{"id":"https://openalex.org/W7172395872","doi":"https://doi.org/10.21203/rs.3.rs-9935321/v1","title":"Progressive Neuroinvasive and Neurodegenerative Disease Due to Potosi Virus in an Immunosuppressed Adult","display_name":"Progressive Neuroinvasive and Neurodegenerative Disease Due to Potosi Virus in an Immunosuppressed Adult","publication_year":2026,"publication_date":"2026-08-04","ids":{"openalex":"https://openalex.org/W7172395872","doi":"https://doi.org/10.21203/rs.3.rs-9935321/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-9935321/v1","doi":"https://doi.org/10.21203/rs.3.rs-9935321/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9935321/v1","pdf_url":"https://www.researchsquare.com/article/rs-9935321/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-9935321/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015307378","display_name":"Julian A. Villalba","orcid":"https://orcid.org/0000-0001-9230-8747","observed_orcids":["https://orcid.org/0000-0001-9230-8747"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian Villalba","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":"https://orcid.org/0000-0001-9230-8747","affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457957","display_name":"Emily H. Davis","orcid":"https://orcid.org/0000-0001-6392-6538","observed_orcids":["https://orcid.org/0000-0001-6392-6538"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Davis","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085348888","display_name":"Kunio Nakamura","orcid":"https://orcid.org/0000-0002-7833-8138","observed_orcids":["https://orcid.org/0000-0002-7833-8138"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunio Nakamura","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":"https://orcid.org/0000-0002-7833-8138","affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067406023","display_name":"Justin Abbatemarco","orcid":"https://orcid.org/0000-0003-1668-4753","observed_orcids":["https://orcid.org/0000-0003-1668-4753"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Abbatemarco","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089599832","display_name":"Kara A. Swenson","orcid":"https://orcid.org/0000-0002-7296-1316","observed_orcids":["https://orcid.org/0000-0002-7296-1316"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara Swenson","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":"https://orcid.org/0000-0002-7296-1316","affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073904968","display_name":"Amanda E. Calvert","orcid":"https://orcid.org/0000-0002-8237-2654","observed_orcids":["https://orcid.org/0000-0002-8237-2654"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Calvert","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113901996","display_name":"Carolyn Gould","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn Gould","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034250594","display_name":"Jennifer Kasten","orcid":"https://orcid.org/0000-0001-6439-9872","observed_orcids":["https://orcid.org/0000-0001-6439-9872"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Jennifer Kasten","raw_affiliation_strings":["Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Infectious Diseases Pathology Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Infectious Diseases Pathology Branch","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210145675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021873304","display_name":"Mark L. Cohen","orcid":"https://orcid.org/0000-0002-9678-5521","observed_orcids":["https://orcid.org/0000-0002-9678-5521"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Cohen","raw_affiliation_strings":["Case western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129071941","display_name":"Paola Loreto-Palacio","orcid":"https://orcid.org/0000-0003-1706-7896","observed_orcids":["https://orcid.org/0000-0003-1706-7896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Loreto-Palacio","raw_affiliation_strings":["National Prion Disease Pathology Surveillance Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Prion Disease Pathology Surveillance Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159936525","display_name":"Georgia Ficarra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia Ficarra","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081735927","display_name":"Tengguo Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tengguo Li","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089800743","display_name":"Sheryll Corchuelo","orcid":"https://orcid.org/0000-0003-2950-9102","observed_orcids":["https://orcid.org/0000-0003-2950-9102"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheryll Corchuelo-Chavarro","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":"https://orcid.org/0000-0003-2950-9102","affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085367996","display_name":"Pamela S. Fair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Pamela Fair","raw_affiliation_strings":["Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Infectious Diseases Pathology Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Infectious Diseases Pathology Branch","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210145675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008582216","display_name":"Marlene DeLeon-Carnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210102376","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/00qzjvm58","country_code":"UG","type":"government","lineage":["https://openalex.org/I4210102376"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","UG","US"],"is_corresponding":false,"raw_author_name":"Marlene DeLeon-Carnes","raw_affiliation_strings":["Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Infectious Diseases Pathology Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention, Division of High-Consequence Pathogens and Pathology, Infectious Diseases Pathology Branch","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210102376","https://openalex.org/I4210145675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006715848","display_name":"Brooke Leitgeb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Leitgeb","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029675794","display_name":"Kimberly D. Machesky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801226506","display_name":"Ohio Department of Health","ror":"https://ror.org/0436zyg08","country_code":"US","type":"government","lineage":["https://openalex.org/I2801226506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Machesky","raw_affiliation_strings":["Ohio Department of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio Department of Health","institution_ids":["https://openalex.org/I2801226506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016796194","display_name":"Carlos M. Isada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Isada","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085171079","display_name":"Hannah Wang","orcid":"https://orcid.org/0000-0002-3712-9188","observed_orcids":["https://orcid.org/0000-0002-3712-9188"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Wang","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044052521","display_name":"Sudeb C. Dalai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudeb Dalai","raw_affiliation_strings":["Stanford University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081374859","display_name":"Steve A. Miller","orcid":"https://orcid.org/0000-0002-9188-3392","observed_orcids":["https://orcid.org/0000-0002-9188-3392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Miller","raw_affiliation_strings":["Delve Bio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Delve Bio","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041498070","display_name":"Robert J Fox","orcid":"https://orcid.org/0000-0002-0950-3865","observed_orcids":["https://orcid.org/0000-0002-0950-3865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J Fox","raw_affiliation_strings":["CCF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCF","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039022235","display_name":"Gabrielle A. Yeaney","orcid":"https://orcid.org/0000-0002-9374-1435","observed_orcids":["https://orcid.org/0000-0002-9374-1435"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabrielle Yeaney","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052663280","display_name":"Holly R. Hughes","orcid":"https://orcid.org/0000-0003-1380-8263","observed_orcids":["https://orcid.org/0000-0003-1380-8263"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Hughes","raw_affiliation_strings":["Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044538745","display_name":"Erin Staples","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin Staples","raw_affiliation_strings":["CDC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CDC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071498317","display_name":"Aaron C. Brault","orcid":"https://orcid.org/0000-0001-5801-3021","observed_orcids":["https://orcid.org/0000-0001-5801-3021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Brault","raw_affiliation_strings":["CDC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CDC","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110777540","display_name":"Julu Bhatnagar","orcid":"https://orcid.org/0000-0002-4357-7833","observed_orcids":["https://orcid.org/0000-0002-4357-7833"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I4210145675","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/047h8wb98","country_code":"KE","type":"government","lineage":["https://openalex.org/I4210145675"]}],"countries":["KE","US"],"is_corresponding":false,"raw_author_name":"Julu Bhatnagar","raw_affiliation_strings":["US Centers for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Centers for Disease Control and Prevention","institution_ids":["https://openalex.org/I1289490764","https://openalex.org/I4210145675"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orthobunyavirus","display_name":"Orthobunyavirus","score":0.9829999804496765},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.8330000042915344},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8109999895095825},{"id":"https://openalex.org/keywords/progressive-dementia","display_name":"progressive dementia","score":0.6200000047683716},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.8100000023841858},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/meningoencephalitis","display_name":"meningoencephalitis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/arboviruses","display_name":"arboviruses","score":0.7450000047683716},{"id":"https://openalex.org/keywords/postmortem-neuropathology","display_name":"postmortem neuropathology","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5958999991416931},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5834000110626221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5541999936103821},{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.5263000130653381},{"id":"https://openalex.org/C148632171","wikidata":"https://www.wikidata.org/wiki/Q7542129","display_name":"Slow virus","level":4,"score":0.5252000093460083},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5012999773025513},{"id":"https://openalex.org/C2778621254","wikidata":"https://www.wikidata.org/wiki/Q2346415","display_name":"Meningoencephalitis","level":2,"score":0.44749999046325684},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44600000977516174},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44339999556541443},{"id":"https://openalex.org/C2777280662","wikidata":"https://www.wikidata.org/wiki/Q163905","display_name":"Lafora disease","level":4,"score":0.41029998660087585},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.38999998569488525},{"id":"https://openalex.org/C2779174946","wikidata":"https://www.wikidata.org/wiki/Q751911","display_name":"RNA virus","level":4,"score":0.3849000036716461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3783000111579895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37130001187324524},{"id":"https://openalex.org/C2779973787","wikidata":"https://www.wikidata.org/wiki/Q609748","display_name":"Emerging infectious disease","level":3,"score":0.3521000146865845},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3345000147819519},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C2779150272","wikidata":"https://www.wikidata.org/wiki/Q1676563","display_name":"JC virus","level":4,"score":0.31949999928474426},{"id":"https://openalex.org/C2780449708","wikidata":"https://www.wikidata.org/wiki/Q11695458","display_name":"Neurocysticercosis","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.3034999966621399},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.28630000352859497},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C2777510210","wikidata":"https://www.wikidata.org/wiki/Q1331256","display_name":"Flaviviridae","level":4,"score":0.26980000734329224},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.25690001249313354},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C2781031778","wikidata":"https://www.wikidata.org/wiki/Q16000255","display_name":"Novel virus","level":4,"score":0.2549000084400177},{"id":"https://openalex.org/C2779734145","wikidata":"https://www.wikidata.org/wiki/Q3053951","display_name":"Viral encephalitis","level":4,"score":0.2506999969482422},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-9935321/v1","doi":"https://doi.org/10.21203/rs.3.rs-9935321/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9935321/v1","pdf_url":"https://www.researchsquare.com/article/rs-9935321/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-9935321/v1","doi":"https://doi.org/10.21203/rs.3.rs-9935321/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9935321/v1","pdf_url":"https://www.researchsquare.com/article/rs-9935321/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7172395872.pdf","grobid_xml":"https://content.openalex.org/works/W7172395872.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1869071094","https://openalex.org/W1891773028","https://openalex.org/W1970997651","https://openalex.org/W1994288121","https://openalex.org/W2001696757","https://openalex.org/W2008758766","https://openalex.org/W2011350586","https://openalex.org/W2057440048","https://openalex.org/W2064988059","https://openalex.org/W2066260623","https://openalex.org/W2114580219","https://openalex.org/W2141981816","https://openalex.org/W2171120876","https://openalex.org/W2172344521","https://openalex.org/W2259815326","https://openalex.org/W2408328645","https://openalex.org/W2595087345","https://openalex.org/W2679545321","https://openalex.org/W2777475433","https://openalex.org/W2922077951","https://openalex.org/W2952481429","https://openalex.org/W2977883158","https://openalex.org/W3094829519","https://openalex.org/W3102798166","https://openalex.org/W3106619470","https://openalex.org/W3124311653","https://openalex.org/W3132911655","https://openalex.org/W3177077093","https://openalex.org/W3184009186","https://openalex.org/W3187717873","https://openalex.org/W3209221616","https://openalex.org/W4210713858","https://openalex.org/W4213166206","https://openalex.org/W4295788287","https://openalex.org/W4311436944","https://openalex.org/W4387446070","https://openalex.org/W4388486753","https://openalex.org/W4390047573","https://openalex.org/W4391055846","https://openalex.org/W4391163923","https://openalex.org/W4402828286","https://openalex.org/W7131411072"],"related_works":["https://openalex.org/W4406501587","https://openalex.org/W2046196001","https://openalex.org/W3081732002","https://openalex.org/W2789827474","https://openalex.org/W1799965348","https://openalex.org/W2418962070","https://openalex.org/W4409963674","https://openalex.org/W2093855942","https://openalex.org/W2413530752","https://openalex.org/W3090106984"],"abstract_inverted_index":{"Abstract":[0],"Potosi":[1],"virus":[2],"(POTV),":[3],"an":[4],"orthobunyavirus":[5],"first":[6,33],"isolated":[7],"in":[8,13,25,51,68,80,116,130,140,205,231],"1989,":[9],"has":[10],"been":[11],"detected":[12,66],"multiple":[14],"mosquito":[15],"species":[16],"across":[17],"the":[18,32,69,134,141,209,225],"United":[19],"States,":[20],"but":[21],"its":[22],"pathogenic":[23],"potential":[24],"humans":[26],"remains":[27],"uncertain.":[28],"Here":[29],"we":[30],"report":[31],"in-depth":[34],"pathological":[35],"and":[36,99,122,153,156,177,223],"pathogenetic":[37],"characterization":[38],"of":[39,63,71,101,118,219],"POTV":[40,67,102,137,195],"central":[41],"nervous":[42],"system":[43],"(CNS)":[44],"infection":[45,103,176,200,214],"manifesting":[46],"as":[47],"rapidly":[48],"progressive":[49,72,178,203],"dementia":[50],"a":[52,83,217],"woman":[53],"receiving":[54],"long-term":[55],"rituximab":[56],"therapy.":[57],"Antemortem":[58],"metagenomic":[59],"next-generation":[60],"sequencing":[61,182],"(mNGS)":[62],"cerebrospinal":[64],"fluid":[65],"setting":[70],"brain":[73],"volume":[74],"loss":[75,159],"on":[76],"longitudinal":[77],"neuroimaging,":[78],"culminating":[79],"death":[81],"almost":[82],"year":[84],"after":[85],"symptom":[86],"onset.":[87],"Comprehensive":[88],"postmortem":[89],"neuropathological":[90],"examination":[91],"demonstrated":[92,126,183],"diffuse":[93],"meningoencephalitis":[94],"with":[95,112,133,151,187,202],"widespread":[96],"spongiform":[97],"neurodegeneration":[98,204],"evidence":[100],"throughout":[104],"all":[105],"evaluated":[106],"CNS":[107,171,199],"subregions":[108],"(n":[109],"=":[110],"75),":[111],"detectable":[113],"viral":[114,131,147,185,213],"replication":[115],"80%":[117],"subregions.":[119],"Quantitative":[120],"spatial":[121],"machine":[123],"learning\u2013based":[124],"analyses":[125],"marked":[127],"regional":[128],"heterogeneity":[129],"burden,":[132],"highest":[135],"genomic":[136],"RNA":[138,148],"levels":[139],"cerebellum":[142],"(p":[143],"<":[144,165],"0.0001),":[145],"where":[146],"density":[149],"correlated":[150],"spongiosis":[152],"severe":[154],"Purkinje":[155],"granule":[157],"cell":[158],"(\u03c1":[160],"up":[161],"to":[162,227],"0.39;":[163],"p":[164],"0.001).":[166],"Hierarchical":[167],"clustering":[168],"identified":[169],"distinct":[170],"compartments":[172],"characterized":[173],"by":[174],"chronic":[175,212],"neurodegeneration,":[179],"while":[180],"comparative":[181],"intrahost":[184],"variation":[186],"region-specific":[188],"mutations.":[189],"Collectively,":[190],"these":[191],"findings":[192],"demonstrate":[193],"that":[194,211],"can":[196],"cause":[197],"persistent":[198],"associated":[201],"B-cell\u2013depleted":[206],"hosts,":[207],"raising":[208],"possibility":[210],"may":[215],"underlie":[216],"subset":[218],"transmissible":[220],"dementia-like":[221],"syndromes":[222],"highlighting":[224],"need":[226],"consider":[228],"emerging":[229],"arboviruses":[230],"unexplained":[232],"neurodegenerative":[233],"disease.":[234]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-05T00:00:00"}