{"id":"https://openalex.org/W7201275698","doi":null,"title":"TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH GENETICALLY ENGINEERED K. LACTIS","display_name":"TREATMENT OF INFLAMMATORY BOWEL DISEASE WITH GENETICALLY ENGINEERED K. LACTIS","publication_year":2025,"publication_date":"2025-04-25","ids":{"openalex":"https://openalex.org/W7201275698"},"language":"en","primary_location":{"id":"pmh:oai:nur.nu.edu.kz:123456789/8428","doi":null,"is_oa":true,"landing_page_url":"https://nur.nu.edu.kz/items/03ba366e-9caf-4902-980e-494052c8eb86/request-a-copy?bitstream=42d4bb96-fb0c-4fea-ad3b-e13a57ed3013","pdf_url":null,"source":{"id":"https://openalex.org/S4377196417","display_name":"Nazarbayev University Repository (Nazarbayev University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60559429","host_organization_name":"Nazarbayev University","host_organization_lineage":["https://openalex.org/I60559429"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master`s thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nur.nu.edu.kz/items/03ba366e-9caf-4902-980e-494052c8eb86/request-a-copy?bitstream=42d4bb96-fb0c-4fea-ad3b-e13a57ed3013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031899099","display_name":"Darya Sadvokassova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sadvokassova, Darya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031899099"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":1.0},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/ccr5-antagonist","display_name":"CCR5 antagonist","score":0.8399999737739563},{"id":"https://openalex.org/keywords/recombinant-yeast","display_name":"recombinant yeast","score":0.8830000162124634},{"id":"https://openalex.org/keywords/intestinal-barrier-function","display_name":"intestinal barrier function","score":0.6869999766349792},{"id":"https://openalex.org/keywords/rorgamma","display_name":"ROR\u03b3","score":0.8220000267028809},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":1.0},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.8174999952316284},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6549999713897705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6255000233650208},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6050000190734863},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.588100016117096},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5670999884605408},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5476999878883362},{"id":"https://openalex.org/C3019111730","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetically engineered","level":3,"score":0.4708999991416931},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.33180001378059387},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3075000047683716},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C2780011460","wikidata":"https://www.wikidata.org/wiki/Q133598","display_name":"Lactococcus lactis","level":4,"score":0.29280000925064087},{"id":"https://openalex.org/C2909240849","wikidata":"https://www.wikidata.org/wiki/Q2300099","display_name":"Intestinal Disorder","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:nur.nu.edu.kz:123456789/8428","doi":null,"is_oa":true,"landing_page_url":"https://nur.nu.edu.kz/items/03ba366e-9caf-4902-980e-494052c8eb86/request-a-copy?bitstream=42d4bb96-fb0c-4fea-ad3b-e13a57ed3013","pdf_url":null,"source":{"id":"https://openalex.org/S4377196417","display_name":"Nazarbayev University Repository (Nazarbayev University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60559429","host_organization_name":"Nazarbayev University","host_organization_lineage":["https://openalex.org/I60559429"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master`s thesis"}],"best_oa_location":{"id":"pmh:oai:nur.nu.edu.kz:123456789/8428","doi":null,"is_oa":true,"landing_page_url":"https://nur.nu.edu.kz/items/03ba366e-9caf-4902-980e-494052c8eb86/request-a-copy?bitstream=42d4bb96-fb0c-4fea-ad3b-e13a57ed3013","pdf_url":null,"source":{"id":"https://openalex.org/S4377196417","display_name":"Nazarbayev University Repository (Nazarbayev University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60559429","host_organization_name":"Nazarbayev University","host_organization_lineage":["https://openalex.org/I60559429"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master`s thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7198876066","https://openalex.org/W4416228648","https://openalex.org/W7198231933","https://openalex.org/W2475757449","https://openalex.org/W2560021848","https://openalex.org/W7198678808","https://openalex.org/W2104482832","https://openalex.org/W3044361043","https://openalex.org/W4380086808","https://openalex.org/W6902502331"],"abstract_inverted_index":{"Inflammatory":[0,139],"bowel":[1],"disease":[2,23],"(IBD)":[3],"is":[4],"an":[5,120],"aggravating":[6],"disorder":[7],"characterized":[8],"by":[9,30,39,145],"mucosal":[10],"inflammation":[11],"of":[12,20,33,54,58,68,85,96,102,123],"the":[13,44,52,82,86,94,106,159,171,181,193],"intestinal":[14,97],"lining.":[15],"The":[16,110,156],"two":[17],"main":[18],"forms":[19],"IBD,":[21],"Crohn's":[22],"and":[24,70,100,116,211],"ulcerative":[25],"colitis,":[26],"can":[27,63],"be":[28],"triggered":[29],"a":[31,48,72,163,188,196],"variety":[32],"factors,":[34],"but":[35,203],"are":[36,206],"mostly":[37],"distinguished":[38],"immunological":[40],"abnormalities,":[41],"among":[42],"which":[43],"CCR5/CCL5":[45],"axis":[46],"has":[47],"profound":[49],"role":[50],"in":[51,90,93,105,167,170],"initiation":[53],"immune":[55],"response":[56],"because":[57],"its":[59],"upregulated":[60],"activity.":[61],"IBD":[62],"tremendously":[64],"worsen":[65],"patients'":[66],"quality":[67],"life":[69],"require":[71],"comprehensive":[73],"approach":[74],"to":[75,80,192,208],"treatment.":[76],"This":[77],"study":[78],"aimed":[79],"evaluate":[81],"therapeutic":[83],"potential":[84],"CCR5":[87,136,160,189],"antagonist":[88],"expressed":[89],"K.":[91],"lactis":[92],"restoration":[95],"barrier":[98],"function":[99],"reduction":[101],"IBD-associated":[103],"symptoms":[104],"C57BL/6":[107],"mouse":[108],"model.":[109],"experiment":[111],"was":[112],"performed":[113],"using":[114],"control":[115],"experimental":[117],"subgroups":[118,152],"with":[119,135],"acute":[121],"form":[122],"disease,":[124],"where":[125],"mice":[126,157],"received":[127],"DSS-only":[128],"treatment":[129],"or":[130],"DSS":[131],"plus":[132],"yeasts":[133],"transformed":[134],"antagonist,":[137],"respectively.":[138],"marker":[140],"ROR\u03b3":[141],"levels,":[142],"mainly":[143],"produced":[144],"Th17":[146],"cells,":[147],"were":[148,178],"estimated":[149],"for":[150,180],"both":[151],"after":[153],"11":[154],"days.":[155],"getting":[158],"inhibitor":[161,190],"demonstrated":[162],"statistically":[164,212],"significant":[165,176],"decrease":[166],"ROR\u03b3-expressing":[168],"cells":[169],"small":[172],"intestine.":[173],"However,":[174],"no":[175],"differences":[177],"identified":[179],"colon.":[182],"These":[183],"findings":[184],"indicate":[185],"that":[186],"delivering":[187],"directly":[191],"intestine":[194],"via":[195],"vector":[197],"could":[198],"have":[199],"some":[200],"beneficial":[201],"effects,":[202],"further":[204],"studies":[205],"required":[207],"obtain":[209],"reliable":[210],"relevant":[213],"results.":[214]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-08-07T00:00:00"}
