{"id":"https://openalex.org/W7196964022","doi":"https://doi.org/10.1111/aogs.70332","title":"Silicon dioxide vaginal gel and short\u2010term high\u2010risk human papillomavirus DNA detectability: A randomized controlled trial","display_name":"Silicon dioxide vaginal gel and short\u2010term high\u2010risk human papillomavirus DNA detectability: A randomized controlled trial","publication_year":2026,"publication_date":"2026-08-05","ids":{"openalex":"https://openalex.org/W7196964022","doi":"https://doi.org/10.1111/aogs.70332","pmid":"https://pubmed.ncbi.nlm.nih.gov/42557865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13443988"},"language":"en","primary_location":{"id":"doi:10.1111/aogs.70332","doi":"https://doi.org/10.1111/aogs.70332","is_oa":true,"landing_page_url":"https://doi.org/10.1111/aogs.70332","pdf_url":null,"source":{"id":"https://openalex.org/S192518766","display_name":"Acta Obstetricia Et Gynecologica Scandinavica","issn_l":"0001-6349","issn":["0001-6349","1600-0412"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Obstetricia et Gynecologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/aogs.70332","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051071092","display_name":"Julia M. Hecken","orcid":"https://orcid.org/0000-0002-9074-5422","observed_orcids":["https://orcid.org/0000-0002-9074-5422"]},"institutions":[{"id":"https://openalex.org/I4210088550","display_name":"Universit\u00e4tsklinik Marien Hospital Herne","ror":"https://ror.org/004h6mc53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210088550"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia M. Hecken","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany"],"raw_orcid":"https://orcid.org/0000-0002-9074-5422","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany","institution_ids":["https://openalex.org/I4210088550","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014109887","display_name":"Cle\ufeffmens Tempfer","orcid":"https://orcid.org/0000-0002-6904-3258","observed_orcids":["https://orcid.org/0000-0002-6904-3258"]},"institutions":[{"id":"https://openalex.org/I4210088550","display_name":"Universit\u00e4tsklinik Marien Hospital Herne","ror":"https://ror.org/004h6mc53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210088550"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clemens B. Tempfer","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany"],"raw_orcid":"https://orcid.org/0000-0002-6904-3258","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany","institution_ids":["https://openalex.org/I4210088550","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144762360","display_name":"Katrin Klaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088550","display_name":"Universit\u00e4tsklinik Marien Hospital Herne","ror":"https://ror.org/004h6mc53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210088550"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Klaus","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany","institution_ids":["https://openalex.org/I4210088550","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004318172","display_name":"Jan Scheich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088550","display_name":"Universit\u00e4tsklinik Marien Hospital Herne","ror":"https://ror.org/004h6mc53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210088550"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Scheich","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany","institution_ids":["https://openalex.org/I4210088550","https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058035345","display_name":"G\u00fcnther A. Rezniczek","orcid":"https://orcid.org/0000-0002-0852-6002","observed_orcids":["https://orcid.org/0000-0002-0852-6002"]},"institutions":[{"id":"https://openalex.org/I4210088550","display_name":"Universit\u00e4tsklinik Marien Hospital Herne","ror":"https://ror.org/004h6mc53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210088550"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"G\u00fcnther A. Rezniczek","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany"],"raw_orcid":"https://orcid.org/0000-0002-0852-6002","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Marien Hospital Herne Klinikum der Ruhr\u2010Universit\u00e4t Bochum  Herne Germany","institution_ids":["https://openalex.org/I4210088550","https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058035345"],"corresponding_institution_ids":["https://openalex.org/I4210088550","https://openalex.org/I904495901"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":4.6124,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.9558087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"105","issue":"11","first_page":"2256","last_page":"2264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9110000133514404},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cervical-hpv-infection","display_name":"cervical HPV infection","score":0.781000018119812},{"id":"https://openalex.org/keywords/intravaginal-gel","display_name":"intravaginal gel","score":0.8669999837875366},{"id":"https://openalex.org/keywords/silica","display_name":"silica","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hpv-clearance","display_name":"HPV clearance","score":0.621999979019165},{"id":"https://openalex.org/keywords/observation-versus-treatment","display_name":"observation versus treatment","score":0.5889999866485596},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6949999928474426},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9229000210762024},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.835099995136261},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6949999928474426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4699999988079071},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.4697999954223633},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.3928999900817871},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.3677999973297119},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3662000000476837},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.35359999537467957},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.33250001072883606},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C2780647465","wikidata":"https://www.wikidata.org/wiki/Q5065348","display_name":"Cervical screening","level":4,"score":0.25859999656677246},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000094302","descriptor_name":"Human Papillomavirus Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000094302","descriptor_name":"Human Papillomavirus Viruses","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000282","descriptor_name":"Administration, Intravaginal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014622","descriptor_name":"Vaginal Creams, Foams, and Jellies","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D058428","descriptor_name":"Silica Gel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/aogs.70332","doi":"https://doi.org/10.1111/aogs.70332","is_oa":true,"landing_page_url":"https://doi.org/10.1111/aogs.70332","pdf_url":null,"source":{"id":"https://openalex.org/S192518766","display_name":"Acta Obstetricia Et Gynecologica Scandinavica","issn_l":"0001-6349","issn":["0001-6349","1600-0412"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Obstetricia et Gynecologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:42557865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42557865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta obstetricia et gynecologica Scandinavica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13443988","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13443988/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Obstet Gynecol Scand","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:db426c0c0fd74504beca420254a19de0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/db426c0c0fd74504beca420254a19de0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Obstetricia et Gynecologica Scandinavica, Vol 105, Iss 11, Pp 2256-2264 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/aogs.70332","doi":"https://doi.org/10.1111/aogs.70332","is_oa":true,"landing_page_url":"https://doi.org/10.1111/aogs.70332","pdf_url":null,"source":{"id":"https://openalex.org/S192518766","display_name":"Acta Obstetricia Et Gynecologica Scandinavica","issn_l":"0001-6349","issn":["0001-6349","1600-0412"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Obstetricia et Gynecologica Scandinavica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2087484885","https://openalex.org/W2093274439","https://openalex.org/W2096913021","https://openalex.org/W2214749775","https://openalex.org/W2752117457","https://openalex.org/W2901813328","https://openalex.org/W2980284610","https://openalex.org/W3145837550","https://openalex.org/W3172722935","https://openalex.org/W4238787293","https://openalex.org/W4382134873","https://openalex.org/W4407731380","https://openalex.org/W4412714075"],"related_works":["https://openalex.org/W4383301461","https://openalex.org/W3187438734","https://openalex.org/W4311799416","https://openalex.org/W4238787293","https://openalex.org/W3096021496","https://openalex.org/W3164877009","https://openalex.org/W3117086480","https://openalex.org/W3172722935","https://openalex.org/W7131064953","https://openalex.org/W4412714075"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Intravaginal":[1],"products,":[2],"including":[3],"silicon":[4,38,267],"dioxide-based":[5,39,268],"gels,":[6],"are":[7],"marketed":[8],"to":[9,85,144,188,240,311],"support":[10,304],"short-term":[11,27,274,292,313],"high-risk":[12],"human":[13],"papillomavirus":[14],"(hrHPV)":[15],"clearance":[16],"or":[17,94],"loss":[18,275],"of":[19,45,88,102,206,264,276,307,329],"detectability,":[20],"but":[21,252],"independent":[22],"randomized":[23,83,116,260],"evidence":[24],"testing":[25],"these":[26],"claims":[28],"against":[29],"observation":[30,55,95,177,224,283],"is":[31],"limited.":[32],"We":[33],"evaluated":[34],"whether":[35],"daily":[36,90,265],"intravaginal":[37,91,266],"gel":[40,92,168,218,255,269],"treatment":[41,93,169,219,270],"increases":[42],"the":[43,115,167,176,204,207,217,223,290,326],"proportion":[44],"women":[46,69,138,164,173,317],"with":[47,54,70,141,254,282],"no":[48,76],"detectable":[49,103,277],"cervical":[50,72,104,278],"hrHPV":[51,73,105,157,279,314],"DNA":[52,106,158,280],"compared":[53,281],"alone.":[56,96,284],"MATERIAL":[57],"AND":[58],"METHODS:":[59],"This":[60],"prospective,":[61],"single-center,":[62],"parallel-group,":[63],"randomized,":[64,140],"open-label":[65],"controlled":[66],"trial":[67,286],"included":[68],"PCR-confirmed":[71],"infection":[74],"and":[75,122,134,171],"indication":[77,320],"for":[78,151,321],"immediate":[79,322],"treatment.":[80,256],"Participants":[81],"were":[82,119,139,149,213,247],"1:1":[84],"3":[86,110,155,262],"months":[87,263],"self-administered":[89],"The":[97,285,300],"primary":[98,208],"outcome":[99],"was":[100,159],"absence":[101],"by":[107,296],"PCR":[108],"at":[109],"months.":[111],"Secondary":[112],"outcomes":[113],"during":[114],"study":[117],"period":[118],"patient-reported":[120],"satisfaction":[121],"adverse":[123,211,331],"events.":[124,332],"TRIAL":[125],"REGISTRATION:":[126],"ClinicalTrials.gov,":[127],"NCT05509413,":[128],"https://clinicaltrials.gov/study/NCT05509413.":[129],"RESULTS:":[130],"Between":[131],"November":[132],"2022":[133],"January":[135],"2025,":[136],"242":[137],"121":[142],"allocated":[143],"each":[145],"group.":[146],"Primary-endpoint":[147],"data":[148],"available":[150],"208":[152],"women.":[153],"At":[154],"months,":[156],"not":[160,201,272,288,303],"detected":[161],"in":[162,166,175,216,222,249,316],"18/99":[163],"(18%)":[165],"group":[170,178,220,225],"23/109":[172],"(21%)":[174],"(absolute":[179],"risk":[180,232],"difference":[181,233],"-2.9":[182],"percentage":[183,235],"points,":[184,236],"95%":[185,237],"CI":[186,238],"-14":[187],"8;":[189],"p":[190,242],"=":[191],"0.60).":[192],"A":[193],"reduced":[194],"post":[195],"hoc":[196],"adjusted":[197],"sensitivity":[198],"analysis":[199],"did":[200,271,287],"materially":[202],"change":[203],"interpretation":[205],"comparison.":[209],"Patient-reported":[210],"events":[212],"more":[214],"frequent":[215],"than":[221],"(32/99":[226],"[32%]":[227],"vs.":[228],"2/106":[229],"[2%];":[230],"absolute":[231],"30":[234],"21":[239],"40;":[241],"<":[243],"0.001).":[244],"Satisfaction":[245],"scores":[246],"high":[248],"both":[250],"groups":[251],"lower":[253],"CONCLUSIONS:":[257],"In":[258],"this":[259,308],"trial,":[261],"improve":[273],"reproduce":[289],"large":[291],"virologic":[293],"benefit":[294],"suggested":[295],"prior":[297],"product-related":[298],"studies.":[299],"findings":[301],"do":[302],"routine":[305],"use":[306],"intervention":[309],"solely":[310],"promote":[312],"non-detectability":[315],"without":[318],"an":[319],"treatment,":[323],"particularly":[324],"given":[325],"higher":[327],"frequency":[328],"local":[330]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-07T00:00:00"}