{"id":"https://openalex.org/W7171661663","doi":"https://doi.org/10.1007/s00436-026-08737-8","title":"Lethal effect of trehalose-6-Phosphate phosphatase inhibitor N-(phenylthio) phthalimide on Trichinella spiralis","display_name":"Lethal effect of trehalose-6-Phosphate phosphatase inhibitor N-(phenylthio) phthalimide on Trichinella spiralis","publication_year":2026,"publication_date":"2026-07-29","ids":{"openalex":"https://openalex.org/W7171661663","doi":"https://doi.org/10.1007/s00436-026-08737-8"},"language":"en","primary_location":{"id":"doi:10.1007/s00436-026-08737-8","doi":"https://doi.org/10.1007/s00436-026-08737-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00436-026-08737-8","pdf_url":null,"source":{"id":"https://openalex.org/S155128447","display_name":"Parasitology Research","issn_l":"0044-3255","issn":["0044-3255","0932-0113","1432-1955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s00436-026-08737-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004299204","display_name":"Jiaming Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaming Hou","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084002058","display_name":"Rulin Ruan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rulin Ruan","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143884216","display_name":"Ting Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhang","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongqing Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqing Yang","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143888196","display_name":"Han Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Xue","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103276519","display_name":"Mingxin Song","orcid":"https://orcid.org/0000-0002-9168-6348","observed_orcids":["https://orcid.org/0000-0002-9168-6348"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingxin Song","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037588320","display_name":"Caixia Han","orcid":"https://orcid.org/0000-0002-3638-2712","observed_orcids":["https://orcid.org/0000-0002-3638-2712"]},"institutions":[{"id":"https://openalex.org/I169572211","display_name":"Northeast Agricultural University","ror":"https://ror.org/0515nd386","country_code":"CN","type":"education","lineage":["https://openalex.org/I169572211"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Caixia Han","raw_affiliation_strings":["Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heilongjiang Key Laboratory for Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin, 150030, China","institution_ids":["https://openalex.org/I169572211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037588320","https://openalex.org/A5103276519"],"corresponding_institution_ids":["https://openalex.org/I169572211"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61945866,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichinella-spiralis","display_name":"Trichinella spiralis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/trehalose-6-phosphate-phosphatase","display_name":"trehalose-6-phosphate phosphatase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/trehalose-biosynthesis","display_name":"trehalose biosynthesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antiparasitic-drug-targets","display_name":"antiparasitic drug targets","score":0.7239999771118164},{"id":"https://openalex.org/keywords/muscle-larvae","display_name":"muscle larvae","score":0.8320000171661377},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.7459999918937683},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.4950000047683716},{"id":"https://openalex.org/keywords/developmental-stages","display_name":"developmental stages","score":0.5979999899864197},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.44999998807907104},{"id":"https://openalex.org/keywords/intestinal-crypts","display_name":"intestinal crypts","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2781320125","wikidata":"https://www.wikidata.org/wiki/Q730937","display_name":"Trichinella spiralis","level":3,"score":0.8276000022888184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.772599995136261},{"id":"https://openalex.org/C2778522978","wikidata":"https://www.wikidata.org/wiki/Q412784","display_name":"Phthalimide","level":2,"score":0.5507000088691711},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4819999933242798},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35530000925064087},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34380000829696655},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.3337000012397766},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32910001277923584},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C21547065","wikidata":"https://www.wikidata.org/wiki/Q418243","display_name":"Acid phosphatase","level":3,"score":0.3068000078201294},{"id":"https://openalex.org/C2777581317","wikidata":"https://www.wikidata.org/wiki/Q630285","display_name":"Trichinella","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00436-026-08737-8","doi":"https://doi.org/10.1007/s00436-026-08737-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00436-026-08737-8","pdf_url":null,"source":{"id":"https://openalex.org/S155128447","display_name":"Parasitology Research","issn_l":"0044-3255","issn":["0044-3255","0932-0113","1432-1955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00436-026-08737-8","doi":"https://doi.org/10.1007/s00436-026-08737-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00436-026-08737-8","pdf_url":null,"source":{"id":"https://openalex.org/S155128447","display_name":"Parasitology Research","issn_l":"0044-3255","issn":["0044-3255","0932-0113","1432-1955"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parasitology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"In":[0],"eukaryotes,":[1],"with":[2,280,321,346],"the":[3,26,70,79,98,169,193,203,236,244,259,270,314,329,334,361,365,390,418,449],"exception":[4],"of":[5,38,43,72,84,120,126,175,205,222,238,252,264,273,284,306,317,337,350,364,388,393,416,421],"mammals,":[6],"trehalose":[7,27,33,47,450],"fulfills":[8],"multiple":[9],"biological":[10],"functions,":[11],"including":[12],"energy":[13],"provision":[14],"and":[15,82,96,162,171,196,207,249,256,261,289,295,298,325,355,378,407,430],"stress":[16],"tolerance.":[17],"Trehalose-6-phosphate":[18],"phosphatase":[19],"(TPP)":[20],"is":[21],"a":[22,32,66,460],"key":[23],"enzyme":[24],"in":[25,50,58,154,243,275],"biosynthetic":[28],"pathway,":[29,452],"rather":[30],"than":[31,341],"synthase":[34],"per":[35],"se.":[36],"Loss":[37],"TPP":[39,64,87,136],"function":[40],"or":[41,56],"knockdown":[42],"its":[44,145,216,300],"expression":[45,119,173],"impairs":[46],"synthesis,":[48],"which":[49],"turn":[51],"leads":[52],"to":[53,94,143,167,181,214,258],"developmental":[54,124,220],"abnormalities":[55],"lethality":[57],"nematodes.":[59],"These":[60],"observations":[61],"suggest":[62],"that":[63,313],"represents":[65],"potential":[67],"target":[68],"for":[69,292,358,456],"development":[71],"anti-parasitic":[73],"therapeutics.":[74],"This":[75],"study":[76],"focused":[77],"on":[78,148],"cloning,":[80],"expression,":[81],"characterization":[83],"Trichinella":[85,111],"spiralis":[86,112,115,128,150,188,224,446],"(TsTPP).":[88],"A":[89],"recombinant":[90,99,194],"plasmid":[91,195],"was":[92,105,129,141,232,331,339],"constructed":[93,192],"express":[95],"purify":[97],"TsTPP":[100,121,176,231,366,394,422],"protein":[101,172],"(rTsTPP),":[102],"whose":[103],"immunogenicity":[104,204],"confirmed":[106],"using":[107],"positive":[108],"serum":[109,200],"from":[110],"(":[113,380,400],"T.":[114,127,149,187,223,445],")-infected":[116],"mouse.":[117],"The":[118,134,309],"at":[122,282,348],"different":[123,219],"stages":[125,221],"determined":[130],"by":[131,303,369,398,425,447],"immunofluorescence":[132,211],"assay.":[133],"specific":[135],"inhibitor":[137],"N-(phenylthio)":[138,437],"phthalimide":[139,438],"(NPP)":[140,439],"employed":[142],"evaluate":[144],"lethal":[146,271,301,442],"effect":[147,272,302],"muscle":[151,253],"larvae":[152,240,254],"(ML)":[153],"vitro.":[155],"Furthermore,":[156,343],"molecular":[157],"methods":[158],"such":[159],"as":[160,459],"qPCR":[161],"Western":[163],"blot":[164],"were":[165,229,396],"used":[166,209],"detect":[168],"transcription":[170,362,391,419],"levels":[174,363,392,420],"upon":[177],"NPP":[178,274,281,323,347,458],"treatment,":[179,389,417],"aiming":[180],"identify":[182],"new":[183,461],"drug":[184,463],"targets":[185],"against":[186,444],".":[189,225],"We":[190],"successfully":[191],"obtained":[197],"rTsTPP.":[198],"Positive":[199],"assays":[201],"demonstrated":[202],"rTsTPP,":[206],"we":[208,277],"indirect":[210],"assay":[212],"(IFA)":[213],"determine":[215],"localization":[217],"across":[218],"Distinct":[226],"distribution":[227],"patterns":[228],"observed:":[230],"diffusely":[233],"distributed":[234],"throughout":[235],"body":[237],"newborn":[239],"(NBL),":[241],"accumulated":[242],"intestinal":[245],"glands,":[246],"midgut":[247],"ampulla":[248],"genital":[250],"primordia":[251],"(ML),":[255],"localized":[257],"mid":[260],"posterior":[262],"intestine":[263],"adult":[265],"worms":[266],"(AW).":[267],"To":[268],"verify":[269],"vitro,":[276],"treated":[278,345],"ML":[279,318,338],"concentrations":[283,349],"12.5,":[285,351],"25,":[286,352],"50,":[287,353],"100,":[288,354],"200":[290,332,356],"\u00b5g/mL":[291,357],"24,":[293],"36,":[294],"48":[296,414],"h,":[297,360],"evaluated":[299],"statistical":[304],"analysis":[305],"worm":[307],"morphology.":[308],"experimental":[310],"results":[311],"showed":[312],"mortality":[315],"rate":[316,336],"gradually":[319],"increased":[320],"increasing":[322],"concentration":[324,330],"culture":[326],"time.":[327],"When":[328],"\u00b5g/mL,":[333],"survival":[335],"less":[340],"50%.":[342],"when":[344],"24":[359],"gene":[367,395,423],"decreased":[368,424],"19%,":[370,426],"23%,":[371,404,427],"30%,":[372],"38%":[373],"(all":[374,409,432],"p":[375,381,401,410,433],"<":[376,382,402,411,434],"0.05),":[377,403],"57%":[379],"0.01),":[383,435],"respectively;":[384],"after":[385,413],"36":[386],"h":[387,415],"reduced":[397],"18%":[399],"35%,":[405],"39%,":[406],"60%":[408],"0.01);":[412],"42%,":[428,429],"65%":[431],"respectively.":[436],"exhibits":[440],"significant":[441],"activity":[443],"inhibiting":[448],"synthesis":[451],"providing":[453],"basic":[454],"data":[455],"future":[457],"clinical":[462],"target.":[464]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-07-30T00:00:00"}
