{"id":"https://openalex.org/W71870292","doi":null,"title":"Effects of capsicum fruit on theophylline absorption and bioavailability in rabbits.","display_name":"Effects of capsicum fruit on theophylline absorption and bioavailability in rabbits.","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W71870292","mag":"71870292","pmid":"https://pubmed.ncbi.nlm.nih.gov/3240714"},"language":"en","primary_location":{"id":"pmid:3240714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3240714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug-nutrient interactions","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110008425","display_name":"Abderrahman Bouraoui","orcid":"https://orcid.org/0000-0002-7881-6574","observed_orcids":["https://orcid.org/0000-0002-7881-6574"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"A Bouraoui","raw_affiliation_strings":["Unit of Pharmacology Faculty of Pharmacy, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Pharmacology Faculty of Pharmacy, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001348319","display_name":"Adn\u00e8ne Toumi","orcid":"https://orcid.org/0000-0003-3461-8098","observed_orcids":["https://orcid.org/0000-0003-3461-8098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Toumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014293536","display_name":"H Ben Mustapha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Ben Mustapha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113560165","display_name":"J.L. Brazier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Brazier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.00838169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"5","issue":"4","first_page":"345","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.05999999865889549,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9120000004768372},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.777999997138977},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8880000114440918},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.7620000243186951},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8928196430206299},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.8528800010681152},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7370067834854126},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.6220726370811462},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6193379163742065},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.610227108001709},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.5018332004547119},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.48066484928131104},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32569751143455505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14102256298065186},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1275554895401001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1081274151802063},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09972608089447021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09504470229148865},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002212","descriptor_name":"Capsicum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010945","descriptor_name":"Plants, Edible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3240714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3240714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug-nutrient interactions","raw_type":"Journal Article"},{"id":"mag:71870292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3240714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985243862","https://openalex.org/W2410226956","https://openalex.org/W2408704313","https://openalex.org/W2084824126","https://openalex.org/W2406173499","https://openalex.org/W2417615668","https://openalex.org/W2144434456","https://openalex.org/W2060824593","https://openalex.org/W2083610014","https://openalex.org/W1985961482"],"abstract_inverted_index":{"Absorption":[0],"and":[1,22,77,120],"bioavailability":[2,121],"of":[3,30,38,97,109,130,132],"theophylline":[4,110],"from":[5],"a":[6,24,106],"sustained-release":[7],"gelatin":[8],"capsule":[9],"were":[10],"investigated":[11],"in":[12,113,118,125,138],"10":[13],"male":[14],"rabbits":[15],"after":[16,103],"oral":[17],"administration":[18,96],"(20":[19],"mg/kg),":[20],"with":[21,127],"without":[23],"ground":[25],"capsicum":[26,39,99,139],"fruit":[27],"suspension.":[28],"Comparison":[29],"pharmacokinetic":[31,119],"parameters":[32,122],"showed":[33],"that":[34],"the":[35,98,128],"concomitant":[36],"absorption":[37],"increases":[40],"areas":[41],"under":[42],"plasma":[43,62,111],"curves":[44],"(from":[45,64,81],"86.06":[46],"+/-":[47,53,66,70,83,87],"9.78":[48],"mg":[49,55],"H/liter":[50],"to":[51,68,85],"138.32":[52],"17.27":[54],"H/liter,":[56],"P":[57,73,90],"less":[58,74,91],"than":[59,75,92],"0.001),":[60],"peak":[61],"levels":[63,112],"6.65":[65],"0.76":[67],"8.78":[69],"0.98":[71],"mg/liter,":[72],"0.01),":[76],"mean":[78],"residence":[79],"times":[80],"14.94":[82],"2.97":[84],"20.98":[86],"5.75":[88],"H,":[89],"0.001).":[93],"A":[94],"second":[95],"suspension,":[100],"11":[101],"hours":[102],"dosing,":[104],"produced":[105],"new":[107],"rise":[108],"every":[114],"rabbit.":[115],"The":[116],"variations":[117],"are":[123],"discussed":[124],"accordance":[126],"mechanisms":[129],"action":[131],"capsaicin,":[133],"an":[134],"active":[135],"compound":[136],"present":[137],"fruit.":[140]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
