{"id":"https://openalex.org/W71991303","doi":"https://doi.org/10.1182/blood.v67.4.1110.1110","title":"Red cell rheology in stomatocyte-echinocyte transformation: roles of cell geometry and cell shape","display_name":"Red cell rheology in stomatocyte-echinocyte transformation: roles of cell geometry and cell shape","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W71991303","doi":"https://doi.org/10.1182/blood.v67.4.1110.1110","mag":"71991303","pmid":"https://pubmed.ncbi.nlm.nih.gov/3955230"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v67.4.1110.1110","doi":"https://doi.org/10.1182/blood.v67.4.1110.1110","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v67.4.1110.1110","pdf_url":"https://ashpublications.org/blood/article-pdf/67/4/1110/593408/1110.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/67/4/1110/593408/1110.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051778032","display_name":"WH Reinhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WH Reinhart","raw_affiliation_strings":["From the Division of Circulatory Physiology and Biophysics, Department of Physiology, Columbia University. College of Physicians and Surgeons, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Circulatory Physiology and Biophysics, Department of Physiology, Columbia University. College of Physicians and Surgeons, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068335042","display_name":"Shu Chien","orcid":"https://orcid.org/0000-0003-0332-285X","observed_orcids":["https://orcid.org/0000-0003-0332-285X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Chien","raw_affiliation_strings":["Department of Physiol- ogy , Columbia Presbyterian Medical Center , 630 W 168th , New York . NY 10032 ","From the Division of Circulatory Physiology and Biophysics, Department of Physiology, Columbia University. College of Physicians and Surgeons, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiol- ogy , Columbia Presbyterian Medical Center , 630 W 168th , New York . NY 10032 ","institution_ids":[]},{"raw_affiliation_string":"From the Division of Circulatory Physiology and Biophysics, Department of Physiology, Columbia University. College of Physicians and Surgeons, New York","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.4144,"has_fulltext":true,"cited_by_count":158,"citation_normalized_percentile":{"value":0.92354627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"67","issue":"4","first_page":"1110","last_page":"1118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.29660001397132874,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.8399999737739563},{"id":"https://openalex.org/keywords/filtration-resistance","display_name":"filtration resistance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.949999988079071},{"id":"https://openalex.org/keywords/sodium-salicylate","display_name":"sodium salicylate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/spicule-formation","display_name":"spicule formation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cell-volume","display_name":"cell volume","score":0.4519999921321869},{"id":"https://openalex.org/keywords/surface-area","display_name":"surface area","score":0.7570000290870667},{"id":"https://openalex.org/keywords/blood-viscosity","display_name":"blood viscosity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C1448646","wikidata":"https://www.wikidata.org/wiki/Q1280691","display_name":"Echinocyte","level":3,"score":0.9751642942428589},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6104480028152466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5221540927886963},{"id":"https://openalex.org/C128489963","wikidata":"https://www.wikidata.org/wiki/Q1187724","display_name":"Filtration (mathematics)","level":2,"score":0.48101407289505005},{"id":"https://openalex.org/C2777738910","wikidata":"https://www.wikidata.org/wiki/Q3790542","display_name":"Sulfinpyrazone","level":3,"score":0.47869351506233215},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3534892499446869},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.27789995074272156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21841612458229065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15181070566177368},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000050","descriptor_name":"Acanthocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004612","descriptor_name":"Elliptocytosis, Hereditary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004906","descriptor_name":"Erythrocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004909","descriptor_name":"Erythrocyte Indices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004913","descriptor_name":"Erythrocytes, Abnormal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012212","descriptor_name":"Rheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012980","descriptor_name":"Sodium Salicylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013103","descriptor_name":"Spherocytosis, Hereditary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014462","descriptor_name":"Ultrafiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v67.4.1110.1110","doi":"https://doi.org/10.1182/blood.v67.4.1110.1110","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v67.4.1110.1110","pdf_url":"https://ashpublications.org/blood/article-pdf/67/4/1110/593408/1110.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v67.4.1110.bloodjournal6741110","doi":"https://doi.org/10.1182/blood.v67.4.1110.bloodjournal6741110","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v67.4.1110.bloodjournal6741110","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:3955230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3955230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v67.4.1110.1110","doi":"https://doi.org/10.1182/blood.v67.4.1110.1110","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v67.4.1110.1110","pdf_url":"https://ashpublications.org/blood/article-pdf/67/4/1110/593408/1110.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6791910906","display_name":"HUMAN BLOOD CELL MEMBRANES IN HEALTH AND DISEASE","funder_award_id":"P01HL016851","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6942040789","display_name":"RHEOLOGY IN CARDIOVASCULAR DISEASES","funder_award_id":"T32HL007114","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W71991303.pdf","grobid_xml":"https://content.openalex.org/works/W71991303.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W183242950","https://openalex.org/W1527507383","https://openalex.org/W1528760252","https://openalex.org/W1998073588","https://openalex.org/W2039114856","https://openalex.org/W2045004941","https://openalex.org/W2062108067","https://openalex.org/W2070129920","https://openalex.org/W2073305583","https://openalex.org/W2166337798","https://openalex.org/W2271112592","https://openalex.org/W2412402333","https://openalex.org/W2428718609","https://openalex.org/W2468981273","https://openalex.org/W2486270432"],"related_works":["https://openalex.org/W1973473842","https://openalex.org/W183242950","https://openalex.org/W2040160289","https://openalex.org/W2987270914","https://openalex.org/W2748811549","https://openalex.org/W4404997119","https://openalex.org/W2988491594","https://openalex.org/W147316967","https://openalex.org/W2052406661","https://openalex.org/W4410521473"],"abstract_inverted_index":{"The":[0,94,180],"influence":[1],"of":[2,5,24,108,113,182,190],"the":[3,6,102,105,116,209,217,227,230,242],"shape":[4,92,215],"red":[7,183],"blood":[8,249],"cell":[9,117,137,167,184,234],"during":[10],"stomatocyte-echinocyte":[11],"transformation":[12,32,45,224,239],"on":[13],"its":[14],"deformability":[15,97],"was":[16,33,67,81,192],"studied":[17],"by":[18,35,46,101,124],"microsieving":[19],"through":[20,61,77,149,229],"pores":[21,66,80,84],"with":[22,157,178],"diameters":[23],"2.6,":[25],"4.5,":[26],"and":[27,39,42,51,63,143,151,166,173,236],"6.9":[28],"micron.":[29],"A":[30],"stomatocytic":[31,223],"produced":[34,123],"chlorpromazine":[36],"(0.02,":[37],"0.1,":[38],"0.5":[40],"mmol/L)":[41],"an":[43,56,135,145,213,237],"echinocytic":[44,238],"sodium":[47],"salicylate":[48],"(7.5,":[49],"30,":[50],"120":[52],"mmol/L).":[53],"For":[54],"spherostomatocytes,":[55],"increase":[57],"in":[58,74,96,219,233,244,248],"filtration":[59,75,147],"resistance":[60,76,148],"2.6":[62,78],"4.5":[64],"micron":[65,79],"observed,":[68],"whereas":[69,111],"for":[70,194,216],"spheroechinocytes,":[71],"a":[72,163,187,222],"decrease":[73],"found.":[82],"Larger":[83],"(6.9":[85],"micron)":[86],"were":[87],"not":[88,162],"sensitive":[89],"to":[90],"those":[91],"changes.":[93],"changes":[95,156],"can":[98],"be":[99,176],"explained":[100],"fact":[103],"that":[104,112,208],"surface":[106,141,171],"area":[107,142,172],"(sphero)-stomatocytes":[109],"decreased,":[110],"(sphero)-echinocytes":[114],"increased;":[115],"volume":[118,138],"remained":[119],"essentially":[120],"constant.":[121],"Echinocytes":[122],"24-hour":[125],"adenosine":[126],"triphosphate":[127],"depletion":[128],"differed":[129],"from":[130],"drug-induced":[131,195],"echinocytes:":[132],"they":[133],"had":[134],"increased":[136,146],"at":[139,186,201],"constant":[140],"consequently":[144],"2.6-":[150],"4.5-micron":[152],"filter":[153],"pores.":[154],"Shape":[155],"spicule":[158],"formation":[159],"are":[160],"therefore":[161],"homogeneous":[164],"entity,":[165],"geometric":[168],"factors":[169],"(eg,":[170],"volume)":[174],"must":[175],"assessed":[177],"care.":[179],"viscosity":[181],"suspensions":[185],"hematocrit":[188],"level":[189],"45%":[191],"higher":[193],"echinocytes":[196],"than":[197],"discocytes":[198],"or":[199],"stomatocytes":[200],"all":[202],"shear":[203],"rates":[204],"tested.":[205],"We":[206],"conclude":[207],"normal":[210],"discocyte":[211],"represents":[212],"optimum":[214],"flow":[218,243],"vivo":[220],"since":[221],"could":[225,240],"impair":[226,241],"passage":[228],"microcirculation":[231],"(decrease":[232],"filterability)":[235],"larger":[245],"vessels":[246],"(increase":[247],"viscosity).":[250]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
