{"id":"https://openalex.org/W7201475399","doi":null,"title":"Regulation of intestinal antimicrobial response in health and aging : new roles of bile acids","display_name":"Regulation of intestinal antimicrobial response in health and aging : new roles of bile acids","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W7201475399"},"language":"en","primary_location":{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/12161","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/12161","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/70760da9-4268-4800-ab43-816679ce8118/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Th\u00e8se de doctorat"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://usherbrooke.scholaris.ca/bitstreams/70760da9-4268-4800-ab43-816679ce8118/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160955386","display_name":"Sarah Tremblay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Tremblay, Sarah","raw_affiliation_strings":["Doctor degree diploma philosophiae doctor (Ph.D.) in microbiology , Faculty of Medicine and Health Sciences , Universit\u00e9 de Sherbrooke , Sherbrooke , Qu\u00e9bec , Canada , J1H 5N4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctor degree diploma philosophiae doctor (Ph.D.) in microbiology , Faculty of Medicine and Health Sciences , Universit\u00e9 de Sherbrooke , Sherbrooke , Qu\u00e9bec , Canada , J1H 5N4","institution_ids":["https://openalex.org/I135117807"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160955386"],"corresponding_institution_ids":["https://openalex.org/I135117807"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.10899999737739563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chenodeoxycholic-acid","display_name":"chenodeoxycholic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6970000267028809},{"id":"https://openalex.org/keywords/intestinal-immunity","display_name":"intestinal immunity","score":0.40700000524520874},{"id":"https://openalex.org/keywords/regiiigamma","display_name":"RegIII\u03b3","score":0.6150000095367432},{"id":"https://openalex.org/keywords/alpha-defensins","display_name":"alpha-defensins","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.7540000081062317},{"id":"https://openalex.org/keywords/caliciform-cells","display_name":"caliciform cells","score":0.6840000152587891},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ileum","display_name":"ileum","score":0.4269999861717224},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.8619999885559082},{"id":"https://openalex.org/keywords/citrobacter-rodentium","display_name":"Citrobacter rodentium","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.4690000116825104},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.42899999022483826},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.510699987411499},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5009999871253967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38179999589920044},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.32679998874664307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3005000054836273},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2953999936580658},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.25360000133514404},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.24779999256134033},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.24330000579357147}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/12161","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/12161","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/70760da9-4268-4800-ab43-816679ce8118/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Th\u00e8se de doctorat"}],"best_oa_location":{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/12161","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/12161","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/70760da9-4268-4800-ab43-816679ce8118/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Th\u00e8se de doctorat"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3676659354","display_name":null,"funder_award_id":"#401949\u20132011","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"},{"id":"https://openalex.org/F4320334841","display_name":"Fonds de recherche du Qu\u00e9bec \u2013 Nature et technologies","ror":"https://ror.org/00b9f9778"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7201475399.pdf","grobid_xml":"https://content.openalex.org/works/W7201475399.grobid-xml"},"referenced_works_count":119,"referenced_works":["https://openalex.org/W62702228","https://openalex.org/W146249449","https://openalex.org/W649893199","https://openalex.org/W1162373941","https://openalex.org/W1482355964","https://openalex.org/W1515146347","https://openalex.org/W1771974095","https://openalex.org/W1902150932","https://openalex.org/W1930879233","https://openalex.org/W1967217097","https://openalex.org/W1969699774","https://openalex.org/W1971681859","https://openalex.org/W1971740873","https://openalex.org/W1973067432","https://openalex.org/W1974616640","https://openalex.org/W1976578226","https://openalex.org/W1977820789","https://openalex.org/W1981068608","https://openalex.org/W1981600259","https://openalex.org/W1982287871","https://openalex.org/W1985848150","https://openalex.org/W1986412893","https://openalex.org/W1988017103","https://openalex.org/W1995586746","https://openalex.org/W1998438993","https://openalex.org/W2000729020","https://openalex.org/W2000818514","https://openalex.org/W2005879027","https://openalex.org/W2010247691","https://openalex.org/W2010446492","https://openalex.org/W2012606594","https://openalex.org/W2014494685","https://openalex.org/W2015396315","https://openalex.org/W2015784622","https://openalex.org/W2017422805","https://openalex.org/W2017995578","https://openalex.org/W2023304735","https://openalex.org/W2030579395","https://openalex.org/W2032782331","https://openalex.org/W2036172771","https://openalex.org/W2037648723","https://openalex.org/W2042082068","https://openalex.org/W2042481588","https://openalex.org/W2044557931","https://openalex.org/W2046006841","https://openalex.org/W2047511413","https://openalex.org/W2049000073","https://openalex.org/W2049169935","https://openalex.org/W2050306701","https://openalex.org/W2058544138","https://openalex.org/W2061048240","https://openalex.org/W2062071068","https://openalex.org/W2062436654","https://openalex.org/W2062729850","https://openalex.org/W2062835892","https://openalex.org/W2064488801","https://openalex.org/W2066411725","https://openalex.org/W2067320696","https://openalex.org/W2068646907","https://openalex.org/W2069077882","https://openalex.org/W2070938244","https://openalex.org/W2072287846","https://openalex.org/W2073578030","https://openalex.org/W2074447950","https://openalex.org/W2074963908","https://openalex.org/W2077590888","https://openalex.org/W2078296200","https://openalex.org/W2081471404","https://openalex.org/W2083422904","https://openalex.org/W2088032711","https://openalex.org/W2088655043","https://openalex.org/W2092474583","https://openalex.org/W2092744572","https://openalex.org/W2095331995","https://openalex.org/W2097121808","https://openalex.org/W2097136349","https://openalex.org/W2098793175","https://openalex.org/W2100649505","https://openalex.org/W2101869267","https://openalex.org/W2104891233","https://openalex.org/W2105274559","https://openalex.org/W2106233765","https://openalex.org/W2106362526","https://openalex.org/W2108281900","https://openalex.org/W2110504545","https://openalex.org/W2112883576","https://openalex.org/W2113945548","https://openalex.org/W2114881954","https://openalex.org/W2120195160","https://openalex.org/W2122292170","https://openalex.org/W2125311914","https://openalex.org/W2126057926","https://openalex.org/W2128800339","https://openalex.org/W2133728642","https://openalex.org/W2134935858","https://openalex.org/W2135484088","https://openalex.org/W2136315377","https://openalex.org/W2137088443","https://openalex.org/W2142942734","https://openalex.org/W2144486743","https://openalex.org/W2151054302","https://openalex.org/W2152714616","https://openalex.org/W2153114262","https://openalex.org/W2155507705","https://openalex.org/W2159155233","https://openalex.org/W2161754779","https://openalex.org/W2164410979","https://openalex.org/W2164640614","https://openalex.org/W2165877587","https://openalex.org/W2188593832","https://openalex.org/W2193546234","https://openalex.org/W2201859789","https://openalex.org/W2326552171","https://openalex.org/W2336536891","https://openalex.org/W2406498263","https://openalex.org/W2417128146","https://openalex.org/W2511217924","https://openalex.org/W2773388190","https://openalex.org/W4211241312"],"related_works":["https://openalex.org/W2803397016","https://openalex.org/W2599078623","https://openalex.org/W2074986879","https://openalex.org/W2945600605","https://openalex.org/W643055956","https://openalex.org/W7208619464","https://openalex.org/W165477442","https://openalex.org/W7020141127","https://openalex.org/W1986418038","https://openalex.org/W1988779510"],"abstract_inverted_index":{"La":[0],"production":[1],"des":[2,61,135,140,195,197,231,247,269,276,279,305,314,333,350,356],"prot\u00e9ines":[3,270],"et":[4,41,63,76,134,145,173,192,220,259,278,317,358],"peptides":[5],"antimicrobiens":[6],"(AMPP)":[7],"est":[8,249,262,307],"un":[9,22,54,227,235,318,327,347,359],"\u00e9l\u00e9ment":[10],"tr\u00e8s":[11],"important":[12],"dans":[13,56,217,288,353],"la":[14,57,65,107,164,213,282,295,344,354],"r\u00e9ponse":[15,108,214],"antimicrobienne":[16,67,109,215],"intestinale.":[17,110],"Les":[18],"sels":[19,51,198,351],"biliaires":[20,52,199,352],"poss\u00e8dent":[21],"m\u00e9tabolisme":[23],"qui":[24],"peut":[25],"\u00eatre":[26],"perturb\u00e9":[27],"lors":[28],"de":[29,59,64,83,86,97,106,131,142,158,167,188,190,193,207,211,221,237,240,254,256,267,281,294,303,321,329],"pathologies":[30],"telles":[31,71],"que":[32,49,72,100,127,155,245],"les":[33,37,50,73,91,147,170,336,364],"maladies":[34],"inflammatoires":[35],"chroniques,":[36],"infections":[38,74],"bact\u00e9riennes,":[39],"l\u2019ob\u00e9sit\u00e9":[40],"le":[42,77,121,218,289],"vieillissement.":[43,78],"Notre":[44],"\u00e9tude":[45,209],"tend":[46],"\u00e0":[47,112,116,182,234],"d\u00e9montrer":[48,84],"jouent":[53],"r\u00f4le":[55,228,349],"r\u00e9gulation":[58,355],"l\u2019expression":[60,130,156,230,246,255,268,332],"AMPP":[62,93,248,334,357],"d\u00e9fense":[66],"en":[68,150,162],"\u00e9tat":[69],"d\u2019inflammation,":[70],"bact\u00e9riennes":[75],"Le":[79,204],"premier":[80],"objectif":[81,206],"\u00e9tait":[82,210],"l\u2019effet":[85],"l\u2019acide":[87],"ch\u00e9nod\u00e9soxycolique":[88],"(CDCA)":[89],"sur":[90,103,139,146,229,331],"majeurs":[92],"produits":[94],"au":[95,292],"niveau":[96],"l\u2019il\u00e9on,":[98],"ainsi":[99,154],"son":[101],"effet":[102,328],"d\u2019autres":[104],"facettes":[105],"Gr\u00e2ce":[111,233],"une":[113,175,252,312],"di\u00e8te":[114],"suppl\u00e9ment\u00e9e":[115],"0,1%":[117],"CDCA,":[118],"donn\u00e9e":[119],"chez":[120,335,363],"mod\u00e8le":[122,236],"murin,":[123],"nous":[124,243,341],"avons":[125],"d\u00e9montr\u00e9":[126],"CDCA":[128,160,224,330],"augmente":[129],"RegIII\u0263,":[132],"RegIII\u03b2":[133],"\u03b1-d\u00e9fensines.":[136],"Il":[137],"agit":[138,161],"populations":[141],"cellules":[143,148,315,322],"immunitaires":[144],"caliciformes":[149,316],"augmentant":[151],"leur":[152],"nombre":[153,320],"relative":[157],"Muc2.":[159],"limitant":[163],"transmission":[165],"syst\u00e9mique":[166],"S.typhimurium":[168],"vers":[169],"organes":[171],"cibles":[172],"permet":[174],"\u00e9limination":[176],"plus":[177],"rapide":[178],"d\u2019une":[179],"infection":[180],"ent\u00e9rique":[181],"C.rodentium.":[183],"Ces":[184],"effets":[185],"semblent":[186],"ind\u00e9pendants":[187],"l\u2019activation":[189,194],"STAT3":[191],"r\u00e9cepteurs":[196],"(FXR,":[200],"PXR,":[201],"TGR5,":[202],"VDR).":[203],"deuxi\u00e8me":[205],"cette":[208],"caract\u00e9riser":[212],"intestinale":[216,284],"vieillissement":[219,290],"v\u00e9rifier":[222],"si":[223],"jouait":[225],"toujours":[226,326],"AMPP.":[232],"souris":[238,337,365],"\u00e2g\u00e9es":[239],"104":[241],"semaines,":[242],"montrons":[244],"alt\u00e9r\u00e9e":[250],":":[251],"baisse":[253],"l\u2019\u03b1-d\u00e9fensine":[257],"20":[258],"du":[260,298],"lysozyme":[261],"observ\u00e9e,":[263],"tandis":[264],"qu\u2019une":[265],"hausse":[266],"Reg3":[271],"se":[272],"produit.":[273],"Une":[274,301],"destruction":[275],"villosit\u00e9s":[277],"changements":[280],"microflore":[283],"sont":[285],"aussi":[286],"observ\u00e9s":[287],"gr\u00e2ce":[291],"s\u00e9quen\u00e7age":[293],"r\u00e9gion":[296],"V4":[297],"g\u00e8ne":[299],"16S.":[300],"disparition":[302],"l\u2019ordre":[304],"Clostridiales":[306],"observ\u00e9e.":[308],"Nous":[309,324],"pouvons":[310],"voir":[311],"dysplasie":[313],"grand":[319],"interm\u00e9diaires.":[323],"obtenons":[325],"\u00e2g\u00e9es.":[338],"En":[339],"conclusion,":[340],"d\u00e9montrons":[342],"pour":[343],"premi\u00e8re":[345],"fois":[346],"nouveau":[348,360],"profil":[361],"antibact\u00e9rien":[362],"vieillissantes.":[366]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-08-07T00:00:00"}
