{"id":"https://openalex.org/W7172503527","doi":"https://doi.org/10.64898/2026.08.04.742801","title":"In situ pulse dispersion estimation via third-harmonic generation interferometric autocorrelation for multiphoton microscopy","display_name":"In situ pulse dispersion estimation via third-harmonic generation interferometric autocorrelation for multiphoton microscopy","publication_year":2026,"publication_date":"2026-08-05","ids":{"openalex":"https://openalex.org/W7172503527","doi":"https://doi.org/10.64898/2026.08.04.742801"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.04.742801","doi":"https://doi.org/10.64898/2026.08.04.742801","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.04.742801","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/05/2026.08.04.742801.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/05/2026.08.04.742801.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013042510","display_name":"Liam Shaughnessy","orcid":"https://orcid.org/0000-0002-0726-6253","observed_orcids":["https://orcid.org/0000-0002-0726-6253"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liam Shaughnessy","raw_affiliation_strings":["Department of Applied Physics, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-0726-6253","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144420368","display_name":"Lauren Vannell","orcid":"https://orcid.org/0009-0001-7735-6166","observed_orcids":["https://orcid.org/0009-0001-7735-6166"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Vannell","raw_affiliation_strings":["Department of Physics, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0009-0001-7735-6166","affiliations":[{"raw_affiliation_string":"Department of Physics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119679306","display_name":"Sulekh Fernando-Peiris","orcid":"https://orcid.org/0009-0001-5070-9371","observed_orcids":["https://orcid.org/0009-0001-5070-9371"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sulekh Fernando-Peiris","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0009-0001-5070-9371","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030679672","display_name":"Cristina Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-5525-3174","observed_orcids":["https://orcid.org/0000-0002-5525-3174"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cristina Rodr\u00edguez","raw_affiliation_strings":["Department of Applied Physics, Yale University, New Haven, CT, USA","Department of Biomedical Engineering, Yale University, New Haven, CT, USA","Howard Hughes Medical Institute, Chevy Chase, MD, USA","Wu Tsai Institute, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-5525-3174","affiliations":[{"raw_affiliation_string":"Department of Applied Physics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Wu Tsai Institute, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030679672"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10566","display_name":"Laser-Matter Interactions and Applications","score":0.21480000019073486,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11788","display_name":"Nonlinear Optical Materials Studies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/group-delay-dispersion","display_name":"group delay dispersion","score":0.6840000152587891},{"id":"https://openalex.org/keywords/third-order-dispersion","display_name":"third-order dispersion","score":0.9990000128746033},{"id":"https://openalex.org/keywords/third-harmonic-generation","display_name":"third harmonic generation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/interferometric-autocorrelation","display_name":"interferometric autocorrelation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/multiphoton-microscopy","display_name":"multiphoton microscopy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/myelinated-nerve-fibers","display_name":"myelinated axons","score":0.7319999933242798},{"id":"https://openalex.org/keywords/deep-tissue-imaging","display_name":"deep tissue imaging","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.78329998254776},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.7035999894142151},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6259999871253967},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.607200026512146},{"id":"https://openalex.org/C178596936","wikidata":"https://www.wikidata.org/wiki/Q844471","display_name":"Ultrashort pulse","level":3,"score":0.5723000168800354},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.559499979019165},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.5170000195503235},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.4876999855041504},{"id":"https://openalex.org/C166689943","wikidata":"https://www.wikidata.org/wiki/Q850283","display_name":"Interferometry","level":2,"score":0.4781999886035919},{"id":"https://openalex.org/C96717886","wikidata":"https://www.wikidata.org/wiki/Q786943","display_name":"Autocorrelator","level":3,"score":0.4666000008583069},{"id":"https://openalex.org/C83581075","wikidata":"https://www.wikidata.org/wiki/Q1361503","display_name":"Excitation","level":2,"score":0.4595000147819519},{"id":"https://openalex.org/C47785574","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Two-photon excitation microscopy","level":3,"score":0.4221000075340271},{"id":"https://openalex.org/C77017923","wikidata":"https://www.wikidata.org/wiki/Q912313","display_name":"Optical microscope","level":3,"score":0.39239999651908875},{"id":"https://openalex.org/C169150495","wikidata":"https://www.wikidata.org/wiki/Q7259675","display_name":"Pulse duration","level":3,"score":0.38749998807907104},{"id":"https://openalex.org/C102595763","wikidata":"https://www.wikidata.org/wiki/Q999719","display_name":"Femtosecond pulse shaping","level":4,"score":0.37070000171661377},{"id":"https://openalex.org/C23845534","wikidata":"https://www.wikidata.org/wiki/Q25303603","display_name":"Group delay dispersion","level":5,"score":0.3375999927520752},{"id":"https://openalex.org/C167735695","wikidata":"https://www.wikidata.org/wiki/Q1777507","display_name":"Femtosecond","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C59994255","wikidata":"https://www.wikidata.org/wiki/Q5276092","display_name":"Digital holographic microscopy","level":3,"score":0.3192000091075897},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C102755159","wikidata":"https://www.wikidata.org/wiki/Q7259683","display_name":"Pulse shaping","level":3,"score":0.27549999952316284},{"id":"https://openalex.org/C168834538","wikidata":"https://www.wikidata.org/wiki/Q3705329","display_name":"Beam (structure)","level":2,"score":0.27410000562667847},{"id":"https://openalex.org/C146139980","wikidata":"https://www.wikidata.org/wiki/Q6934848","display_name":"Multiphoton intrapulse interference phase scan","level":5,"score":0.2653999924659729},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C5297727","wikidata":"https://www.wikidata.org/wiki/Q786970","display_name":"Autocorrelation","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.04.742801","doi":"https://doi.org/10.64898/2026.08.04.742801","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.04.742801","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/05/2026.08.04.742801.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.04.742801","doi":"https://doi.org/10.64898/2026.08.04.742801","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.04.742801","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/05/2026.08.04.742801.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7172503527.pdf","grobid_xml":"https://content.openalex.org/works/W7172503527.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3133980931","https://openalex.org/W7168095960","https://openalex.org/W7092564616","https://openalex.org/W2067966059","https://openalex.org/W2093670498","https://openalex.org/W2389940398","https://openalex.org/W2248923637","https://openalex.org/W3037718123","https://openalex.org/W2005500278","https://openalex.org/W1994477298"],"abstract_inverted_index":{"ABSTRACT":[0],"Three-photon":[1],"microscopy":[2,202],"enables":[3,194],"deep-tissue":[4],"imaging":[5,55],"but":[6],"is":[7],"highly":[8],"sensitive":[9],"to":[10,81,100],"excitation":[11,16,114],"pulse":[12,130,168,198],"quality,":[13],"since":[14],"three-photon":[15],"efficiency":[17],"scales":[18],"with":[19,66,120],"the":[20,34,45,89,101,124,136,152,156,171,179],"cube":[21],"of":[22,123,185],"instantaneous":[23],"intensity.":[24],"Group-delay":[25],"dispersion":[26,30],"(GDD)":[27],"and":[28,36,71,85,111,182],"third-order":[29],"(TOD)":[31],"accumulated":[32],"through":[33],"laser":[35,126],"microscope":[37,102,117],"optics":[38],"can":[39],"substantially":[40],"reduce":[41],"peak":[42],"intensity":[43],"at":[44,88,108,139],"focal":[46,91],"plane,":[47,92],"yet":[48],"these":[49],"quantities":[50],"are":[51],"rarely":[52],"measured":[53],"where":[54],"occurs.":[56],"Here,":[57],"we":[58,128,163],"use":[59],"third-harmonic":[60],"generation":[61],"(THG)":[62],"interferometric":[63],"autocorrelation,":[64],"together":[65],"Dispersion":[67],"Look-Up-Table":[68],"Estimation":[69],"(D-LUTE)":[70],"a":[72,95,183,187],"joint":[73],"two-measurement":[74],"fitting":[75],"procedure":[76],"validated":[77],"on":[78],"synthetic":[79],"data,":[80],"estimate":[82],"baseline":[83],"GDD":[84],"TOD":[86],"directly":[87],"objective":[90],"requiring":[93],"only":[94],"compact":[96],"autocorrelator":[97],"module":[98],"added":[99],"beam":[103],"path.":[104],"Applying":[105],"this":[106],"method":[107],"1300":[109],"nm":[110,113],"1600":[112],"across":[115,200],"two":[116,153],"systems":[118],"equipped":[119],"different":[121],"units":[122],"same":[125],"model,":[127],"find":[129],"durations":[131],"1.4-to":[132],"1.7-fold":[133],"longer":[134],"than":[135],"transform":[137],"limit":[138],"every":[140],"condition,":[141],"driven":[142],"predominantly":[143],"by":[144,148],"TOD,":[145],"which":[146],"varied":[147],"roughly":[149],"2.7-fold":[150],"between":[151,178],"systems.":[154],"Using":[155],"endogenous":[157],"THG":[158],"signal":[159],"from":[160],"myelinated":[161],"fibers,":[162],"further":[164],"demonstrate":[165],"in":[166,170,196],"vivo":[167],"characterization":[169],"mouse":[172],"brain,":[173],"finding":[174],"no":[175],"measurable":[176],"broadening":[177],"tissue":[180],"surface":[181],"depth":[184],"nearly":[186],"millimeter.":[188],"This":[189],"low-cost,":[190],"easily":[191],"implemented":[192],"approach":[193],"routine,":[195],"situ":[197],"monitoring":[199],"multiphoton":[201],"platforms.":[203]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-06T00:00:00"}
