{"id":"https://openalex.org/W7202012148","doi":null,"title":"Extended histocompatibility : genomic prediction of kidney transplant outcome","display_name":"Extended histocompatibility : genomic prediction of kidney transplant outcome","publication_year":2024,"publication_date":"2024-09-17","ids":{"openalex":"https://openalex.org/W7202012148"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/585878","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/585878","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"G5 Artikkeliv\u00e4it\u00f6skirja"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/585878","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015427926","display_name":"Salla Markkinen","orcid":"https://orcid.org/0000-0002-4892-1269","observed_orcids":["https://orcid.org/0000-0002-4892-1269"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Markkinen, Salla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015427926"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/histocompatibility-testing","display_name":"histocompatibility testing","score":0.7080000042915344},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.5899999737739563},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.8709999918937683},{"id":"https://openalex.org/keywords/brain-dead-donors","display_name":"brain-dead donors","score":0.6710000038146973},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.7329999804496765},{"id":"https://openalex.org/keywords/transplant-outcome-prediction","display_name":"transplant outcome prediction","score":0.8040000200271606},{"id":"https://openalex.org/keywords/long-term-graft-survival","display_name":"long-term graft survival","score":0.6899999976158142},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.7146999835968018},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6812999844551086},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6685000061988831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6521000266075134},{"id":"https://openalex.org/C202965653","wikidata":"https://www.wikidata.org/wiki/Q2664028","display_name":"Histocompatibility","level":4,"score":0.6520000100135803},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5123000144958496},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4772000014781952},{"id":"https://openalex.org/C168444539","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Organ transplantation","level":3,"score":0.4767000079154968},{"id":"https://openalex.org/C2909478873","wikidata":"https://www.wikidata.org/wiki/Q3991680","display_name":"Histocompatibility Testing","level":4,"score":0.47200000286102295},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.42419999837875366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4165000021457672},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.329800009727478},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.29600000381469727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.27059999108314514},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C2780179540","wikidata":"https://www.wikidata.org/wiki/Q1765748","display_name":"Transplant rejection","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2581999897956848},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/585878","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/585878","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"G5 Artikkeliv\u00e4it\u00f6skirja"}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/585878","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/585878","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"G5 Artikkeliv\u00e4it\u00f6skirja"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7234354615211487,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Kidney":[0],"transplantation":[1,118,173,241,253,261,282],"is":[2,23,34,69,174],"an":[3,10,185],"established,":[4],"cost-effective":[5],"treatment":[6],"for":[7,77,116,295],"patients":[8],"with":[9,138,280,315],"endstage":[11],"kidney":[12,18,139,234,240,252,260,310],"disease.":[13],"The":[14,56,210,236,255,274],"annual":[15],"number":[16],"of":[17,38,58,109,146,161,187,212,233,276,299,301,309,318],"transplantations":[19,30],"performed":[20],"in":[21,28,124,248,305],"Finland":[22],"approximately":[24],"250.":[25],"A":[26],"hurdle":[27],"all":[29,158],"between":[31,63,179,239,270],"two":[32,188],"individuals":[33],"the":[35,39,45,54,59,64,72,89,113,125,149,213,231,266,277,281,296,302,307,313,316,339],"immunological":[36,51],"recognition":[37],"transplanted":[40,264],"graft":[41,303],"as":[42,105],"foreign":[43],"by":[44,156,204],"recipient.":[46],"This":[47,289],"often":[48],"leads":[49],"to":[50,70,83,98,144,172,175,216,227,325,329,337],"attack":[52],"against":[53,88],"graft.":[55,90],"goal":[57],"prior":[60],"histocompatibility":[61,93],"testing":[62],"recipient":[65,207,242],"and":[66,80,86,120,181,191,197,243,272,333,336],"organ":[67,117],"donor":[68,180,205,245,304],"find":[71],"immunologically":[73],"most":[74],"suitable":[75],"transplant":[76,140,331],"each":[78],"patient":[79],"this":[81],"way":[82],"reduce":[84],"complications":[85,119,332],"immunization":[87],"Despite":[91],"current":[92],"testing,":[94],"we":[95,321],"are":[96,136],"unable":[97],"adequately":[99],"predict":[100,228,330],"severe":[101],"transplantation-related":[102],"complications,":[103],"such":[104],"rejection.":[106],"Genomic":[107],"screenings":[108],"risk":[110,151,166,221],"factors":[111,222],"outside":[112],"HLA":[114],"genes":[115],"long-term":[121,334],"survival":[122],"started":[123],"last":[126],"decade.":[127],"Genome-wide":[128],"association":[129,275],"studies":[130],"(GWAS)":[131],"have":[132,194],"reported":[133],"variants":[134,208],"that":[135,223],"associated":[137],"outcomes.":[141],"In":[142,312],"addition":[143],"effects":[145,160],"single":[147],"variants,":[148],"genomic":[150,220,319],"can":[152],"also":[153,291],"be":[154,225,323],"estimated":[155,285],"combining":[157],"low-level":[159],"GWAS":[162],"results":[163],"into":[164],"polygenic":[165],"scores":[167],"(PRS).":[168],"An":[169],"approach":[170],"particular":[171],"study":[176],"genome-level":[177],"matching":[178],"patient.":[182],"Transplantation":[183],"involves":[184],"interaction":[186],"independent":[189],"genomes,":[190],"resulting":[192],"mismatches":[193],"complex":[195],"mechanisms":[196,340],"potentially":[198],"larger":[199],"effect":[200],"sizes":[201],"than":[202],"conferred":[203],"or":[206],"alone.":[209],"aim":[211],"thesis":[214,290],"was":[215,246],"identify":[217],"novel":[218],"non-HLA":[219],"could":[224],"utilized":[226,292],"more":[229],"accurately":[230],"outcome":[232],"transplantation.":[235,311],"genome":[237],"variation":[238],"brain-dead":[244],"determined":[247],"a":[249],"retrospective":[250],"adult":[251],"cohort.":[254],"Finnish":[256],"cohort":[257],"included":[258],"1,025":[259],"patient-donor":[262],"pairs":[263],"at":[265],"Helsinki":[267],"University":[268],"Hospital":[269],"2007":[271],"2017.":[273],"genome-wide":[278],"compatibility":[279],"outcomes":[283,308],"were":[284],"using":[286],"statistical":[287],"methods.":[288],"PRS":[293],"estimates":[294],"major":[297],"causes":[298],"death":[300],"predicting":[306],"future,":[314],"help":[317],"information,":[320],"may":[322],"able":[324],"create":[326],"better":[327],"tools":[328],"survival,":[335],"understand":[338],"behind":[341],"extended":[342],"histocompatibility.":[343]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-08-09T00:00:00"}