://openalex.org/W7202080065","doi":"https://doi.org/10.1177/10499091261474447","pmid":"https://pubmed.ncbi.nlm.nih.gov/42572401"},"language":"en","primary_location":{"id":"doi:10.1177/10499091261474447","doi":"https://doi.org/10.1177/10499091261474447","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10499091261474447","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/10499091261474447?download=true","source":{"id":"https://openalex.org/S92692057","display_name":"American Journal of Hospice and Palliative Medicine\u00ae","issn_l":"1049-9091","issn":["1049-9091","1938-2715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hospice and Palliative Medicine\u00ae","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/10499091261474447?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121593197","display_name":"ANNA CAROLINE DE SOUSA BELO","orcid":"https://orcid.org/0009-0005-9087-8195","observed_orcids":["https://orcid.org/0009-0005-9087-8195"]},"institutions":[{"id":"https://openalex.org/I4210164671","display_name":"Hospital S\u00e3o Domingos","ror":"https://ror.org/05ng03c96","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210164671"]},{"id":"https://openalex.org/I47327664","display_name":"Universidade Federal do Maranh\u00e3o","ror":"https://ror.org/043fhe951","country_code":"BR","type":"education","lineage":["https://openalex.org/I47327664"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anna Caroline de Sousa Belo","raw_affiliation_strings":["Department of Nursing, Hospital S\u00e3o Domingos, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","Postgraduate Program in Adult Health, Universidade Federal do Maranh\u00e3o (UFMA)"],"raw_orcid":"https://orcid.org/0009-0005-9087-8195","affiliations":[{"raw_affiliation_string":"Department of Nursing, Hospital S\u00e3o Domingos, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210164671"]},{"raw_affiliation_string":"Postgraduate Program in Adult Health, Universidade Federal do Maranh\u00e3o (UFMA)","institution_ids":["https://openalex.org/I47327664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081786428","display_name":"Allan Bruno Alves de Sousa Santos","orcid":"https://orcid.org/0000-0001-6412-7164","observed_orcids":["https://orcid.org/0000-0001-6412-7164"]},"institutions":[{"id":"https://openalex.org/I4210164671","display_name":"Hospital S\u00e3o Domingos","ror":"https://ror.org/05ng03c96","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210164671"]},{"id":"https://openalex.org/I47327664","display_name":"Universidade Federal do Maranh\u00e3o","ror":"https://ror.org/043fhe951","country_code":"BR","type":"education","lineage":["https://openalex.org/I47327664"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Allan Bruno Alves de Sousa Santos","raw_affiliation_strings":["Department of Nursing, Hospital S\u00e3o Domingos, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","Postgraduate Program in Adult Health, Universidade Federal do Maranh\u00e3o (UFMA)"],"raw_orcid":"https://orcid.org/0000-0001-6412-7164","affiliations":[{"raw_affiliation_string":"Department of Nursing, Hospital S\u00e3o Domingos, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210164671"]},{"raw_affiliation_string":"Postgraduate Program in Adult Health, Universidade Federal do Maranh\u00e3o (UFMA)","institution_ids":["https://openalex.org/I47327664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081786428"],"corresponding_institution_ids":["https://openalex.org/I4210164671","https://openalex.org/I47327664"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"10499091261474447","last_page":"10499091261474447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10177","display_name":"Palliative Care and End-of-Life Issues","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10177","display_name":"Palliative Care and End-of-Life Issues","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13340","display_name":"Palliative and Oncologic Care","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":1.0},{"id":"https://openalex.org/keywords/thirst","display_name":"thirst","score":0.9580000042915344},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.9559999704360962},{"id":"https://openalex.org/keywords/end-of-life-care","display_name":"end-of-life care","score":1.0},{"id":"https://openalex.org/keywords/symptom-management","display_name":"symptom management","score":0.5680000185966492},{"id":"https://openalex.org/keywords/oral-care","display_name":"oral care","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C2778713406","wikidata":"https://www.wikidata.org/wiki/Q474187","display_name":"Thirst","level":2,"score":0.9412000179290771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8263000249862671},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.7526000142097473},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5960000157356262},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5116000175476074},{"id":"https://openalex.org/C2994186709","wikidata":"https://www.wikidata.org/wiki/Q29483","display_name":"Palliative care","level":2,"score":0.48420000076293945},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43560001254081726},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3774000108242035},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.3695000112056732},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3158999979496002},{"id":"https://openalex.org/C3017845882","wikidata":"https://www.wikidata.org/wiki/Q876776","display_name":"Fluid intake","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.29350000619888306},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C153997805","wikidata":"https://www.wikidata.org/wiki/Q42240","display_name":"Research ethics","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2572000026702881},{"id":"https://openalex.org/C2779318504","wikidata":"https://www.wikidata.org/wiki/Q1438035","display_name":"Research design","level":2,"score":0.2572000026702881}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/10499091261474447","doi":"https://doi.org/10.1177/10499091261474447","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10499091261474447","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/10499091261474447?download=true","source":{"id":"https://openalex.org/S92692057","display_name":"American Journal of Hospice and Palliative Medicine\u00ae","issn_l":"1049-9091","issn":["1049-9091","1938-2715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hospice and Palliative Medicine\u00ae","raw_type":"journal-article"},{"id":"pmid:42572401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42572401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of hospice & palliative care","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/10499091261474447","doi":"https://doi.org/10.1177/10499091261474447","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10499091261474447","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/10499091261474447?download=true","source":{"id":"https://openalex.org/S92692057","display_name":"American Journal of Hospice and Palliative Medicine\u00ae","issn_l":"1049-9091","issn":["1049-9091","1938-2715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hospice and Palliative Medicine\u00ae","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202080065.pdf","grobid_xml":"https://content.openalex.org/works/W7202080065.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1860065393","https://openalex.org/W1980224044","https://openalex.org/W2014828795","https://openalex.org/W2032506622","https://openalex.org/W2047519643","https://openalex.org/W2069945296","https://openalex.org/W2074768690","https://openalex.org/W2139031123","https://openalex.org/W2165010366","https://openalex.org/W2280130161","https://openalex.org/W2952341850","https://openalex.org/W2963352710","https://openalex.org/W2970684805","https://openalex.org/W2990648940","https://openalex.org/W3012687267","https://openalex.org/W3015856298","https://openalex.org/W3098553703","https://openalex.org/W3118615836","https://openalex.org/W3133017888","https://openalex.org/W4200079301","https://openalex.org/W4237667148","https://openalex.org/W4321487298","https://openalex.org/W4385648939"],"related_works":["https://openalex.org/W4321487298","https://openalex.org/W4399981612","https://openalex.org/W4385648939","https://openalex.org/W7116774450","https://openalex.org/W7010663786","https://openalex.org/W6965431891","https://openalex.org/W4387582303","https://openalex.org/W7112525618","https://openalex.org/W2139031123","https://openalex.org/W4210628744"],"abstract_inverted_index":{"BackgroundXerostomia":[0],"and":[1,8,36,42,74,87,101,133,163,180,204],"thirst":[2,37,205],"are":[3,202],"among":[4],"the":[5,15,26,32,82,126,136,152,167],"most":[6],"prevalent":[7],"distressing":[9],"symptoms":[10],"in":[11,20,38,140,160,166],"palliative":[12,41],"care,":[13,144],"yet":[14],"effectiveness":[16,27],"of":[17,28,34,77,85,90,151,156,170,181],"relieving":[18],"interventions":[19,30],"this":[21],"population":[22],"remains":[23,206],"uncertain.ObjectiveTo":[24],"evaluate":[25],"symptomatic":[29],"on":[31],"intensity":[33],"xerostomia":[35],"adults":[39],"receiving":[40],"end-of-life":[43],"care.DesignSystematic":[44],"review":[45],"with":[46],"synthesis":[47,179],"without":[48],"meta-analysis":[49],"(SWiM),":[50],"reported":[51],"per":[52],"PRISMA":[53],"2020.MethodsWe":[54],"searched":[55],"five":[56,119],"databases":[57],"from":[58],"inception":[59],"to":[60,190,195],"June":[61],"2026":[62],"for":[63,116,122,177],"randomized":[64],"controlled":[65],"trials.":[66],"Two":[67],"reviewers":[68],"independently":[69],"selected":[70],"studies,":[71],"extracted":[72],"data,":[73],"assessed":[75],"risk":[76],"bias":[78,157],"(RoB":[79],"2).":[80],"Given":[81],"small":[83],"number":[84],"studies":[86],"incomplete":[88],"reporting":[89],"dispersion":[91],"measures,":[92],"data":[93,115],"were":[94,98,109],"not":[95],"imputed;":[96],"results":[97],"synthesized":[99],"narratively":[100],"structured":[102,191],"by":[103],"comparator":[104],"type.ResultsSix":[105],"trials":[106,120,147,162,201],"(235":[107],"participants)":[108],"included.":[110],"No":[111],"outcome":[112],"had":[113],"sufficient":[114],"meta-analysis.":[117],"Of":[118],"evaluable":[121],"xerostomia,":[123],"two":[124],"favored":[125,135],"intervention,":[127],"three":[128,161],"showed":[129,148],"no":[130,149],"clear":[131],"difference,":[132],"none":[134],"comparator.":[137],"Benefit":[138],"clustered":[139],"comparisons":[141],"against":[142],"usual":[143],"whereas":[145],"placebo-controlled":[146],"advantage":[150],"active":[153],"agent.":[154,198],"Risk":[155],"was":[158,172],"high":[159],"raised":[164],"concerns":[165],"remainder;":[168],"certainty":[169],"evidence":[171],"very":[173,182],"low.ConclusionsEvidence":[174],"is":[175],"insufficient":[176],"quantitative":[178],"low":[183],"certainty.":[184],"Symptom":[185],"improvement":[186],"appears":[187],"more":[188],"attributable":[189],"oral":[192],"care":[193],"than":[194],"any":[196],"specific":[197],"Larger,":[199],"better-reported":[200],"needed,":[203],"markedly":[207],"understudied.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-10T00:00:00"}
