{"id":"https://openalex.org/W7201847634","doi":"https://doi.org/10.1093/noajnl/vdag161.137","title":"TLSB-19 CENTRAL NERVOUS SYSTEM DISSEMINATION IN METASTATIC LOBULAR BREAST CANCER: A HISTOLOGY-BASED ANALYSIS","display_name":"TLSB-19 CENTRAL NERVOUS SYSTEM DISSEMINATION IN METASTATIC LOBULAR BREAST CANCER: A HISTOLOGY-BASED ANALYSIS","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7201847634","doi":"https://doi.org/10.1093/noajnl/vdag161.137"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdag161.137","doi":"https://doi.org/10.1093/noajnl/vdag161.137","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdag161.137","pdf_url":"https://academic.oup.com/noa/article-pdf/8/Supplement_6/vdag161.137/70398782/vdag161.137.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/8/Supplement_6/vdag161.137/70398782/vdag161.137.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034961078","display_name":"Guilherme Nader Marta","orcid":"https://orcid.org/0000-0001-7864-3637","observed_orcids":["https://orcid.org/0000-0001-7864-3637"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guilherme Nader-Marta","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Noah Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Graham","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055824815","display_name":"Anna Gorfinkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Gorfinkel","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096326867","display_name":"Eliza Kallfelz","orcid":"https://orcid.org/0009-0000-6203-4642","observed_orcids":["https://orcid.org/0009-0000-6203-4642"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eliza Kallfelz","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Celine Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celine Ibrahim","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095376449","display_name":"Catherine Stever","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine E Stever","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053598597","display_name":"Rebecca A. Ottesen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A Ottesen","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146059214","display_name":"Gregory Kirkner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Kirkner","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053035881","display_name":"Meixuan Luo","orcid":"https://orcid.org/0009-0006-3533-5718","observed_orcids":["https://orcid.org/0009-0006-3533-5718"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda Luo","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027527568","display_name":"Thomas Grinda","orcid":"https://orcid.org/0000-0002-8567-9627","observed_orcids":["https://orcid.org/0000-0002-8567-9627"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thomas Grinda","raw_affiliation_strings":["Institut Gustave Roussy , Paris,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Gustave Roussy , Paris,","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025041221","display_name":"Craig Snow","orcid":"https://orcid.org/0009-0007-1572-4895","observed_orcids":["https://orcid.org/0009-0007-1572-4895"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Snow","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775802","display_name":"Erica L. Mayer","orcid":"https://orcid.org/0000-0001-5430-8957","observed_orcids":["https://orcid.org/0000-0001-5430-8957"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica L Mayer","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069056507","display_name":"Sara M. Tolaney","orcid":"https://orcid.org/0000-0002-5940-8671","observed_orcids":["https://orcid.org/0000-0002-5940-8671"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara M Tolaney","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062515397","display_name":"Nabihah Tayob","orcid":"https://orcid.org/0000-0001-6088-167X","observed_orcids":["https://orcid.org/0000-0001-6088-167X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabihah Tayob","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013516632","display_name":"Sarah LeNoir Sammons","orcid":"https://orcid.org/0000-0003-2589-9422","observed_orcids":["https://orcid.org/0000-0003-2589-9422"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah L Sammons","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055137470","display_name":"Jos\u00e9 Pablo Leone","orcid":"https://orcid.org/0000-0002-8537-652X","observed_orcids":["https://orcid.org/0000-0002-8537-652X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Pablo Leone","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022319770","display_name":"NU Lin","orcid":"https://orcid.org/0000-0003-2263-5413","observed_orcids":["https://orcid.org/0000-0003-2263-5413"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy U Lin","raw_affiliation_strings":["Dana-Farber Cancer Institute , Boston,","Harvard Medical School , Boston,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute , Boston,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School , Boston,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2615,"currency":"USD","value_usd":2615},"apc_paid":{"value":2615,"currency":"USD","value_usd":2615},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58521998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"Supplement_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9018999934196472,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-lobular-carcinoma","display_name":"invasive lobular carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/central-nervous-system-metastases","display_name":"central nervous system metastasis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.8259999752044678},{"id":"https://openalex.org/keywords/histology","display_name":"histology","score":0.40299999713897705},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.5690000057220459},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9330000281333923},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.9079999923706055},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5509999990463257},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5220000147819519},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.32899999618530273},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.4519999921321869},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6039999723434448},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8256000280380249},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6409000158309937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5670999884605408},{"id":"https://openalex.org/C2776372563","wikidata":"https://www.wikidata.org/wiki/Q929221","display_name":"Invasive lobular carcinoma","level":5,"score":0.5626999735832214},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5465999841690063},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4526999890804291},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4471000134944916},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4447999894618988},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.41819998621940613},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3874000012874603},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3797999918460846},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37459999322891235},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.35830000042915344},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.35589998960494995},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.3336000144481659},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31850001215934753},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.26510000228881836},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.2630000114440918},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.260699987411499}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/noajnl/vdag161.137","doi":"https://doi.org/10.1093/noajnl/vdag161.137","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdag161.137","pdf_url":"https://academic.oup.com/noa/article-pdf/8/Supplement_6/vdag161.137/70398782/vdag161.137.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13448278","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13448278/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdag161.137","doi":"https://doi.org/10.1093/noajnl/vdag161.137","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdag161.137","pdf_url":"https://academic.oup.com/noa/article-pdf/8/Supplement_6/vdag161.137/70398782/vdag161.137.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7201847634.pdf","grobid_xml":"https://content.openalex.org/works/W7201847634.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162017595","https://openalex.org/W7130719078","https://openalex.org/W7223097862","https://openalex.org/W2494488625","https://openalex.org/W4376613961","https://openalex.org/W4396590585","https://openalex.org/W7162535647","https://openalex.org/W2575041620","https://openalex.org/W7129229659","https://openalex.org/W4410808872"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Invasive":[2],"lobular":[3],"carcinoma":[4,16],"(ILC)":[5],"exhibits":[6],"distinct":[7],"biological":[8],"and":[9,39,88,111,146,156,235,244,249,282],"metastatic":[10,63],"behavior":[11],"compared":[12],"with":[13,62,67,120,164,214,226,289],"invasive":[14],"breast":[15],"of":[17,24,36,60,154,158,167,242,246,294],"no":[18,215],"special":[19],"type":[20],"(BC-NST),":[21],"yet":[22],"patterns":[23],"central":[25],"nervous":[26],"system":[27],"(CNS)":[28],"dissemination":[29,266],"remain":[30],"incompletely":[31],"defined.":[32],"We":[33],"examined":[34],"determinants":[35],"CNS":[37,47,73,89,149,168,196,222,265,272],"metastases":[38],"LMD":[40,92,238],"to":[41],"assess":[42],"whether":[43],"histology":[44,87],"confers":[45],"independent":[46],"risk.":[48],"Methods":[49],"Retrospective":[50],"analysis":[51],"using":[52,95],"data":[53],"from":[54],"EMBRACE,":[55],"a":[56,290],"prospectively":[57],"maintained":[58],"cohort":[59],"patients":[61,119],"BC":[64],"(mBC).":[65],"Patients":[66],"BC-NST":[68,155,204,243],"or":[69,91],"ILC":[70,159,161,202,247,254,276,285],"were":[71,93,100,126,198,224],"included.":[72],"mets":[74,80,90,150,169,197,223],"was":[75,139,162,188,250],"defined":[76],"as":[77],"parenchymal":[78],"brain":[79],"and/or":[81],"leptomeningeal":[82],"disease":[83],"(LMD).":[84],"Associations":[85],"between":[86],"evaluated":[94],"logistic":[96],"regression.":[97],"Multivariable":[98],"models":[99],"adjusted":[101,256],"for":[102],"age,":[103,228],"tumor":[104,281],"grade,":[105,230],"hormone":[106],"receptor":[107],"status,":[108,110,232],"HER2":[109,143],"de":[112],"novo":[113],"versus":[114],"recurrent":[115,135,236],"presentation.":[116,237],"Results":[117],"3835":[118],"mBC":[121],"(3247":[122],"BC-NST;":[123],"588":[124],"ILC)":[125],"included":[127],"(median":[128],"follow-up,":[129],"16.4":[130],"years).":[131],"Overall,":[132],"78.2%":[133],"had":[134],"disease;":[136],"subtype":[137],"distribution":[138],"HR+/HER2":[140],"\u2212":[141],"(61.2%),":[142],"+":[144],"(19.7%),":[145],"TNBC":[147,210],"(19.1%).":[148],"occurred":[151,239],"in":[152,170,190,201,217,240,253,255,267,275],"26.4%":[153],"17.5%":[157],"cases.":[160],"associated":[163,225,288],"lower":[165,271],"odds":[166],"unadjusted":[171],"analyses":[172,257],"(OR":[173,182,205,211,258],"0.59;":[174],"95%":[175],"CI,":[176],"0.47\u20130.74)":[177],"but":[178],"not":[179],"after":[180],"adjustment":[181],"1.08;":[183],"0.83\u20131.41).":[184],"No":[185],"histology-based":[186],"difference":[187,216],"observed":[189],"HER2+":[191,233],"disease.":[192],"Among":[193],"HER2\u2212":[194],"tumors,":[195],"less":[199],"frequent":[200,252],"than":[203],"0.63;":[206],"0.49\u20130.81),":[207],"driven":[208],"by":[209,280],"0.25;":[212],"0.06\u20130.74),":[213],"HR+/HER2\u2212.":[218],"In":[219],"multivariable":[220],"models,":[221],"younger":[227],"higher":[229,292],"ER/PR-negative":[231],"disease,":[234],"5.7%":[241],"11.1%":[245],"cases":[248],"more":[251],"3.52;":[259],"2.44\u20135.05).":[260],"Conclusion":[261],"Histology":[262],"differentially":[263],"influences":[264],"mBC.":[268],"Although":[269],"the":[270],"metastasis":[273],"risk":[274,293],"can":[277],"be":[278],"explained":[279],"clinical":[283],"factors,":[284],"remains":[286],"independently":[287],"markedly":[291],"LMD.":[295]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-08T00:00:00"}