{"id":"https://openalex.org/W7172492400","doi":"https://doi.org/10.29313/jiff.v9i2.9121","title":"Development of a Nanoemulsion Formulation of Cassava Leaf Extract (Manihot esculenta Crantz) to Enhance Antioxidant Activity and Formula Stability","display_name":"Development of a Nanoemulsion Formulation of Cassava Leaf Extract (Manihot esculenta Crantz) to Enhance Antioxidant Activity and Formula Stability","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7172492400","doi":"https://doi.org/10.29313/jiff.v9i2.9121"},"language":"id","primary_location":{"id":"doi:10.29313/jiff.v9i2.9121","doi":"https://doi.org/10.29313/jiff.v9i2.9121","is_oa":true,"landing_page_url":"https://doi.org/10.29313/jiff.v9i2.9121","pdf_url":null,"source":{"id":"https://openalex.org/S4210181649","display_name":"Jurnal Ilmiah Farmasi Farmasyifa","issn_l":"2598-6376","issn":["2598-6376","2599-0047"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314978","host_organization_name":"Bandung Islamic University","host_organization_lineage":["https://openalex.org/P4310314978"],"host_organization_lineage_names":["Bandung Islamic University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Ilmiah Farmasi Farmasyifa","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.29313/jiff.v9i2.9121","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144444752","display_name":"Syamsul Ma'arif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260937","display_name":"Universitas An Nasher","ror":"https://ror.org/04gs1am02","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405260937"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Syamsul Ma'arif","raw_affiliation_strings":["Unversitas An Nasher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unversitas An Nasher","institution_ids":["https://openalex.org/I4405260937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063830981","display_name":"Yetti Hariningsih","orcid":"https://orcid.org/0009-0009-5001-0091","observed_orcids":["https://orcid.org/0009-0009-5001-0091"]},"institutions":[{"id":"https://openalex.org/I4405260937","display_name":"Universitas An Nasher","ror":"https://ror.org/04gs1am02","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405260937"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yetti Hariningsih","raw_affiliation_strings":["Universitas An Nasher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas An Nasher","institution_ids":["https://openalex.org/I4405260937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009417063","display_name":"Eva Luviriani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260937","display_name":"Universitas An Nasher","ror":"https://ror.org/04gs1am02","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405260937"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Eva Luviriani","raw_affiliation_strings":["Universitas An Nasher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas An Nasher","institution_ids":["https://openalex.org/I4405260937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144390190","display_name":"Salwa Fadhila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260937","display_name":"Universitas An Nasher","ror":"https://ror.org/04gs1am02","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405260937"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Salwa Fadhila","raw_affiliation_strings":["Universitas An Nasher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas An Nasher","institution_ids":["https://openalex.org/I4405260937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5144395309","display_name":"Vishnu Arya Nugraha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vishnu Arya Nugraha","raw_affiliation_strings":["Universitas YPIB Majalengka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas YPIB Majalengka","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"2","first_page":"111","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.4059999883174896,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.4059999883174896,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.21809999644756317,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cassava-leaf-extract","display_name":"cassava leaf extract","score":0.902999997138977},{"id":"https://openalex.org/keywords/cassava","display_name":"cassava","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/formulation-stability","display_name":"formulation stability","score":0.7850000262260437},{"id":"https://openalex.org/keywords/natural-antioxidants","display_name":"natural antioxidants","score":0.574999988079071},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8379999995231628},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tannins","display_name":"tannins","score":0.8259999752044678},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.6669999957084656},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.8960000276565552},{"id":"https://openalex.org/keywords/storage-stability","display_name":"storage stability","score":0.5730000138282776},{"id":"https://openalex.org/keywords/cosmetic-formulation","display_name":"cosmetic formulation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/surfactants","display_name":"surfactants","score":0.4869999885559082},{"id":"https://openalex.org/keywords/co-surfactants","display_name":"cosurfactants","score":0.8769999742507935},{"id":"https://openalex.org/keywords/preservatives","display_name":"preservatives","score":0.5230000019073486},{"id":"https://openalex.org/keywords/homogenization","display_name":"homogenization","score":0.531000018119812},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.8119999766349792},{"id":"https://openalex.org/keywords/abts","display_name":"ABTS","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7045000195503235},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6431999802589417},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4584999978542328},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.39809998869895935},{"id":"https://openalex.org/C2781031786","wikidata":"https://www.wikidata.org/wiki/Q287582","display_name":"ABTS","level":4,"score":0.3790999948978424},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2702000141143799},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.1981000006198883},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.19660000503063202},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1599999964237213},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.15109999477863312}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29313/jiff.v9i2.9121","doi":"https://doi.org/10.29313/jiff.v9i2.9121","is_oa":true,"landing_page_url":"https://doi.org/10.29313/jiff.v9i2.9121","pdf_url":null,"source":{"id":"https://openalex.org/S4210181649","display_name":"Jurnal Ilmiah Farmasi Farmasyifa","issn_l":"2598-6376","issn":["2598-6376","2599-0047"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314978","host_organization_name":"Bandung Islamic University","host_organization_lineage":["https://openalex.org/P4310314978"],"host_organization_lineage_names":["Bandung Islamic University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Ilmiah Farmasi Farmasyifa","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29313/jiff.v9i2.9121","doi":"https://doi.org/10.29313/jiff.v9i2.9121","is_oa":true,"landing_page_url":"https://doi.org/10.29313/jiff.v9i2.9121","pdf_url":null,"source":{"id":"https://openalex.org/S4210181649","display_name":"Jurnal Ilmiah Farmasi Farmasyifa","issn_l":"2598-6376","issn":["2598-6376","2599-0047"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310314978","host_organization_name":"Bandung Islamic University","host_organization_lineage":["https://openalex.org/P4310314978"],"host_organization_lineage_names":["Bandung Islamic University"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jurnal Ilmiah Farmasi Farmasyifa","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404027819","https://openalex.org/W4411614858","https://openalex.org/W7218244034","https://openalex.org/W7216908175","https://openalex.org/W7215141403","https://openalex.org/W4391515903","https://openalex.org/W4409857386","https://openalex.org/W4318814954","https://openalex.org/W3080768271","https://openalex.org/W4385815892"],"abstract_inverted_index":{"Daun":[0],"singkong":[1,51,160,211],"memiliki":[2],"senyawa":[3,24,32],"bioaktif":[4],"flavonoid,":[5],"fenol,":[6],"dan":[7,23,56,85,93,111,120,149,163,169,181,189,216],"tanin":[8],"(antioksidan":[9],"alami).":[10],"Namun,":[11],"pemanfaatannya":[12],"dalam":[13],"sediaan":[14,38,47,81,207],"farmasi":[15],"atau":[16],"kosmetik":[17],"masih":[18],"terbatas":[19],"karena":[20],"kelarutannya":[21],"rendah":[22],"aktifnya":[25],"mudah":[26],"terdegradasi.":[27],"Teknologi":[28],"nanopartikel":[29],"dapat":[30,212],"menstabilkan":[31],"aktif":[33],"dengan":[34,67,69,87,117,137],"membuat":[35],"ukuran":[36,106,139],"partikel":[37,140],"menjadi":[39],"lebih":[40,172],"kecil.":[41],"Penelitian":[42],"ini":[43,61,203],"bertujuan":[44],"untuk":[45],"mengembangkan":[46],"nanoemulsi":[48,82,136,208],"ekstrak":[49,157,209],"daun":[50,159,210],"guna":[52],"meningkatkan":[53,213],"aktivitas":[54,214],"antioksidan":[55,115,155,176,215],"stabilitas":[57,123,217],"formula.":[58,218],"Metode":[59],"penelitian":[60,132],"berupa":[62],"eksperimental":[63],"laboratorium,":[64],"yang":[65,133],"diawali":[66],"maserasi":[68],"pelarut":[70,94],"etanol,":[71],"kemudian":[72],"dilakukan":[73],"skrining":[74],"fitokimia":[75],"lalu":[76],"diformulasikan":[77],"kedalam":[78],"3":[79],"formulasi":[80,101],"(F1,":[83],"F2":[84],"F3)":[86],"kombinasi":[88],"minyak,":[89],"surfaktan,":[90],"kosurfaktan,":[91],"pengawet":[92],"melalui":[95,126],"metode":[96,118,161,179],"homogenizer":[97],"berkecepatan":[98],"tinggi.":[99],"Karakterisasi":[100],"meliputi":[102],"organoleptis,":[103],"pH,":[104],"viskositas,":[105],"partikel,":[107],"poli":[108],"indeks":[109],"dispersitas":[110],"zeta":[112,151],"potensial.":[113],"Aktivitas":[114,154,175],"diuji":[116],"DPPH":[119,162,180],"ABTS,":[121],"serta":[122],"formulanya":[124],"dievaluasi":[125],"penyimpanan":[127],"selama":[128,193],"14":[129,194],"hari.":[130],"Hasil":[131],"diperoleh":[134],"formula":[135],"karakteristik":[138],"berkisar":[141],"114-":[142],"123":[143],"nm,":[144],"nilai":[145],"PDI":[146],"0,311-":[147],"0,340,":[148],"potensial":[150],"40-43":[152],"mV.":[153],"IC50":[156,177],"kasar":[158],"ABTS":[164,182],"masing":[165,166,183,184],"85,61":[167],"\u00b5g/ml":[168,188],"80,76":[170],"\u00b5g/ml,":[171],"kecil":[173],"daripada":[174],"Nanoemulsi":[178],"kurang":[185],"dari":[186],"37,77":[187],"40,58":[190],"\u00b5g/ml.":[191],"Penyimpanan":[192],"hari":[195],"menunjukan":[196,204],"tidak":[197],"terjadinya":[198],"pemisahan":[199],"pada":[200],"nanoemulsi.":[201],"Temuan":[202],"bahwa":[205],"pengembangan":[206]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-06T00:00:00"}