{"id":"https://openalex.org/W7199516567","doi":null,"title":"Advanced nanostructured systems for targeted drug delivery in the posterior segment of the eye","display_name":"Advanced nanostructured systems for targeted drug delivery in the posterior segment of the eye","publication_year":2026,"publication_date":"2026-04-14","ids":{"openalex":"https://openalex.org/W7199516567"},"language":"it","primary_location":{"id":"pmh:oai:etd.adm.unipi.it:etd-04082026-131225","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-04082026-131225/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-04082026-131225/","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065276055","display_name":"Mariacristina Di Gangi","orcid":"https://orcid.org/0000-0003-1317-1119","observed_orcids":["https://orcid.org/0000-0003-1317-1119"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"DI GANGI, MARIACRISTINA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065276055"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.9589999914169312},{"id":"https://openalex.org/keywords/posterior-segment-of-the-eye","display_name":"posterior segment of the eye","score":0.9890000224113464},{"id":"https://openalex.org/keywords/retinal-drug-delivery","display_name":"retinal drug delivery","score":0.8679999709129333},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/triamcinolone","display_name":"triamcinolone","score":0.7950000166893005},{"id":"https://openalex.org/keywords/corticosteroid-delivery","display_name":"corticosteroid delivery","score":0.9049999713897705},{"id":"https://openalex.org/keywords/surfactant-composition","display_name":"surfactant composition","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ex-vivo-permeation","display_name":"ex vivo permeation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nanocarrier-design","display_name":"nanocarrier design","score":0.6579999923706055},{"id":"https://openalex.org/keywords/topical-administration","display_name":"topical administration","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C113520495","wikidata":"https://www.wikidata.org/wiki/Q2359854","display_name":"Posterior segment of eyeball","level":2,"score":0.7757999897003174},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7401999831199646},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6931999921798706},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5501000285148621},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.5491999983787537},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48410001397132874},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.4781000018119812},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.4666999876499176},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4442000091075897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.439300000667572},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4009000062942505},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3968999981880188},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.39579999446868896},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.36660000681877136},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3481000065803528},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C2985948822","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"Focused ultrasound","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.26759999990463257},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.25780001282691956},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:etd.adm.unipi.it:etd-04082026-131225","doi":null,"is_oa":false,"landing_page_url":"https://etd.adm.unipi.it/theses/available/etd-04082026-131225/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401800","display_name":"Electronic Theses and Dissertations Repository (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://etd.adm.unipi.it/theses/available/etd-04082026-131225/","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2848740392","https://openalex.org/W4399880333","https://openalex.org/W2509051842","https://openalex.org/W3123592063","https://openalex.org/W4375930464","https://openalex.org/W7217280484","https://openalex.org/W7162317521","https://openalex.org/W4410833893","https://openalex.org/W1999240903","https://openalex.org/W4316687599"],"abstract_inverted_index":{"This":[0],"doctoral":[1],"thesis":[2],"focused":[3],"on":[4,94],"the":[5,33,38,42,48,63,79,95,123,161,181,186,189,203],"design":[6,194],"and":[7,25,30,58,74,97,135],"development":[8,49],"of":[9,35,41,50,56,65,100,192,205],"innovative":[10],"ocular":[11],"drug":[12,178,197],"delivery":[13,55,159,198],"systems":[14],"for":[15,32,53,62,85,103,157,176,212,216],"topical":[16],"administration.":[17],"Three":[18],"different":[19],"nanostructured":[20],"platforms,":[21],"polymeric":[22,26],"nanomicelles,":[23],"liposomes,":[24],"nanoparticles,":[27],"were":[28],"investigated":[29],"optimized":[31,124],"treatment":[34,64],"diseases":[36],"affecting":[37],"posterior":[39,104,162,217],"segment":[40,105,218],"eye.":[43],"The":[44,90,140],"first":[45],"chapter":[46,92],"describes":[47,150],"Poloxamer-based":[51],"nanomicelles":[52],"retinal":[54,66],"protein-":[57],"peptide-based":[59],"therapeutics,":[60],"useful":[61],"diseases.":[67,219],"Following":[68,120],"comprehensive":[69],"physico-chemical":[70],"characterization,":[71],"cytotoxic":[72],"assessment,":[73],"in":[75,132,144,195],"vitro":[76,133],"release":[77,134],"studies,":[78],"most":[80],"promising":[81,210],"system":[82],"was":[83,111,126],"selected":[84],"ex":[86,136],"vivo":[87,137],"permeation":[88,138],"evaluation.":[89],"second":[91],"focuses":[93],"formulation":[96,125],"physicochemical":[98],"characterization":[99],"Triamcinolone-loaded":[101],"liposomes":[102],"delivery.":[106],"A":[107],"systematic":[108],"screening":[109],"approach":[110],"employed":[112],"to":[113,131,160],"correlate":[114],"surfactant":[115],"composition":[116],"with":[117,146],"particle":[118],"properties.":[119],"this":[121,184],"screening,":[122],"further":[127],"evaluated":[128],"through":[129],"subjected":[130],"analysis.":[139],"final":[141],"chapter,":[142],"conducted":[143],"collaboration":[145],"Prof.":[147],"C.":[148],"Alvarez-Lorenzo,":[149],"biomimetic":[151],"red":[152],"Blood":[153],"cell":[154],"(RBC)-coated":[155],"nanoparticles":[156],"corticosteroid":[158],"segment.":[163],"These":[164,200],"novel":[165],"nanoplatforms":[166],"offer":[167],"a":[168,209],"non-invasive,":[169],"targeted":[170,214],"strategy,":[171],"demonstrating":[172],"significant":[173],"translational":[174],"potential":[175],"enhancing":[177,196],"bioavailability":[179],"within":[180],"retina.":[182],"In":[183],"context,":[185],"results":[187],"highlight":[188],"pivotal":[190],"role":[191],"nanocarrier":[193],"performance.":[199],"findings":[201],"support":[202],"investigation":[204],"advanced":[206],"nanotechnologies":[207],"as":[208],"strategy":[211],"developing":[213],"therapies":[215]},"counts_by_year":[],"updated_date":"2026-09-13T09:14:26.050021","created_date":"2026-08-07T00:00:00"}