{"id":"https://openalex.org/W7201839222","doi":"https://doi.org/10.1007/s00424-026-03227-3","title":"Structural compatibility enables functional co-assembly of Kir2.1 channels and the voltage-sensing domain of voltage-sensitive phosphatases","display_name":"Structural compatibility enables functional co-assembly of Kir2.1 channels and the voltage-sensing domain of voltage-sensitive phosphatases","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7201839222","doi":"https://doi.org/10.1007/s00424-026-03227-3"},"language":"en","primary_location":{"id":"doi:10.1007/s00424-026-03227-3","doi":"https://doi.org/10.1007/s00424-026-03227-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00424-026-03227-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00424-026-03227-3.pdf","source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00424-026-03227-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107319568","display_name":"Anagha Gopalakrishnan Nair","orcid":"https://orcid.org/0009-0002-4857-6554","observed_orcids":["https://orcid.org/0009-0002-4857-6554"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anagha Gopalakrishnan Nair","raw_affiliation_strings":["Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany"],"raw_orcid":"https://orcid.org/0009-0002-4857-6554","affiliations":[{"raw_affiliation_string":"Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040768927","display_name":"Philipp R\u00fchl","orcid":"https://orcid.org/0000-0002-3554-3107","observed_orcids":["https://orcid.org/0000-0002-3554-3107"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp R\u00fchl","raw_affiliation_strings":["Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3554-3107","affiliations":[{"raw_affiliation_string":"Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146057699","display_name":"Lina Seeber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lina Seeber","raw_affiliation_strings":["Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023729627","display_name":"Toshinori Hoshi","orcid":"https://orcid.org/0000-0002-0702-1918","observed_orcids":["https://orcid.org/0000-0002-0702-1918"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshinori Hoshi","raw_affiliation_strings":["Department of Physiology, University of Pennsylvania, Philadelphia, USA"],"raw_orcid":"https://orcid.org/0000-0002-0702-1918","affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056081784","display_name":"Roland Schoenherr","orcid":"https://orcid.org/0000-0002-7666-5776","observed_orcids":["https://orcid.org/0000-0002-7666-5776"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland Sch\u00f6nherr","raw_affiliation_strings":["Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0633-0775","affiliations":[{"raw_affiliation_string":"Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072746141","display_name":"Stefan H. Heinemann","orcid":"https://orcid.org/0000-0002-4144-0251","observed_orcids":["https://orcid.org/0000-0002-4144-0251"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan H. Heinemann","raw_affiliation_strings":["Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4144-0251","affiliations":[{"raw_affiliation_string":"Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Hans-Kn\u00f6ll-Str. 2, 07745, Jena, Germany","institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072746141"],"corresponding_institution_ids":["https://openalex.org/I4210134900","https://openalex.org/I76198965"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"478","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kir2-1","display_name":"Kir2.1","score":0.984000027179718},{"id":"https://openalex.org/keywords/inwardly-rectifying-potassium-channels","display_name":"inwardly rectifying potassium channels","score":0.8339999914169312},{"id":"https://openalex.org/keywords/voltage-sensing-domain","display_name":"voltage-sensing domain","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hydrophobic-interface","display_name":"hydrophobic interface","score":0.777999997138977},{"id":"https://openalex.org/keywords/voltage-imaging","display_name":"voltage imaging","score":0.49799999594688416},{"id":"https://openalex.org/keywords/membrane-protein-interactions","display_name":"membrane protein interactions","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49709999561309814},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.49390000104904175},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4828000068664551},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4494999945163727},{"id":"https://openalex.org/C2778648169","wikidata":"https://www.wikidata.org/wiki/Q967768","display_name":"Compatibility (geochemistry)","level":2,"score":0.4352000057697296},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4311999976634979},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4171999990940094},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4147000014781952},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4020000100135803},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.40130001306533813},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.39800000190734863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3765000104904175},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.37040001153945923},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.36880001425743103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35850000381469727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3433000147342682},{"id":"https://openalex.org/C3019336641","wikidata":"https://www.wikidata.org/wiki/Q55643886","display_name":"Fluorescent protein","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2808000147342682},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.2761000096797943},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.25459998846054077},{"id":"https://openalex.org/C70636015","wikidata":"https://www.wikidata.org/wiki/Q4300350","display_name":"Molecular biophysics","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C197153747","wikidata":"https://www.wikidata.org/wiki/Q24780316","display_name":"SH2 domain","level":4,"score":0.25119999051094055},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00424-026-03227-3","doi":"https://doi.org/10.1007/s00424-026-03227-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00424-026-03227-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00424-026-03227-3.pdf","source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","raw_type":"journal-article"},{"id":"doi:10.64898/2026.08.07.743441","doi":"https://doi.org/10.64898/2026.08.07.743441","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.07.743441","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/07/2026.08.07.743441.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1007/s00424-026-03227-3","doi":"https://doi.org/10.1007/s00424-026-03227-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00424-026-03227-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00424-026-03227-3.pdf","source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5822844670","display_name":null,"funder_award_id":"91819480","funder_id":"https://openalex.org/F4320320875","funder_display_name":"Deutscher Akademischer Austauschdienst"},{"id":"https://openalex.org/G5873538239","display_name":null,"funder_award_id":"705944SH","funder_id":"https://openalex.org/F4320315019","funder_display_name":"Simons Foundation Autism Research Initiative"}],"funders":[{"id":"https://openalex.org/F4320315019","display_name":"Simons Foundation Autism Research Initiative","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7201839222.pdf","grobid_xml":"https://content.openalex.org/works/W7201839222.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1494072490","https://openalex.org/W1964343715","https://openalex.org/W1965191256","https://openalex.org/W1973170319","https://openalex.org/W1983523125","https://openalex.org/W1990771438","https://openalex.org/W2001427760","https://openalex.org/W2004689585","https://openalex.org/W2011596003","https://openalex.org/W2013853780","https://openalex.org/W2040091117","https://openalex.org/W2053120786","https://openalex.org/W2058287296","https://openalex.org/W2062382534","https://openalex.org/W2068524893","https://openalex.org/W2073344615","https://openalex.org/W2085780871","https://openalex.org/W2098567877","https://openalex.org/W2125872855","https://openalex.org/W2134678210","https://openalex.org/W2139181039","https://openalex.org/W2143070723","https://openalex.org/W2161227647","https://openalex.org/W2167279371","https://openalex.org/W2169753248","https://openalex.org/W2793834942","https://openalex.org/W2796608944","https://openalex.org/W2996619516","https://openalex.org/W3083406432","https://openalex.org/W3201700770","https://openalex.org/W4307188282","https://openalex.org/W4387581717","https://openalex.org/W4390968204","https://openalex.org/W4392165422","https://openalex.org/W4393161485","https://openalex.org/W4394694796","https://openalex.org/W4396721167","https://openalex.org/W4398183991","https://openalex.org/W4402665526","https://openalex.org/W4413775264","https://openalex.org/W4414163764","https://openalex.org/W4416542252","https://openalex.org/W7203532164"],"related_works":["https://openalex.org/W2049520220","https://openalex.org/W2169753248","https://openalex.org/W2042966809","https://openalex.org/W2061267962","https://openalex.org/W1976091359","https://openalex.org/W2142094786","https://openalex.org/W4211116471","https://openalex.org/W4213147265","https://openalex.org/W2010300123","https://openalex.org/W2068407301"],"abstract_inverted_index":{"Abstract":[0],"Voltage-sensing":[1],"domains":[2],"(VSDs),":[3],"which":[4],"are":[5,17],"integral":[6],"parts":[7],"of":[8,26,116,124,159],"voltage-gated":[9],"K":[10,41,144],"+":[11,42],"channel":[12],"(K":[13],"V":[14,145],")":[15],"proteins,":[16],"highly":[18],"modular":[19],"protein":[20,73],"components":[21],"that":[22,83,105,135,150,174],"function":[23],"largely":[24],"independently":[25,67,175],"ion-conducting":[27],"pores":[28],"\u2013":[29],"a":[30,48,53,101],"property":[31],"exploited":[32],"in":[33,113,155,163],"genetically":[34],"encoded":[35],"voltage":[36,165],"indicators":[37],"(GEVIs).":[38],"Conversely,":[39],"inward-rectifier":[40],"channels":[43],"such":[44],"as":[45],"Kir2.1":[46,77,125],"possess":[47],"pore-only":[49,69,136],"architecture":[50],"and":[51,60,70,78,87,137,148],"lack":[52],"VSD.":[54],"Here,":[55],"we":[56],"demonstrate":[57],"an":[58],"unexpected":[59,156],"functionally":[61],"relevant":[62],"structural":[63],"compatibility":[64],"between":[65],"the":[66,114,117,122,128,172],"evolved":[68,176],"VSD-only":[71,138],"membrane":[72,151,178],"families.":[74],"When":[75],"co-expressed,":[76],"ASAP-type":[79],"GEVIs":[80],"form":[81],"complexes":[82,186],"constrain":[84],"VSD":[85,115],"movement":[86],"markedly":[88],"interfere":[89],"with":[90,97,187],"voltage-dependent":[91],"fluorescence":[92],"responses.":[93],"Molecular":[94],"modeling":[95],"combined":[96],"targeted":[98],"mutagenesis":[99],"identified":[100],"conserved":[102],"hydrophobic":[103],"interface":[104],"mediates":[106],"this":[107],"interaction.":[108],"A":[109],"single":[110],"bulky":[111],"substitution":[112],"GEVI":[118],"rEstus-NI":[119],"(A79W)":[120],"disrupted":[121],"impact":[123],"while":[126],"preserving":[127],"GEVI\u2019s":[129],"voltage-sensing":[130],"performance.":[131],"These":[132],"findings":[133],"suggest":[134],"proteins":[139,152,179],"can":[140],"assemble":[141,181],"into":[142,182],"functional":[143,177,189],"-like":[146],"architectures,":[147],"highlight":[149],"may":[153,180],"engage":[154],"interactions":[157],"capable":[158],"altering":[160],"experimental":[161],"readouts":[162],"physiological":[164,192],"imaging":[166],"studies.":[167],"The":[168],"study":[169],"also":[170],"raises":[171],"possibility":[173],"previously":[183],"unrecognized":[184],"higher-order":[185],"distinct":[188],"properties":[190],"under":[191],"conditions.":[193]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-08T00:00:00"}
