{"id":"https://openalex.org/W7171552003","doi":"https://doi.org/10.1016/j.bglo.2026.100136","title":"LymphGen molecular subtyping reveals therapeutic heterogeneity beyond cell-of-origin classification in Indian DLBCL","display_name":"LymphGen molecular subtyping reveals therapeutic heterogeneity beyond cell-of-origin classification in Indian DLBCL","publication_year":2026,"publication_date":"2026-07-28","ids":{"openalex":"https://openalex.org/W7171552003","doi":"https://doi.org/10.1016/j.bglo.2026.100136"},"language":"en","primary_location":{"id":"doi:10.1016/j.bglo.2026.100136","doi":"https://doi.org/10.1016/j.bglo.2026.100136","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bglo.2026.100136","pdf_url":"https://www.sciencedirect.com/science/article/pii/S3050565826000764/pdf","source":{"id":"https://openalex.org/S5407047402","display_name":"Blood Global Hematology","issn_l":"3050-5658","issn":["3050-5658"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Global Hematology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7171552003"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S3050565826000764/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086970973","display_name":"Shrinidhi Nathany","orcid":"https://orcid.org/0000-0001-6006-6309","observed_orcids":["https://orcid.org/0000-0001-6006-6309"]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shrinidhi Nathany","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139179937","display_name":"Moin Makda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Moin Makda","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023776617","display_name":"Anusha Swaminathan","orcid":"https://orcid.org/0009-0007-0530-2963","observed_orcids":["https://orcid.org/0009-0007-0530-2963"]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anusha Swaminathan","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":"https://orcid.org/0009-0007-0530-2963","affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139168811","display_name":"Hrithik Bagga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hrithik Bagga","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019072347","display_name":"Haristuti Verma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Haristuti Verma","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061126496","display_name":"Swarsat Kaushik Nath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Swarsat K. Nath","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055185081","display_name":"Siddharth Sagar","orcid":"https://orcid.org/0000-0001-5439-2407","observed_orcids":["https://orcid.org/0000-0001-5439-2407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siddharth Sagar","raw_affiliation_strings":["Agilus Diagnostics, Gurugram, Haryana, India"],"raw_orcid":"https://orcid.org/0000-0001-5439-2407","affiliations":[{"raw_affiliation_string":"Agilus Diagnostics, Gurugram, Haryana, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067080994","display_name":"Dinesh Bhurani","orcid":"https://orcid.org/0000-0001-8066-8913","observed_orcids":["https://orcid.org/0000-0001-8066-8913"]},"institutions":[{"id":"https://openalex.org/I4210092995","display_name":"Rajiv Gandhi Cancer Institute and Research Centre","ror":"https://ror.org/00e7cvg05","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210092995"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dinesh Bhurani","raw_affiliation_strings":["Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India","institution_ids":["https://openalex.org/I4210092995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123395750","display_name":"Ranjit Kumar Sahoo","orcid":"https://orcid.org/0000-0002-4130-724X","observed_orcids":["https://orcid.org/0000-0002-4130-724X"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ranjit Kumar Sahoo","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049643058","display_name":"Panda Rastogi Neha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neha Rastogi Panda","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069559988","display_name":"Madhur Arora","orcid":"https://orcid.org/0009-0009-3968-6218","observed_orcids":["https://orcid.org/0009-0009-3968-6218"]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhur Arora","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143810978","display_name":"Ragesh R Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ragesh R. Nair","raw_affiliation_strings":["Meitra Hospital, Edakkad, Kozhikode, Kerala, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meitra Hospital, Edakkad, Kozhikode, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036428417","display_name":"Gopinathan Mathiyazhagan","orcid":"https://orcid.org/0000-0002-1643-2129","observed_orcids":["https://orcid.org/0000-0002-1643-2129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gopinath Mathiyazhagan","raw_affiliation_strings":["MGM Health care, THIRUVANNAMALAI DIST, Tamil Nadu, India"],"raw_orcid":"https://orcid.org/0000-0002-1643-2129","affiliations":[{"raw_affiliation_string":"MGM Health care, THIRUVANNAMALAI DIST, Tamil Nadu, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057059242","display_name":"Akshay Lahoti","orcid":"https://orcid.org/0000-0001-8121-6919","observed_orcids":["https://orcid.org/0000-0001-8121-6919"]},"institutions":[{"id":"https://openalex.org/I2801183603","display_name":"Mahatma Gandhi Memorial Medical College","ror":"https://ror.org/0223apb60","country_code":"IN","type":"education","lineage":["https://openalex.org/I138272832","https://openalex.org/I2801183603"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akshay Lahoti","raw_affiliation_strings":["MGM Medical College, A.B. Road, Indore, Madhya Pradesh, India"],"raw_orcid":"https://orcid.org/0000-0001-8121-6919","affiliations":[{"raw_affiliation_string":"MGM Medical College, A.B. Road, Indore, Madhya Pradesh, India","institution_ids":["https://openalex.org/I2801183603"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akash Khandelwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I264201830","display_name":"Fortis Healthcare","ror":"https://ror.org/018596x49","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I264201830"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akash Khandelwal","raw_affiliation_strings":["Fortis Hospital, Shalimar Bagh, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Hospital, Shalimar Bagh, New Delhi, India","institution_ids":["https://openalex.org/I264201830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128795244","display_name":"Mohit Agarwal","orcid":"https://orcid.org/0009-0003-6278-6758","observed_orcids":["https://orcid.org/0009-0003-6278-6758"]},"institutions":[{"id":"https://openalex.org/I264201830","display_name":"Fortis Healthcare","ror":"https://ror.org/018596x49","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I264201830"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohit Agarwal","raw_affiliation_strings":["Fortis Hospital, Shalimar Bagh, New Delhi, India"],"raw_orcid":"https://orcid.org/0009-0003-6278-6758","affiliations":[{"raw_affiliation_string":"Fortis Hospital, Shalimar Bagh, New Delhi, India","institution_ids":["https://openalex.org/I264201830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138534584","display_name":"Niti Raizada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152136","display_name":"Fortis Hospital","ror":"https://ror.org/04qxdaz55","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210152136"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Niti Krishna Raizada","raw_affiliation_strings":["Fortis Hospital BG Road, Bangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Hospital BG Road, Bangalore, Karnataka, India","institution_ids":["https://openalex.org/I4210152136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102796082","display_name":"A. K. Gupta","orcid":"https://orcid.org/0000-0003-3755-3154","observed_orcids":["https://orcid.org/0000-0003-3755-3154"]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aastha Gupta","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":"https://orcid.org/0000-0003-3755-3154","affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113348704","display_name":"Nikhil M Kumar","orcid":"https://orcid.org/0009-0002-6375-9981","observed_orcids":["https://orcid.org/0009-0002-6375-9981"]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nikhil M. Kumar","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":"https://orcid.org/0009-0002-6375-9981","affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018590570","display_name":"Vikas Dua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikas Dua","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074099976","display_name":"Bhargava Rahul","orcid":"https://orcid.org/0000-0001-5769-8073","observed_orcids":["https://orcid.org/0000-0001-5769-8073"]},"institutions":[{"id":"https://openalex.org/I4210108369","display_name":"Fortis Memorial Research Institute","ror":"https://ror.org/01h7phh70","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210108369"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rahul Bhargava","raw_affiliation_strings":["Fortis Memorial Research Institute Gurugram, Haryana, India"],"raw_orcid":"https://orcid.org/0000-0001-5769-8073","affiliations":[{"raw_affiliation_string":"Fortis Memorial Research Institute Gurugram, Haryana, India","institution_ids":["https://openalex.org/I4210108369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":5.0893,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.8931636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"2","issue":"4","first_page":"100136","last_page":"100136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-of-origin-classification","display_name":"cell-of-origin classification","score":0.9850000143051147},{"id":"https://openalex.org/keywords/myd88-mutation","display_name":"MYD88 mutation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cd79b-mutation","display_name":"CD79B mutation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.527999997138977},{"id":"https://openalex.org/keywords/sgk1","display_name":"SGK1","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tumor-suppressor-loss","display_name":"tumor suppressor loss","score":0.8550000190734863},{"id":"https://openalex.org/keywords/actionable-mutations","display_name":"actionable mutations","score":0.46299999952316284},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.5400000214576721},{"id":"https://openalex.org/keywords/indian-patients","display_name":"Indian patients","score":0.49300000071525574},{"id":"https://openalex.org/keywords/genetic-heterogeneity","display_name":"genetic heterogeneity","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.7939000129699707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5120000243186951},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47429999709129333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3212999999523163},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.274399995803833},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26980000734329224},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2596000134944916},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.25}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bglo.2026.100136","doi":"https://doi.org/10.1016/j.bglo.2026.100136","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bglo.2026.100136","pdf_url":"https://www.sciencedirect.com/science/article/pii/S3050565826000764/pdf","source":{"id":"https://openalex.org/S5407047402","display_name":"Blood Global Hematology","issn_l":"3050-5658","issn":["3050-5658"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Global Hematology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ccd369fde1ef41c286a2340b97ad00ae","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ccd369fde1ef41c286a2340b97ad00ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Global Hematology, Vol 2, Iss 4, Pp 100136- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bglo.2026.100136","doi":"https://doi.org/10.1016/j.bglo.2026.100136","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bglo.2026.100136","pdf_url":"https://www.sciencedirect.com/science/article/pii/S3050565826000764/pdf","source":{"id":"https://openalex.org/S5407047402","display_name":"Blood Global Hematology","issn_l":"3050-5658","issn":["3050-5658"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Global Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7171552003.pdf","grobid_xml":"https://content.openalex.org/works/W7171552003.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1020989877","https://openalex.org/W1969582706","https://openalex.org/W1973297032","https://openalex.org/W1979223485","https://openalex.org/W2003262666","https://openalex.org/W2058015212","https://openalex.org/W2096596684","https://openalex.org/W2116382435","https://openalex.org/W2147246240","https://openalex.org/W2158267770","https://openalex.org/W2266154500","https://openalex.org/W2495508741","https://openalex.org/W2762450632","https://openalex.org/W2797584152","https://openalex.org/W2801763724","https://openalex.org/W2884078955","https://openalex.org/W2922237910","https://openalex.org/W2923453543","https://openalex.org/W2998974505","https://openalex.org/W3012464003","https://openalex.org/W3016044607","https://openalex.org/W3037474453","https://openalex.org/W3092484545","https://openalex.org/W3122661941","https://openalex.org/W3132205831","https://openalex.org/W3168402132","https://openalex.org/W4283271244","https://openalex.org/W4283381496","https://openalex.org/W4317989607","https://openalex.org/W4362731342","https://openalex.org/W4394785367","https://openalex.org/W4399797672","https://openalex.org/W7124461715"],"related_works":["https://openalex.org/W7116840058","https://openalex.org/W7149176404","https://openalex.org/W7124461715","https://openalex.org/W4226421357","https://openalex.org/W2902987035","https://openalex.org/W4417021394","https://openalex.org/W3091408048","https://openalex.org/W2606955897","https://openalex.org/W3091150140","https://openalex.org/W2986732524"],"abstract_inverted_index":{"Diffuse":[0],"large":[1],"B-cell":[2],"lymphoma":[3],"(DLBCL)":[4],"is":[5,89],"molecularly":[6],"heterogeneous,":[7],"yet":[8],"standard":[9,168],"cell-of-origin":[10],"(COO)":[11],"classification":[12],"fails":[13],"to":[14,48,234],"capture":[15],"actionable":[16,216],"biology.":[17],"Systematic":[18],"genetic":[19,65,189],"profiling":[20],"remains":[21],"unmapped":[22],"in":[23,194,239],"South":[24],"Asian":[25],"populations,":[26],"who":[27],"exhibit":[28],"a":[29,92],"decade-younger":[30],"age":[31],"of":[32,94,133,153,171,196,200,210],"onset.":[33],"We":[34],"performed":[35],"targeted":[36,229],"next-generation":[37],"sequencing":[38],"on":[39],"pre-treatment":[40],"diagnostic":[41],"biopsies":[42],"from":[43],"186":[44],"Indian":[45,223],"DLBCL":[46],"patients":[47,211],"evaluate":[49],"LymphGen":[50,56,236],"molecular":[51,224,230],"subtyping":[52,190],"against":[53],"COO":[54,61,85],"classification.":[55],"re-stratification":[57],"showed":[58],"that":[59],"every":[60],"category":[62],"contained":[63],"multiple":[64],"subtypes":[66],"with":[67,113,126,159],"distinct":[68],"driver":[69],"genes,":[70],"co-mutation":[71],"patterns,":[72],"and":[73,109,120,139,163,178,198,226,237],"mutation":[74],"types.":[75],"This":[76,129],"COO\u2013genotype":[77],"mismatch":[78],"persisted":[79],"even":[80],"when":[81],"we":[82],"modelled":[83],"perfect":[84],"assignment,":[86],"indicating":[87],"it":[88],"structural,":[90],"not":[91],"artefact":[93],"imperfect":[95],"immunohistochemistry.":[96],"The":[97],"MCD":[98],"subtype":[99],"(18.8%)":[100],"was":[101],"missense-predominant":[102],"(71.3%":[103],"missense),":[104],"characterised":[105],"by":[106],"recurrent":[107],"MYD88":[108,179],"CD79B":[110],"mutations":[111,154],"consistent":[112,125,158],"proximal":[114],"NF-kB/BCR":[115],"activation,":[116],"whereas":[117],"EZB":[118],"(22.6%)":[119],"BN2":[121],"(18.3%)":[122],"were":[123],"truncation-predominant,":[124],"tumour-suppressor":[127],"loss.":[128],"cohort":[130],"demonstrated":[131],"enrichment":[132],"N1":[134],"(9.1%":[135],"vs":[136,142],"\u223c3%":[137],"Western)":[138,144],"A53":[140,146],"(15.6%":[141],"\u223c12%":[143],"subtypes.":[145],"carried":[147,212],"the":[148],"highest":[149],"LOH/biallelic":[150],"signature":[151],"(21.3%":[152],"at":[155,213],"VAF":[156],">50%),":[157],"TP53":[160,177],"biallelic":[161],"inactivation":[162],"known":[164],"poor":[165],"prognosis":[166],"under":[167],"immunochemotherapy.":[169],"Independent":[170],"COO,":[172],"VAF-based":[173],"clonal":[174],"ordering":[175],"identified":[176],"as":[180,232],"early":[181,222],"founding":[182],"events":[183],"versus":[184],"late":[185],"BCL2/SGK1":[186],"acquisition.":[187],"Furthermore,":[188],"reassigned":[191],"risk":[192],"biology":[193],"17%":[195],"non-GCB":[197],"23%":[199],"GCB":[201],"cases,":[202],"resolving":[203],"all":[204],"32":[205],"COO-unclassified":[206],"cases.":[207],"Overall,":[208],"72%":[209],"least":[214],"one":[215],"lesion.":[217],"These":[218],"data":[219],"provide":[220],"an":[221],"reference":[225],"support":[227],"integrating":[228],"classifiers":[231],"adjuncts":[233],"comprehensive":[235],"FISH":[238],"frontline":[240],"workflows.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-29T00:00:00"}
