{"id":"https://openalex.org/W7202071065","doi":"https://doi.org/10.1093/bjs/znag093.002","title":"Circulating tumor cells in the prospective clinical study SCAN-B-loc for breast cancer patients with local recurrence","display_name":"Circulating tumor cells in the prospective clinical study SCAN-B-loc for breast cancer patients with local recurrence","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7202071065","doi":"https://doi.org/10.1093/bjs/znag093.002"},"language":"en","primary_location":{"id":"doi:10.1093/bjs/znag093.002","doi":"https://doi.org/10.1093/bjs/znag093.002","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bjs/znag093.002","pdf_url":"https://academic.oup.com/bjs/article-pdf/113/Supplement_9/znag093.002/70602585/znag093.002.pdf","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bjs/article-pdf/113/Supplement_9/znag093.002/70602585/znag093.002.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146703141","display_name":"Amanda Falkenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Amanda Falkenberg","raw_affiliation_strings":["Department of Surgery/Oncology, Lund University , Lund ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery/Oncology, Lund University , Lund ,","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073001719","display_name":"Tommaso De Marchi","orcid":"https://orcid.org/0000-0002-4845-1084","observed_orcids":["https://orcid.org/0000-0002-4845-1084"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tommaso De Marchi","raw_affiliation_strings":["Department of Surgery/Oncology, Lund University , Lund ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery/Oncology, Lund University , Lund ,","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058989650","display_name":"Cecilia Magnusson","orcid":"https://orcid.org/0000-0002-0186-7736","observed_orcids":["https://orcid.org/0000-0002-0186-7736"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Cecilia Magnusson","raw_affiliation_strings":["Department of Translational Medicine, Lund University , Malm\u00f6 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Medicine, Lund University , Malm\u00f6 ,","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032035385","display_name":"Linnea Huss","orcid":"https://orcid.org/0000-0002-8597-9224","observed_orcids":["https://orcid.org/0000-0002-8597-9224"]},"institutions":[{"id":"https://openalex.org/I4210132623","display_name":"Helsingborgs lasarett","ror":"https://ror.org/03am3jt82","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210132623"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Linnea Huss","raw_affiliation_strings":["Department of Surgery, Helsingborg General Hospital , Helsingborg ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Helsingborg General Hospital , Helsingborg ,","institution_ids":["https://openalex.org/I4210132623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136332495","display_name":"Laila Shakhtour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150155","display_name":"Centralsjukhuset Kristianstad","ror":"https://ror.org/04sn2hb78","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210150155"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Laila Shakhtour","raw_affiliation_strings":["Department of Surgery, Kristianstad Central Hospital , Kristianstad ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kristianstad Central Hospital , Kristianstad ,","institution_ids":["https://openalex.org/I4210150155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013097988","display_name":"Ana Bosch Campos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ana Bosch Campos","raw_affiliation_strings":["Department of Oncology, Sk\u00e5ne University Hospital , Lund ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Sk\u00e5ne University Hospital , Lund ,","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053411065","display_name":"Thomas Laurell","orcid":"https://orcid.org/0000-0002-2486-3607","observed_orcids":["https://orcid.org/0000-0002-2486-3607"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Laurell","raw_affiliation_strings":["Department of Biomedical Engineering, Lund University , Lund ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Lund University , Lund ,","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014246482","display_name":"Emma Nim\u00e9us","orcid":"https://orcid.org/0000-0003-0262-9083","observed_orcids":["https://orcid.org/0000-0003-0262-9083"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Emma Nim\u00e9us","raw_affiliation_strings":["Department of Surgery, Sk\u00e5ne University Hospital , Malm\u00f6 ,","Department of Surgery/Oncology, Lund University , Lund ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Sk\u00e5ne University Hospital , Malm\u00f6 ,","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Surgery/Oncology, Lund University , Lund ,","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3797,"currency":"GBP","value_usd":5007},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"113","issue":"Supplement_9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4503999948501587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4503999948501587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.33980000019073486,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.10639999806880951,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acoustophoresis","display_name":"acoustophoresis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ctc-enrichment","display_name":"CTC enrichment","score":0.7300000190734863},{"id":"https://openalex.org/keywords/ctc-clusters","display_name":"CTC clusters","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ki-67-expression","display_name":"Ki-67 expression","score":0.7770000100135803},{"id":"https://openalex.org/keywords/t-stage","display_name":"T stage","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lymph-node-involvement","display_name":"lymph node involvement","score":0.6790000200271606},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9513999819755554},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.90420001745224},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7163000106811523},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6915000081062317},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6794000267982483},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6294000148773193},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.42910000681877136},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C2987828669","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical study","level":2,"score":0.37790000438690186},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.32120001316070557},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30399999022483826},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.301800012588501},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C118646709","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA15-3","level":4,"score":0.2540999948978424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/bjs/znag093.002","doi":"https://doi.org/10.1093/bjs/znag093.002","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bjs/znag093.002","pdf_url":"https://academic.oup.com/bjs/article-pdf/113/Supplement_9/znag093.002/70602585/znag093.002.pdf","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/bjs/znag093.002","doi":"https://doi.org/10.1093/bjs/znag093.002","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bjs/znag093.002","pdf_url":"https://academic.oup.com/bjs/article-pdf/113/Supplement_9/znag093.002/70602585/znag093.002.pdf","source":{"id":"https://openalex.org/S61740008","display_name":"British journal of surgery","issn_l":"0007-1323","issn":["0007-1323","1365-2168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7202071065.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006435270","https://openalex.org/W1966365049","https://openalex.org/W2887812668","https://openalex.org/W4405531394","https://openalex.org/W2030585483","https://openalex.org/W6902385172","https://openalex.org/W2395906155","https://openalex.org/W2391982256","https://openalex.org/W6939975649","https://openalex.org/W3007131738"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"SCAN-B-loc":[2,76],"is":[3],"a":[4,63,136,215,247],"prospective":[5,69],"clinical":[6,231],"study":[7,70,77],"for":[8,24],"breast":[9,43,221],"cancer":[10],"patients":[11,73,132],"with":[12,16,190,236],"local":[13],"recurrences":[14,28],"(LR)":[15],"the":[17,48,75,100,139,182,239],"purpose":[18],"to":[19,56],"find":[20],"new":[21,30],"blood-based":[22],"markers":[23,40],"LR":[25,61],"and":[26,29,50,84,118,122,133,159,164,177,230,243],"distant":[27],"treatment":[31],"strategies.":[32],"Circulating":[33],"tumor":[34],"cells":[35],"(CTCs)":[36],"are":[37,54],"established":[38],"prognostic":[39],"in":[41,60,105,130,135,173,214,246],"metastatic":[42],"cancer.":[44,222],"We":[45],"investigated":[46],"whether":[47],"number":[49],"characteristics":[51],"of":[52,138,184,218],"CTCs":[53,79,129,172,198],"linked":[55],"adverse":[57],"clinicopathological":[58,116],"variables":[59,117,232],"using":[62,82],"novel":[64],"enrichment":[65],"method.":[66],"Methods":[67],"This":[68],"included":[71],"25":[72],"from":[74,108],"(2024\u20132026).":[78],"were":[80,97,113,153,199],"enriched":[81],"acoustophoresis":[83],"classified":[85],"as":[86],"classic":[87],"CTCs,":[88,90],"EpCAM-low":[89,197],"CTC":[91,119,144,157,185,211,228],"clusters,":[92],"or":[93],"CTC-WBC":[94],"clusters.":[95],"Cutoffs":[96],"defined":[98],"by":[99],"highest":[101],"cell":[102],"count":[103,145],"found":[104],"blood":[106],"samples":[107],"healthy":[109],"donors.":[110],"Primary":[111],"outcomes":[112],"associations":[114],"between":[115,155,227],"counts":[120,158,229],"(total":[121],"subpopulations).":[123],"Results":[124],"The":[125,141,223],"method":[126],"successfully":[127],"identified":[128],"all":[131],"subpopulations":[134,212],"majority":[137],"cohort.":[140,249],"median":[142],"total":[143,156],"was":[146,187],"12":[147],"(range":[148],"2\u2013119).":[149],"Significant":[150],"inverse":[151,225],"correlations":[152,226],"observed":[154],"T-stage":[160],"(P":[161,167,194],"=":[162,168,195],"0.008)":[163],"Ki67":[165],"expression":[166],"0.047),":[169],"indicating":[170],"fewer":[171],"more":[174],"advanced":[175],"stages":[176],"highly":[178],"proliferative":[179],"tumors.":[180],"Furthermore,":[181],"presence":[183],"clusters":[186],"significantly":[188],"associated":[189],"no":[191,204],"nodal":[192],"involvement":[193],"0.018).":[196],"frequently":[200],"detected":[201,210],"but":[202],"showed":[203],"significant":[205],"correlations.":[206],"Discussion":[207],"Acoustophoresis":[208],"effectively":[209],"even":[213],"patient":[216],"cohort":[217,241],"not":[219],"disseminated":[220],"unexpected":[224],"should":[233],"be":[234],"interpreted":[235],"caution":[237],"given":[238],"limited":[240],"size":[242],"require":[244],"validation":[245],"larger":[248]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-08-10T00:00:00"}