{"id":"https://openalex.org/W7171531440","doi":"https://doi.org/10.12669/pjms.42.8.13372","title":"Assessing Outcome of tPA Therapy in Patients with Acute Ischemic Stroke (0-three hours)","display_name":"Assessing Outcome of tPA Therapy in Patients with Acute Ischemic Stroke (0-three hours)","publication_year":2026,"publication_date":"2026-07-27","ids":{"openalex":"https://openalex.org/W7171531440","doi":"https://doi.org/10.12669/pjms.42.8.13372","pmid":"https://pubmed.ncbi.nlm.nih.gov/42668893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13525510"},"language":"en","primary_location":{"id":"doi:10.12669/pjms.42.8.13372","doi":"https://doi.org/10.12669/pjms.42.8.13372","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.8.13372","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/13372/11562","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pjms.org.pk/index.php/pjms/article/download/13372/11562","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093588373","display_name":"Amna Tariq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amna Tariq","raw_affiliation_strings":["Amna Tariq, FCPS, FEBN. Resident, Department of Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amna Tariq, FCPS, FEBN. Resident, Department of Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104102023","display_name":"Muhammad Adnan Aslam","orcid":"https://orcid.org/0000-0001-5704-3878","observed_orcids":["https://orcid.org/0000-0001-5704-3878"]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Adnan Aslam","raw_affiliation_strings":["Muhammad Adnan Aslam Head of Department Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muhammad Adnan Aslam Head of Department Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072752297","display_name":"Qasim Bashir","orcid":"https://orcid.org/0000-0002-2012-9579","observed_orcids":["https://orcid.org/0000-0002-2012-9579","https://orcid.org/0009-0001-9032-9314"]},"institutions":[{"id":"https://openalex.org/I4405254933","display_name":"Punjab Institute of Neurosciences","ror":"https://ror.org/02dha3k90","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4405254933"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Qasim Bashir","raw_affiliation_strings":["Qasim Bashir, MBBS, M.D (USA), ABPN, UCNS (Neurocritical Care), ABMS (Vascular Neurology), FSVIN (USA), CAST Certified in Neuroendovascular Surgery (USA). Head of Department Neurology, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qasim Bashir, MBBS, M.D (USA), ABPN, UCNS (Neurocritical Care), ABMS (Vascular Neurology), FSVIN (USA), CAST Certified in Neuroendovascular Surgery (USA). Head of Department Neurology, Punjab Institute of Neurosciences (PINS), Lahore, Pakistan","institution_ids":["https://openalex.org/I4405254933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121666091","display_name":"Sabina Nayab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sabina Nayab","raw_affiliation_strings":["Sabina Nayab Resident, Department of Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sabina Nayab Resident, Department of Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5143816667","display_name":"Aamir Hayat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125830269","display_name":"Services Institute of Medical Sciences","ror":"https://ror.org/04c1d9r22","country_code":"PK","type":"education","lineage":["https://openalex.org/I125830269"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Aamir Hayat","raw_affiliation_strings":["Aamir Hayat Resident, Department of Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aamir Hayat Resident, Department of Neurology, Services Institute of Medical Sciences (SIMS), Lahore, Pakistan","institution_ids":["https://openalex.org/I125830269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072752297"],"corresponding_institution_ids":["https://openalex.org/I4405254933"],"apc_list":{"value":400,"currency":"USD","value_usd":400},"apc_paid":{"value":400,"currency":"USD","value_usd":400},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"8","first_page":"1914","last_page":"1918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.5849999785423279},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.843999981880188},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neurological-improvement","display_name":"neurological improvement","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nihss","display_name":"NIHSS","score":0.8489999771118164},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.9279999732971191},{"id":"https://openalex.org/keywords/time-to-treatment","display_name":"time to treatment","score":0.8389999866485596},{"id":"https://openalex.org/keywords/stroke-subtypes","display_name":"stroke subtypes","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9819999933242798},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.807200014591217},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.6305000185966492},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.6086000204086304},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.52920001745224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5076000094413757},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.43880000710487366},{"id":"https://openalex.org/C2993918154","wikidata":"https://www.wikidata.org/wiki/Q12131","display_name":"Functional impairment","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.37059998512268066},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3027999997138977},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.2540999948978424}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.12669/pjms.42.8.13372","doi":"https://doi.org/10.12669/pjms.42.8.13372","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.8.13372","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/13372/11562","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13525510","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13525510/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13525510/pdf/PJMS-42-8-1914.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pak J Med Sci","raw_type":"Text"},{"id":"pmid:42668893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42668893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.12669/pjms.42.8.13372","doi":"https://doi.org/10.12669/pjms.42.8.13372","is_oa":true,"landing_page_url":"https://doi.org/10.12669/pjms.42.8.13372","pdf_url":"https://pjms.org.pk/index.php/pjms/article/download/13372/11562","source":{"id":"https://openalex.org/S83180243","display_name":"Pakistan Journal of Medical Sciences","issn_l":"1681-715X","issn":["1681-715X","1682-024X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319271","host_organization_name":"Professional Medical Publications","host_organization_lineage":["https://openalex.org/P4310319271"],"host_organization_lineage_names":["Professional Medical Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7171531440.pdf","grobid_xml":"https://content.openalex.org/works/W7171531440.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2939495229","https://openalex.org/W2980479003","https://openalex.org/W2993044194","https://openalex.org/W3005294805","https://openalex.org/W3032066383","https://openalex.org/W3047939314","https://openalex.org/W3081451312","https://openalex.org/W3087401844","https://openalex.org/W3157630068","https://openalex.org/W3180187119","https://openalex.org/W3197233575","https://openalex.org/W4200289412","https://openalex.org/W4200444653","https://openalex.org/W4293171008","https://openalex.org/W4311236797","https://openalex.org/W4318919553","https://openalex.org/W4321497223","https://openalex.org/W4376867934","https://openalex.org/W4383315551","https://openalex.org/W4403465468"],"related_works":["https://openalex.org/W2139202032","https://openalex.org/W4414546200","https://openalex.org/W7213030617","https://openalex.org/W2620654293","https://openalex.org/W7218148275","https://openalex.org/W2026000119","https://openalex.org/W1978903658","https://openalex.org/W2286474307","https://openalex.org/W7220798094","https://openalex.org/W2737540174"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"determine":[2],"the":[3,207,215],"frequency":[4],"of":[5,22,24,59,96,151,169,217],"good":[6,99,156],"functional":[7,71,100,157,194],"outcome":[8,72],"and":[9,70,79,153,175,193,201],"significant":[10,90,161],"neurological":[11,91,145,192],"improvement":[12,65,84,146,195],"for":[13],"patients":[14,48],"treated":[15],"with":[16,49,73],"tPA":[17,55,170,187,204],"within":[18,56,206],"first":[19],"three":[20,57,208],"hours":[21,58,209],"onset":[23,61],"acute":[25,50],"ischemic":[26,51],"stroke.":[27],"Methodology:":[28],"This":[29],"cross-sectional":[30],"study":[31],"was":[32,66,87,147],"conducted":[33],"at":[34,77,117,123],"Neurology":[35],"Department,":[36],"Services":[37],"Hospital,":[38],"Lahore,":[39],"from":[40,113,133],"October":[41],"2024":[42],"to":[43,119,137,190,203],"April":[44],"2025.":[45],"Total":[46],"51":[47],"stroke":[52,173],"who":[53],"received":[54],"symptom":[60],"were":[62,103,163],"included.":[63],"Neurological":[64],"assessed":[67],"using":[68,105],"NIHSS,":[69],"Modified":[74],"Rankin":[75],"Scale":[76],"baseline":[78,118,199],"after":[80],"90":[81,124],"days;":[82],"\u22654-point":[83],"in":[85,149,196],"NIHSS":[86,110],"considered":[88],"as":[89],"improvement,":[92],"while":[93,129,185],"mRS":[94,131],"scores":[95],"0-2":[97],"indicated":[98],"outcome.":[101],"Data":[102],"analyzed":[104],"SPSS":[106],"v26.":[107],"Results:":[108],"Mean":[109],"score":[111],"improved":[112,132],"12.31":[114],"\u00b1":[115,121,135,139],"5.42":[116],"7.96":[120],"7.05":[122],"days":[125],"(p":[126,141,177],"<":[127,142],"0.001),":[128],"mean":[130],"4.02":[134],"1.04":[136],"2.90":[138],"1.81":[140],"0.001).":[143],"Significant":[144],"seen":[148],"54.9%":[150],"patients,":[152,198],"49.0%":[154],"achieved":[155],"outcomes.":[158,220],"No":[159],"statistically":[160],"associations":[162],"found":[164],"between":[165],"gender,":[166],"age,":[167],"time":[168,202],"administration,":[171],"or":[172],"subtype":[174],"outcomes":[176],">":[178],"0.05).":[179],"Conclusion:":[180],"These":[181],"findings":[182],"suggest":[183],"that":[184],"intravenous":[186],"therapy":[188],"led":[189],"meaningful":[191],"many":[197],"demographics":[200],"administration":[205],"window":[210],"did":[211],"not":[212],"significantly":[213],"influence":[214],"likelihood":[216],"achieving":[218],"favourable":[219]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-07-29T00:00:00"}