{"id":"https://openalex.org/W7201888377","doi":"https://doi.org/10.1016/j.rpth.2026.106903","title":"Factors associated with postextraction bleeding in patients with hemophilia: a multicenter retrospective cohort study","display_name":"Factors associated with postextraction bleeding in patients with hemophilia: a multicenter retrospective cohort study","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7201888377","doi":"https://doi.org/10.1016/j.rpth.2026.106903","pmid":"https://pubmed.ncbi.nlm.nih.gov/42668549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13524683"},"language":"en","primary_location":{"id":"doi:10.1016/j.rpth.2026.106903","doi":"https://doi.org/10.1016/j.rpth.2026.106903","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.106903","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.rpth.2026.106903","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148017780","display_name":"Kazumi Atarashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumi Atarashi","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146051938","display_name":"Hiroshi Nakamura","orcid":"https://orcid.org/0000-0001-6473-7667","observed_orcids":["https://orcid.org/0000-0001-6473-7667"]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nakamura","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104082320","display_name":"Kotaro Kaneko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Kaneko","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I158929114"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056351329","display_name":"Mirai Higaki","orcid":"https://orcid.org/0000-0002-1589-5041","observed_orcids":["https://orcid.org/0000-0002-1589-5041"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mirai Higaki","raw_affiliation_strings":["Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110785374","display_name":"Kuniko Mizuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuniko Mizuta","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146045793","display_name":"Kotaro Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090647","display_name":"Nagoya University Hospital","ror":"https://ror.org/008zz8m46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210090647"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotaro Sato","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I4210090647","https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024338193","display_name":"Takahiro Yagyuu","orcid":"https://orcid.org/0000-0003-3490-2371","observed_orcids":["https://orcid.org/0000-0003-3490-2371"]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takahiro Yagyuu","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3490-2371","affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024338193"],"corresponding_institution_ids":["https://openalex.org/I64926303"],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5138417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"6","first_page":"106903","last_page":"106903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilia","display_name":"hemophilia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hemophilia-b","display_name":"hemophilia B","score":1.0},{"id":"https://openalex.org/keywords/tooth-extraction","display_name":"tooth extraction","score":0.9769999980926514},{"id":"https://openalex.org/keywords/postoperative-bleeding","display_name":"postoperative bleeding","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.9909999966621399},{"id":"https://openalex.org/keywords/primary-wound-closure","display_name":"primary closure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/multiple-extractions","display_name":"multiple extractions","score":0.75},{"id":"https://openalex.org/keywords/risk-factors-for-bleeding","display_name":"bleeding risk factors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/local-hemostasis","display_name":"local hemostasis","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.845300018787384},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7289999723434448},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.41990000009536743},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.39149999618530273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.321399986743927},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.30309998989105225},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.27250000834465027},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2662999927997589}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002836","descriptor_name":"Hemophilia B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014081","descriptor_name":"Tooth Extraction","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019106","descriptor_name":"Postoperative Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D019106","descriptor_name":"Postoperative Hemorrhage","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D019106","descriptor_name":"Postoperative Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.rpth.2026.106903","doi":"https://doi.org/10.1016/j.rpth.2026.106903","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.106903","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13524683","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13524683/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13524683/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pract Thromb Haemost","raw_type":"Text"},{"id":"pmid:42668549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42668549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and practice in thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7d87c34b40034d26aef3eefcb04b8ba5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7d87c34b40034d26aef3eefcb04b8ba5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis, Vol 10, Iss 6, Pp 106903- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.rpth.2026.106903","doi":"https://doi.org/10.1016/j.rpth.2026.106903","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.rpth.2026.106903","pdf_url":null,"source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7201888377.pdf","grobid_xml":"https://content.openalex.org/works/W7201888377.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1722477279","https://openalex.org/W1965548407","https://openalex.org/W1974930764","https://openalex.org/W2026336161","https://openalex.org/W2101455869","https://openalex.org/W2118936603","https://openalex.org/W2123507756","https://openalex.org/W2149708933","https://openalex.org/W2169308708","https://openalex.org/W2612405547","https://openalex.org/W2748942347","https://openalex.org/W3093434330","https://openalex.org/W4285817622","https://openalex.org/W4297259472","https://openalex.org/W4322503225","https://openalex.org/W4377695233","https://openalex.org/W4401019622"],"related_works":["https://openalex.org/W3093434330","https://openalex.org/W1965548407","https://openalex.org/W3001515015","https://openalex.org/W2051044437","https://openalex.org/W4200438621","https://openalex.org/W2101455869","https://openalex.org/W3148565132","https://openalex.org/W2034309487","https://openalex.org/W2469442234","https://openalex.org/W1974930764"],"abstract_inverted_index":{"Background:":[0],"Postextraction":[1,71],"bleeding,":[2],"a":[3,126,162],"form":[4],"of":[5,128,139,220,233],"postoperative":[6,129],"hemorrhage,":[7],"remains":[8,208],"challenging":[9],"in":[10,64,114,211],"hemophilia,":[11],"yet":[12],"multicenter":[13,47],"evidence":[14],"linking":[15],"bleeding":[16,33,72,76,123,146,192,207,241],"to":[17,30,68],"extraction":[18,58,138],"technique":[19],"and":[20,35,41,108,118,176,185,218,239],"local":[21],"hemostatic":[22],"measures":[23],"is":[24],"limited.":[25],"Objectives:":[26],"This":[27,45],"study":[28],"aimed":[29],"determine":[31],"postextraction":[32,206,226],"incidence":[34,147,164],"identify":[36],"associated":[37,143,160,190,224],"factors":[38],"at":[39,59,125,165],"procedure":[40,136,168],"tooth":[42,57,177],"levels.":[43],"Methods:":[44],"retrospective":[46,234],"cohort":[48,96],"included":[49,97],"patients":[50,99],"with":[51,144,161,191,225],"hemophilia":[52,61,103,212],"A":[53],"or":[54],"B":[55],"undergoing":[56],"4":[60],"care":[62],"centers":[63],"Japan":[65],"(January":[66],"2013":[67],"March":[69],"2023).":[70],"was":[73,92,159,189,223],"defined":[74],"as":[75],"not":[77],"controlled":[78],"by":[79,237],"gauze":[80],"compression":[81],"requiring":[82],"additional":[83],"intervention":[84],"within":[85],"14":[86],"days.":[87],"Multivariable":[88],"logistic":[89],"regression":[90],"analysis":[91],"performed.":[93],"Results:":[94],"The":[95],"198":[98],"(hemophilia":[100],"A,":[101],"161;":[102],"B,":[104],"37),":[105],"271":[106],"procedures,":[107],"512":[109],"extracted":[110],"teeth.":[111],"Bleeding":[112],"occurred":[113,124],"33":[115],"procedures":[116],"(12.2%)":[117],"38":[119],"teeth":[120,141],"(7.4%);":[121],"first":[122],"mean":[127],"day":[130],"5.3":[131],"(median":[132],"6).":[133],"At":[134],"the":[135,167],"level,":[137],"\u22654":[140],"were":[142,202],"higher":[145],"(adjusted":[148,170,179,193],"odds":[149],"ratio":[150],"[OR]":[151],"2.60,":[152],"95%":[153,173,182,196],"CI":[154,174,183,197],"1.02-6.65).":[155],"Tranexamic":[156],"acid":[157,222],"use":[158],"lower":[163],"both":[166],"level":[169,178],"OR":[171,180,194],"0.43,":[172],"0.20-0.93)":[175],"0.38,":[181],"0.18-0.78),":[184],"primary":[186],"wound":[187],"closure":[188],"11.2,":[195],"1.42-89.3).":[198],"No":[199],"thrombotic":[200],"events":[201],"documented.":[203],"Conclusion:":[204],"Delayed":[205],"relatively":[209],"common":[210],"despite":[213],"specialist":[214],"care.":[215],"Multiple":[216],"extractions":[217],"nonuse":[219],"tranexamic":[221],"bleeding.":[227],"Findings":[228],"require":[229],"cautious":[230],"interpretation":[231],"because":[232],"design,":[235],"confounding":[236],"indication,":[238],"limited":[240],"events.":[242]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-08T00:00:00"}