{"id":"https://openalex.org/W7202038121","doi":"https://doi.org/10.1038/s41598-026-66231-8","title":"DNA methylation changes following rapid maxillary expansion in children","display_name":"DNA methylation changes following rapid maxillary expansion in children","publication_year":2026,"publication_date":"2026-08-09","ids":{"openalex":"https://openalex.org/W7202038121","doi":"https://doi.org/10.1038/s41598-026-66231-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42575944"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-66231-8","doi":"https://doi.org/10.1038/s41598-026-66231-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-66231-8","pdf_url":"https://www.nature.com/articles/s41598-026-66231-8_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-66231-8_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146252241","display_name":"Takayuki Ishiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Ishiyama","raw_affiliation_strings":["Department of Orthodontics, School of Dentistry, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, School of Dentistry, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102725737","display_name":"Masahiro Takahashi","orcid":"https://orcid.org/0000-0003-1509-6845","observed_orcids":["https://orcid.org/0000-0003-1509-6845"]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiro Takahashi","raw_affiliation_strings":["Department of Orthodontics, School of Dentistry, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan. takahashi.masahiro@kdu.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, School of Dentistry, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan. takahashi.masahiro@kdu.ac.jp","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035591974","display_name":"Hiromi Kamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Kamura","raw_affiliation_strings":["Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020202999","display_name":"Tomoko Kawai","orcid":"https://orcid.org/0000-0001-8137-0334","observed_orcids":["https://orcid.org/0000-0001-8137-0334"]},"institutions":[{"id":"https://openalex.org/I4210132193","display_name":"National Center For Child Health and Development","ror":"https://ror.org/03fvwxc59","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210132193"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Kawai","raw_affiliation_strings":["Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan","institution_ids":["https://openalex.org/I4210132193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022995997","display_name":"Atsushi Tajima","orcid":"https://orcid.org/0000-0001-6808-5491","observed_orcids":["https://orcid.org/0000-0001-6808-5491"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Tajima","raw_affiliation_strings":["Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019849200","display_name":"Tetsutaro Yamaguchi","orcid":"https://orcid.org/0000-0001-9806-7163","observed_orcids":["https://orcid.org/0000-0001-9806-7163"]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsutaro Yamaguchi","raw_affiliation_strings":["Department of Orthodontics, School of Dentistry, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, School of Dentistry, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka, Kanagawa, 238-8580, Japan","institution_ids":["https://openalex.org/I47951555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102725737"],"corresponding_institution_ids":["https://openalex.org/I47951555"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62523858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":"24724","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.23880000412464142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapid-maxillary-expansion","display_name":"rapid maxillary expansion","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.6359999775886536},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.9229999780654907},{"id":"https://openalex.org/keywords/midpalatal-suture","display_name":"midpalatal suture","score":0.9679999947547913},{"id":"https://openalex.org/keywords/maxillary-transverse-deficiency","display_name":"maxillary transverse deficiency","score":0.8840000033378601},{"id":"https://openalex.org/keywords/orthodontic-treatment","display_name":"orthodontic treatment","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8804000020027161},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8543000221252441},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7289999723434448},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.699999988079071},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.6965000033378601},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.5020999908447266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41519999504089355},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.400299996137619},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3292999863624573},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3255000114440918},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3158999979496002},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.3009999990463257},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.28679999709129333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28189998865127563},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27219998836517334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2578999996185303},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25589999556541443},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010155","descriptor_name":"Palatal Expansion Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010155","descriptor_name":"Palatal Expansion Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010155","descriptor_name":"Palatal Expansion Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-026-66231-8","doi":"https://doi.org/10.1038/s41598-026-66231-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-66231-8","pdf_url":"https://www.nature.com/articles/s41598-026-66231-8_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:42575944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42575944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13458071","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13458071/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13458071/pdf/41598_2026_Article_66231.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:24405cb2dab54df18671a05995add361","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/24405cb2dab54df18671a05995add361","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:01288:0007480394","doi":null,"is_oa":true,"landing_page_url":"https://kanazawa-u.repo.nii.ac.jp/records/2004984","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-66231-8","doi":"https://doi.org/10.1038/s41598-026-66231-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-66231-8","pdf_url":"https://www.nature.com/articles/s41598-026-66231-8_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6442223191261292}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3449602532","display_name":"\u6b6f\u6839\u9577\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u56e0\u5b50\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306e\u30d2\u30c8\u30b2\u30ce\u30e0\u89e3\u6790","funder_award_id":"24K20091","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5808158265","display_name":"\u591a\u6570\u6b6f\u4fb5\u8972\u6027\u6b6f\u981a\u90e8\u5916\u90e8\u5438\u53ce\u5bb6\u7cfb\u304b\u3089\u7d10\u89e3\u304f\u6b6f\u6839\u5438\u53ce\u306e\u767a\u75c7\u6a5f\u5e8f","funder_award_id":"24K13185","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7184328369","display_name":"Elucidation of genetic factors associated with craniofacial morphology in individuals with Down syndrome and three-dimensional morphometric analysis","funder_award_id":"21K10195","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8296083021","display_name":null,"funder_award_id":"FY2024","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8634816322","display_name":"\u30d2\u30c8\u982d\u84cb\u7e2b\u5408\u306e\u591a\u69d8\u6027\u306b\u95a2\u3059\u308b\u907a\u4f1d\u5b66\u89e3\u6790","funder_award_id":"24K02109","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202038121.pdf","grobid_xml":"https://content.openalex.org/works/W7202038121.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1594526962","https://openalex.org/W1963769347","https://openalex.org/W1967064280","https://openalex.org/W2003291827","https://openalex.org/W2009461942","https://openalex.org/W2011494779","https://openalex.org/W2015107785","https://openalex.org/W2042439449","https://openalex.org/W2063446841","https://openalex.org/W2079668133","https://openalex.org/W2081098333","https://openalex.org/W2101870168","https://openalex.org/W2121877240","https://openalex.org/W2146512944","https://openalex.org/W2147981316","https://openalex.org/W2261451134","https://openalex.org/W2305187190","https://openalex.org/W2529024004","https://openalex.org/W2535626658","https://openalex.org/W2596399952","https://openalex.org/W2738305358","https://openalex.org/W2745417329","https://openalex.org/W2770380542","https://openalex.org/W2805415233","https://openalex.org/W2898187296","https://openalex.org/W2911749984","https://openalex.org/W2919386822","https://openalex.org/W2967903998","https://openalex.org/W3080647408","https://openalex.org/W3083494112","https://openalex.org/W4313643069","https://openalex.org/W4387220344","https://openalex.org/W4387326649","https://openalex.org/W4393573272","https://openalex.org/W4403479110","https://openalex.org/W4404467999","https://openalex.org/W4411472453"],"related_works":[],"abstract_inverted_index":{"Rapid":[0],"maxillary":[1,13],"expansion":[2],"(RME)":[3],"is":[4],"a":[5,191],"widely":[6],"used":[7],"orthodontic":[8,78],"intervention":[9],"for":[10,121,193],"correcting":[11],"transverse":[12],"deficiencies.":[14],"By":[15],"mechanically":[16],"separating":[17],"the":[18,50,106,125],"midpalatal":[19],"suture,":[20],"RME":[21,73,81,126,172],"improves":[22],"occlusal":[23],"relationships":[24],"and":[25,35,82,94,98,136,169,189],"induces":[26],"tissue":[27],"repair":[28],"processes":[29],"similar":[30],"to":[31,158,164],"fracture":[32,39],"healing.":[33],"Inflammation":[34],"bone":[36],"regeneration":[37],"following":[38],"are":[40],"regulated":[41],"by":[42],"epigenetic":[43,57,184],"mechanisms,":[44],"such":[45],"as":[46],"DNA":[47,66,100,181],"methylation.":[48],"However,":[49],"effects":[51],"of":[52],"RME-induced":[53],"mechanical":[54],"stimulation":[55],"on":[56],"dynamics":[58],"in":[59,69,149,179,187],"humans":[60],"remain":[61],"unclear.":[62],"We":[63],"evaluated":[64],"genome-wide":[65,99],"methylation":[67,101,113],"changes":[68,146,178],"saliva":[70,188],"associated":[71,160,175],"with":[72,80,161,176],"treatment.":[74],"Twenty":[75],"patients":[76],"undergoing":[77],"treatment":[79,96],"four":[83],"untreated":[84],"controls":[85],"were":[86,90,131,147,156],"enrolled.":[87],"Saliva":[88],"samples":[89],"collected":[91],"before":[92],"(T0)":[93],"after":[95],"(T1),":[97],"profiling":[102],"was":[103,115],"performed":[104],"using":[105,117],"Illumina":[107],"Infinium":[108],"HumanMethylationEPIC":[109],"v2.0":[110],"BeadChip.":[111],"Differential":[112],"analysis":[114],"conducted":[116],"linear":[118],"models":[119],"accounting":[120],"within-subject":[122],"correlations.":[123],"In":[124],"group,":[127],"164":[128],"CpG":[129,154],"sites":[130,155],"differentially":[132,152],"methylated":[133,153],"between":[134],"T0":[135],"T1":[137],"(false":[138],"discovery":[139],"rate":[140],"<":[141],"0.05),":[142],"whereas":[143],"no":[144],"significant":[145],"observed":[148],"controls.":[150],"The":[151],"annotated":[157],"genes":[159],"biological":[162],"responses":[163,185],"RME,":[165],"including":[166],"inflammatory":[167],"pathways":[168],"metabolic":[170],"processes.":[171],"may":[173],"be":[174],"measurable":[177],"salivary":[180],"methylation,":[182],"suggesting":[183],"detectable":[186],"providing":[190],"basis":[192],"future":[194],"mechanistic":[195],"investigations.":[196]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-08-10T00:00:00"}
