{"id":"https://openalex.org/W7171661993","doi":"https://doi.org/10.1007/s00277-026-07169-9","title":"Distinct clinical associations of baseline and treatment-emergent hypogammaglobulinemia in diffuse large B-cell lymphoma: a retrospective real-world cohort study","display_name":"Distinct clinical associations of baseline and treatment-emergent hypogammaglobulinemia in diffuse large B-cell lymphoma: a retrospective real-world cohort study","publication_year":2026,"publication_date":"2026-07-30","ids":{"openalex":"https://openalex.org/W7171661993","doi":"https://doi.org/10.1007/s00277-026-07169-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/42934312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710625"},"language":"en","primary_location":{"id":"doi:10.1007/s00277-026-07169-9","doi":"https://doi.org/10.1007/s00277-026-07169-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07169-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00277-026-07169-9.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s00277-026-07169-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069059255","display_name":"Utku \u0130ltar","orcid":"https://orcid.org/0000-0001-7129-418X","observed_orcids":["https://orcid.org/0000-0001-7129-418X"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Utku Iltar","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143955657","display_name":"Tugba Karacamli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tugba Karacamli","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Akdeniz University, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Akdeniz University, Antalya, 07100, Turkey","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143900481","display_name":"Sinem Oztekin","orcid":"https://orcid.org/0000-0002-9654-1172","observed_orcids":["https://orcid.org/0000-0002-9654-1172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sinem Oztekin","raw_affiliation_strings":["Department of Internal Medicine, Finike State Hospital, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Finike State Hospital, Antalya, 07100, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027470060","display_name":"\u00dcnal Ata\u015f","orcid":"https://orcid.org/0000-0001-5897-6514","observed_orcids":["https://orcid.org/0000-0001-5897-6514"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Unal Atas","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey. vrlunalatas@gmail.com"],"raw_orcid":"https://orcid.org/0000-0001-5897-6514","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey. vrlunalatas@gmail.com","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140671122","display_name":"Ece Vural","orcid":"https://orcid.org/0000-0002-2754-8995","observed_orcids":["https://orcid.org/0000-0002-2754-8995"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ece Vural","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007578242","display_name":"Orhan Kemal Y\u00fccel","orcid":"https://orcid.org/0000-0002-0455-1382","observed_orcids":["https://orcid.org/0000-0002-0455-1382"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Orhan Kemal Yucel","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087112104","display_name":"Ozan Salim","orcid":"https://orcid.org/0000-0001-6687-0189","observed_orcids":["https://orcid.org/0000-0001-6687-0189"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozan Salim","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086328341","display_name":"Levent \u00dcndar","orcid":"https://orcid.org/0000-0002-9853-5075","observed_orcids":["https://orcid.org/0000-0002-9853-5075"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Levent Undar","raw_affiliation_strings":["Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Akdeniz University, Antalya, 07100, Turkey","institution_ids":["https://openalex.org/I197907453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027470060"],"corresponding_institution_ids":["https://openalex.org/I197907453"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54857741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.5600000023841858},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/infectious-complications","display_name":"infectious complications","score":0.7870000004768372},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/serum-igg","display_name":"serum IgG","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8636000156402588},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.718500018119812},{"id":"https://openalex.org/C2777805810","wikidata":"https://www.wikidata.org/wiki/Q1047559","display_name":"Hypogammaglobulinemia","level":3,"score":0.6292999982833862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6090999841690063},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.5604000091552734},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5357999801635742},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.41589999198913574},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3370000123977661},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26820001006126404}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00277-026-07169-9","doi":"https://doi.org/10.1007/s00277-026-07169-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07169-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00277-026-07169-9.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710625","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710625/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710625/pdf/277_2026_Article_7169.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Hematol","raw_type":"Text"},{"id":"pmid:42934312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of hematology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:80f46cd5f0144c01bd433f7b030cb9ec","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/80f46cd5f0144c01bd433f7b030cb9ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Annals of Hematology, Vol 105, Iss 11 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s00277-026-07169-9","doi":"https://doi.org/10.1007/s00277-026-07169-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00277-026-07169-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00277-026-07169-9.pdf","source":{"id":"https://openalex.org/S163204731","display_name":"Annals of Hematology","issn_l":"0939-5555","issn":["0939-5555","1432-0584"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7171661993.pdf","grobid_xml":"https://content.openalex.org/works/W7171661993.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1969998568","https://openalex.org/W2028375716","https://openalex.org/W2072858201","https://openalex.org/W2133195608","https://openalex.org/W2525822080","https://openalex.org/W2900348232","https://openalex.org/W2921072067","https://openalex.org/W2946644420","https://openalex.org/W3013422630","https://openalex.org/W3093131926","https://openalex.org/W3156420966","https://openalex.org/W3164010709","https://openalex.org/W4213231895","https://openalex.org/W4220891004","https://openalex.org/W4221083133","https://openalex.org/W4387096236","https://openalex.org/W4405020574"],"related_works":["https://openalex.org/W4405020574","https://openalex.org/W7202091554","https://openalex.org/W2986983193","https://openalex.org/W4379981377","https://openalex.org/W1557367249","https://openalex.org/W2949195118","https://openalex.org/W3093131926","https://openalex.org/W2550941807","https://openalex.org/W2379084069","https://openalex.org/W4379979660"],"abstract_inverted_index":{"Hypogammaglobulinemia":[0,48],"is":[1],"increasingly":[2],"recognized":[3],"in":[4,24,116,178,189,206],"B-cell":[5,27],"malignancies,":[6],"but":[7,164],"whether":[8],"its":[9],"clinical":[10,95,204],"significance":[11,224],"differs":[12],"by":[13,98],"timing,":[14],"present":[15],"at":[16,43],"diagnosis":[17],"versus":[18],"developing":[19],"after":[20],"treatment,":[21],"remains":[22],"unclear":[23],"diffuse":[25],"large":[26],"lymphoma":[28],"(DLBCL).":[29],"We":[30],"retrospectively":[31],"evaluated":[32],"181":[33],"adults":[34],"with":[35,40,80,85,88,118,122,136,141,175,215],"newly":[36],"diagnosed":[37],"DLBCL":[38],"treated":[39],"rituximab-based":[41],"immunochemotherapy":[42],"a":[44,91,190,211],"tertiary":[45],"referral":[46],"center.":[47],"was":[49,133,165,173,186],"defined":[50],"as":[51,59],"serum":[52],"IgG":[53],"<":[54],"7":[55],"g/L":[56],"and":[57,82,102,113,125,146,152,200,219,235],"classified":[58],"baseline":[60,94],"hypogammaglobulinemia":[61,64,127],"(BHG),":[62],"treatment-emergent":[63],"(TEHG),":[65],"or":[66],"absent.":[67],"Among":[68],"the":[69,137,179,222],"study":[70],"population,":[71],"107":[72],"patients":[73,117],"(59.1%)":[74],"developed":[75],"hypogammaglobulinemia,":[76],"including":[77],"30":[78],"(16.6%)":[79],"BHG":[81,89,119,132,159,199,209],"77":[83],"(42.5%)":[84],"TEHG.":[86],"Patients":[87],"exhibited":[90],"more":[92],"adverse":[93],"profile":[96],"characterized":[97],"poorer":[99],"performance":[100],"status":[101],"higher-risk":[103],"disease":[104],"features.":[105],"Complete":[106],"response":[107],"rates":[108],"differed":[109],"significantly":[110],"across":[111],"groups":[112],"were":[114],"lowest":[115],"(73.3%)":[120],"compared":[121],"TEHG":[123,172,201,226],"(88.3%)":[124],"no":[126],"(94.6%)":[128],"(p":[129],"=":[130],"0.008).":[131],"also":[134],"associated":[135,174],"poorest":[138],"survival":[139,144,148],"outcomes,":[140,221],"median":[142],"progression-free":[143],"(PFS)":[145],"overall":[147],"(OS)":[149],"of":[150,170,225,232],"26.4":[151],"30.9":[153],"months,":[154],"respectively.":[155],"In":[156],"multivariable":[157,181],"analyses,":[158],"independently":[160],"predicted":[161],"infectious":[162],"complications":[163],"not":[166,187],"an":[167],"independent":[168],"predictor":[169],"PFS.":[171],"shorter":[176],"PFS":[177],"primary":[180],"model;":[182],"however,":[183],"this":[184],"association":[185],"confirmed":[188],"prespecified":[191],"6-month":[192],"landmark":[193],"analysis.":[194],"These":[195],"findings":[196],"suggest":[197],"that":[198],"represent":[202],"distinct":[203],"states":[205],"DLBCL.":[207],"While":[208],"identifies":[210],"clinically":[212],"vulnerable":[213],"subgroup":[214],"increased":[216],"infection":[217],"risk":[218],"inferior":[220],"prognostic":[223],"should":[227],"be":[228],"interpreted":[229],"cautiously":[230],"because":[231],"non-protocolized":[233],"monitoring":[234],"potential":[236],"ascertainment":[237],"bias.":[238]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-07-30T00:00:00"}
