{"id":"https://openalex.org/W7171539902","doi":"https://doi.org/10.1093/jimmun/vkag141.105","title":"An epigenetic polarity governing T cell tolerance for commensal microbiota 2250947","display_name":"An epigenetic polarity governing T cell tolerance for commensal microbiota 2250947","publication_year":2026,"publication_date":"2026-07-28","ids":{"openalex":"https://openalex.org/W7171539902","doi":"https://doi.org/10.1093/jimmun/vkag141.105"},"language":"en","primary_location":{"id":"doi:10.1093/jimmun/vkag141.105","doi":"https://doi.org/10.1093/jimmun/vkag141.105","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jimmun/vkag141.105","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052519799","display_name":"Wenjun Huang","orcid":"https://orcid.org/0000-0002-2765-3381","observed_orcids":["https://orcid.org/0000-0002-2765-3381","https://orcid.org/0009-0004-4356-8410"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjun Huang","raw_affiliation_strings":["St. Jude Children\u2019s Res. Hosp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Res. Hosp","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056386839","display_name":"Yongqiang Feng","orcid":"https://orcid.org/0000-0002-2320-5063","observed_orcids":["https://orcid.org/0000-0002-2320-5063"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongqiang Feng","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361814","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-2611-8918","observed_orcids":["https://orcid.org/0000-0002-2611-8918"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143810013","display_name":"Lei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085757220","display_name":"Wojciech Rosikiewicz","orcid":"https://orcid.org/0000-0001-7031-3430","observed_orcids":["https://orcid.org/0000-0001-7031-3430"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wojciech Rosikiewicz","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064409505","display_name":"Beisi Xu","orcid":"https://orcid.org/0000-0003-0099-858X","observed_orcids":["https://orcid.org/0000-0003-0099-858X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beisi Xu","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076877802","display_name":"Wenjie Qi","orcid":"https://orcid.org/0009-0006-0656-567X","observed_orcids":["https://orcid.org/0009-0006-0656-567X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjie Qi","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012049637","display_name":"Xiaolei Hao","orcid":"https://orcid.org/0000-0003-3413-2338","observed_orcids":["https://orcid.org/0000-0003-3413-2338"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolei Hao","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134534534","display_name":"Minghong He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minghong He","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069804787","display_name":"Ti\u2010Cheng Chang","orcid":"https://orcid.org/0000-0001-5302-9147","observed_orcids":["https://orcid.org/0000-0001-5302-9147"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ti-Cheng Chang","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082046547","display_name":"Laura J. Janke","orcid":"https://orcid.org/0000-0002-9871-6239","observed_orcids":["https://orcid.org/0000-0002-9871-6239"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Janke","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143832507","display_name":"Menglin Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menglin Jiang","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143757479","display_name":"Lu Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Bai","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125530485","display_name":"Vivek Choudhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Choudhary","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086448818","display_name":"chunliang li","orcid":"https://orcid.org/0000-0002-5938-5510","observed_orcids":["https://orcid.org/0000-0002-5938-5510"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunliang Li","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ellie Margolis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellie Margolis","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018214540","display_name":"Shondra M. Pruett\u2010Miller","orcid":"https://orcid.org/0000-0002-3793-585X","observed_orcids":["https://orcid.org/0000-0002-3793-585X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shondra Pruett-Miller","raw_affiliation_strings":["St. Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54269442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"215","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wdr82","display_name":"WDR82","score":0.878000020980835},{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.8730000257492065},{"id":"https://openalex.org/keywords/t-cell-tolerance","display_name":"T cell tolerance","score":0.5870000123977661},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/commensal-microbiota","display_name":"commensal microbiota","score":0.8339999914169312},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.7760000228881836},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.6100000143051147},{"id":"https://openalex.org/keywords/spontaneous-colitis","display_name":"spontaneous colitis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.515999972820282},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.609000027179718},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.746999979019165},{"id":"https://openalex.org/keywords/rorc","display_name":"RORC","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.8356000185012817},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7720000147819519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7156000137329102},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6819000244140625},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.5430999994277954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5260999798774719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5102999806404114},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.4674000144004822},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.462799996137619},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4244999885559082},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40130001306533813},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3817000091075897},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.36399999260902405},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.3506999909877777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.29339998960494995},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.27639999985694885},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.2745000123977661},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/jimmun/vkag141.105","doi":"https://doi.org/10.1093/jimmun/vkag141.105","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jimmun/vkag141.105","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4167903661727905,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"T":[2,25,70,173],"cells":[3],"differentiate":[4],"into":[5],"subtypes":[6,27],"to":[7,76,186],"maintain":[8],"immune":[9,140,157],"tolerance":[10],"or":[11,92],"mount":[12],"inflammatory":[13],"response":[14],"upon":[15],"antigen":[16],"stimulation.":[17],"This":[18,83],"raises":[19],"questions":[20],"about":[21],"whether":[22],"and":[23,60,65,79,115,126,171,181,195],"how":[24],"cell":[26],"rely":[28],"on":[29],"fundamentally":[30],"distinct":[31],"epigenetic":[32,153,165],"programs.":[33],"Methods":[34],"Using":[35],"Wdr82,":[36],"a":[37,47,103,135,160],"component":[38],"of":[39,62,73,119,146,176,193],"the":[40,58,117,130,144,164],"Set1/COMPASS":[41,97],"histone":[42],"H3K4":[43],"methyltransferase":[44],"complex,":[45],"as":[46,124],"model,":[48],"we":[49],"discover":[50],"that":[51,167],"this":[52,177],"pathway":[53,108,133],"is":[54,85,109],"broadly":[55],"required":[56,111],"for":[57,112,116],"activation":[59,78],"function":[61],"both":[63],"Te":[64,77],"Treg":[66,94,113,120,170],"cells.":[67,174],"Results":[68],"Counterintuitively,":[69],"cell-specific":[71],"deletion":[72],"Wdr82":[74],"leads":[75],"lethal":[80],"spontaneous":[81],"colitis.":[82],"dysregulation":[84],"nearly":[86],"completely":[87],"prevented":[88],"by":[89,179],"microbiome":[90],"depletion":[91],"wild-type":[93],"transfer.":[95],"Mechanistically,":[96],"complex":[98],"interacts":[99],"with":[100],"Foxp3":[101],"in":[102,138,143],"TCR-signaling":[104],"dependent":[105],"manner.":[106],"H3K4me3":[107,132],"preferentially":[110],"induction":[114],"expression":[118],"functional":[121],"genes":[122],"such":[123],"Il10":[125],"Rorc.":[127],"Conclusion":[128],"Thus,":[129],"generic":[131],"plays":[134],"biased":[136],"role":[137],"Treg-dependent":[139],"homeostasis":[141],"particularly":[142],"presence":[145],"commensal":[147],"microbiota.":[148],"Our":[149],"study":[150],"depicts":[151],"an":[152],"polarity":[154],"governing":[155],"Treg-mediated":[156],"tolerance,":[158],"highlighting":[159],"fundamental":[161],"asymmetry":[162,178],"at":[163],"level":[166],"differentially":[168],"regulates":[169],"conventional":[172],"Perturbation":[175],"genetic":[180],"environmental":[182],"factors":[183],"would":[184],"lead":[185],"autoimmune":[187],"dysregulation.":[188],"Funding":[189],"Source":[190],"National":[191],"Institute":[192],"Allergy":[194],"Infectious":[196],"Diseases":[197],"Topic":[198],"Categories":[199],"Immune":[200],"Response":[201],"Regulation:":[202],"Molecular":[203],"Mechanisms":[204],"(IRM)":[205]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-07-29T00:00:00"}
