{"id":"https://openalex.org/W7202050402","doi":"https://doi.org/10.3389/fauot.2026.1872446","title":"Polygenic risk for hearing abilities and longitudinal cognitive outcomes in older adults","display_name":"Polygenic risk for hearing abilities and longitudinal cognitive outcomes in older adults","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202050402","doi":"https://doi.org/10.3389/fauot.2026.1872446"},"language":"en","primary_location":{"id":"doi:10.3389/fauot.2026.1872446","doi":"https://doi.org/10.3389/fauot.2026.1872446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fauot.2026.1872446","pdf_url":"https://www.frontiersin.org/journals/audiology-and-otology/articles/10.3389/fauot.2026.1872446/pdf","source":{"id":"https://openalex.org/S4387287097","display_name":"Frontiers in Audiology and Otology","issn_l":"2813-6055","issn":["2813-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Audiology and Otology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/audiology-and-otology/articles/10.3389/fauot.2026.1872446/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012869954","display_name":"Uzma Shaheen Akhtar","orcid":"https://orcid.org/0000-0002-2923-3583","observed_orcids":["https://orcid.org/0000-0002-2923-3583"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Uzma S. Akhtar","raw_affiliation_strings":["Emerging Auditory Research Lab, Department of Communication Disorders and Sciences, Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging Auditory Research Lab, Department of Communication Disorders and Sciences, Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011843654","display_name":"Shinya Tasaki","orcid":"https://orcid.org/0000-0003-3656-7394","observed_orcids":["https://orcid.org/0000-0003-3656-7394"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinya Tasaki","raw_affiliation_strings":["Department of Neurological Sciences, Rush University","Rush Alzheimer's Disease Center, Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University","institution_ids":["https://openalex.org/I49886154"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101861093","display_name":"Jingyun Yang","orcid":"https://orcid.org/0000-0002-2289-2666","observed_orcids":["https://orcid.org/0000-0002-2289-2666"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingyun Yang","raw_affiliation_strings":["Department of Neurological Sciences, Rush University","Rush Alzheimer's Disease Center, Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University","institution_ids":["https://openalex.org/I49886154"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070294274","display_name":"Sue E. Leurgans","orcid":"https://orcid.org/0000-0003-2536-1665","observed_orcids":["https://orcid.org/0000-0003-2536-1665"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue E. Leurgans","raw_affiliation_strings":["Department of Neurological Sciences, Rush University","Rush Alzheimer's Disease Center, Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, Rush University","institution_ids":["https://openalex.org/I49886154"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074131748","display_name":"Valeriy Shafiro","orcid":"https://orcid.org/0000-0002-5722-748X","observed_orcids":["https://orcid.org/0000-0002-5722-748X"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeriy Shafiro","raw_affiliation_strings":["Emerging Auditory Research Lab, Department of Communication Disorders and Sciences, Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging Auditory Research Lab, Department of Communication Disorders and Sciences, Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022309484","display_name":"Raj C. Shah","orcid":"https://orcid.org/0000-0001-9706-9730","observed_orcids":["https://orcid.org/0000-0001-9706-9730"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj C. Shah","raw_affiliation_strings":["Department of Family and Preventive Medicine, Rush University","Rush Alzheimer's Disease Center, Rush University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Preventive Medicine, Rush University","institution_ids":["https://openalex.org/I49886154"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center, Rush University","institution_ids":["https://openalex.org/I49886154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012869954"],"corresponding_institution_ids":["https://openalex.org/I49886154"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5964532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8759999871253967},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7760000228881836},{"id":"https://openalex.org/keywords/polygenic-risk","display_name":"polygenic risk","score":0.8980000019073486},{"id":"https://openalex.org/keywords/central-auditory-processing","display_name":"central auditory processing","score":0.7129999995231628},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pure-tone-audiometry","display_name":"pure tone audiometry","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cognitive-screening","display_name":"cognitive screening","score":0.48100000619888306},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.8331999778747559},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.6707000136375427},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.6111999750137329},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5645999908447266},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5037000179290771},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.3734000027179718},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.33799999952316284},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3000999987125397},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C2780801066","wikidata":"https://www.wikidata.org/wiki/Q323808","display_name":"Hearing aid","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C99209842","wikidata":"https://www.wikidata.org/wiki/Q643696","display_name":"Speech perception","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C134290984","wikidata":"https://www.wikidata.org/wiki/Q5141241","display_name":"Cognitive skill","level":3,"score":0.2524999976158142},{"id":"https://openalex.org/C2780566141","wikidata":"https://www.wikidata.org/wiki/Q3065932","display_name":"Cognitive disorder","level":4,"score":0.2515999972820282}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fauot.2026.1872446","doi":"https://doi.org/10.3389/fauot.2026.1872446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fauot.2026.1872446","pdf_url":"https://www.frontiersin.org/journals/audiology-and-otology/articles/10.3389/fauot.2026.1872446/pdf","source":{"id":"https://openalex.org/S4387287097","display_name":"Frontiers in Audiology and Otology","issn_l":"2813-6055","issn":["2813-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Audiology and Otology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f81bb7c4fe7046468e1b8e9285abb0cc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f81bb7c4fe7046468e1b8e9285abb0cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Audiology and Otology, Vol 4 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fauot.2026.1872446","doi":"https://doi.org/10.3389/fauot.2026.1872446","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fauot.2026.1872446","pdf_url":"https://www.frontiersin.org/journals/audiology-and-otology/articles/10.3389/fauot.2026.1872446/pdf","source":{"id":"https://openalex.org/S4387287097","display_name":"Frontiers in Audiology and Otology","issn_l":"2813-6055","issn":["2813-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Audiology and Otology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202050402.pdf","grobid_xml":"https://content.openalex.org/works/W7202050402.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1951605185","https://openalex.org/W1966100017","https://openalex.org/W1993901829","https://openalex.org/W1995917539","https://openalex.org/W2022716475","https://openalex.org/W2075295076","https://openalex.org/W2077119043","https://openalex.org/W2116994906","https://openalex.org/W2119519240","https://openalex.org/W2135374418","https://openalex.org/W2162801491","https://openalex.org/W2404559385","https://openalex.org/W2763781586","https://openalex.org/W2775253012","https://openalex.org/W2792948907","https://openalex.org/W2896440310","https://openalex.org/W3011857650","https://openalex.org/W3023455414","https://openalex.org/W3080841363","https://openalex.org/W3082235859","https://openalex.org/W3082818205","https://openalex.org/W3088453568","https://openalex.org/W3185167866","https://openalex.org/W3206884599","https://openalex.org/W4220657602","https://openalex.org/W4223591189","https://openalex.org/W4224310190","https://openalex.org/W4294343752","https://openalex.org/W4308374520","https://openalex.org/W4401164724","https://openalex.org/W4403258828","https://openalex.org/W4406080622","https://openalex.org/W4409712258","https://openalex.org/W4410439816","https://openalex.org/W7124847995"],"related_works":["https://openalex.org/W4327735420","https://openalex.org/W2980614569","https://openalex.org/W3086075320","https://openalex.org/W2122522567","https://openalex.org/W2903432973","https://openalex.org/W7118065507","https://openalex.org/W2898760072","https://openalex.org/W7171667330","https://openalex.org/W3201316838","https://openalex.org/W6927322498"],"abstract_inverted_index":{"Introduction":[0],"Hearing":[1],"loss":[2,24,105,304],"(HL)":[3],"is":[4,37],"a":[5,77,113,124,150],"major":[6],"modifiable":[7],"risk":[8],"factor":[9],"for":[10,68,71,272],"cognitive":[11,26,50,92,140,181,186,200,210,237,273,306],"decline":[12,27],"and":[13,25,73,116,243,281,297,305],"dementia,":[14],"particularly":[15],"Alzheimer's":[16],"disease":[17],"(AD).":[18],"However,":[19,278],"the":[20,121,127,191,203,227,233,253,262,289],"relationship":[21],"between":[22,301],"hearing":[23,57,104,111,144,157,175,195,303],"as":[28,269],"influenced":[29],"by":[30],"common":[31],"biological":[32],"factors,":[33],"i.e.":[34],"genetic":[35,69],"predisposition,":[36],"not":[38,178,207,231,247],"fully":[39,287],"understood.":[40],"Furthermore,":[41],"auditory":[42,163,266,280,294],"behavioral":[43],"tests":[44,214,268,296],"may":[45],"be":[46],"potential":[47],"biomarkers":[48],"of":[49,80,126,185,215,235,264,291],"decline.":[51],"This":[52],"retrospective":[53],"study":[54],"examined":[55],"whether":[56],"abilities":[58,145],"were":[59,146,220,246],"associated":[60,179,198,222,248],"with":[61,180,199,208,223,232,249],"cognition":[62,96,225,251],"among":[63],"older":[64,82,276],"adults,":[65],"after":[66],"controlling":[67],"predisposition":[70],"HL":[72],"AD.":[74],"Methods":[75],"In":[76,123,190,239],"longitudinal":[78],"cohort":[79],"3,232":[81],"adults":[83],"(":[84,129],"M":[85,133],"=":[86,131,134],"78.0":[87],"\u00b1":[88,136],"8":[89],"years;":[90],"mean":[91,139],"follow-up,":[93,141],"6.9":[94],"years)":[95],"was":[97,106,177,197],"assessed":[98,107],"annually":[99],"across":[100],"five":[101],"domains.":[102],"Self-reported":[103],"using":[108,154],"questions":[109],"about":[110],"in":[112,275],"quiet":[114],"environment":[115],"difficulty":[117],"understanding":[118],"speech":[119],"on":[120],"phone.":[122],"subset":[125],"participants":[128],"n":[130],"113;":[132],"76.0":[135],"6":[137],"years,":[138],"8.6":[142],"years),":[143],"also":[147],"measured":[148],"at":[149,202,226,252],"single":[151],"time":[152],"point,":[153],"four":[155],"different":[156],"assessments,":[158],"including":[159],"tasks":[160],"assessing":[161],"central":[162,265,293],"processing":[164,267,295],"abilities.":[165],"Results":[166],"Linear":[167],"mixed":[168],"effects":[169],"modeling":[170],"results":[171],"showed":[172],"that":[173],"self-reported":[174],"ability":[176,196,245,274],"level":[182,201],"or":[183,256],"rate":[184,234],"change":[187],"during":[188],"follow-up.":[189],"measured-hearing":[192],"subset,":[193],"global":[194,224,250],"analytic":[204,228,254],"baseline,":[205,229],"but":[206,230],"subsequent":[209,236],"change.":[211,238],"Specifically,":[212],"two":[213],"complex":[216],"spectral":[217],"pattern":[218],"discrimination":[219],"significantly":[221],"contrast,":[240],"pure-tone":[241],"audiometry":[242],"speech-in-noise":[244],"baseline":[255],"longitudinally.":[257],"Discussion":[258],"Current":[259],"findings":[260],"support":[261],"utility":[263],"screening":[270],"tools":[271],"adults.":[277],"large-scale":[279],"neurophysiological":[282],"studies":[283],"are":[284],"needed":[285],"to":[286,298],"assess":[288],"feasibility":[290],"novel":[292],"clarify":[299],"relationships":[300],"genetics,":[302],"decline/dementia.":[307]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2026-08-10T00:00:00"}
