{"id":"https://openalex.org/W7171534528","doi":"https://doi.org/10.3389/fvets.2026.1861746","title":"Treatment of canine otitis externa: a randomized, double-blinded, clinical field study comparing the hydrocortisone aceponate monotherapy to a multi-agent reference product","display_name":"Treatment of canine otitis externa: a randomized, double-blinded, clinical field study comparing the hydrocortisone aceponate monotherapy to a multi-agent reference product","publication_year":2026,"publication_date":"2026-07-28","ids":{"openalex":"https://openalex.org/W7171534528","doi":"https://doi.org/10.3389/fvets.2026.1861746","pmid":"https://pubmed.ncbi.nlm.nih.gov/42582328","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13457320"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2026.1861746","doi":"https://doi.org/10.3389/fvets.2026.1861746","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1861746","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1861746/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1861746/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143807418","display_name":"Tomoko Kuwahara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko Kuwahara","raw_affiliation_strings":["Nippon Virbac Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nippon Virbac Co. Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052723974","display_name":"Laure Poincelot","orcid":"https://orcid.org/0009-0002-3078-9789","observed_orcids":["https://orcid.org/0009-0002-3078-9789"]},"institutions":[{"id":"https://openalex.org/I5336590","display_name":"Virbac (France)","ror":"https://ror.org/05maa9n89","country_code":"FR","type":"company","lineage":["https://openalex.org/I5336590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Laure Poincelot","raw_affiliation_strings":["Virbac SA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virbac SA","institution_ids":["https://openalex.org/I5336590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064038333","display_name":"P. Jasmin","orcid":"https://orcid.org/0000-0002-5328-7792","observed_orcids":["https://orcid.org/0000-0002-5328-7792"]},"institutions":[{"id":"https://openalex.org/I5336590","display_name":"Virbac (France)","ror":"https://ror.org/05maa9n89","country_code":"FR","type":"company","lineage":["https://openalex.org/I5336590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Jasmin","raw_affiliation_strings":["Virbac SA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virbac SA","institution_ids":["https://openalex.org/I5336590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113071572","display_name":"Alice Bidaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5336590","display_name":"Virbac (France)","ror":"https://ror.org/05maa9n89","country_code":"FR","type":"company","lineage":["https://openalex.org/I5336590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alice Bidaud","raw_affiliation_strings":["Virbac SA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virbac SA","institution_ids":["https://openalex.org/I5336590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5143767559","display_name":"Gen Kinoshita","orcid":"https://orcid.org/0009-0005-8026-9476","observed_orcids":["https://orcid.org/0009-0005-8026-9476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gen Kinoshita","raw_affiliation_strings":["Nippon Virbac Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nippon Virbac Co. Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052723974"],"corresponding_institution_ids":["https://openalex.org/I5336590"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":12.0108,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.97078507,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"13","issue":null,"first_page":"1861746","last_page":"1861746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.5088000297546387,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.15870000422000885,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10861","display_name":"Ear Surgery and Otitis Media","score":0.13220000267028809,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-otitis-externa","display_name":"canine otitis externa","score":0.9620000123977661},{"id":"https://openalex.org/keywords/corticosteroid-monotherapy","display_name":"corticosteroid monotherapy","score":0.9200000166893005},{"id":"https://openalex.org/keywords/terbinafine","display_name":"terbinafine","score":0.8659999966621399},{"id":"https://openalex.org/keywords/florfenicol","display_name":"florfenicol","score":0.984000027179718},{"id":"https://openalex.org/keywords/betamethasone-acetate","display_name":"betamethasone acetate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6700000166893005},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.578000009059906},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antibiotic-avoidance","display_name":"antibiotic avoidance","score":0.5870000123977661},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2776439223","wikidata":"https://www.wikidata.org/wiki/Q480700","display_name":"Otitis","level":2,"score":0.8425999879837036},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8391000032424927},{"id":"https://openalex.org/C2778744145","wikidata":"https://www.wikidata.org/wiki/Q27102474","display_name":"Hydrocortisone acetate","level":3,"score":0.5838000178337097},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.4961000084877014},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4812999963760376},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4724000096321106},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.43459999561309814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3847000002861023},{"id":"https://openalex.org/C2994123057","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Cure rate","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C2780076632","wikidata":"https://www.wikidata.org/wiki/Q1640326","display_name":"Ear disease","level":3,"score":0.367000013589859},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C2991862235","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Animal health","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C2987828669","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical study","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2678000032901764},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2540000081062317}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2026.1861746","doi":"https://doi.org/10.3389/fvets.2026.1861746","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1861746","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1861746/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmid:42582328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42582328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13457320","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13457320/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1ac5a20e8f27435bbd7a4a4a73c2b29c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1ac5a20e8f27435bbd7a4a4a73c2b29c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2026.1861746","doi":"https://doi.org/10.3389/fvets.2026.1861746","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1861746","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1861746/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324870","display_name":"Virbac","ror":"https://ror.org/05maa9n89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7171534528.pdf","grobid_xml":"https://content.openalex.org/works/W7171534528.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1563214700","https://openalex.org/W1676463999","https://openalex.org/W2028388672","https://openalex.org/W2060881964","https://openalex.org/W2083006853","https://openalex.org/W2143534091","https://openalex.org/W2155707781","https://openalex.org/W2171648439","https://openalex.org/W2184109513","https://openalex.org/W2294333737","https://openalex.org/W2606686256","https://openalex.org/W2751252352","https://openalex.org/W2764277195","https://openalex.org/W2783759585","https://openalex.org/W2887564303","https://openalex.org/W2895866422","https://openalex.org/W2990315997","https://openalex.org/W3165197381","https://openalex.org/W4388020752","https://openalex.org/W4389742040","https://openalex.org/W4408101590","https://openalex.org/W4410145292","https://openalex.org/W4412890156"],"related_works":["https://openalex.org/W4389742040","https://openalex.org/W2187548763","https://openalex.org/W1539714229","https://openalex.org/W2769967518","https://openalex.org/W7044007821","https://openalex.org/W2895866422","https://openalex.org/W2889223556","https://openalex.org/W2041796732","https://openalex.org/W4414438253","https://openalex.org/W4392656152"],"abstract_inverted_index":{"Erythemato-ceruminous":[0],"otitis":[1,209],"externa":[2,210],"(ECOE)":[3],"is":[4],"a":[5,30,41,121,184,204],"canine":[6],"inflammatory":[7],"condition":[8],"very":[9],"frequently":[10],"involving":[11],"secondary":[12],"microbial":[13],"infections.":[14],"This":[15,199],"multicentric,":[16],"masked,":[17],"randomized,":[18],"clinical":[19,79,176],"field":[20],"trial":[21],"in":[22,53,102,140,156,211],"Japan":[23],"evaluated":[24],"the":[25,89,146,150],"efficacy":[26,93,151],"and":[27,76,81,135,162,177],"safety":[28],"of":[29,158,182],"hydrocortisone":[31],"aceponate":[32],"(HCA)":[33],"spray":[34],"solution":[35],"(Cortotic\u2122,":[36],"Virbac,":[37],"France)":[38],"compared":[39],"to":[40,126,173],"terbinafine/florfenicol/betamethasone":[42],"acetate":[43],"ear":[44],"gel":[45],"(Osurnia\u2122,":[46],"Bussan":[47],"Animal":[48],"Health":[49],"CO":[50],"Ltd,":[51],"Japan)":[52],"200":[54],"dogs":[55],"with":[56],"ECOE":[57,193],"(OTIS3":[58],"\u2265":[59],"5).":[60],"Dogs":[61],"received":[62],"either":[63],"Cortotic\u2122":[64,119,161,170,202],"daily":[65],"for":[66,160,164,191,208],"7":[67],"or":[68,71,108,154],"14":[69],"days":[70],"Osurnia\u2122":[72,127,174],"on":[73],"Days":[74],"0":[75],"7.":[77],"OTIS3":[78,103,123],"evaluation":[80],"cytological":[82,106,178],"examinations":[83],"were":[84,132,168],"conducted,":[85],"as":[86,88,152,203],"well":[87],"subjective":[90],"veterinarian":[91],"product":[92],"evaluation.":[94],"Results":[95],"showed":[96,120],"no":[97],"significant":[98],"differences":[99],"between":[100],"groups":[101],"score":[104],"reduction,":[105,107,124],"treatment":[109],"success":[110,130],"rates":[111,131],"at":[112],"any":[113],"time":[114],"point.":[115],"On":[116,143],"Day":[117,144],"28,":[118,145],"72.1%":[122],"comparable":[125],"76.1%.":[128],"Treatment":[129],"also":[133],"similar,":[134],"relapse":[136],"rate":[137],"was":[138],"low":[139],"both":[141],"groups.":[142],"veterinarians":[147],"subjectively":[148],"assessed":[149],"good":[153],"excellent":[155],"83%":[157],"cases":[159],"87%":[163],"Osurnia\u2122.":[165],"Both":[166],"treatments":[167],"well-tolerated.":[169],"demonstrated":[171],"non-inferiority":[172],"regarding":[175],"efficacy.":[179],"The":[180],"use":[181],"Cortotic\u2122,":[183],"corticosteroid-monotherapy,":[185],"can":[186],"offer":[187],"an":[188],"effective":[189],"strategy":[190],"managing":[192],"while":[194],"avoiding":[195],"unnecessary":[196],"antibiotic":[197],"exposure.":[198],"study":[200],"supports":[201],"first-line":[205],"therapeutic":[206],"option":[207],"dogs.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-29T00:00:00"}
