{"id":"https://openalex.org/W7202035359","doi":"https://doi.org/10.3390/allergies6040036","title":"The Aeroallergen Exposome in Argentina: Geographical Heterogeneity and Molecular Sensitization Profiles in Allergic Rhinitis and Asthma","display_name":"The Aeroallergen Exposome in Argentina: Geographical Heterogeneity and Molecular Sensitization Profiles in Allergic Rhinitis and Asthma","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7202035359","doi":"https://doi.org/10.3390/allergies6040036"},"language":"en","primary_location":{"id":"doi:10.3390/allergies6040036","doi":"https://doi.org/10.3390/allergies6040036","is_oa":true,"landing_page_url":"https://doi.org/10.3390/allergies6040036","pdf_url":null,"source":{"id":"https://openalex.org/S4210238126","display_name":"Allergies","issn_l":"2313-5786","issn":["2313-5786"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/allergies6040036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025719019","display_name":"Jorge Fernando Maspero","orcid":"https://orcid.org/0000-0001-9750-2346","observed_orcids":["https://orcid.org/0000-0001-9750-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Fernando M\u00e1spero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024361994","display_name":"Martina Indiveri","orcid":"https://orcid.org/0000-0002-3021-9615","observed_orcids":["https://orcid.org/0000-0002-3021-9615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martina Indiveri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3021-9615","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023456089","display_name":"Solange Gaviot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Solange Gaviot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111980749","display_name":"Ledit Ardusso","orcid":"https://orcid.org/0000-0002-4179-2126","observed_orcids":["https://orcid.org/0000-0002-4179-2126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ledit Ardusso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107603429","display_name":"Esteban I Garramone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esteban Garramone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053099272","display_name":"M\u00f3nica De Gennaro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00f3nica De Gennaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001403829","display_name":"Mar\u00eda In\u00e9s Ant\u00fanez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria In\u00e9s Ant\u00fanez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146217352","display_name":"Cecilia Fornari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Fornari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108281639","display_name":"Eva Abel Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Abel Fern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146211877","display_name":"Ana Elena Fern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Elena Fern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146176065","display_name":"Mar\u00eda Jos\u00e9 Mart\u00ednez","orcid":"https://orcid.org/0009-0009-3221-8235","observed_orcids":["https://orcid.org/0009-0009-3221-8235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Jos\u00e9 Mart\u00ednez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-3221-8235","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127221121","display_name":"Tania Gal\u00e1n Diez","orcid":"https://orcid.org/0000-0001-9756-0044","observed_orcids":["https://orcid.org/0000-0001-9756-0044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tania Gal\u00e1n-D\u00edez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146232121","display_name":"Ruperto Gonz\u00e1lez-P\u00e9rez","orcid":"https://orcid.org/0000-0002-6664-0276","observed_orcids":["https://orcid.org/0000-0002-6664-0276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruperto Gonz\u00e1lez-P\u00e9rez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6664-0276","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064688179","display_name":"Fernando Pineda","orcid":"https://orcid.org/0000-0001-8366-9145","observed_orcids":["https://orcid.org/0000-0001-8366-9145"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fernando Pineda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8366-9145","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064688179"],"corresponding_institution_ids":[],"apc_list":{"value":1000,"currency":"CHF","value_usd":1207},"apc_paid":{"value":1000,"currency":"CHF","value_usd":1207},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4","first_page":"36","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ige-sensitization","display_name":"IgE sensitization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.875},{"id":"https://openalex.org/keywords/regional-heterogeneity","display_name":"regional heterogeneity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/house-dust-mites","display_name":"house dust mites","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pollen-allergens","display_name":"pollen allergens","score":0.8420000076293945},{"id":"https://openalex.org/keywords/fel-d-1","display_name":"Fel d 1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cockroach-allergens","display_name":"cockroach allergens","score":0.7490000128746033},{"id":"https://openalex.org/keywords/asthma-phenotypes","display_name":"asthma phenotypes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/asthma-severity","display_name":"asthma severity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/argentina","display_name":"Argentina","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C2778391694","wikidata":"https://www.wikidata.org/wiki/Q4688176","display_name":"Aeroallergen","level":4,"score":0.8188999891281128},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.8138999938964844},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7652999758720398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6847000122070312},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.6669999957084656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6348000168800354},{"id":"https://openalex.org/C2779711295","wikidata":"https://www.wikidata.org/wiki/Q2441993","display_name":"Mite","level":2,"score":0.6026999950408936},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6025999784469604},{"id":"https://openalex.org/C2779673145","wikidata":"https://www.wikidata.org/wiki/Q7263653","display_name":"Pyroglyphidae","level":5,"score":0.6019999980926514},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.4975000023841858},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.4869000017642975},{"id":"https://openalex.org/C74962801","wikidata":"https://www.wikidata.org/wiki/Q5215707","display_name":"Dander","level":4,"score":0.4666000008583069},{"id":"https://openalex.org/C3020633164","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Allergic asthma","level":3,"score":0.3968999981880188},{"id":"https://openalex.org/C2909556404","wikidata":"https://www.wikidata.org/wiki/Q4688176","display_name":"Airborne allergen","level":4,"score":0.3797999918460846},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.34060001373291016}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/allergies6040036","doi":"https://doi.org/10.3390/allergies6040036","is_oa":true,"landing_page_url":"https://doi.org/10.3390/allergies6040036","pdf_url":null,"source":{"id":"https://openalex.org/S4210238126","display_name":"Allergies","issn_l":"2313-5786","issn":["2313-5786"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergies","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202608.0484.v1","doi":"https://doi.org/10.20944/preprints202608.0484.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202608.0484.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.3390/allergies6040036","doi":"https://doi.org/10.3390/allergies6040036","is_oa":true,"landing_page_url":"https://doi.org/10.3390/allergies6040036","pdf_url":null,"source":{"id":"https://openalex.org/S4210238126","display_name":"Allergies","issn_l":"2313-5786","issn":["2313-5786"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergies","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1969980812","https://openalex.org/W1984059424","https://openalex.org/W2033493064","https://openalex.org/W2098602416","https://openalex.org/W2114574938","https://openalex.org/W2138649409","https://openalex.org/W2144712546","https://openalex.org/W2287940103","https://openalex.org/W2536171827","https://openalex.org/W2732858253","https://openalex.org/W2792596323","https://openalex.org/W2915639287","https://openalex.org/W2918901119","https://openalex.org/W3037678227","https://openalex.org/W3041698572","https://openalex.org/W3164583297","https://openalex.org/W3179054865","https://openalex.org/W3199905416","https://openalex.org/W4381617964","https://openalex.org/W4387643909","https://openalex.org/W4387879092","https://openalex.org/W4390544330","https://openalex.org/W4405954223","https://openalex.org/W4407905247","https://openalex.org/W4409725827","https://openalex.org/W4412118348","https://openalex.org/W4414200686","https://openalex.org/W7128777656"],"related_works":["https://openalex.org/W7128777656","https://openalex.org/W4417370486","https://openalex.org/W7213417478","https://openalex.org/W4321599371","https://openalex.org/W7164533316","https://openalex.org/W7221025476","https://openalex.org/W4416193013","https://openalex.org/W2588302540","https://openalex.org/W2092842988","https://openalex.org/W4411802509"],"abstract_inverted_index":{"Background:":[0],"The":[1,86,103],"distribution":[2],"of":[3,189,286],"airborne":[4],"allergens":[5],"varies":[6],"across":[7,90,222,268],"climatic":[8],"and":[9,12,37,56,83,98,120,129,149,155,180,211,228],"ecological":[10],"settings":[11],"may":[13],"shape":[14],"region-specific":[15],"molecular":[16,84,87,280],"sensitization":[17,24,88,208,219,267,281],"profiles.":[18],"Objective:":[19],"To":[20],"characterize":[21],"component-level":[22],"IgE":[23,69],"in":[25,33,136,203,265],"patients":[26,52,107],"with":[27,42,53,185,235],"allergic":[28,127],"rhinitis":[29,128,251],"and/or":[30,64],"asthma":[31,223,236],"recruited":[32],"four":[34],"Argentine":[35],"locations":[36],"to":[38],"explore":[39],"its":[40],"relationship":[41],"clinical":[43,91],"phenotype.":[44],"Methods:":[45],"This":[46],"multicenter":[47],"cross-sectional":[48],"study":[49],"included":[50],"377":[51],"respiratory":[54],"allergy":[55],"at":[57],"least":[58],"one":[59,284],"positive":[60,65,232],"skin":[61],"prick":[62],"test":[63],"sIgE.":[66],"Serum":[67],"specific":[68],"was":[70,93,198,209,248],"measured":[71],"using":[72,95],"an":[73],"ALEX":[74],"multiplex.":[75],"Regional":[76],"profiles":[77],"were":[78],"summarized":[79],"by":[80,170,214],"allergen":[81,289],"source":[82],"component.":[85],"burden":[89,220],"phenotypes":[92,224],"assessed":[94],"Kruskal\u2013Wallis":[96],"tests":[97],"Spearman":[99],"rank":[100],"correlation.":[101],"Results:":[102],"cohort":[104],"comprised":[105],"100":[106],"from":[108,112,116,122],"Buenos":[109,137],"Aires,":[110,138],"105":[111],"San":[113,163],"Rafael-Mendoza,":[114],"62":[115],"Santa":[117,156],"Rosa-La":[118,157],"Pampa,":[119],"110":[121],"Rosario-Santa":[123,153],"Fe;":[124],"374":[125],"had":[126,131],"186":[130],"asthma.":[132],"Mite":[133],"components":[134],"predominated":[135],"where":[139],"Der":[140,143,146,150],"p":[141,144,147,175,178,242,255],"1,":[142,173,176,179,183],"2,":[145],"23,":[148],"f":[151],"2.":[152],"Fe":[154],"Pampa":[158],"showed":[159,229],"intermediate":[160],"mite":[161],"sensitization.":[162],"Rafael-Mendoza":[164],"displayed":[165],"a":[166,191,230],"pollen-dominant":[167],"pattern,":[168],"led":[169],"Ole":[171],"e":[172],"Lol":[174],"Phl":[177],"Sal":[181],"k":[182],"together":[184],"the":[186,199,287],"highest":[187],"frequency":[188],"Alt":[190],"1":[192,197],"recognition":[193],"(32.4%).":[194],"Fel":[195],"d":[196],"leading":[200],"epithelial":[201],"component":[202,285],"all":[204],"centers,":[205],"whereas":[206],"cockroach":[207],"infrequent":[210],"mainly":[212],"represented":[213],"Bla":[215],"g":[216],"9.":[217],"Molecular":[218,259],"differed":[221],"(p":[225],"=":[226,240,243,253,256],"0.0127)":[227],"weak":[231],"monotonic":[233],"association":[234,247],"severity":[237],"(Spearman":[238],"\u03c1":[239],"0.184,":[241],"0.0117).":[244],"No":[245],"corresponding":[246],"observed":[249],"for":[250],"(\u03c1":[252],"\u22120.067,":[254],"0.1949).":[257],"Conclusions:":[258],"profiling":[260],"identified":[261],"marked":[262],"regional":[263],"heterogeneity":[264],"aeroallergen":[266],"Argentina.":[269],"These":[270],"findings":[271],"support":[272],"geographically":[273],"informed":[274],"diagnostic":[275],"assessment":[276],"while":[277],"emphasizing":[278],"that":[279],"represents":[282],"only":[283],"broader":[288],"exposome.":[290]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-10T00:00:00"}