{"id":"https://openalex.org/W7197384792","doi":null,"title":"Mod\u00e9lisation mol\u00e9culaire d'analogues cyclises de l'enk\u00e9phaline : diff\u00e9rentiation des r\u00e9cepteurs opiac\u00e9s [mu] et [delta]","display_name":"Mod\u00e9lisation mol\u00e9culaire d'analogues cyclises de l'enk\u00e9phaline : diff\u00e9rentiation des r\u00e9cepteurs opiac\u00e9s [mu] et [delta]","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W7197384792"},"language":"fr","primary_location":{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/15505","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11143/15505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"M\u00e9moire de ma\u00eetrise"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113980966","display_name":"G. Villeneuve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Villeneuve, G\u00e9rald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113980966"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.7200000286102295},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":1.0},{"id":"https://openalex.org/keywords/opioid-receptor-selectivity","display_name":"opioid receptor selectivity","score":0.6809999942779541},{"id":"https://openalex.org/keywords/conformational-analysis","display_name":"conformational analysis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.5600000023841858},{"id":"https://openalex.org/keywords/molecular-mechanics","display_name":"molecular mechanics","score":0.5379999876022339},{"id":"https://openalex.org/keywords/endogenous-opioids","display_name":"endogenous opioids","score":0.4950000047683716},{"id":"https://openalex.org/keywords/morphine-analgesia","display_name":"morphine analgesia","score":0.6259999871253967},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.33799999952316284},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.32519999146461487},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.26010000705718994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17219999432563782},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.13459999859333038},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1257999986410141},{"id":"https://openalex.org/C2984739757","wikidata":"https://www.wikidata.org/wiki/Q3695508","display_name":"Mechanical vibration","level":3,"score":0.08669999986886978},{"id":"https://openalex.org/C198621165","wikidata":"https://www.wikidata.org/wiki/Q3743588","display_name":"Strong electrolyte","level":4,"score":0.07919999957084656},{"id":"https://openalex.org/C2992537987","wikidata":"https://www.wikidata.org/wiki/Q396340","display_name":"Agricultural economy","level":3,"score":0.07680000364780426},{"id":"https://openalex.org/C2780553513","wikidata":"https://www.wikidata.org/wiki/Q17118003","display_name":"Midbrain reticular formation","level":4,"score":0.07569999992847443}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/15505","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11143/15505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"M\u00e9moire de ma\u00eetrise"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Les":[0,169,281],"propri\u00e9t\u00e9s":[1],"analg\u00e9siques":[2],"de":[3,7,16,20,59,65,67,105,139,144,176,185,187,193,201,221,231,251,267,279,283,287,299,326,337,358,380,387,395,406,434,454,479],"la":[4,40,43,63,120,188,215,247,284,288,314,347,443,452,466,469],"morphine":[5],"et":[6,42,82,101,157,254,272,286,297,430,468,475],"ses":[8,93],"d\u00e9riv\u00e9s":[9],"sont":[10,179,303],"connues":[11],"depuis":[12],"fort":[13],"longtemps.":[14],"L'existence":[15],"substances":[17],"endog\u00e8nes":[18,36],"capables":[19],"produire":[21],"des":[22,97,114,199,217,229,249,361,369,413],"effets":[23,77],"similaires":[24,371],"pouvait":[25],"donc":[26],"\u00eatre":[27,38,73],"postul\u00e9e.":[28],"Ce":[29],"n'est":[30],"qu'en":[31],"1975":[32],"que":[33,262,317,389,402],"deux":[34,145,341],"ligands":[35],"devaient":[37],"isol\u00e9s:":[39],"Met5":[41],"Leu5":[44],"enk\u00e9phaline":[45],"(Tyr-Gly-Gly-Phe-Met,":[46],"Tyr-Gly-Gly-Phe-Leu).":[47],"La":[48,196,378],"synth\u00e8se":[49,467],"d'analogues":[50,478],"\u00e0":[51,95,113,181,214,332,353,372,448,464],"ces":[52,301],"compos\u00e9s":[53],"naturels":[54],"allait":[55],"permettre,":[56],"entre":[57],"autre,":[58],"mettre":[60],"en":[61,110,235],"\u00e9vidence":[62,111],"pr\u00e9sence":[64],"sous-classes":[66,71,94,104,250],"r\u00e9cepteurs":[68,106,252],"opiac\u00e9s.":[69],"Ces":[70,103,460],"peuvent":[72],"distingu\u00e9es":[74],"par":[75,83,305,321,339],"les":[76,84,238,340,403],"physiologiques":[78,86],"diff\u00e9rents":[79],"qu'elles":[80,88],"entrainent":[81],"localisations":[85],"diff\u00e9rentes":[87],"occupent.":[89],"On":[90],"d\u00e9signe":[91],"ordinairement":[92],"l'aide":[96],"lettres":[98],"grecques":[99],"[mu],[delta],[kappa]":[100],"[sigma].":[102],"opiac\u00e9s":[107],"furent":[108],"mises":[109],"gr\u00e2ce":[112,136,213],"analogues":[115],"rigidifi\u00e9s":[116],"qui":[117,382,441],"n'avaient":[118],"pas":[119,312],"libert\u00e9":[121],"conformationnelle":[122,133],"pour":[123,246,393,451],"interagir":[124],"avec":[125,191,203,233,237,363,375],"n'importe":[126],"quel":[127],"sous-r\u00e9cepteur.":[128],"Cet":[129],"ouvrage":[130],"pr\u00e9sente":[131],"l'\u00e9tude":[132],"d\u00e9taill\u00e9e,":[134],"effectu\u00e9e":[135],"aux":[137,276,294],"techniques":[138],"mod\u00e9lisation":[140,476],"mol\u00e9culaire":[141,190,474],"sur":[142],"ordinateur,":[143],"d\u00e9rives":[146],"rigidifi\u00e9s:":[147],"H-Tyr-c[":[148],"N[delta]":[149],"(D)Orn-Gly-Phe-Leu]":[150],"(CDOLE)":[151],"s\u00e9lectif":[152,160,211],"au":[153,161,437],"r\u00e9cepteur":[154,162,260,399],"opiac\u00e9":[155,205],"[mu]":[156,253,261,457],"H-Tyr-(D)pen-Gly-Phe-Cys-NH2":[158],"(CDPDC)":[159],"[delta]":[163],"(Pen":[164],"=":[165],"[beta,beta]":[166,404],"dim\u00e9thyl":[167,405],"cyst\u00e9ine).":[168],"calculs":[170],"\u00e9nerg\u00e9tiques":[171],"r\u00e9alis\u00e9s":[172],"dans":[173,417,424],"le":[174,257,265,385,425],"cadre":[175],"cette":[177],"\u00e9tude":[178],"fait":[180],"partir":[182],"du":[183,225,259,290,350,355,398,409,427],"champ":[184],"force":[186],"m\u00e9canique":[189],"l'emploi":[192],"param\u00e8tres":[194],"empiriques.":[195],"comparaison":[197,236],"structurelle":[198],"conform\u00e8res":[200],"CDOLE":[202,268],"l'alcaloide":[204],"7[alpha]":[206],"[1(R)":[207],"l-hydroxy-l-m\u00e9thyl-3-":[208],"ph\u00e9nylpropyl]-6,14,endo-\u00e9th\u00e9no-t\u00e9trahydo-oripavine":[209],"(PEO":[210],"[mu])":[212],"superposition":[216,379],"pharmacophores,":[218],"nous":[219,263,366,390,462],"permet":[220,367],"proposer":[222,465],"un":[223,243,482],"mod\u00e8le":[224,258,328,344,397],"sous-r\u00e9cepteur":[226],"[mu].":[227],"L'\u00e9tude":[228,360],"superpositions":[230,362,370],"CDPDC":[232,365,381,480],"PEO,":[234],"pr\u00e9c\u00e9dentes":[239],"superpositions,":[240],"a":[241],"fourni":[242],"\u00e9l\u00e9ment":[244],"structurel":[245],"diff\u00e9rentiation":[248],"[delta].":[255,459],"Dans":[256],"proposons,":[264],"macrocycle":[266,438],"est":[269,329],"relativement":[270],"plat":[271],"se":[273,292,383],"retrouve":[274],"coplanaire":[275],"cycles":[277,295],"ABCE":[278],"PEO.":[280,359],"noyaux":[282],"tyrosine":[285],"ph\u00e9nylalanine":[289],"peptide":[291],"superposent":[293],"A":[296],"F":[298],"l'alcalo\u00efde;":[300],"derniers":[302],"s\u00e9par\u00e9s":[304],"10.5A.":[306],"L'azote":[307],"terminal":[308],"peptidique":[309,439],"n'occupe":[310],"toutefois":[311],"exactement":[313],"m\u00eame":[315],"position":[316],"chez":[318],"PEO":[319],"(diff\u00e8re":[320],"0.8A).":[322],"Une":[323],"caract\u00e9ristique":[324],"importante":[325],"ce":[327,440,449],"qu'il":[330],"conduit":[331],"une":[333,418],"occupation":[334],"commune":[335],"maximale":[336],"l'espace":[338],"mol\u00e9cules.":[342],"Notre":[343],"place":[345],"aussi":[346],"chaine":[348],"lat\u00e9rale":[349],"r\u00e9sidu":[351],"2":[352],"proximit\u00e9":[354],"groupement":[356],"C17C18":[357],"l'analogue":[364,376],"d'obtenir":[368],"celles":[373],"obtenues":[374],"CDOLE.":[377],"rapproche":[384],"plus":[386],"celle":[388],"avons":[391],"utilis\u00e9e":[392],"l'\u00e9laboration":[394],"notre":[396],"[mu],":[400],"montre":[401],"Pen2":[407],"sortent":[408],"volume":[410],"commun.":[411],"Chacun":[412],"m\u00e9thyles":[414],"pointe":[415],"cependant":[416],"direction":[419],"diff\u00e9rente,":[420],"l'un":[421],"(pro":[422,432],"S)":[423],"prolongement":[426],"grand":[428],"cycle,":[429],"l'autre":[431],"R)":[433],"fa\u00e7on":[435],"perpendiculaire":[436],"sugg\u00e8re":[442],"possibilit\u00e9":[444],"d'un":[445],"centre":[446],"st\u00e9r\u00e9osp\u00e9cifique":[447],"niveau":[450],"modulation":[453],"l'activit\u00e9":[455],"analg\u00e9siante":[456],"ou":[458],"observations":[461],"conduisent":[463],"caract\u00e9risation":[470],"(DRX,":[471],"RMN,":[472],"dynamique":[473],"mol\u00e9culaire)":[477],"poss\u00e9dant":[481],"C2[beta]":[483],"chiral.":[484]},"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2026-08-07T00:00:00"}