{"id":"https://openalex.org/W71984142","doi":"https://doi.org/10.1016/s0021-9258(17)36239-7","title":"Apolipoprotein AIMilano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant.","display_name":"Apolipoprotein AIMilano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant.","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W71984142","doi":"https://doi.org/10.1016/s0021-9258(17)36239-7","mag":"71984142","pmid":"https://pubmed.ncbi.nlm.nih.gov/3934174"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)36239-7","doi":"https://doi.org/10.1016/s0021-9258(17)36239-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","pdf_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064838089","display_name":"Guido Franceschini","orcid":"https://orcid.org/0000-0003-2687-1771","observed_orcids":["https://orcid.org/0000-0003-2687-1771"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Franceschini","raw_affiliation_strings":["From the Center","Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047773572","display_name":"Giuseppe Vecchio","orcid":"https://orcid.org/0000-0002-3002-8501","observed_orcids":["https://orcid.org/0000-0002-3002-8501"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Vecchio","raw_affiliation_strings":["From the Center","Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G Gianfranceschi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Gianfranceschi","raw_affiliation_strings":["From the Center","Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021823875","display_name":"D Magani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Magani","raw_affiliation_strings":["From the Center","Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113778252","display_name":"Cesare R. Sirtori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C R Sirtori","raw_affiliation_strings":["From the Center","Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Istituto di Chimica degli Ormoni, Consiglio Nazionale delle Ricerche, Milan, Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.788,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.60185576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"260","issue":"30","first_page":"16321","last_page":"16325"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lipid-binding","display_name":"lipid binding","score":0.7929999828338623},{"id":"https://openalex.org/keywords/dimyristoylphosphatidylcholine","display_name":"dimyristoylphosphatidylcholine","score":0.871999979019165},{"id":"https://openalex.org/keywords/association-rate","display_name":"association rate","score":0.5109999775886536},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.8690000176429749},{"id":"https://openalex.org/keywords/alpha-helical-content","display_name":"alpha-helical content","score":0.8690000176429749},{"id":"https://openalex.org/keywords/high-density-lipoprotein","display_name":"high-density lipoprotein","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7973862886428833},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.6237826943397522},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5868237018585205},{"id":"https://openalex.org/C56623246","wikidata":"https://www.wikidata.org/wiki/Q14916272","display_name":"Apolipoprotein C2","level":5,"score":0.5373213887214661},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4372238516807556},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.41335806250572205},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.19229885935783386},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.1759902834892273},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.1165803074836731},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.059996843338012695}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001054","descriptor_name":"Apolipoproteins A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001054","descriptor_name":"Apolipoproteins A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001054","descriptor_name":"Apolipoproteins A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008075","descriptor_name":"Lipoproteins, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)36239-7","doi":"https://doi.org/10.1016/s0021-9258(17)36239-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","pdf_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:3934174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3934174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)36239-7","doi":"https://doi.org/10.1016/s0021-9258(17)36239-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","pdf_url":"https://doi.org/10.1016/s0021-9258(17)36239-7","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1579385211","display_name":null,"funder_award_id":"1 R01 HL28961-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4506528640","display_name":"GENETIC STUDIES OF THE AI MILANO APOLIPOPROTEIN VARIANT","funder_award_id":"R01HL028961","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320322651","display_name":"Consiglio Nazionale delle Ricerche","ror":"https://ror.org/04zaypm56"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W71984142.pdf","grobid_xml":"https://content.openalex.org/works/W71984142.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1040508368","https://openalex.org/W1517085507","https://openalex.org/W1523045600","https://openalex.org/W1541852335","https://openalex.org/W1543992215","https://openalex.org/W1546448997","https://openalex.org/W1564728203","https://openalex.org/W1571190262","https://openalex.org/W1581379253","https://openalex.org/W1585878980","https://openalex.org/W1589122120","https://openalex.org/W1775749144","https://openalex.org/W1812628919","https://openalex.org/W1848840005","https://openalex.org/W1973052017","https://openalex.org/W1993506721","https://openalex.org/W2006370393","https://openalex.org/W2007710555","https://openalex.org/W2013264428","https://openalex.org/W2014170297","https://openalex.org/W2022761661","https://openalex.org/W2023400042","https://openalex.org/W2033299688","https://openalex.org/W2043872467","https://openalex.org/W2052287240","https://openalex.org/W2056153196","https://openalex.org/W2061704447","https://openalex.org/W2064778636","https://openalex.org/W2073072310","https://openalex.org/W2079564988","https://openalex.org/W2086098111","https://openalex.org/W2090975152","https://openalex.org/W2094768566","https://openalex.org/W2113006405","https://openalex.org/W2123916335","https://openalex.org/W2168224634","https://openalex.org/W2188157781","https://openalex.org/W2341310987"],"related_works":["https://openalex.org/W2415606335","https://openalex.org/W1977309168","https://openalex.org/W2061877338","https://openalex.org/W1640254299","https://openalex.org/W2079769778","https://openalex.org/W143369091","https://openalex.org/W3202561575","https://openalex.org/W2084199826","https://openalex.org/W2092266405","https://openalex.org/W160523320"],"abstract_inverted_index":{"The":[0],"lipid":[1,172],"binding":[2],"properties":[3],"of":[4,11,27,56,67,92,131,136,149,154,167,176,206,218,247,258,296,308,310,320],"apolipoprotein":[5,13,179,199],"(apo)":[6],"AIMilMo,":[7],"a":[8,101,107,162,212,226,253],"molecular":[9],"variant":[10,31,69,115],"human":[12],"AI,":[14],"characterized":[15],"by":[16,24,46,62,81,96,145,161,275,281,290,317],"the":[17,25,30,39,63,68,85,89,114,125,128,132,155,165,177,181,191,202,216,282,291,318],"Arg173":[18],"e":[19,301],"Cys":[20],"substitution,":[21],"was":[22,94,271],"investigated":[23,95],"use":[26],"dimyristoylphosphatidylcholine":[28,59],"liposomes.Both":[29],"AIM^^,,":[32],"and":[33,52,98,106,190,225,234,241,244,263,286,289],"normal":[34,73,119],"AI":[35,200],"are":[36],"incorporated":[37],"to":[38,72,118,223,337],"same":[40],"extent":[41],"in":[42,113,124,164,171,180,215,232,273,315,330],"stable":[43],"complexes":[44],"isolated":[45,86],"gel":[47],"filtration,":[48],"showing":[49],"similar":[50],"dimensions":[51],"stoichiometries.A":[53],"higher":[54,102],"affinity":[55],"apo-AIMihO":[57],"for":[58,196],"is":[60,77,143,158,201,252],"suggested":[61],"faster":[64],"association":[65,139],"rate":[66,140],"apoprotein":[70,116,137],"compared":[71,117],"AI;":[74],"similarly,":[75],"apo-AIMiI,,":[76],"more":[78],"readily":[79],"displaced":[80],"guanidine":[82],"hydrochloride":[83],"from":[84,221],"dimyristoylphosphatidylcholine-apoprotein":[87],"complexes.When":[88],"secondary":[90],"structure":[91],"apo-AI~lm,,":[93],"spectrofluoroscopy":[97],"circular":[99],"dichroism,":[100],"fluorescence":[103],"peak":[104],"wavelength":[105],"lower":[108],"a-helical":[109,134],"content":[110],"were":[111,313],"detected":[112,231],"AI.The":[120,138],"substitution":[121],"Arg1'3":[122],".-,Cys":[123],"dramatically":[126],"alters":[127],"amphipathic":[129],"nature":[130],"modified":[133],"fragment":[135],"with":[141,183,266,332],"lipids":[142,184],"accelerated":[144,188],"an":[146],"increased":[147,245],"exposure":[148],"hydrophobic":[150],"residues.The":[151],"reduced":[152],"stability":[153],"lipid-apoprotein":[156],"particles":[157],"possibly":[159,192],"mediated":[160],"reduction":[163],"number":[166],"helical":[168],"segments":[169],"involved":[170],"association.The":[173],"high":[174,208],"flexibility":[175],"AIMilano":[178],"interaction":[182],"may":[185],"explain":[186],"its":[187],"catabolism":[189],"improved":[193],"uptake":[194],"capacities":[195],"tissue":[197],"lipids.Human":[198],"major":[203],"protein":[204],"constituent":[205],"plasma":[207,224,239],"density":[209],"lipoproteins.HDL*":[210],"play":[211],"critical":[213],"role":[214],"process":[217],"cholesterol":[219,243],"transport":[220],"tissues":[222],"significant":[227],"correlation":[228],"has":[229],"been":[230],"clinical":[233],"epidemiological":[235],"studies":[236],"between":[237],"low":[238],"apo-AI":[240],"HDL":[242],"risk":[246],"premature":[248],"cardiovascular":[249],"disease":[250],"(1,2).Apo-AI":[251],"single":[254],"polypeptide":[255],"chain,":[256],"composed":[257],"243":[259],"amino":[260],"acids":[261],"(3),":[262],"can":[264],"interact":[265],"different":[267],"phos-*":[268],"This":[269],"work":[270],"supported":[272],"part":[274,316],"Grant":[276],"1":[277],"RO1":[278],"HL28961-01":[279],"awarded":[280],"National":[283],"Heart,":[284],"Lung":[285],"Blood":[287],"Institute":[288],"Consiglio":[292],"Nazionale":[293],"delle":[294,304],"Ricerche":[295],"Italy":[297],"(PF":[298],"Ingegneria":[299],"Genetica":[300],"Basi":[302],"Malecolari":[303],"Malattie":[305],"Ereditarie).The":[306],"costs":[307],"publication":[309],"this":[311,339],"article":[312,323],"defrayed":[314],"payment":[319],"page":[321],"charges.This":[322],"must":[324],"therefore":[325],"be":[326],"hereby":[327],"marked":[328],"\"advertisement\"":[329],"accordance":[331],"18":[333],"U.S.C.Section":[334],"1734":[335],"solely":[336],"indicate":[338],"fact.":[340]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}