{"id":"https://openalex.org/W7171532336","doi":"https://doi.org/10.64898/2026.07.27.740945","title":"Prolonged developmental programming of somatostatin neurons defines adolescent remodeling of the prelimbic, but not barrel, cortex","display_name":"Prolonged developmental programming of somatostatin neurons defines adolescent remodeling of the prelimbic, but not barrel, cortex","publication_year":2026,"publication_date":"2026-07-28","ids":{"openalex":"https://openalex.org/W7171532336","doi":"https://doi.org/10.64898/2026.07.27.740945","pmid":"https://pubmed.ncbi.nlm.nih.gov/42619819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13483930"},"language":"en","primary_location":{"id":"doi:10.64898/2026.07.27.740945","doi":"https://doi.org/10.64898/2026.07.27.740945","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.27.740945","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/28/2026.07.27.740945.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/28/2026.07.27.740945.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014980296","display_name":"Avery R. Sicher","orcid":"https://orcid.org/0000-0002-4742-8771","observed_orcids":["https://orcid.org/0000-0002-4742-8771"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avery R Sicher","raw_affiliation_strings":["Department of Biology, Penn State University, University Park, PA, USA 16802","Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072813404","display_name":"Lauren N. Beloate","orcid":"https://orcid.org/0000-0002-7704-674X","observed_orcids":["https://orcid.org/0000-0002-7704-674X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren N. Beloate","raw_affiliation_strings":["Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143860755","display_name":"Varya Zlotnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varya Zlotnik","raw_affiliation_strings":["Department of Biology, Penn State University, University Park, PA, USA 16802","Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056726344","display_name":"Keith R. Griffith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Griffith","raw_affiliation_strings":["Department of Biology, Penn State University, University Park, PA, USA 16802","Molecular, Cellular, and Integrative Biosciences PhD Program, Penn State University, University Park, PA, USA 16802","Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Molecular, Cellular, and Integrative Biosciences PhD Program, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143792394","display_name":"Erin Wolfanger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Wolfanger","raw_affiliation_strings":["Department of Biology, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025961178","display_name":"Hayreddin Said \u00dcnsal","orcid":"https://orcid.org/0009-0000-6906-2144","observed_orcids":["https://orcid.org/0009-0000-6906-2144"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hayreddin Said \u00dcnsal","raw_affiliation_strings":["Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017318365","display_name":"Nanyin Zhang","orcid":"https://orcid.org/0000-0002-5824-9058","observed_orcids":["https://orcid.org/0000-0002-5824-9058"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nanyin Zhang","raw_affiliation_strings":["Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040454401","display_name":"Nicole A. Crowley","orcid":"https://orcid.org/0000-0002-1142-7929","observed_orcids":["https://orcid.org/0000-0002-1142-7929"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole A. Crowley","raw_affiliation_strings":["Department of Biology, Penn State University, University Park, PA, USA 16802","Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802"],"raw_orcid":"https://orcid.org/0000-0002-1142-7929","affiliations":[{"raw_affiliation_string":"Department of Biology, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Neuroscience Institute, The Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA 16802","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040454401"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.11879999935626984,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-interneurons","display_name":"somatostatin interneurons","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prelimbic-cortex","display_name":"prelimbic cortex","score":0.7689999938011169},{"id":"https://openalex.org/keywords/somatosensory-barrel-cortex","display_name":"somatosensory barrel cortex","score":0.906000018119812},{"id":"https://openalex.org/keywords/adolescent-brain-development","display_name":"adolescent brain development","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cortical-maturation","display_name":"cortical maturation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dendritic-remodeling","display_name":"dendritic remodeling","score":0.9620000123977661},{"id":"https://openalex.org/keywords/developmental-plasticity","display_name":"developmental plasticity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8151999711990356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6333000063896179},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6162999868392944},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.61080002784729},{"id":"https://openalex.org/C2781347215","wikidata":"https://www.wikidata.org/wiki/Q4863332","display_name":"Barrel cortex","level":3,"score":0.5608000159263611},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5483999848365784},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5385000109672546},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.45260000228881836},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.4521999955177307},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4514000117778778},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.4260999858379364},{"id":"https://openalex.org/C2779617337","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Soma","level":2,"score":0.40540000796318054},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.3847000002861023},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C2779934784","wikidata":"https://www.wikidata.org/wiki/Q16259058","display_name":"Infralimbic cortex","level":4,"score":0.3677000105381012},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.32030001282691956},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C86878447","wikidata":"https://www.wikidata.org/wiki/Q5266812","display_name":"Developmental plasticity","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C2776861996","wikidata":"https://www.wikidata.org/wiki/Q241849","display_name":"Sensory processing","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.07.27.740945","doi":"https://doi.org/10.64898/2026.07.27.740945","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.27.740945","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/28/2026.07.27.740945.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42619819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42619819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13483930","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13483930/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.07.27.740945","doi":"https://doi.org/10.64898/2026.07.27.740945","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.27.740945","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/28/2026.07.27.740945.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G349909306","display_name":"Investigating the effects of adolescent binge drinking on prelimbic somatostatin circuitry","funder_award_id":"F31AA030455","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000871994","display_name":"Sex-dependent shifts in behavioral profiles and cortical signaling following adolescent binge drinking","funder_award_id":"R01AA031472","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000892827","display_name":"Prelimbic somatostatin peptide signaling in binge ethanol consumption","funder_award_id":"R01AA029403","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000913995","display_name":"Developmental Exposure Alcohol Research Center","funder_award_id":"P50AA017823","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000918775","display_name":"Research Training in Physiological Adaptations to Stress","funder_award_id":"T32GM154124","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7171532336.pdf","grobid_xml":"https://content.openalex.org/works/W7171532336.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1986214383","https://openalex.org/W1988387613","https://openalex.org/W1991762922","https://openalex.org/W2004544578","https://openalex.org/W2011370294","https://openalex.org/W2017486254","https://openalex.org/W2024080671","https://openalex.org/W2040073285","https://openalex.org/W2044555278","https://openalex.org/W2066101989","https://openalex.org/W2096388312","https://openalex.org/W2113359311","https://openalex.org/W2131980109","https://openalex.org/W2158046593","https://openalex.org/W2162499463","https://openalex.org/W2170465865","https://openalex.org/W2256316452","https://openalex.org/W2257395058","https://openalex.org/W2344328763","https://openalex.org/W2404064029","https://openalex.org/W2463995212","https://openalex.org/W2510451242","https://openalex.org/W2782653800","https://openalex.org/W2788172302","https://openalex.org/W2790140753","https://openalex.org/W2905028708","https://openalex.org/W2912897320","https://openalex.org/W2921355666","https://openalex.org/W2921744971","https://openalex.org/W2946685581","https://openalex.org/W2953277664","https://openalex.org/W2995488791","https://openalex.org/W3004366574","https://openalex.org/W3041447453","https://openalex.org/W3048219143","https://openalex.org/W3048685979","https://openalex.org/W3082162714","https://openalex.org/W3093993831","https://openalex.org/W3136165260","https://openalex.org/W3148916402","https://openalex.org/W3159462218","https://openalex.org/W3159995594","https://openalex.org/W3172099106","https://openalex.org/W4200594931","https://openalex.org/W4280598609","https://openalex.org/W4367624203","https://openalex.org/W4388759313","https://openalex.org/W4412785376","https://openalex.org/W7123765794"],"related_works":["https://openalex.org/W4394603326","https://openalex.org/W7213231667","https://openalex.org/W4392547197","https://openalex.org/W4409894336","https://openalex.org/W7155599651","https://openalex.org/W2905028708","https://openalex.org/W2257395058","https://openalex.org/W2004190647","https://openalex.org/W4400564226","https://openalex.org/W4389555712"],"abstract_inverted_index":{"Higher":[0],"order":[1,223],"association":[2,224],"cortices":[3],"like":[4],"the":[5,33,68,132,147,161,203,220,235,330],"prefrontal":[6],"cortex":[7,225,231],"(PFC)":[8],"mature":[9],"over":[10],"a":[11,40,48,112,120,138,164,189,199,286,318],"longer":[12,140],"developmental":[13,115,158,207,241,249],"window":[14,141,242],"than":[15,149,299],"sensory":[16,49,151,230,264],"cortices,":[17],"but":[18,234,334],"whether":[19],"genetically":[20,165,254],"defined":[21,166,255],"interneuron":[22],"populations":[23],"follow":[24],"this":[25,154,239],"region-wide":[26],"delayed":[27,186],"trajectory":[28,116,124],"remains":[29,226],"unclear.":[30],"We":[31,65,246],"compared":[32],"postnatal":[34],"development":[35],"of":[36,70,102,131,142,163,182,192,213],"somatostatin-expressing":[37],"interneurons":[38],"in":[39,117,125,146,150,272,302,325],"higher-order":[41],"cortical":[42,50,76],"region":[43,51],"(prelimbic":[44],"cortex;":[45,54],"PLC)":[46],"and":[47,62,99,119,134,136,206,279,296,306,328],"(somatosensory":[52],"barrel":[53],"S1BF)":[55],"across":[56,79],"adolescence":[57],"using":[58],"complementary":[59],"structural,":[60],"electrophysiological,":[61],"circuit":[63,194],"analyses.":[64],"found":[66],"that":[67,248,292],"maturation":[69,130,187],"SST":[71,82,90,171],"neurons":[72,83,91,172],"within":[73,253],"these":[74],"two":[75],"regions":[77],"differs":[78],"time.":[80],"S1BF":[81,118,135],"exhibited":[84],"relatively":[85],"linear":[86,114],"maturation,":[87,98],"whereas":[88],"PLC":[89,133,148],"underwent":[92],"continued":[93],"dendritic":[94,183],"remodeling,":[95],"nonlinear":[96],"intrinsic":[97],"age-dependent":[100],"refinement":[101],"inhibitory":[103,167,280,289],"output":[104,179],"onto":[105],"pyramidal":[106,177],"neurons.":[107],"Multivariate":[108],"analyses":[109],"likewise":[110],"supported":[111],"more":[113,121,294],"prolonged,":[122],"heterogeneous":[123],"PLC.":[126],"This":[127,282],"suggests":[128],"divergent":[129],"supports":[137],"broader,":[139],"critical":[143],"cellular":[144,200,236],"plasticity":[145,205],"cortices.":[152],"Together,":[153],"reflects":[155],"an":[156],"extended":[157,322],"program":[159],"at":[160],"level":[162],"cell":[168,273,290],"type.":[169],"Because":[170],"are":[173],"positioned":[174],"to":[175,210,261,285],"regulate":[176],"neuron":[178],"via":[180],"control":[181],"integration,":[184],"their":[185],"is":[188,251],"crucial":[190],"reflection":[191],"overall":[193,331],"function.":[195],"These":[196],"findings":[197],"provide":[198],"framework":[201],"for":[202,238,321],"prolonged":[204,240],"vulnerability":[208],"known":[209],"be":[211],"characteristic":[212],"adolescent":[214,323],"prelimbic":[215,288,311,326],"cortex.":[216],"Significance":[217],"statement:":[218],"Within":[219],"brain,":[221],"higher":[222],"plastic":[227],"long":[228],"after":[229,263],"has":[232,243],"matured,":[233],"basis":[237],"remained":[244],"unknown.":[245],"find":[247],"timing":[250],"encoded":[252],"microcircuits.":[256],"Prelimbic":[257],"somatostatin":[258,265],"circuits":[259,266,312],"continue":[260],"remodel":[262],"have":[267],"largely":[268],"stabilized":[269],"through":[270],"changes":[271],"shape,":[274],"action":[275],"potential":[276],"firing":[277],"dynamics,":[278],"signaling.":[281],"work":[283],"points":[284],"specific":[287],"type":[291],"matures":[293],"slowly,":[295],"less":[297],"linearly,":[298],"its":[300],"counterparts":[301],"other":[303],"brain":[304],"regions,":[305],"may":[307],"help":[308],"explain":[309],"why":[310],"remain":[313],"vulnerable":[314],"during":[315,339],"adolescence,":[316],"representing":[317],"biological":[319],"substrate":[320],"remodeling":[324],"cortex,":[327],"potentially":[329],"extensive":[332],"flexibility,":[333],"also":[335],"cognitive":[336],"susceptibility,":[337],"seen":[338],"adolescence.":[340]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-29T00:00:00"}