{"id":"https://openalex.org/W7172425790","doi":"https://doi.org/10.1007/s00702-026-03246-5","title":"Add-on safinamide and amantadine in Filipino Parkinson\u2019s disease patients with motor fluctuations: a retrospective exploratory cohort study","display_name":"Add-on safinamide and amantadine in Filipino Parkinson\u2019s disease patients with motor fluctuations: a retrospective exploratory cohort study","publication_year":2026,"publication_date":"2026-08-04","ids":{"openalex":"https://openalex.org/W7172425790","doi":"https://doi.org/10.1007/s00702-026-03246-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42550256"},"language":"en","primary_location":{"id":"doi:10.1007/s00702-026-03246-5","doi":"https://doi.org/10.1007/s00702-026-03246-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00702-026-03246-5","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5139585468","display_name":"Yvone Noelle A. Sermense","orcid":"https://orcid.org/0009-0006-4650-3692","observed_orcids":["https://orcid.org/0009-0006-4650-3692"]},"institutions":[{"id":"https://openalex.org/I4405279074","display_name":"Medical Center Manila","ror":"https://ror.org/00zeg0323","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4405279074"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Yvone Noelle A. Sermense","raw_affiliation_strings":["Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines. ynasermense@gmail.com"],"raw_orcid":"https://orcid.org/0009-0006-4650-3692","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines. ynasermense@gmail.com","institution_ids":["https://openalex.org/I4405279074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043206162","display_name":"Raymond L. Rosales","orcid":"https://orcid.org/0000-0001-6387-1389","observed_orcids":["https://orcid.org/0000-0001-6387-1389"]},"institutions":[{"id":"https://openalex.org/I82904351","display_name":"University of Santo Tomas","ror":"https://ror.org/00d25af97","country_code":"PH","type":"education","lineage":["https://openalex.org/I82904351"]}],"countries":["PH"],"is_corresponding":true,"raw_author_name":"Raymond L. Rosales","raw_affiliation_strings":["Center for Neurodiagnostic and Therapeutic Services, Metropolitan Medical Center, Manila, Philippines. rlrosales@ust.edu.ph","Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines. rlrosales@ust.edu.ph","Research Center for Health Sciences, University of Santo Tomas, Manila, Philippines. rlrosales@ust.edu.ph"],"raw_orcid":"https://orcid.org/0000-0001-6387-1389","affiliations":[{"raw_affiliation_string":"Center for Neurodiagnostic and Therapeutic Services, Metropolitan Medical Center, Manila, Philippines. rlrosales@ust.edu.ph","institution_ids":[]},{"raw_affiliation_string":"Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines. rlrosales@ust.edu.ph","institution_ids":[]},{"raw_affiliation_string":"Research Center for Health Sciences, University of Santo Tomas, Manila, Philippines. rlrosales@ust.edu.ph","institution_ids":["https://openalex.org/I82904351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074481760","display_name":"Michelle J Tanglao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405279074","display_name":"Medical Center Manila","ror":"https://ror.org/00zeg0323","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I4405279074"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Michelle J. Tanglao","raw_affiliation_strings":["Center for Neurodiagnostic and Therapeutic Services, Metropolitan Medical Center, Manila, Philippines"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodiagnostic and Therapeutic Services, Metropolitan Medical Center, Manila, Philippines","institution_ids":["https://openalex.org/I4405279074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043206162","https://openalex.org/A5139585468"],"corresponding_institution_ids":["https://openalex.org/I4405279074","https://openalex.org/I82904351"],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12569","display_name":"Restless Legs Syndrome Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8870000243186951},{"id":"https://openalex.org/keywords/motor-fluctuations","display_name":"motor fluctuations","score":0.7900000214576721},{"id":"https://openalex.org/keywords/safinamide","display_name":"safinamide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/amantadine","display_name":"amantadine","score":1.0},{"id":"https://openalex.org/keywords/dopamine-replacement-therapy","display_name":"dopamine replacement therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/on-off-time","display_name":"on-off time","score":0.5619999766349792},{"id":"https://openalex.org/keywords/motor-complications","display_name":"motor complications","score":0.7239999771118164},{"id":"https://openalex.org/keywords/unified-parkinson-s-disease-rating-scale","display_name":"Unified Parkinson's Disease Rating Scale","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hoehn-and-yahr-stage","display_name":"Hoehn and Yahr stage","score":0.9129999876022339},{"id":"https://openalex.org/keywords/levodopa-equivalent-daily-dose","display_name":"levodopa equivalent daily dose","score":0.8050000071525574},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7059999704360962},{"id":"https://openalex.org/keywords/filipino-patients","display_name":"Filipino patients","score":0.8989999890327454},{"id":"https://openalex.org/keywords/treatment-comparison","display_name":"treatment comparison","score":0.492000013589859},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.6340000033378601},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.9900000095367432},{"id":"https://openalex.org/keywords/levodopa-induced-dyskinesia","display_name":"levodopa-induced dyskinesia","score":0.6370000243186951},{"id":"https://openalex.org/keywords/akinesia","display_name":"akinesia","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8004999756813049},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.6442000269889832},{"id":"https://openalex.org/C2777374534","wikidata":"https://www.wikidata.org/wiki/Q409761","display_name":"Amantadine","level":2,"score":0.567799985408783},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5529000163078308},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.5501999855041504},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5457000136375427},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5397999882698059},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48649999499320984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4790000021457672},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.4187999963760376},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.40689998865127563},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.39890000224113464},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35089999437332153},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.2842999994754791},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C2778258207","wikidata":"https://www.wikidata.org/wiki/Q600203","display_name":"Dopamine agonist","level":4,"score":0.2770000100135803},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2623000144958496}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00702-026-03246-5","doi":"https://doi.org/10.1007/s00702-026-03246-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00702-026-03246-5","pdf_url":null,"source":{"id":"https://openalex.org/S1737980","display_name":"Journal of Neural Transmission","issn_l":"0300-9564","issn":["0300-9564","1435-1463"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Transmission","raw_type":"journal-article"},{"id":"pmid:42550256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42550256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission (Vienna, Austria : 1996)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1631523450","https://openalex.org/W1727176495","https://openalex.org/W2064188882","https://openalex.org/W2610902102","https://openalex.org/W2890827157","https://openalex.org/W3038426978","https://openalex.org/W3045772558","https://openalex.org/W3094227256","https://openalex.org/W3142666124","https://openalex.org/W4210552228","https://openalex.org/W4307567915","https://openalex.org/W4308591063","https://openalex.org/W4366988954","https://openalex.org/W4386531948","https://openalex.org/W4397003450","https://openalex.org/W4404374390","https://openalex.org/W4408208852","https://openalex.org/W4409538297","https://openalex.org/W4415766976"],"related_works":["https://openalex.org/W7126232325","https://openalex.org/W2274833306","https://openalex.org/W1631523450","https://openalex.org/W2342524039","https://openalex.org/W2809387902","https://openalex.org/W4404374390","https://openalex.org/W2090018318","https://openalex.org/W7220859795","https://openalex.org/W4366988954","https://openalex.org/W2979364557"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-05T00:00:00"}
