{"id":"https://openalex.org/W7196993316","doi":"https://doi.org/10.12938/bmfh.2026-043","title":"Shenling Baizhu powder associated with alleviating inflammation and intestinal mucosal microbiota injury in mice with diarrhea induced by a lard diet and fatigued state","display_name":"Shenling Baizhu powder associated with alleviating inflammation and intestinal mucosal microbiota injury in mice with diarrhea induced by a lard diet and fatigued state","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7196993316","doi":"https://doi.org/10.12938/bmfh.2026-043","pmid":"https://pubmed.ncbi.nlm.nih.gov/42871958","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13659319"},"language":"en","primary_location":{"id":"doi:10.12938/bmfh.2026-043","doi":"https://doi.org/10.12938/bmfh.2026-043","is_oa":true,"landing_page_url":"https://doi.org/10.12938/bmfh.2026-043","pdf_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-043/_pdf","source":{"id":"https://openalex.org/S4210171784","display_name":"Bioscience of Microbiota Food and Health","issn_l":"2186-3342","issn":["2186-3342","2186-6953"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of Microbiota, Food and Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-043/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145905693","display_name":"Wenjing HUANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing HUANG","raw_affiliation_strings":["School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5145603008","display_name":"Jing LIU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing LIU","raw_affiliation_strings":["School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711795","display_name":"Miao Jiang","orcid":"https://orcid.org/0000-0002-3681-9494","observed_orcids":["https://orcid.org/0000-0002-3681-9494","https://orcid.org/0009-0002-9138-8997"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao JIANG","raw_affiliation_strings":["School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5145559961","display_name":"Ying CAI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying CAI","raw_affiliation_strings":["School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China","institution_ids":["https://openalex.org/I14992734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042627872","display_name":"\u8c2d\u5468\u8fdb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhoujin TAN","raw_affiliation_strings":["School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Medicine, Hunan University of Chinese              Medicine, Changsha 410208, Hunan Province, China","institution_ids":["https://openalex.org/I14992734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042627872"],"corresponding_institution_ids":["https://openalex.org/I14992734"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44427486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"4","first_page":"307","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shenling-baizhu-powder","display_name":"Shenling Baizhu Powder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.6539999842643738},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9049999713897705},{"id":"https://openalex.org/keywords/helicobacter","display_name":"Helicobacter","score":0.8420000076293945},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8180000185966492},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":1.0},{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.9599999785423279},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.7588000297546387},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5649999976158142},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5374000072479248},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5088000297546387},{"id":"https://openalex.org/C2910850605","wikidata":"https://www.wikidata.org/wiki/Q210352","display_name":"Mucosal inflammation","level":3,"score":0.5080000162124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4975000023841858},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.4828000068664551},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47119998931884766},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4221000075340271},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.38679999113082886},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.3637000024318695},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.358599990606308},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.33379998803138733},{"id":"https://openalex.org/C2780832600","wikidata":"https://www.wikidata.org/wiki/Q134684","display_name":"Helicobacter","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2778426112","wikidata":"https://www.wikidata.org/wiki/Q3055380","display_name":"Enteropathy","level":3,"score":0.27630001306533813},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.271699994802475},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C2993801374","wikidata":"https://www.wikidata.org/wiki/Q156103","display_name":"Acute gastroenteritis","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.25780001282691956}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.12938/bmfh.2026-043","doi":"https://doi.org/10.12938/bmfh.2026-043","is_oa":true,"landing_page_url":"https://doi.org/10.12938/bmfh.2026-043","pdf_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-043/_pdf","source":{"id":"https://openalex.org/S4210171784","display_name":"Bioscience of Microbiota Food and Health","issn_l":"2186-3342","issn":["2186-3342","2186-6953"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of Microbiota, Food and Health","raw_type":"journal-article"},{"id":"pmid:42871958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42871958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of microbiota, food and health","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13659319","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13659319/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosci Microbiota Food Health","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.12938/bmfh.2026-043","doi":"https://doi.org/10.12938/bmfh.2026-043","is_oa":true,"landing_page_url":"https://doi.org/10.12938/bmfh.2026-043","pdf_url":"https://www.jstage.jst.go.jp/article/bmfh/advpub/0/advpub_2026-043/_pdf","source":{"id":"https://openalex.org/S4210171784","display_name":"Bioscience of Microbiota Food and Health","issn_l":"2186-3342","issn":["2186-3342","2186-6953"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience of Microbiota, Food and Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3089686607","display_name":null,"funder_award_id":"81874460","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7196993316.pdf","grobid_xml":"https://content.openalex.org/works/W7196993316.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1523737655","https://openalex.org/W1695808756","https://openalex.org/W1977328678","https://openalex.org/W2145189896","https://openalex.org/W2329512817","https://openalex.org/W2499576648","https://openalex.org/W2616825195","https://openalex.org/W2886213241","https://openalex.org/W2891808294","https://openalex.org/W2987199459","https://openalex.org/W3081348282","https://openalex.org/W3086885273","https://openalex.org/W3109240650","https://openalex.org/W3109460733","https://openalex.org/W3133422916","https://openalex.org/W3199464300","https://openalex.org/W3216630803","https://openalex.org/W3217631758","https://openalex.org/W4213418289","https://openalex.org/W4220758943","https://openalex.org/W4282922292","https://openalex.org/W4283763451","https://openalex.org/W4284687307","https://openalex.org/W4291179417","https://openalex.org/W4294719198","https://openalex.org/W4307870679","https://openalex.org/W4308948089","https://openalex.org/W4319304438","https://openalex.org/W4361758321","https://openalex.org/W4376127679","https://openalex.org/W4376612739","https://openalex.org/W4377138179","https://openalex.org/W4377565846","https://openalex.org/W4378228349","https://openalex.org/W4386153036","https://openalex.org/W4386850345","https://openalex.org/W4401635756","https://openalex.org/W4406454968","https://openalex.org/W4412882617"],"related_works":["https://openalex.org/W7167224069","https://openalex.org/W4401635756","https://openalex.org/W7204554924","https://openalex.org/W4295567518","https://openalex.org/W4413969231","https://openalex.org/W4399558598","https://openalex.org/W4319304438","https://openalex.org/W4378228349","https://openalex.org/W3044865310","https://openalex.org/W4386609880"],"abstract_inverted_index":{"The":[0,95],"intestinal":[1,96,110,141,192],"microbiota":[2,204],"plays":[3],"a":[4,36,54,118],"crucial":[5],"role":[6],"in":[7,121,206],"the":[8,59,107,127,133,154,157,203],"onset":[9],"of":[10,71,78,103,145,159],"diarrhea":[11],"and":[12,43,88,117,149,181,183,188,201],"can":[13],"be":[14],"modulated":[15],"through":[16],"dietary":[17],"changes.":[18],"Shenling":[19],"Baizhu":[20],"powder":[21],"(SLBZ)":[22],"has":[23],"been":[24],"shown":[25],"to":[26],"regulate":[27],"diarrhea.":[28,151,209],"Thirty":[29],"Kunming":[30],"mice":[31,207],"were":[32,93,123],"randomly":[33],"divided":[34],"into":[35],"normal":[37],"group":[38,41,45,61,135],"(MCN),":[39],"model":[40],"(MMD),":[42],"SLBZ":[44,65,131,190],"(MSLBZ).":[46],"Diarrhea":[47],"was":[48,98,162,167,176],"induced":[49],"by":[50],"fatigue":[51],"combined":[52],"with":[53,76,126,153,179,186,208],"high-fat":[55],"diet.":[56],"After":[57,130],"modeling,":[58],"MSLBZ":[60,134],"received":[62],"145.6":[63],"g/(kg\u00b7d)":[64],"for":[66,100],"7":[67],"days.":[68],"Pathological":[69],"examination":[70],"small":[72],"intestine":[73],"tissues,":[74],"along":[75],"measurements":[77],"interleukin":[79,82],"6":[80],"(IL-6),":[81],"17":[83],"(IL-17),":[84],"immunoglobulin":[85],"A":[86],"(sIgA),":[87],"mucin":[89],"2":[90],"(Muc2)":[91],"levels,":[92],"conducted.":[94],"mucosa":[97],"extracted":[99],"high-throughput":[101],"sequencing":[102],"16S":[104],"rRNA.":[105],"In":[106],"MMD":[108,155],"group,":[109,156],"damage,":[111,142,194],"lymphocyte":[112],"infiltration,":[113],"decreased":[114,143],"sIgA,":[115,148],"diarrhea,":[116],"significant":[119],"increase":[120],"Helicobacter":[122,166],"observed":[124],"compared":[125],"MCN":[128],"group.":[129],"treatment,":[132],"exhibited":[136],"improved":[137],"body":[138],"weight,":[139],"reduced":[140],"levels":[144],"IL-6,":[146],"increased":[147],"alleviated":[150],"Compared":[152],"abundance":[158],"Duncaniella":[160,174],"freteri":[161,175],"significantly":[163],"higher,":[164],"while":[165],"markedly":[168],"reduced.":[169],"Correlation":[170],"analysis":[171],"showed":[172],"that":[173],"positively":[177],"correlated":[178,185],"sIgA":[180,199],"Muc2":[182],"negatively":[184],"IL-6":[187],"IL-17.":[189],"alleviates":[191],"mucosal":[193],"reduces":[195],"pro-inflammatory":[196],"cytokines,":[197],"enhances":[198],"production,":[200],"restores":[202],"balance":[205]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-07T00:00:00"}