{"id":"https://openalex.org/W7202031214","doi":"https://doi.org/10.1111/acel.70661","title":"Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland","display_name":"Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7202031214","doi":"https://doi.org/10.1111/acel.70661","pmid":"https://pubmed.ncbi.nlm.nih.gov/41648548","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12871682"},"language":"en","primary_location":{"id":"doi:10.1111/acel.70661","doi":"https://doi.org/10.1111/acel.70661","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70661","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/acel.70661","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102980683","display_name":"Edmund Charles Jenkins","orcid":"https://orcid.org/0000-0002-6448-090X","observed_orcids":["https://orcid.org/0000-0002-6448-090X"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmund Charles Jenkins","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109356730","display_name":"Mrittika Chattopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrittika Chattopadhyay","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036561161","display_name":"Thelma Mashaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thelma Mashaka","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114739312","display_name":"Dmitry Polushakov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry Polushakov","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074812948","display_name":"Miguel Torres\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0003-1589-8936","observed_orcids":["https://orcid.org/0000-0003-1589-8936"]},"institutions":[{"id":"https://openalex.org/I4210132884","display_name":"Barcelona Institute of Science and Technology","ror":"https://ror.org/03kpps236","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210132884"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Torres-Martin","raw_affiliation_strings":["Center for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1589-8936","affiliations":[{"raw_affiliation_string":"Center for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132884","https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160410625","display_name":"Daniela Sia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Sia","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Liver Diseases, New York, 10029, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Liver Diseases, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160520775","display_name":"Igor Bado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Bado","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Oncological Sciences, New York, 10029, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Oncological Sciences, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033039574","display_name":"Doris Germain","orcid":"https://orcid.org/0000-0001-6597-0196","observed_orcids":["https://orcid.org/0000-0001-6597-0196"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Doris Germain","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-6597-0196","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033039574"],"corresponding_institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47475509,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"8","first_page":"e70661","last_page":"e70661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.09709999710321426,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-incidence","display_name":"breast cancer incidence","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.5329999923706055},{"id":"https://openalex.org/keywords/aging-signatures","display_name":"aging signatures","score":0.6019999980926514},{"id":"https://openalex.org/keywords/breast-cancer-susceptibility","display_name":"breast cancer susceptibility","score":0.5360000133514404},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8485999703407288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7623999714851379},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.7148000001907349},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5368000268936157},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4634000062942505},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.438400000333786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.391400009393692},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3806999921798706},{"id":"https://openalex.org/C15224491","wikidata":"https://www.wikidata.org/wiki/Q7169338","display_name":"Permissive","level":2,"score":0.3407000005245209},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.2840999960899353},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.28360000252723694},{"id":"https://openalex.org/C2776880931","wikidata":"https://www.wikidata.org/wiki/Q6745783","display_name":"Breast development","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2624000012874603},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25189998745918274},{"id":"https://openalex.org/C2779777497","wikidata":"https://www.wikidata.org/wiki/Q1775519","display_name":"Mouse mammary tumor virus","level":3,"score":0.25130000710487366},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.25110000371932983}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1111/acel.70661","doi":"https://doi.org/10.1111/acel.70661","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70661","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"doi:10.64898/2026.01.21.700824","doi":"https://doi.org/10.64898/2026.01.21.700824","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.01.21.700824","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/01/25/2026.01.21.700824.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13454215","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13454215/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13454215/pdf/ACEL-25-e70661.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"},{"id":"pmid:41648548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41648548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42572130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42572130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11679300","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12871682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/acel.70661","doi":"https://doi.org/10.1111/acel.70661","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70661","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000918186","display_name":"Understanding the influence of Mitochondrial DNA haplotypes on breast aging and cancer","funder_award_id":"R01AG075589","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306548","display_name":"Samuel Waxman Cancer Research Foundation","ror":"https://ror.org/02qva2y28"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202031214.pdf","grobid_xml":"https://content.openalex.org/works/W7202031214.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1500191647","https://openalex.org/W1580867012","https://openalex.org/W2005301839","https://openalex.org/W2053604149","https://openalex.org/W2068104926","https://openalex.org/W2091383719","https://openalex.org/W2108219444","https://openalex.org/W2112299930","https://openalex.org/W2114589445","https://openalex.org/W2121966499","https://openalex.org/W2127464720","https://openalex.org/W2138600889","https://openalex.org/W2150959753","https://openalex.org/W2161661351","https://openalex.org/W2163119252","https://openalex.org/W2281758534","https://openalex.org/W2475166975","https://openalex.org/W2518959324","https://openalex.org/W2533210290","https://openalex.org/W2584978674","https://openalex.org/W2726132839","https://openalex.org/W2974419980","https://openalex.org/W2994160326","https://openalex.org/W3006410729","https://openalex.org/W3009868920","https://openalex.org/W3015059022","https://openalex.org/W3019679086","https://openalex.org/W3081296598","https://openalex.org/W3110637034","https://openalex.org/W3134167221","https://openalex.org/W3197335886","https://openalex.org/W3202704197","https://openalex.org/W4283723802","https://openalex.org/W4285041315","https://openalex.org/W4286251110","https://openalex.org/W4313199537","https://openalex.org/W4362657000","https://openalex.org/W4376604893","https://openalex.org/W4386418585","https://openalex.org/W4401585036","https://openalex.org/W4412203461"],"related_works":["https://openalex.org/W7125705042","https://openalex.org/W4404588147","https://openalex.org/W2114369115","https://openalex.org/W4317104762","https://openalex.org/W4387895254","https://openalex.org/W135496545","https://openalex.org/W2407279003","https://openalex.org/W4416273781","https://openalex.org/W2022373732","https://openalex.org/W6987856614"],"abstract_inverted_index":{"The":[0],"incidence":[1],"of":[2,12,78,93,137,155,163,222,224,237,248],"breast":[3,34,61,100,196,226,238],"cancer":[4,35,101,138,156,197],"shows":[5],"its":[6],"largest":[7],"peak":[8,17],"around":[9,18],"the":[10,47,55,58,60,79,85,89,120,123,135,150,153,189,202,217,225,234,245],"age":[11],"65":[13,184],"but":[14,110,140],"also":[15],"a":[16,21,65,169],"45":[19,51,182,210],"indicating":[20],"bimodal":[22,90,121,170,192,235],"distribution.":[23],"While":[24],"some":[25],"potential":[26],"explanations,":[27],"such":[28],"as":[29],"age-related":[30],"enrichment":[31],"in":[32,119,149,178,185,194,206],"specific":[33],"sub-types":[36],"and":[37,52,96,107,115,128,175,183,199,211,228],"BRCA1/2":[38],"mutations":[39],"were":[40],"proposed,":[41],"they":[42,230],"do":[43],"not":[44,141],"explain":[45],"why":[46],"peaks":[48],"are":[49,103,111,131],"at":[50,105,113,126,142,160,209],"65,":[53],"raising":[54],"possibility":[56,218],"that":[57,201,219,229],"way":[59],"ages":[62],"may":[63,231],"play":[64],"role.":[66],"Here":[67],"using":[68],"two":[69,74,195],"mouse":[70],"models,":[71],"we":[72,167,187],"show":[73],"distinct":[75,220],"aging":[76,171,223],"patterns":[77,221],"mammary":[80,124,190],"gland;":[81],"one":[82],"being":[83],"progressive,":[84],"other":[86],"bimodal.":[87],"In":[88],"model,":[91,122,152],"waves":[92],"overlapping":[94],"genes":[95],"proteins":[97],"associated":[98],"with":[99,181],"pathways":[102],"observed":[104],"11":[106,127,174],"19":[108,129,176],"months":[109,130,162,177],"absent":[112],"3":[114],"14":[116,143,161],"months.":[117],"Further,":[118,240],"glands":[125],"more":[132],"permissive":[133],"to":[134,233,244],"growth":[136,154],"cells":[139,157],"or":[144],">":[145],"22":[146],"months,":[147],"while":[148],"progressive":[151],"increases":[158],"starting":[159],"age.":[164],"Using":[165],"scRNAseq,":[166],"established":[168],"signature.":[172],"Since":[173],"mice":[179],"correlate":[180],"humans,":[186],"tested":[188],"gland-derived":[191],"signature":[193,203],"databases":[198],"found":[200],"is":[204],"enriched":[205],"women":[207],"diagnosed":[208],"65.":[212],"Therefore,":[213],"our":[214,241],"study":[215,242],"raises":[216],"exist":[227],"contribute":[232],"distribution":[236],"cancer.":[239],"adds":[243],"growing":[246],"evidence":[247],"non-linear":[249],"aging.":[250]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-10T00:00:00"}