{"id":"https://openalex.org/W7202070936","doi":"https://doi.org/10.1021/acs.joc.6c02226","title":"Expanding the Reactivity of Bifunctional Reagents: Photoinduced Access to Imino Carbonyl Compounds and Tetrahydrofurans","display_name":"Expanding the Reactivity of Bifunctional Reagents: Photoinduced Access to Imino Carbonyl Compounds and Tetrahydrofurans","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7202070936","doi":"https://doi.org/10.1021/acs.joc.6c02226"},"language":"en","primary_location":{"id":"doi:10.1021/acs.joc.6c02226","doi":"https://doi.org/10.1021/acs.joc.6c02226","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.joc.6c02226","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.joc.6c02226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037816388","display_name":"Aida Jaafar","orcid":"https://orcid.org/0000-0001-6420-1897","observed_orcids":["https://orcid.org/0000-0001-6420-1897"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Aida Jaafar","raw_affiliation_strings":["Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146801844","display_name":"Andrea D\u00e1vila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andrea D\u00e1vila","raw_affiliation_strings":["Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,"],"raw_orcid":"https://orcid.org/0009-0008-3147-6673","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146667971","display_name":"Christian Alconchel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Christian Alconchel","raw_affiliation_strings":["Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,"],"raw_orcid":"https://orcid.org/0009-0003-9192-8911","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048133699","display_name":"Mar\u00eda Jes\u00fas Cabrera\u2010Afonso","orcid":"https://orcid.org/0000-0002-3736-3206","observed_orcids":["https://orcid.org/0000-0002-3736-3206"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda J. Cabrera-Afonso","raw_affiliation_strings":["Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","University of Valencia , , Avda. Vicent Andr\u00e9s Estell\u00e9s 22 , , ,"],"raw_orcid":"https://orcid.org/0000-0002-3736-3206","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"University of Valencia , , Avda. Vicent Andr\u00e9s Estell\u00e9s 22 , , ,","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011514503","display_name":"M. Ribagorda","orcid":"https://orcid.org/0000-0001-7185-4095","observed_orcids":["https://orcid.org/0000-0001-7185-4095"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Ribagorda","raw_affiliation_strings":["Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","Institute for Advanced Research in Chemical Sciences (IAdChem) , , ,"],"raw_orcid":"https://orcid.org/0000-0001-7185-4095","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM) , , ,","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Institute for Advanced Research in Chemical Sciences (IAdChem) , , ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13253","display_name":"Photolysis and Reactive Intermediates","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12570","display_name":"Photopolymerization techniques and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkoxy-radicals","display_name":"alkoxy radicals","score":0.9110000133514404},{"id":"https://openalex.org/keywords/iminyl-radicals","display_name":"iminyl radicals","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tetrahydrofuran","display_name":"tetrahydrofuran","score":0.9570000171661377},{"id":"https://openalex.org/keywords/beta-scission","display_name":"\u03b2-scission","score":0.8709999918937683},{"id":"https://openalex.org/keywords/visible-light-photocatalysis","display_name":"visible light photocatalysis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/radical-chain-mechanism","display_name":"radical chain mechanism","score":0.5529999732971191},{"id":"https://openalex.org/keywords/energy-transfer","display_name":"energy transfer","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2780443040","wikidata":"https://www.wikidata.org/wiki/Q3737863","display_name":"Bifunctional","level":3,"score":0.8651000261306763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8141999840736389},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.7601000070571899},{"id":"https://openalex.org/C2776254738","wikidata":"https://www.wikidata.org/wiki/Q81406","display_name":"Alkene","level":3,"score":0.7189000248908997},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.6769999861717224},{"id":"https://openalex.org/C90150868","wikidata":"https://www.wikidata.org/wiki/Q39513","display_name":"Alkoxy group","level":3,"score":0.6333000063896179},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5234000086784363},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.4410000145435333},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.3653999865055084},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31209999322891235},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.30489999055862427},{"id":"https://openalex.org/C190667039","wikidata":"https://www.wikidata.org/wiki/Q3738104","display_name":"Chemoselectivity","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C169912494","wikidata":"https://www.wikidata.org/wiki/Q1994007","display_name":"Nitroxide mediated radical polymerization","level":5,"score":0.262800008058548},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C2777332933","wikidata":"https://www.wikidata.org/wiki/Q170409","display_name":"Functional group","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.joc.6c02226","doi":"https://doi.org/10.1021/acs.joc.6c02226","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.joc.6c02226","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv.15007244/v1","doi":"https://doi.org/10.26434/chemrxiv.15007244/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15007244/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1021/acs.joc.6c02226","doi":"https://doi.org/10.1021/acs.joc.6c02226","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.joc.6c02226","pdf_url":null,"source":{"id":"https://openalex.org/S205050996","display_name":"The Journal of Organic Chemistry","issn_l":"0022-3263","issn":["0022-3263","1520-6904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Organic Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W2059538074","https://openalex.org/W2257141273","https://openalex.org/W2515171599","https://openalex.org/W2526888048","https://openalex.org/W2557188228","https://openalex.org/W2781335263","https://openalex.org/W2785830129","https://openalex.org/W2885117403","https://openalex.org/W2886605610","https://openalex.org/W2895180111","https://openalex.org/W2895338435","https://openalex.org/W2899001868","https://openalex.org/W2911107095","https://openalex.org/W2921315508","https://openalex.org/W2923064950","https://openalex.org/W2944163934","https://openalex.org/W2963924723","https://openalex.org/W2963975056","https://openalex.org/W2992139016","https://openalex.org/W3003715675","https://openalex.org/W3005835005","https://openalex.org/W3013629528","https://openalex.org/W3013818783","https://openalex.org/W3087029581","https://openalex.org/W3204337960","https://openalex.org/W3212555056","https://openalex.org/W4232028199","https://openalex.org/W4234059794","https://openalex.org/W4289261136","https://openalex.org/W4292367777","https://openalex.org/W4380363113","https://openalex.org/W4390539886","https://openalex.org/W4393903105","https://openalex.org/W4399431944","https://openalex.org/W4400042365","https://openalex.org/W4400682672","https://openalex.org/W4401949825","https://openalex.org/W4403299914","https://openalex.org/W4403597625","https://openalex.org/W4403879592","https://openalex.org/W4408098219"],"related_works":["https://openalex.org/W7202255021","https://openalex.org/W4407982594","https://openalex.org/W4321748216","https://openalex.org/W4388487296","https://openalex.org/W2833321390","https://openalex.org/W4413450037","https://openalex.org/W7161819705","https://openalex.org/W3119446891","https://openalex.org/W4234948557","https://openalex.org/W2807024249"],"abstract_inverted_index":{"Abstract":[0],"Alkoxy":[1],"radicals":[2,74],"are":[3,86],"versatile":[4],"intermediates":[5],"capable":[6],"of":[7,17,33,57,123],"engaging":[8],"in":[9,50,119],"diverse":[10],"reaction":[11],"pathways;":[12],"however,":[13],"the":[14,30,53,69,120],"selective":[15],"exploitation":[16],"their":[18],"reactivity":[19],"under":[20],"mild":[21],"conditions":[22],"remains":[23],"a":[24],"significant":[25],"challenge.":[26],"Herein,":[27],"we":[28],"expand":[29],"synthetic":[31],"utility":[32],"N-oxime-derived":[34],"bifunctional":[35,70],"radical":[36,43,55],"reagents":[37],"by":[38,89],"exploiting":[39],"two":[40],"complementary":[41],"alkoxy":[42,73],"pathways,":[44],"\u03b2-scission":[45,78],"and":[46,92,109,115,126],"intramolecular":[47],"alkene":[48],"cyclization,":[49],"combination":[51],"with":[52,95,111],"metal-free":[54],"1,2-carboimination":[56],"activated":[58,90],"alkenes.":[59],"Under":[60],"visible-light":[61],"irradiation":[62],"using":[63],"5CzBN":[64],"as":[65],"an":[66,131],"organic":[67],"photocatalyst,":[68],"precursors":[71],"generate":[72],"that":[75],"undergo":[76],"substrate-controlled":[77],"or":[79],"cyclization":[80],"to":[81,104],"produce":[82],"carbon-centered":[83],"radicals,":[84],"which":[85],"regioselectively":[87],"trapped":[88],"alkenes":[91],"subsequently":[93],"coupled":[94],"iminyl":[96],"radicals.":[97],"This":[98],"modular":[99],"strategy":[100],"provides":[101],"direct":[102],"access":[103],"remotely":[105],"imino-functionalized":[106],"carbonyl":[107],"compounds":[108],"tetrahydrofurans":[110],"broad":[112],"substrate":[113],"scope":[114],"excellent":[116],"chemoselectivity,":[117],"including":[118],"late-stage":[121],"functionalization":[122],"complex":[124],"biomolecules":[125],"pharmaceuticals.":[127],"Mechanistic":[128],"studies":[129],"support":[130],"energy-transfer-initiated":[132],"radical-chain":[133],"mechanism.":[134]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-10T00:00:00"}