{"id":"https://openalex.org/W7172000467","doi":"https://doi.org/10.1177/08258597261461797","title":"Continuous Intravenous Lidocaine for Refractory Cancer Pain in Palliative Care: A Multicenter Feasibility Study","display_name":"Continuous Intravenous Lidocaine for Refractory Cancer Pain in Palliative Care: A Multicenter Feasibility Study","publication_year":2026,"publication_date":"2026-07-31","ids":{"openalex":"https://openalex.org/W7172000467","doi":"https://doi.org/10.1177/08258597261461797","pmid":"https://pubmed.ncbi.nlm.nih.gov/42536632"},"language":"en","primary_location":{"id":"doi:10.1177/08258597261461797","doi":"https://doi.org/10.1177/08258597261461797","is_oa":false,"landing_page_url":"https://doi.org/10.1177/08258597261461797","pdf_url":null,"source":{"id":"https://openalex.org/S54203203","display_name":"Journal of Palliative Care","issn_l":"0825-8597","issn":["0825-8597","2369-5293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Palliative Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092590042","display_name":"Damien Bruyat","orcid":"https://orcid.org/0009-0008-3901-1985","observed_orcids":["https://orcid.org/0009-0008-3901-1985"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Damien Bruyat","raw_affiliation_strings":["Assistance Publique des H\u00f4pitaux de Marseille (AP-HM"],"raw_orcid":"https://orcid.org/0009-0008-3901-1985","affiliations":[{"raw_affiliation_string":"Assistance Publique des H\u00f4pitaux de Marseille (AP-HM","institution_ids":["https://openalex.org/I4210087487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016870769","display_name":"Matthieu Frasca","orcid":"https://orcid.org/0000-0003-3723-7231","observed_orcids":["https://orcid.org/0000-0003-3723-7231"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Matthieu Frasca","raw_affiliation_strings":["EPICENE Team, Bordeaux Population Health Research Center, INSERM U1219, University of Bordeaux, Bordeaux, France","University Hospital Centre Bordeaux"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPICENE Team, Bordeaux Population Health Research Center, INSERM U1219, University of Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"raw_affiliation_string":"University Hospital Centre Bordeaux","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017902824","display_name":"Karine Baumstarck","orcid":"https://orcid.org/0000-0003-3602-6766","observed_orcids":["https://orcid.org/0000-0003-3602-6766"]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4405267116","display_name":"Centre d\u2019Etudes et de Recherche sur les Services de Sant\u00e9 et la Qualit\u00e9 de Vie","ror":"https://ror.org/019d11s20","country_code":"FR","type":"facility","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405267116"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karine Baumstarck","raw_affiliation_strings":["CEReSS\u2013Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEReSS\u2013Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4405267116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053778470","display_name":"Dorian Protzenko","orcid":"https://orcid.org/0009-0002-9065-2899","observed_orcids":["https://orcid.org/0009-0002-9065-2899"]},"institutions":[{"id":"https://openalex.org/I4210150996","display_name":"H\u00f4pital Priv\u00e9 Guillaume de Varye","ror":"https://ror.org/04j0edb32","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210150996"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dorian Protzenko","raw_affiliation_strings":["H\u00f4pital Priv\u00e9 Guillaume de Varye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Priv\u00e9 Guillaume de Varye","institution_ids":["https://openalex.org/I4210150996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060034866","display_name":"Didier Mayeur","orcid":"https://orcid.org/0000-0003-4724-7871","observed_orcids":["https://orcid.org/0000-0003-4724-7871"]},"institutions":[{"id":"https://openalex.org/I4210094685","display_name":"Centre Georges Fran\u00e7ois Leclerc","ror":"https://ror.org/00pjqzf38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210094685","https://openalex.org/I4210141925"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Mayeur","raw_affiliation_strings":["Georges-Fran\u00e7ois Leclerc Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georges-Fran\u00e7ois Leclerc Centre","institution_ids":["https://openalex.org/I4210094685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010976586","display_name":"Sylvie Kirscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157673","display_name":"Institut Sainte Catherine","ror":"https://ror.org/04q9mdf26","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210157673"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Kirscher","raw_affiliation_strings":["Institut Sainte Catherine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Sainte Catherine","institution_ids":["https://openalex.org/I4210157673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028776601","display_name":"Zeinab Hamidou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4405267116","display_name":"Centre d\u2019Etudes et de Recherche sur les Services de Sant\u00e9 et la Qualit\u00e9 de Vie","ror":"https://ror.org/019d11s20","country_code":"FR","type":"facility","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405267116"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zeinab Hamidou","raw_affiliation_strings":["CEReSS\u2013Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEReSS\u2013Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4405267116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070587841","display_name":"Gis\u00e8le Chvetzoff","orcid":"https://orcid.org/0000-0002-2957-1531","observed_orcids":["https://orcid.org/0000-0002-2957-1531"]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]},{"id":"https://openalex.org/I4405267116","display_name":"Centre d\u2019Etudes et de Recherche sur les Services de Sant\u00e9 et la Qualit\u00e9 de Vie","ror":"https://ror.org/019d11s20","country_code":"FR","type":"facility","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405267116"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gisele Chvetzoff","raw_affiliation_strings":["CEReSS\u2013Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France","Department of Supportive Care, L\u00e9on B\u00e9rard Center, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEReSS\u2013Health Service Research and Quality of Life Center, Aix-Marseille University, Marseille, France","institution_ids":["https://openalex.org/I21491767","https://openalex.org/I4405267116"]},{"raw_affiliation_string":"Department of Supportive Care, L\u00e9on B\u00e9rard Center, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045172802","display_name":"S\u00e9bastien Salas","orcid":"https://orcid.org/0000-0001-6222-5027","observed_orcids":["https://orcid.org/0000-0001-6222-5027"]},"institutions":[{"id":"https://openalex.org/I4210087487","display_name":"Assistance Publique H\u00f4pitaux de Marseille","ror":"https://ror.org/002cp4060","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I21491767","https://openalex.org/I4210087487"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastien Salas","raw_affiliation_strings":["Assistance Publique des H\u00f4pitaux de Marseille (AP-HM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistance Publique des H\u00f4pitaux de Marseille (AP-HM","institution_ids":["https://openalex.org/I4210087487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"4","first_page":"424","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13340","display_name":"Palliative and Oncologic Care","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/continuous-intravenous-infusion","display_name":"continuous intravenous infusion","score":0.9129999876022339},{"id":"https://openalex.org/keywords/refractory-cancer-pain","display_name":"refractory cancer pain","score":0.8820000290870667},{"id":"https://openalex.org/keywords/opioid-refractory-pain","display_name":"opioid-refractory pain","score":0.9549999833106995},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.5860000252723694},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/feasibility","display_name":"feasibility","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9318000078201294},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.8324999809265137},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6935999989509583},{"id":"https://openalex.org/C2994186709","wikidata":"https://www.wikidata.org/wiki/Q29483","display_name":"Palliative care","level":2,"score":0.6685000061988831},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5960999727249146},{"id":"https://openalex.org/C2778904085","wikidata":"https://www.wikidata.org/wiki/Q3712728","display_name":"Cancer pain","level":3,"score":0.5871999859809875},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5651999711990356},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5218999981880188},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5212000012397766},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5117999911308289},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48890000581741333},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.39579999446868896},{"id":"https://openalex.org/C2779158186","wikidata":"https://www.wikidata.org/wiki/Q303646","display_name":"Hydromorphone","level":4,"score":0.37940001487731934},{"id":"https://openalex.org/C2780052408","wikidata":"https://www.wikidata.org/wiki/Q4967024","display_name":"Brief Pain Inventory","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C3018112808","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Continuous infusion","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.3140999972820282},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.301800012588501},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25839999318122864},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C2777197265","wikidata":"https://www.wikidata.org/wiki/Q4379667","display_name":"Nerve block","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C2776429440","wikidata":"https://www.wikidata.org/wiki/Q17147916","display_name":"Intractable pain","level":2,"score":0.2517000138759613}],"mesh":[{"descriptor_ui":"D000072716","descriptor_name":"Cancer Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010166","descriptor_name":"Palliative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/08258597261461797","doi":"https://doi.org/10.1177/08258597261461797","is_oa":false,"landing_page_url":"https://doi.org/10.1177/08258597261461797","pdf_url":null,"source":{"id":"https://openalex.org/S54203203","display_name":"Journal of Palliative Care","issn_l":"0825-8597","issn":["0825-8597","2369-5293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Palliative Care","raw_type":"journal-article"},{"id":"pmid:42536632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42536632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of palliative care","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05736248v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05736248","pdf_url":null,"source":{"id":"https://openalex.org/S4406922393","display_name":"HAL AMU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Palliative Care, 2026, pp.8258597261461797. &#x27E8;10.1177/08258597261461797&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1490240620","https://openalex.org/W1972842876","https://openalex.org/W1986782242","https://openalex.org/W2009725664","https://openalex.org/W2027010723","https://openalex.org/W2042024474","https://openalex.org/W2052953863","https://openalex.org/W2062885664","https://openalex.org/W2077069417","https://openalex.org/W2083726186","https://openalex.org/W2086767306","https://openalex.org/W2090335194","https://openalex.org/W2099757921","https://openalex.org/W2128412489","https://openalex.org/W2131863361","https://openalex.org/W2138601738","https://openalex.org/W2139833086","https://openalex.org/W2144694293","https://openalex.org/W2154637671","https://openalex.org/W2155412494","https://openalex.org/W2161344815","https://openalex.org/W2162296777","https://openalex.org/W2181137729","https://openalex.org/W2201033947","https://openalex.org/W2323825455","https://openalex.org/W2331364533","https://openalex.org/W2766035804","https://openalex.org/W2810172375","https://openalex.org/W2907444629","https://openalex.org/W2969774829","https://openalex.org/W3008760826","https://openalex.org/W3018497876","https://openalex.org/W3087574675","https://openalex.org/W3115432028","https://openalex.org/W3125678757","https://openalex.org/W3201520306","https://openalex.org/W4224138878","https://openalex.org/W4310780757","https://openalex.org/W4317436309"],"related_works":["https://openalex.org/W2156959962","https://openalex.org/W1986782242","https://openalex.org/W4410946262","https://openalex.org/W4402325485","https://openalex.org/W2027010723","https://openalex.org/W4402325414","https://openalex.org/W2282822689","https://openalex.org/W3018497876","https://openalex.org/W2991321071","https://openalex.org/W3008760826"],"abstract_inverted_index":{"ObjectivesTo":[0],"assess":[1],"the":[2,88,125,142,160,208,215,222],"feasibility":[3,40,191],"and":[4,21,119,139,185,230],"tolerability":[5],"of":[6,164,224],"continuous":[7,48,193],"low-dose":[8,194],"intravenous":[9,49,173,195],"lidocaine":[10,50,63,138,161,174,196],"infusion":[11,51,175],"in":[12,30,42,52,124,151,156,227],"patients":[13,53,121,165],"with":[14,54,93,180],"opioid-refractory":[15,55],"cancer":[16,56],"pain":[17,28,71,111,148,152],"receiving":[18],"palliative":[19,43,228],"care,":[20],"to":[22,46,61,67,169],"explore":[23],"its":[24],"potential":[25],"impact":[26],"on":[27],"outcomes":[29,109],"real-world":[31],"clinical":[32],"conditions.MethodsWe":[33],"conducted":[34],"a":[35,94,100,200],"multicenter,":[36],"randomized,":[37],"double-blind,":[38],"placebo-controlled":[39],"study":[41,216],"care":[44,229],"units":[45],"evaluate":[47],"pain.":[57],"Patients":[58],"were":[59,122,154],"randomized":[60,225],"receive":[62],"(5":[64],"mg/kg/day,":[65],"increased":[66],"8":[68,170],"mg/kg/day":[69],"if":[70],"reduction":[72,102],"was":[73,85,135,176,212,217],"<30%":[74],"after":[75],"24":[76],"h)":[77],"or":[78,145],"placebo":[79,140],"for":[80,141,146],"48":[81],"h.":[82],"Pain":[83,90],"intensity":[84,153],"assessed":[86],"using":[87],"Numeric":[89],"Intensity":[91],"Scale,":[92],"clinically":[95,201],"meaningful":[96,202],"response":[97],"defined":[98],"as":[99],"\u226530%":[101],"from":[103],"baseline":[104],"at":[105],"40":[106],"min.":[107],"Secondary":[108],"included":[110,123],"evolution":[112],"over":[113,205],"time,":[114],"neuropathic":[115],"pain,":[116],"symptom":[117],"burden,":[118],"tolerability.ResultsThirty-five":[120],"final":[126],"analysis":[127],"(18":[128],"lidocaine,":[129],"17":[130],"placebo).":[131],"No":[132],"significant":[133],"difference":[134],"observed":[136,155],"between":[137],"primary":[143],"endpoint":[144],"secondary":[147],"outcomes.":[149],"Reductions":[150],"both":[157],"groups.":[158],"In":[159],"group,":[162],"61%":[163],"required":[166],"dose":[167],"escalation":[168],"mg/kg/day.":[171],"Continuous":[172],"generally":[177],"well":[178],"tolerated,":[179],"mostly":[181],"mild":[182],"adverse":[183],"events":[184],"no":[186],"unexpected":[187],"toxicity.ConclusionIn":[188],"this":[189],"multicenter":[190],"study,":[192],"did":[197],"not":[198,213],"demonstrate":[199],"analgesic":[203],"benefit":[204],"placebo.":[206],"As":[207],"planned":[209],"sample":[210],"size":[211],"reached,":[214],"underpowered.":[218],"These":[219],"findings":[220],"highlight":[221],"challenges":[223],"trials":[226],"may":[231],"inform":[232],"future":[233],"feasibility-oriented":[234],"designs.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-01T00:00:00"}