{"id":"https://openalex.org/W7171538038","doi":"https://doi.org/10.2174/011570159x495837260717044104","title":"Mechanisms and Applications of Transcranial Ultrasound Stimulation in Neurological Disorders and Psychiatric Conditions","display_name":"Mechanisms and Applications of Transcranial Ultrasound Stimulation in Neurological Disorders and Psychiatric Conditions","publication_year":2026,"publication_date":"2026-07-24","ids":{"openalex":"https://openalex.org/W7171538038","doi":"https://doi.org/10.2174/011570159x495837260717044104","pmid":"https://pubmed.ncbi.nlm.nih.gov/42517391"},"language":"en","primary_location":{"id":"doi:10.2174/011570159x495837260717044104","doi":"https://doi.org/10.2174/011570159x495837260717044104","is_oa":false,"landing_page_url":"https://doi.org/10.2174/011570159x495837260717044104","pdf_url":null,"source":{"id":"https://openalex.org/S85221069","display_name":"Current Neuropharmacology","issn_l":"1570-159X","issn":["1570-159X","1875-6190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126655745","display_name":"Mingyue Wei","orcid":"https://orcid.org/0009-0000-0658-4340","observed_orcids":["https://orcid.org/0009-0000-0658-4340"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyue Wei","raw_affiliation_strings":["School of Basic Medicine, Qingdao University, Qingdao, China","School of Social Development, University of Health and Rehabilitation Sciences, Qingdao, China"],"raw_orcid":"https://orcid.org/0009-0000-0658-4340","affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024"]},{"raw_affiliation_string":"School of Social Development, University of Health and Rehabilitation Sciences, Qingdao, China","institution_ids":["https://openalex.org/I4405280210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102599650","display_name":"Yunjie Sui","orcid":"https://orcid.org/0009-0004-4882-4073","observed_orcids":["https://orcid.org/0009-0004-4882-4073"]},"institutions":[{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjie Sui","raw_affiliation_strings":["School of Social Development, University of Health and Rehabilitation Sciences, Qingdao, China"],"raw_orcid":"https://orcid.org/0009-0004-4882-4073","affiliations":[{"raw_affiliation_string":"School of Social Development, University of Health and Rehabilitation Sciences, Qingdao, China","institution_ids":["https://openalex.org/I4405280210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033816398","display_name":"Xue Xia","orcid":"https://orcid.org/0000-0002-8318-7880","observed_orcids":["https://orcid.org/0000-0002-8318-7880"]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]},{"id":"https://openalex.org/I4405280210","display_name":"University of Health and Rehabilitation Sciences","ror":"https://ror.org/02kjtx631","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280210"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xue Xia","raw_affiliation_strings":["Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, China","School of Social Development, University of Health and Rehabilitation Sciences, Qingdao, China"],"raw_orcid":"https://orcid.org/0000-0002-8318-7880","affiliations":[{"raw_affiliation_string":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, China","institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"]},{"raw_affiliation_string":"School of Social Development, University of Health and Rehabilitation Sciences, Qingdao, China","institution_ids":["https://openalex.org/I4405280210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033816398"],"corresponding_institution_ids":["https://openalex.org/I4210119987","https://openalex.org/I4405280210"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50240315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcranial-ultrasound-stimulation","display_name":"transcranial ultrasound stimulation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-invasive-neuromodulation","display_name":"non-invasive neuromodulation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":1.0},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.996999979019165},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9959999918937683},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.9639999866485596},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.984000027179718},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":1.0},{"id":"https://openalex.org/keywords/neural-oscillations","display_name":"neural oscillations","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/blood-brain-barrier-opening","display_name":"blood-brain barrier opening","score":0.9210000038146973},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ultrasound-safety","display_name":"ultrasound safety","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.9020000100135803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7443000078201294},{"id":"https://openalex.org/C2777803708","wikidata":"https://www.wikidata.org/wiki/Q603398","display_name":"Transcranial direct-current stimulation","level":3,"score":0.7437000274658203},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7261999845504761},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.49709999561309814},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.49639999866485596},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.4388999938964844},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.3684999942779541},{"id":"https://openalex.org/C2081992","wikidata":"https://www.wikidata.org/wiki/Q5133838","display_name":"Clinical neuroscience","level":3,"score":0.36570000648498535},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3321000039577484},{"id":"https://openalex.org/C2985948822","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"Focused ultrasound","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C2780112193","wikidata":"https://www.wikidata.org/wiki/Q693519","display_name":"Essential tremor","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.2531999945640564},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.2517000138759613},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2174/011570159x495837260717044104","doi":"https://doi.org/10.2174/011570159x495837260717044104","is_oa":false,"landing_page_url":"https://doi.org/10.2174/011570159x495837260717044104","pdf_url":null,"source":{"id":"https://openalex.org/S85221069","display_name":"Current Neuropharmacology","issn_l":"1570-159X","issn":["1570-159X","1875-6190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:42517391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42517391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current neuropharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6375599503517151,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Transcranial":[0],"ultrasound":[1],"stimulation":[2,150],"(TUS)":[3],"is":[4],"an":[5],"emerging":[6],"non-invasive":[7],"neuromodulation":[8,169],"strategy":[9],"with":[10,99],"high":[11],"spatial":[12],"precision":[13],"and":[14,21,37,51,63,80,89,92,111,121,136,155,166],"the":[15,128],"ability":[16],"to":[17,116],"target":[18],"both":[19],"cortical":[20],"deep":[22],"brain":[23],"regions.":[24],"This":[25,124],"review":[26,125],"summarizes":[27],"recent":[28],"progress":[29],"in":[30,34,118,134],"low-intensity,":[31],"non-thermal":[32],"TUS":[33,58,159],"representative":[35],"neurological":[36],"psychiatric":[38],"disorders,":[39,50],"including":[40],"Parkinson's":[41],"disease,":[42,44],"Alzheimer's":[43],"epilepsy,":[45],"ischemic":[46],"stroke,":[47],"depression,":[48],"anxiety":[49],"schizophrenia.":[52],"Current":[53],"preclinical":[54,135],"evidence":[55,143],"suggests":[56],"that":[57],"may":[59,104,160],"alleviate":[60],"disease-related":[61],"pathological":[62],"functional":[64],"abnormalities":[65],"by":[66],"regulating":[67],"neurotransmitter":[68],"release,":[69],"enhancing":[70],"neurotrophic":[71],"factor":[72],"expression,":[73],"promoting":[74],"synaptic":[75],"plasticity,":[76],"modulating":[77],"neural":[78],"oscillations":[79],"circuit":[81],"connectivity,":[82],"improving":[83],"cerebral":[84],"blood":[85],"flow,":[86],"suppressing":[87],"neuroinflammation":[88],"oxidative":[90],"stress,":[91],"facilitating":[93],"blood-brain":[94],"barrier":[95],"opening":[96],"when":[97],"combined":[98],"microbubbles.":[100],"These":[101],"biological":[102],"effects":[103],"act":[105],"across":[106],"molecular,":[107],"cellular,":[108],"synaptic,":[109],"circuit,":[110],"system":[112],"levels,":[113],"ultimately":[114],"contributing":[115],"improvements":[117],"motor,":[119],"cognitive,":[120],"emotional":[122],"dysfunction.":[123],"also":[126],"discusses":[127],"marked":[129],"heterogeneity":[130],"of":[131,149],"acoustic":[132],"parameters":[133],"clinical":[137,157],"studies,":[138],"as":[139,141],"well":[140],"current":[142],"on":[144],"safety.":[145],"With":[146],"further":[147],"standardization":[148],"parameters,":[151],"deeper":[152],"mechanistic":[153],"understanding,":[154],"stronger":[156],"evidence,":[158],"develop":[161],"into":[162],"a":[163],"safe,":[164],"precise,":[165],"clinically":[167],"translatable":[168],"strategy.":[170]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2026-07-29T00:00:00"}
