{"id":"https://openalex.org/W7197485403","doi":null,"title":"Ya\u015flanan beyinde inflamasyon s\u00fcrecinin etkisi: in Vitro ve Ex Vivo modellerinden elde edilen kan\u0131tlar","display_name":"Ya\u015flanan beyinde inflamasyon s\u00fcrecinin etkisi: in Vitro ve Ex Vivo modellerinden elde edilen kan\u0131tlar","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W7197485403"},"language":"en","primary_location":{"id":"pmh:oai:repository.bilkent.edu.tr:11693/113840","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11693/113840","pdf_url":"https://repository.bilkent.edu.tr/bitstreams/b1913338-ad50-47cf-b596-ec6f89789e1c/download","source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.bilkent.edu.tr/bitstreams/b1913338-ad50-47cf-b596-ec6f89789e1c/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144583656","display_name":"Serena Sevdiye Akt\u00fcrk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Akt\u00fcrk, Serena Sevdiye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5144583656"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.7369999885559082},{"id":"https://openalex.org/keywords/copper-sulfate","display_name":"copper sulfate","score":0.753000020980835},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9539999961853027},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/intermittent-fasting","display_name":"intermittent fasting","score":0.8370000123977661},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":1.0},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.6169999837875366},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.5989999771118164},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.5929999947547913},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4546000063419342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.399399995803833},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38510000705718994},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22830000519752502},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21279999613761902},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2078000009059906}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.bilkent.edu.tr:11693/113840","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11693/113840","pdf_url":"https://repository.bilkent.edu.tr/bitstreams/b1913338-ad50-47cf-b596-ec6f89789e1c/download","source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:repository.bilkent.edu.tr:11693/113840","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11693/113840","pdf_url":"https://repository.bilkent.edu.tr/bitstreams/b1913338-ad50-47cf-b596-ec6f89789e1c/download","source":{"id":"https://openalex.org/S4306400079","display_name":"Bilkent University Institutional Repository (Bilkent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I168864056","host_organization_name":"Bilkent University","host_organization_lineage":["https://openalex.org/I168864056"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7197485403.pdf","grobid_xml":"https://content.openalex.org/works/W7197485403.grobid-xml"},"referenced_works_count":161,"referenced_works":["https://openalex.org/W30031754","https://openalex.org/W1482715126","https://openalex.org/W1526860677","https://openalex.org/W1572421661","https://openalex.org/W1629202041","https://openalex.org/W1768846296","https://openalex.org/W1965281877","https://openalex.org/W1970637701","https://openalex.org/W1975915404","https://openalex.org/W1976165637","https://openalex.org/W1976856337","https://openalex.org/W1977718987","https://openalex.org/W1978529094","https://openalex.org/W1980006560","https://openalex.org/W1981477005","https://openalex.org/W1990928498","https://openalex.org/W1992949974","https://openalex.org/W1999477136","https://openalex.org/W2004301150","https://openalex.org/W2009812771","https://openalex.org/W2011361113","https://openalex.org/W2019249853","https://openalex.org/W2021264577","https://openalex.org/W2025344981","https://openalex.org/W2025665129","https://openalex.org/W2026367730","https://openalex.org/W2026410063","https://openalex.org/W2028036560","https://openalex.org/W2032019813","https://openalex.org/W2042518400","https://openalex.org/W2042610494","https://openalex.org/W2044261235","https://openalex.org/W2048823427","https://openalex.org/W2050794881","https://openalex.org/W2052899770","https://openalex.org/W2053429123","https://openalex.org/W2056994440","https://openalex.org/W2061169091","https://openalex.org/W2064325393","https://openalex.org/W2065443966","https://openalex.org/W2070117784","https://openalex.org/W2074053057","https://openalex.org/W2075614768","https://openalex.org/W2079356804","https://openalex.org/W2082402714","https://openalex.org/W2088906043","https://openalex.org/W2091600573","https://openalex.org/W2094071539","https://openalex.org/W2096180958","https://openalex.org/W2096701179","https://openalex.org/W2097713126","https://openalex.org/W2100664594","https://openalex.org/W2106098248","https://openalex.org/W2118804183","https://openalex.org/W2119302018","https://openalex.org/W2122526759","https://openalex.org/W2124343538","https://openalex.org/W2124799502","https://openalex.org/W2126525177","https://openalex.org/W2129155846","https://openalex.org/W2140323371","https://openalex.org/W2147180300","https://openalex.org/W2149731746","https://openalex.org/W2149771125","https://openalex.org/W2163135664","https://openalex.org/W2167941289","https://openalex.org/W2168422679","https://openalex.org/W2169168591","https://openalex.org/W2172747923","https://openalex.org/W2174111058","https://openalex.org/W2290642869","https://openalex.org/W2294130257","https://openalex.org/W2341128841","https://openalex.org/W2476178591","https://openalex.org/W2484398392","https://openalex.org/W2516246660","https://openalex.org/W2517534055","https://openalex.org/W2525535049","https://openalex.org/W2526904236","https://openalex.org/W2529118875","https://openalex.org/W2554874133","https://openalex.org/W2557016092","https://openalex.org/W2558558963","https://openalex.org/W2561790794","https://openalex.org/W2585828739","https://openalex.org/W2589338077","https://openalex.org/W2593182837","https://openalex.org/W2601873186","https://openalex.org/W2609551750","https://openalex.org/W2612991505","https://openalex.org/W2620571099","https://openalex.org/W2625095347","https://openalex.org/W2735527928","https://openalex.org/W2758132316","https://openalex.org/W2761586844","https://openalex.org/W2773711501","https://openalex.org/W2776096008","https://openalex.org/W2804281681","https://openalex.org/W2805954132","https://openalex.org/W2884391850","https://openalex.org/W2891513200","https://openalex.org/W2893000446","https://openalex.org/W2898772374","https://openalex.org/W2911493122","https://openalex.org/W2913940235","https://openalex.org/W2922119294","https://openalex.org/W2922247092","https://openalex.org/W2922807795","https://openalex.org/W2923614429","https://openalex.org/W2942640408","https://openalex.org/W2946450000","https://openalex.org/W2948954475","https://openalex.org/W2952128048","https://openalex.org/W2962834367","https://openalex.org/W2964483356","https://openalex.org/W2964520925","https://openalex.org/W2988310131","https://openalex.org/W2993497584","https://openalex.org/W2996589793","https://openalex.org/W3010445821","https://openalex.org/W3012404234","https://openalex.org/W3015467907","https://openalex.org/W3023320726","https://openalex.org/W3032592468","https://openalex.org/W3035837170","https://openalex.org/W3042141026","https://openalex.org/W3044145717","https://openalex.org/W3047765583","https://openalex.org/W3056264410","https://openalex.org/W3083270987","https://openalex.org/W3109503458","https://openalex.org/W3112344668","https://openalex.org/W3120557981","https://openalex.org/W3156027165","https://openalex.org/W3157646413","https://openalex.org/W3162051090","https://openalex.org/W3164057829","https://openalex.org/W3166558641","https://openalex.org/W3179285756","https://openalex.org/W3204968811","https://openalex.org/W3205438960","https://openalex.org/W3213632775","https://openalex.org/W4210869088","https://openalex.org/W4220673359","https://openalex.org/W4220723147","https://openalex.org/W4221089363","https://openalex.org/W4234317413","https://openalex.org/W4281696767","https://openalex.org/W4285588603","https://openalex.org/W4293048639","https://openalex.org/W4296849175","https://openalex.org/W4308034710","https://openalex.org/W4313531093","https://openalex.org/W4317666349","https://openalex.org/W4319298546","https://openalex.org/W4365146865","https://openalex.org/W4366483073","https://openalex.org/W4366830198","https://openalex.org/W4378516687","https://openalex.org/W4384699817","https://openalex.org/W4401366103"],"related_works":["https://openalex.org/W7099084869","https://openalex.org/W836012353","https://openalex.org/W7045662144","https://openalex.org/W2417026224","https://openalex.org/W1987879233","https://openalex.org/W6988024650","https://openalex.org/W7057224352","https://openalex.org/W2419463470","https://openalex.org/W3101220287","https://openalex.org/W2071589356"],"abstract_inverted_index":{"Aging":[0],"is":[1,8,76,148,275],"a":[2,11,289],"complex":[3],"and":[4,39,53,57,66,87,96,102,135,164,192,204,231,318,334,342,406],"dynamic":[5],"process":[6],"that":[7,142,272,346,358,394],"characterized":[9],"by":[10,246],"gradual":[12],"decline":[13],"over":[14,138],"time":[15],"in":[16,33,60,293,299,312,325,340,368,383,409,422],"the":[17,61,71,77,83,103,106,113,126,159,194,223,238,243,261,265,300,330,374,376,395,424],"physiological":[18],"integrity":[19,137],"of":[20,63,70,73,82,89,93,105,115,130,161,196,225,240,263,267,316,371,380,397],"organisms.":[21],"Several":[22],"cellular":[23,40,48],"mechanisms":[24],"contribute":[25,364],"to":[26,46,144,146,157,176,221,256,259,365],"aging,":[27],"including":[28],"telomere":[29],"shortening,":[30],"damage":[31],"accumulation":[32],"DNA,":[34],"disabled":[35],"macroautophagy,":[36],"mitochondrial":[37],"dysfunction,":[38],"senescence.":[41],"These":[42],"processes,":[43],"consecutively,":[44],"lead":[45],"impaired":[47],"function,":[49],"declined":[50],"tissue":[51],"repair,":[52],"stem":[54],"cell":[55,248],"exhaustion":[56],"are":[58,111,155],"seen":[59],"development":[62],"neurodegenerative":[64],"disorders":[65],"healthy":[67],"aging.":[68,429],"One":[69],"hallmarks":[72],"brain":[74,202,239],"aging":[75,333],"altered":[78],"chronic":[79,335],"inflammatory":[80,280,291],"status":[81],"brain.":[84],"The":[85,269],"over-activation":[86],"polarization":[88],"microglia,":[90],"increased":[91],"secretion":[92],"pro-inflammatory":[94],"cytokines":[95],"reactive":[97],"oxygen":[98],"species,":[99],"inflammasome":[100],"activation,":[101],"upregulation":[104],"NF-":[107],"\u03baB":[108],"signaling":[109],"pathway":[110],"among":[112],"markers":[114,322,356],"neuroinflammation.":[116],"This":[117],"mechanism's":[118],"anticipated":[119],"effects":[120,224],"include":[121],"dysregulated":[122],"nutrition":[123],"sensing":[124],"via":[125],"mTOR":[127,229],"(mammalian":[128],"target":[129],"rapamycin)":[131],"pathway,":[132],"decreased":[133],"neurogenesis,":[134,405],"synaptic":[136],"time.":[139],"Another":[140],"element":[141],"contributes":[143],"vulnerability":[145],"inflammation":[147,168,179,197,235,321,362],"genetic":[149,170],"predisposition.":[150],"Hence,":[151],"additional":[152],"research":[153],"endeavors":[154],"required":[156],"investigate":[158,186],"influence":[160],"dietary":[162,414],"interventions":[163,417],"therapeutic":[165],"modalities":[166],"targeting":[167],"on":[169,183,214,237],"pathways.":[171],"Thus,":[172],"this":[173,218,390],"study":[174,391],"aimed":[175],"understand":[177],"how":[178],"can":[180,350],"be":[181],"triggered":[182],"different":[184],"models,":[185],"potential":[187,379],"inflammation-related":[188],"biomarkers":[189],"with":[190],"meta-analysis":[191],"observe":[193],"effect":[195],"for":[198,217,282,354],"both":[199,215],"zebrafish":[200,241],"primary":[201,247,257],"cells":[203,258],"murine":[205,294],"microglial":[206,295],"cells.":[207,296],"We":[208],"conducted":[209],"short-term":[210],"copper":[211,273,301,348],"sulfate":[212,274],"treatments":[213],"models":[216],"objective.":[219],"Moreover,":[220,413],"examine":[222],"intermittent":[226,381],"fasting,":[227],"an":[228,234,276,410],"downregulator,":[230],"high-fat":[232],"diet,":[233],"inducer,":[236],"at":[242],"molecular":[244],"level":[245],"culture":[249],"method.":[250],"Finally,":[251],"we":[252],"applied":[253],"rapamycin+DMSO":[254],"treatment":[255,319],"assess":[260],"possibility":[262],"reversing":[264],"progression":[266],"inflammation.":[268,336],"results":[270],"showed":[271],"efficient":[277],"oxidative":[278,310,403],"stress-induced":[279],"reagent":[281],"zebrafish;":[283],"however,":[284],"it":[285],"did":[286],"not":[287],"cause":[288],"direct":[290],"response":[292],"For":[297],"zebrafish,":[298],"sulfate+DMSO":[302],"treated":[303],"group,":[304,320],"age":[305],"affected":[306],"Nrf2a":[307],"mRNA,":[308],"altering":[309],"stress":[311],"old":[313,326,343,384],"animals.":[314],"Regardless":[315],"diet":[317],"were":[323],"higher":[324],"animals,":[327],"which":[328],"underscores":[329],"association":[331],"between":[332],"Elevated":[337],"Lc3b":[338],"levels":[339],"young":[341],"animals":[344,385],"captured":[345],"high":[347],"concentrations":[349],"trigger":[351],"autophagy.":[352],"Results":[353],"neurogenesis":[355,367,378],"revealed":[357],"overfeeding":[359],"or":[360,415],"acute":[361],"could":[363,418],"compromised":[366],"advanced":[369],"stages":[370],"life.":[372],"On":[373],"contrary,":[375],"enhanced":[377],"fasting":[382],"was":[386],"revealed.":[387],"In":[388],"conclusion,":[389],"has":[392],"demonstrated":[393],"modulation":[396],"neuroinflammatory":[398,426],"responses,":[399],"as":[400,402],"well":[401],"stress,":[404],"autophagy,":[407],"occurs":[408],"age-related":[411],"manner.":[412],"pharmaceutical":[416],"yield":[419],"comprehensive":[420],"outcomes":[421],"perceiving":[423],"brain's":[425],"profile":[427],"during":[428]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-07T00:00:00"}