{"id":"https://openalex.org/W7201843176","doi":"https://doi.org/10.1038/s41416-026-03569-w","title":"A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability","display_name":"A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability","publication_year":2026,"publication_date":"2026-08-07","ids":{"openalex":"https://openalex.org/W7201843176","doi":"https://doi.org/10.1038/s41416-026-03569-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42567898","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740292"},"language":"en","primary_location":{"id":"doi:10.1038/s41416-026-03569-w","doi":"https://doi.org/10.1038/s41416-026-03569-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-026-03569-w","pdf_url":"https://www.nature.com/articles/s41416-026-03569-w.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41416-026-03569-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048595676","display_name":"Elien Hilgert","orcid":"https://orcid.org/0000-0002-4715-6972","observed_orcids":["https://orcid.org/0000-0002-4715-6972"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210118715","display_name":"Cancer Research Institute Ghent","ror":"https://ror.org/02afm7029","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210118715"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elien Hilgert","raw_affiliation_strings":["Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-4715-6972","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210118715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050006580","display_name":"Lisa Depestel","orcid":"https://orcid.org/0000-0001-5690-3258","observed_orcids":["https://orcid.org/0000-0001-5690-3258"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210118715","display_name":"Cancer Research Institute Ghent","ror":"https://ror.org/02afm7029","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210118715"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lisa Depestel","raw_affiliation_strings":["Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-5690-3258","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210118715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015213142","display_name":"Nadine Van Roy","orcid":"https://orcid.org/0000-0003-0247-2223","observed_orcids":["https://orcid.org/0000-0003-0247-2223"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210118715","display_name":"Cancer Research Institute Ghent","ror":"https://ror.org/02afm7029","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210118715"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nadine Van Roy","raw_affiliation_strings":["Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210118715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146057689","display_name":"Stephen Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Roberts","raw_affiliation_strings":["Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060684280","display_name":"Kaat Durinck","orcid":"https://orcid.org/0000-0003-1762-5739","observed_orcids":["https://orcid.org/0000-0003-1762-5739"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210118715","display_name":"Cancer Research Institute Ghent","ror":"https://ror.org/02afm7029","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210118715"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Kaat Durinck","raw_affiliation_strings":["Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. kaat.durinck@ugent.be"],"raw_orcid":"https://orcid.org/0000-0003-1762-5739","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. kaat.durinck@ugent.be","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210118715"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032769404","display_name":"Frank Speleman","orcid":"https://orcid.org/0000-0002-6628-8559","observed_orcids":["https://orcid.org/0000-0002-6628-8559"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210118715","display_name":"Cancer Research Institute Ghent","ror":"https://ror.org/02afm7029","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210118715"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Frank Speleman","raw_affiliation_strings":["Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6628-8559","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Medicine, Faculty of Medicine & Health Sciences, Ghent University; Cancer Research Institute Ghent (CRIG), Ghent, Belgium","institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210118715"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060684280"],"corresponding_institution_ids":["https://openalex.org/I32597200","https://openalex.org/I4210118715"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"135","issue":"10","first_page":"1557","last_page":"1568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chromosome-17q-gain","display_name":"chromosome 17q gain","score":0.9269999861717224},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8830000162124634},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.8259999752044678},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9350000023841858},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9179999828338623},{"id":"https://openalex.org/keywords/replication-fork-dynamics","display_name":"replication fork dynamics","score":0.972000002861023},{"id":"https://openalex.org/keywords/oncogene-amplification","display_name":"oncogene amplification","score":0.902999997138977},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.7170000076293945},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.5360000133514404},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7721999883651733},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6861000061035156},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.642300009727478},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.3865000009536743},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3562999963760376},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35359999537467957},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.33000001311302185},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.3248000144958496},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C47924181","wikidata":"https://www.wikidata.org/wiki/Q668633","display_name":"Chromosome 3","level":4,"score":0.274399995803833},{"id":"https://openalex.org/C2992772720","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Chromosome number","level":5,"score":0.27000001072883606},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.26930001378059387},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.2572000026702881}],"mesh":[{"descriptor_ui":"D002886","descriptor_name":"Chromosomes, Human, Pair 17","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41416-026-03569-w","doi":"https://doi.org/10.1038/s41416-026-03569-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-026-03569-w","pdf_url":"https://www.nature.com/articles/s41416-026-03569-w.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740292","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740292/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740292/pdf/41416_2026_Article_3569.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:42567898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42567898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41416-026-03569-w","doi":"https://doi.org/10.1038/s41416-026-03569-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-026-03569-w","pdf_url":"https://www.nature.com/articles/s41416-026-03569-w.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2234064689","display_name":"BRIP1 controlling replicative stress in the neuroblastoma tumor genome: functional exploration and zebrafish modelling","funder_award_id":"11C3921N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G3792944899","display_name":"The role of BRIP1 in MYCN driven neuroblastoma formation: from mechanism to drugging","funder_award_id":"G087221N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322603","display_name":"Universiteit Gent","ror":"https://ror.org/00cv9y106"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320331790","display_name":"Stichting Villa Joep","ror":"https://ror.org/01qpa4x48"},{"id":"https://openalex.org/F4320335227","display_name":"Bijzonder Onderzoeksfonds UGent","ror":"https://ror.org/00cv9y106"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7201843176.pdf","grobid_xml":"https://content.openalex.org/works/W7201843176.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W1836973230","https://openalex.org/W1855851918","https://openalex.org/W1915238740","https://openalex.org/W1969855459","https://openalex.org/W1980830652","https://openalex.org/W1985420075","https://openalex.org/W1985889132","https://openalex.org/W1989059483","https://openalex.org/W1990098145","https://openalex.org/W1991616035","https://openalex.org/W1993567700","https://openalex.org/W1997895136","https://openalex.org/W2001342979","https://openalex.org/W2004954333","https://openalex.org/W2007144687","https://openalex.org/W2011595404","https://openalex.org/W2020783280","https://openalex.org/W2022354436","https://openalex.org/W2031515890","https://openalex.org/W2040860750","https://openalex.org/W2045069136","https://openalex.org/W2050128145","https://openalex.org/W2057831681","https://openalex.org/W2062500929","https://openalex.org/W2068167166","https://openalex.org/W2081934185","https://openalex.org/W2091063098","https://openalex.org/W2093442957","https://openalex.org/W2094127052","https://openalex.org/W2098682719","https://openalex.org/W2109173575","https://openalex.org/W2133880683","https://openalex.org/W2139349931","https://openalex.org/W2139533680","https://openalex.org/W2143139301","https://openalex.org/W2144690533","https://openalex.org/W2151052146","https://openalex.org/W2158349729","https://openalex.org/W2161954865","https://openalex.org/W2162923414","https://openalex.org/W2165656117","https://openalex.org/W2213548494","https://openalex.org/W2233302010","https://openalex.org/W2258476076","https://openalex.org/W2327054845","https://openalex.org/W2330923897","https://openalex.org/W2556688586","https://openalex.org/W2557435811","https://openalex.org/W2599927223","https://openalex.org/W2608961468","https://openalex.org/W2609243345","https://openalex.org/W2637518033","https://openalex.org/W2743954317","https://openalex.org/W2766401090","https://openalex.org/W2793785833","https://openalex.org/W2806593114","https://openalex.org/W2811371244","https://openalex.org/W2888513680","https://openalex.org/W2902229746","https://openalex.org/W2922545572","https://openalex.org/W2969025212","https://openalex.org/W2985349530","https://openalex.org/W2989789620","https://openalex.org/W2994565852","https://openalex.org/W2999172028","https://openalex.org/W3002604990","https://openalex.org/W3004359474","https://openalex.org/W3005974465","https://openalex.org/W3014348148","https://openalex.org/W3015398789","https://openalex.org/W3028623550","https://openalex.org/W3032991700","https://openalex.org/W3036761926","https://openalex.org/W3042190218","https://openalex.org/W3081246627","https://openalex.org/W3093008191","https://openalex.org/W3099143699","https://openalex.org/W3111248719","https://openalex.org/W3119400275","https://openalex.org/W3127281995","https://openalex.org/W3139168979","https://openalex.org/W3139436654","https://openalex.org/W3179065218","https://openalex.org/W3183156925","https://openalex.org/W3184057816","https://openalex.org/W3188111258","https://openalex.org/W3199434918","https://openalex.org/W3201570266","https://openalex.org/W3202693025","https://openalex.org/W3202933076","https://openalex.org/W3209536297","https://openalex.org/W3210220496","https://openalex.org/W3217487724","https://openalex.org/W3217537052","https://openalex.org/W4210455210","https://openalex.org/W4223581684","https://openalex.org/W4225477709","https://openalex.org/W4235326614","https://openalex.org/W4237378684","https://openalex.org/W4281486974","https://openalex.org/W4283011521","https://openalex.org/W4285385872","https://openalex.org/W4293809710","https://openalex.org/W4302424483","https://openalex.org/W4307922066","https://openalex.org/W4307930434","https://openalex.org/W4309912258","https://openalex.org/W4309947467","https://openalex.org/W4311193933","https://openalex.org/W4311988892","https://openalex.org/W4313557392","https://openalex.org/W4321018996","https://openalex.org/W4327693030","https://openalex.org/W4360999556","https://openalex.org/W4362522571","https://openalex.org/W4362636088","https://openalex.org/W4378627871","https://openalex.org/W4381194491","https://openalex.org/W4382542850","https://openalex.org/W4385708659","https://openalex.org/W4385857846","https://openalex.org/W4385997304","https://openalex.org/W4386496483","https://openalex.org/W4386601642","https://openalex.org/W4387159228","https://openalex.org/W4388667208","https://openalex.org/W4390325546","https://openalex.org/W4391629220","https://openalex.org/W4392358121","https://openalex.org/W4395076259","https://openalex.org/W4399187723","https://openalex.org/W4399428631","https://openalex.org/W4400409783","https://openalex.org/W4402267158","https://openalex.org/W4404487491","https://openalex.org/W4405869089","https://openalex.org/W4406603202","https://openalex.org/W4406917203","https://openalex.org/W4410031905","https://openalex.org/W4410189394","https://openalex.org/W4411206522","https://openalex.org/W4416193103","https://openalex.org/W4416740418","https://openalex.org/W7131393279","https://openalex.org/W7163418265","https://openalex.org/W7170142432"],"related_works":["https://openalex.org/W2740836679","https://openalex.org/W2999467739","https://openalex.org/W7204227873","https://openalex.org/W7154736334","https://openalex.org/W7106852459","https://openalex.org/W4416740418","https://openalex.org/W4409625710","https://openalex.org/W2343481154","https://openalex.org/W2001234313","https://openalex.org/W4408181515"],"abstract_inverted_index":{"Neuroblastoma":[0],"is":[1,18,38,98],"characterised":[2],"by":[3,21,139],"extensive":[4],"genomic":[5],"instability":[6],"despite":[7],"a":[8,84],"marked":[9],"paucity":[10],"of":[11,86,101,136,164],"recurrent":[12,49],"somatic":[13],"mutations.":[14],"Instead,":[15],"the":[16,91,99,137,162],"disease":[17],"predominantly":[19],"driven":[20],"chromosomal":[22,26],"alterations,":[23],"including":[24],"segmental":[25],"imbalances,":[27],"small":[28],"structural":[29],"variants,":[30],"and":[31,62,68,94,120,149,160],"oncogene":[32],"amplification.":[33],"A":[34],"major":[35],"unmet":[36],"challenge":[37],"identifying":[39],"key":[40],"oncogenic":[41],"drivers,":[42],"beyond":[43],"MYCN":[44],"amplification,":[45],"hidden":[46],"within":[47],"these":[48,75],"DNA":[50,121,150],"copy":[51,76,142],"number":[52],"alterations.":[53],"Extra":[54],"wild-type":[55],"gene":[56],"copies":[57],"can":[58],"alter":[59],"expression":[60],"levels":[61],"thus":[63],"contribute":[64],"to":[65,81],"tumour":[66],"development":[67,163],"affect":[69],"survival.":[70],"Increasing":[71],"evidence":[72],"suggests":[73],"that":[74,124],"number-affected":[77],"genes":[78,112,144],"confer":[79],"resistance":[80],"replication":[82,117,146],"stress,":[83],"hallmark":[85],"high-risk":[87],"neuroblastoma":[88,159],"tumours.":[89],"Among":[90],"most":[92],"frequent":[93],"prognostically":[95],"significant":[96],"alterations":[97],"gain":[100],"chromosome":[102],"17q.":[103],"In":[104],"this":[105],"review,":[106],"we":[107,125],"discuss":[108],"selected":[109],"top-ranked":[110],"candidate":[111],"on":[113],"17q":[114,141],"implicated":[115],"in":[116,157],"fork":[118],"dynamics":[119],"damage":[122,151],"repair":[123,152],"previously":[126],"identified":[127],"through":[128],"an":[129],"integrative":[130],"functional":[131],"genomics":[132],"study.":[133],"Improved":[134],"understanding":[135],"mechanisms":[138],"which":[140],"number-driven":[143],"regulate":[145],"stress":[147],"responses":[148],"may":[153],"expose":[154],"fundamental":[155],"vulnerabilities":[156],"aggressive":[158],"guide":[161],"novel":[165],"targeted":[166],"therapeutic":[167],"strategies.":[168]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-08T00:00:00"}
