{"id":"https://openalex.org/W7202071695","doi":"https://doi.org/10.64898/2026.08.09.26359976","title":"Genomically Adjusted Radiation Dose Predicts Outcomes in Pediatric Brain Tumors and Supports Biologically Personalized Radiotherapy","display_name":"Genomically Adjusted Radiation Dose Predicts Outcomes in Pediatric Brain Tumors and Supports Biologically Personalized Radiotherapy","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202071695","doi":"https://doi.org/10.64898/2026.08.09.26359976"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.09.26359976","doi":"https://doi.org/10.64898/2026.08.09.26359976","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.09.26359976","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.09.26359976.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.09.26359976.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018865657","display_name":"Nikhil Joshi","orcid":"https://orcid.org/0000-0001-9258-4960","observed_orcids":["https://orcid.org/0000-0001-9258-4960"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Joshi","raw_affiliation_strings":["Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0001-9258-4960","affiliations":[{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022972017","display_name":"Drew T. Bergman","orcid":"https://orcid.org/0000-0002-8314-7088","observed_orcids":["https://orcid.org/0000-0002-8314-7088"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew Bergman","raw_affiliation_strings":["Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-8314-7088","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063335628","display_name":"Shivani Nellore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivani Nellore","raw_affiliation_strings":["Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146960584","display_name":"Peng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Chen","raw_affiliation_strings":["Department of Physics, Case Western Reserve University, Cleveland, OH, USA","Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147046388","display_name":"Erin Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Murphy","raw_affiliation_strings":["Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102780197","display_name":"Saad Sheikh","orcid":"https://orcid.org/0000-0002-8303-6070","observed_orcids":["https://orcid.org/0000-0002-8303-6070"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saad Sheikh","raw_affiliation_strings":["Department of Radiation Oncology, University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh PA","institution_ids":["https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065983314","display_name":"Michael Joseph Lariviere","orcid":"https://orcid.org/0000-0002-1662-5086","observed_orcids":["https://orcid.org/0000-0002-1662-5086"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael LaRiviere","raw_affiliation_strings":["Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1662-5086","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027053969","display_name":"Jessica Foster","orcid":"https://orcid.org/0000-0002-8001-5960","observed_orcids":["https://orcid.org/0000-0002-8001-5960"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Foster","raw_affiliation_strings":["Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","Division of Oncology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Oncology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026750626","display_name":"Jill Durkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Durkin","raw_affiliation_strings":["Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057545891","display_name":"Anuoluwapo Ajao","orcid":"https://orcid.org/0000-0001-6057-1276","observed_orcids":["https://orcid.org/0000-0001-6057-1276"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuoluwapo Ajao","raw_affiliation_strings":["Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA","School of Medicine, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"School of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119827687","display_name":"Thomas Matulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Matulis","raw_affiliation_strings":["Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089165680","display_name":"Ronica H. Nanda","orcid":"https://orcid.org/0000-0002-3748-8674","observed_orcids":["https://orcid.org/0000-0002-3748-8674"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronica Nanda","raw_affiliation_strings":["Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060238737","display_name":"Kosj Yamoah","orcid":"https://orcid.org/0000-0001-9055-3538","observed_orcids":["https://orcid.org/0000-0001-9055-3538"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kosj Yamoah","raw_affiliation_strings":["Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076875996","display_name":"Stacie L. Stapleton","orcid":"https://orcid.org/0000-0001-6459-4360","observed_orcids":["https://orcid.org/0000-0001-6459-4360"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210098865","display_name":"Johns Hopkins All Children's Hospital","ror":"https://ror.org/013x5cp73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210098865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacie Stapleton","raw_affiliation_strings":["University of South Florida, Johns Hopkins Medicine, Johns Hopkins All Children\u2019s Hospital, Cancer and Blood Disorders Institute, St Petersburg, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Johns Hopkins Medicine, Johns Hopkins All Children\u2019s Hospital, Cancer and Blood Disorders Institute, St Petersburg, FL, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2613432","https://openalex.org/I4210098865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135202251","display_name":"Chris J. Beltran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Beltran","raw_affiliation_strings":["Department of Medical Physics, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086603901","display_name":"Steven A. Eschrich","orcid":"https://orcid.org/0000-0002-9833-2788","observed_orcids":["https://orcid.org/0000-0002-9833-2788"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven A. Eschrich","raw_affiliation_strings":["Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137452123","display_name":"Javier F. Torres-Roca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier F. Torres-Roca","raw_affiliation_strings":["Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024863178","display_name":"Jacob G. Scott","orcid":"https://orcid.org/0000-0003-2971-7673","observed_orcids":["https://orcid.org/0000-0003-2971-7673"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jacob G. Scott","raw_affiliation_strings":["Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA","Department of Physics, Case Western Reserve University, Cleveland, OH, USA","Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA","School of Medicine, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Department of Physics, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"School of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5024863178"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I36373038","https://openalex.org/I4405287411","https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-radiosensitivity","display_name":"tumor radiosensitivity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.7649999856948853},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":1.0},{"id":"https://openalex.org/keywords/ependymoma","display_name":"ependymoma","score":1.0},{"id":"https://openalex.org/keywords/linear-quadratic-model","display_name":"linear-quadratic model","score":0.8659999966621399},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6100000143051147},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.781000018119812},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/personalized-radiotherapy","display_name":"personalized radiotherapy","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8799999952316284},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7623000144958496},{"id":"https://openalex.org/C2781432949","wikidata":"https://www.wikidata.org/wiki/Q1346753","display_name":"Ependymoma","level":2,"score":0.593999981880188},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5634999871253967},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.534500002861023},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.45899999141693115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4323999881744385},{"id":"https://openalex.org/C2987700449","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Radiation dose","level":2,"score":0.35899999737739563},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.352400004863739},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.34200000762939453},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3140999972820282},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.27630001306533813},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.257099986076355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.09.26359976","doi":"https://doi.org/10.64898/2026.08.09.26359976","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.09.26359976","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.09.26359976.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.09.26359976","doi":"https://doi.org/10.64898/2026.08.09.26359976","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.09.26359976","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.09.26359976.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202071695.pdf","grobid_xml":"https://content.openalex.org/works/W7202071695.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7165738633","https://openalex.org/W3209155972","https://openalex.org/W2566074209","https://openalex.org/W3209491034","https://openalex.org/W4206905321","https://openalex.org/W3191762479","https://openalex.org/W4413972235","https://openalex.org/W2591807412","https://openalex.org/W3094085867","https://openalex.org/W2896799944"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Radiotherapy":[2],"is":[3,27,69,266],"a":[4,74,102,147,219,224],"cornerstone":[5],"of":[6,54,115,235,263],"treatment":[7],"for":[8,31],"pediatric":[9,66,84,229],"central":[10],"nervous":[11],"system":[12],"(CNS)":[13],"tumors,":[14,231],"but":[15],"dose":[16,40,48,109,120,158,196,246,259],"selection":[17],"remains":[18],"uniform":[19,252],"despite":[20],"interpatient":[21,165],"variability":[22,166],"in":[23,29,65,167,276],"tumor":[24,43,135,270],"radiosensitivity.":[25],"This":[26],"consequential":[28],"children,":[30],"whom":[32],"toxicity":[33,275],"can":[34],"have":[35],"lifelong":[36],"effects.":[37],"Genomic-adjusted":[38],"radiation":[39,47,108,119],"(GARD)":[41],"integrates":[42],"genomics":[44],"with":[45,86,107,121,174,200,214,242],"delivered":[46],"to":[49,268],"quantify":[50],"the":[51,93,111,232],"biological":[52,168,233],"effect":[53,234],"radiotherapy":[55,145,236,253,265],"and":[56,80,117,123,137,186,255],"has":[57],"been":[58],"validated":[59],"across":[60],"adult":[61],"malignancies.":[62],"Its":[63],"relevance":[64],"CNS":[67,230],"tumors":[68],"unknown.":[70],"Methods":[71],"We":[72],"performed":[73],"cohort":[75,150],"study":[76],"using":[77,101,128],"gene":[78],"expression":[79],"data":[81],"from":[82,92],"246":[83],"patients":[85,154,204],"high-grade":[87],"glioma,":[88],"medulloblastoma,":[89],"or":[90],"ependymoma":[91],"Children\u2019s":[94],"Brain":[95],"Tumor":[96],"Network.":[97],"GARD":[98,116,162,171,217,239],"was":[99,159,172,197,211,240,247],"calculated":[100],"sequencing-adapted":[103],"radiosensitivity":[104],"index":[105],"integrated":[106],"through":[110],"linear\u2013quadratic":[112],"model.":[113],"Associations":[114],"physical":[118,157,245],"event-free":[122,176],"overall":[124,187],"survival":[125,177,188],"were":[126],"evaluated":[127],"Cox":[129],"proportional":[130],"hazards":[131],"models":[132],"stratified":[133],"by":[134,238],"type":[136],"anatomic":[138],"location.":[139],"Patients":[140],"who":[141,205],"did":[142,206],"not":[143,198,207,212],"receive":[144,208],"comprised":[146],"negative":[148],"control":[149,271],"(sham-GARD).":[151],"Results":[152],"Among":[153,203],"receiving":[155],"radiotherapy,":[156,209],"uniform,":[160],"whereas":[161,244],"showed":[163],"substantial":[164],"effect.":[169],"Higher":[170],"associated":[173,199,213,241],"improved":[175],"(hazard":[178],"ratio":[179],"[HR]":[180],"0\u00b790,":[181,190],"95%":[182,191],"CI":[183,192],"0\u00b783\u20130\u00b797;":[184],"p=0\u00b7004)":[185],"(HR":[189],"0\u00b783\u20130\u00b799;":[193],"p=0\u00b7018).":[194],"Physical":[195],"either":[201],"endpoint.":[202],"sham-GARD":[210],"outcomes,":[215,243],"supporting":[216],"as":[218],"treatment-specific":[220],"predictor":[221],"rather":[222],"than":[223],"prognostic":[225],"biomarker.":[226],"Conclusions":[227],"In":[228],"quantified":[237],"not.":[248],"These":[249],"findings":[250],"challenge":[251],"dosing":[254],"support":[256],"genomically":[257],"informed":[258],"individualization.":[260],"Prospective":[261],"evaluation":[262],"GARD-guided":[264],"warranted":[267],"optimize":[269],"while":[272],"minimizing":[273],"long-term":[274],"children.":[277]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-10T00:00:00"}
