{"id":"https://openalex.org/W7201939360","doi":null,"title":"Bisphenol A in preeclampsia","display_name":"Bisphenol A in preeclampsia","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W7201939360"},"language":"fr","primary_location":{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/9606","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/9606","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/a56b1394-3ccc-4ce4-bb20-cacce7b293b5/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"M\u00e9moire de ma\u00eetrise"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://usherbrooke.scholaris.ca/bitstreams/a56b1394-3ccc-4ce4-bb20-cacce7b293b5/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012223460","display_name":"Alexandra Chapdelaine","orcid":"https://orcid.org/0000-0002-8018-6321","observed_orcids":["https://orcid.org/0000-0002-8018-6321"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chapdelaine, Alexandra","raw_affiliation_strings":[", D\u00e9partement d'Obst\u00e9trique-Gyn\u00e9cologie , Directeur de recherche Dre Nadia Caron , D\u00e9partement de M\u00e9decine , \u00c9valuatrice externe Pr Abdelouahed Khalil , D\u00e9partement de M\u00e9decine , \u00c9valuateur interne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", D\u00e9partement d'Obst\u00e9trique-Gyn\u00e9cologie , Directeur de recherche Dre Nadia Caron , D\u00e9partement de M\u00e9decine , \u00c9valuatrice externe Pr Abdelouahed Khalil , D\u00e9partement de M\u00e9decine , \u00c9valuateur interne","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012223460"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.9509999752044678},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":1.0},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.984000027179718},{"id":"https://openalex.org/keywords/serotonin-metabolism","display_name":"serotonin metabolism","score":0.8040000200271606},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9440000057220459},{"id":"https://openalex.org/keywords/maternal-hypertension","display_name":"maternal hypertension","score":0.777999997138977},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.6819999814033508},{"id":"https://openalex.org/keywords/placental-metabolism","display_name":"placental metabolism","score":0.8029999732971191},{"id":"https://openalex.org/keywords/trophoblast","display_name":"trophoblast","score":0.7979999780654907},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7687000036239624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7195000052452087},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.6988000273704529},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.6274999976158142},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.51910001039505},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.47850000858306885},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.45680001378059387},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.446399986743927},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4415000081062317},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.42899999022483826},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4097000062465668},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.37959998846054077},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3285999894142151},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3246999979019165},{"id":"https://openalex.org/C2779684741","wikidata":"https://www.wikidata.org/wiki/Q271980","display_name":"Bisphenol A","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3095000088214874},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.2605000138282776},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.2603999972343445},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.25440001487731934},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2777118369","wikidata":"https://www.wikidata.org/wiki/Q420885","display_name":"Tranylcypromine","level":4,"score":0.2535000145435333},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/9606","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/9606","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/a56b1394-3ccc-4ce4-bb20-cacce7b293b5/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"M\u00e9moire de ma\u00eetrise"}],"best_oa_location":{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/9606","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/9606","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/a56b1394-3ccc-4ce4-bb20-cacce7b293b5/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"M\u00e9moire de ma\u00eetrise"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311614","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7201939360.pdf","grobid_xml":"https://content.openalex.org/works/W7201939360.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1958756232","https://openalex.org/W2015016465","https://openalex.org/W2152586799","https://openalex.org/W2299377172"],"related_works":["https://openalex.org/W2160621661","https://openalex.org/W4321366752","https://openalex.org/W2768870994","https://openalex.org/W4414299509","https://openalex.org/W4400943120","https://openalex.org/W2896399818","https://openalex.org/W4206232012","https://openalex.org/W4405854493","https://openalex.org/W2990337657","https://openalex.org/W2965473248"],"abstract_inverted_index":{"Preeclampsia":[0],"(PE)":[1],"is":[2,20,260,339],"an":[3,96,125],"hypertensive":[4],"disorder":[5],"of":[6,24,45,57,81,95,103,119,131,137,173,218,234,265,293,337,353,360,382],"pregnancy":[7],"characterized":[8],"by":[9,37,303],"a":[10,38,315,354],"generalized":[11],"endothelial":[12],"dysfunction":[13],"where":[14],"the":[15,43,55,63,79,93,101,104,117,120,129,135,162,171,174,202,216,222,227,252,257,266,291,334,345,351,357,363,373,378],"response":[16],"to":[17,26,62,100,300,314],"vasodilatation":[18],"signals":[19],"compromised.":[21],"The":[22,324],"binding":[23],"serotonin":[25,47,306],"its":[27,158,183,370,383],"S[subscript":[28],"2]":[29],"receptor":[30],"subtype":[31],"2":[32],"releases":[33],"vasoconstrictor":[34],"molecules":[35],"which,":[36],"positive":[39,51],"retroaction":[40,52],"loop,":[41],"stimulates":[42,54],"release":[44],"more":[46,77],"from":[48,191],"platelets.":[49],"This":[50,89,272,287,308,348],"loop":[53],"vasoconstriction":[56],"blood":[58],"vessels":[59],"and":[60,148,185,194,205,231,240,255,329,341,369,376],"contributes":[61],"hypertension":[64,302],"in":[65,78,86,128,144,177,188,210,221,263,283,295,362,365],"women":[66,82,178,192,211,297,366],"with":[67,83,179,193,212,236,305,367],"PE.":[68,196,213],"Previously,":[69],"we":[70,181,225],"showed":[71,109,149,200,244],"that":[72,110,150,201,245,256,277,290,333],"Bisphenol":[73],"A":[74,123,197],"(BPA)":[75],"accumulates":[76],"placenta":[80,364],"PE":[84,368],"than":[85],"normotensive":[87],"women.":[88],"accumulation":[90,176,292,309,359],"may":[91],"be":[92,170,312],"result":[94,282],"impaired":[97],"metabolization":[98],"due":[99],"action":[102],"\u03b2-Glucuronidase":[105],"(GUSB).":[106],"Animal":[107],"studies":[108],"BPA":[111,138,155,175,235,247,294,338,361],"at":[112,139,152],"high":[113,278,284],"dose":[114,141],"could":[115,169,248,298,310],"lower":[116,157],"activity":[118,159,184,204],"monoamine":[121],"oxidase":[122],"(MAO-A),":[124],"enzyme":[126],"implicated":[127],"metabolism":[130,220,259,336],"serotonin.":[132],"We":[133,243],"studied":[134,182,226],"impact":[136,217,371],"low":[140,153],"(10":[142],"ng/ml)":[143],"trophoblastic":[145],"primary":[146],"cells":[147],"even":[151],"dose,":[154],"can":[156],"without":[160,195],"affecting":[161],"protein":[163,186,206],"expression.":[164],"To":[165,214],"determine":[166],"if":[167],"GUSB":[168,203],"cause":[172],"PE,":[180],"expression":[187,207],"placental":[189,219,258,335,374],"biopsies":[190],"nonsignificant":[198],"tendency":[199],"were":[208],"higher":[209,316],"study":[215,288,349],"fetal":[223,232,253,285,330],"exposure,":[224],"relation":[228],"between":[229,269,327],"maternal":[230,246,279,301,328],"concentrations":[233],"linear":[237],"regression":[238],"analysis":[239],"Spearman\u2019s":[241],"correlation.":[242],"not":[249,343],"precisely":[250],"predict":[251],"exposure":[254,280,331],"probably":[261,322],"limited":[262,340],"light":[264],"strong":[267,273,325],"correlation":[268,274,326],"both":[270],"variables.":[271],"also":[275],"implied":[276],"would":[281],"exposure.":[286],"shows":[289],"preeclamptic":[296],"contribute":[299],"interacting":[304],"levels.":[307],"partially":[311],"attributed":[313],"GUSB,":[317],"but":[318],"other":[319],"factors":[320],"are":[321],"implicated.":[323],"implies":[332],"does":[342],"protect":[344],"fetus":[346],"significantly.":[347],"suggests":[350],"basis":[352],"mechanism":[355],"explaining":[356],"abnormal":[358],"on":[372],"MAO-A":[375,380],"potentially,":[377],"foetal":[379],"because":[381],"physico-chemical":[384],"properties.":[385]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-08-08T00:00:00"}