{"id":"https://openalex.org/W7171531377","doi":"https://doi.org/10.1016/j.clim.2026.110754","title":"Metabolic syndrome and increased inflammatory burden in active rheumatoid arthritis: An exploratory focus on hematologic markers","display_name":"Metabolic syndrome and increased inflammatory burden in active rheumatoid arthritis: An exploratory focus on hematologic markers","publication_year":2026,"publication_date":"2026-07-28","ids":{"openalex":"https://openalex.org/W7171531377","doi":"https://doi.org/10.1016/j.clim.2026.110754","pmid":"https://pubmed.ncbi.nlm.nih.gov/42521108"},"language":"en","primary_location":{"id":"doi:10.1016/j.clim.2026.110754","doi":"https://doi.org/10.1016/j.clim.2026.110754","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2026.110754","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047892321","display_name":"Amina Arroul-Lammali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Amina Arroul-Lammali","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria. Electronic address: arroul_lammali@hotmail.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria. Electronic address: arroul_lammali@hotmail.fr","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041659760","display_name":"Dalila Mezioug","orcid":"https://orcid.org/0000-0003-2815-3546","observed_orcids":["https://orcid.org/0000-0003-2815-3546"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Dalila Mezioug","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143846670","display_name":"Rayene Mammeri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rayene Mammeri","raw_affiliation_strings":["Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110829739","display_name":"Fadia Rahal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fadia Rahal","raw_affiliation_strings":["Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112672903","display_name":"Fella HANNI","orcid":"https://orcid.org/0000-0002-0713-2597","observed_orcids":["https://orcid.org/0000-0002-0713-2597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fella Hanni","raw_affiliation_strings":["Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143816907","display_name":"Fadila Boudjaafar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fadila Boudjaafar","raw_affiliation_strings":["Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Ben Aknoun Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029448104","display_name":"Chafika Haouichet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chafika Haouichat","raw_affiliation_strings":["Rheumatology Department, Douera Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Douera Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143857389","display_name":"Hafida Rahmouni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hafida Rahmouni","raw_affiliation_strings":["Rheumatology Department, Douera Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Douera Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143838964","display_name":"Tahar Djamel Touat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tahar Djamel Touat","raw_affiliation_strings":["Rheumatology Department, Douera Hospital EHS, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Department, Douera Hospital EHS, Algiers, Algeria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080184519","display_name":"Zineb Djeraba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Zineb Djeraba","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018282249","display_name":"Imene Soufli","orcid":"https://orcid.org/0000-0002-4431-6512","observed_orcids":["https://orcid.org/0000-0002-4431-6512"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Imene Soufli","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063169669","display_name":"Fatmazohra Djaballah-Ider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Fatmazohra Djaballah-Ider","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076589960","display_name":"Sarah Benchabane","orcid":"https://orcid.org/0000-0002-2563-9009","observed_orcids":["https://orcid.org/0000-0002-2563-9009"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Sarah Benchabane","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046764360","display_name":"Fahima Ameur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Fahima Ameur","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076560787","display_name":"Arezki Samer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Arezki Samer","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015442605","display_name":"Rania Sihem Boussa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Rania Sihem Boussa","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074110142","display_name":"Houda Belguendouz","orcid":"https://orcid.org/0000-0003-3641-4291","observed_orcids":["https://orcid.org/0000-0003-3641-4291"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Houda Belguendouz","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042109271","display_name":"Chafia Touil\u2013Boukoffa","orcid":"https://orcid.org/0000-0001-7728-2147","observed_orcids":["https://orcid.org/0000-0001-7728-2147","https://orcid.org/0000-0001-8026-9373"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Chafia Touil-Boukoffa","raw_affiliation_strings":["Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria; Member of Algerian Academy of Sciences and Technology (AAST), Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Biology (LBCM), Cytokines and NO Synthases Team, Faculty of Biological Sciences, USTHB (University of Sciences and Technology), Algiers, Algeria; Member of Algerian Academy of Sciences and Technology (AAST), Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047892321"],"corresponding_institution_ids":["https://openalex.org/I157169809"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"287","issue":null,"first_page":"110754","last_page":"110754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/inflammatory-burden","display_name":"inflammatory burden","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hematologic-markers","display_name":"hematologic markers","score":0.6660000085830688},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8999999761581421},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9879999756813049},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5950000286102295},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8331999778747559},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7322999835014343},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.5088000297546387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46129998564720154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44440001249313354},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.3955000042915344},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.28929999470710754},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C2908741605","wikidata":"https://www.wikidata.org/wiki/Q1963588","display_name":"Hematologic disorders","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.clim.2026.110754","doi":"https://doi.org/10.1016/j.clim.2026.110754","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clim.2026.110754","pdf_url":null,"source":{"id":"https://openalex.org/S37169408","display_name":"Clinical Immunology","issn_l":"1521-6616","issn":["1521-6616","1521-7035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:42521108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42521108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology (Orlando, Fla.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335006","display_name":"Agence Th\u00e9matique de Recherche en Sciences de la Sant\u00e9","ror":"https://ror.org/00rt0xj75"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1965148312","https://openalex.org/W1978644929","https://openalex.org/W2014610874","https://openalex.org/W2034746193","https://openalex.org/W2038174150","https://openalex.org/W2051507420","https://openalex.org/W2052770133","https://openalex.org/W2055291298","https://openalex.org/W2057954706","https://openalex.org/W2063250550","https://openalex.org/W2066152672","https://openalex.org/W2070616542","https://openalex.org/W2119519672","https://openalex.org/W2120317645","https://openalex.org/W2130717716","https://openalex.org/W2135086300","https://openalex.org/W2145390384","https://openalex.org/W2147121896","https://openalex.org/W2157665037","https://openalex.org/W2162129832","https://openalex.org/W2168941634","https://openalex.org/W2518112886","https://openalex.org/W2519795941","https://openalex.org/W2586166443","https://openalex.org/W2759888937","https://openalex.org/W2921233414","https://openalex.org/W2981324746","https://openalex.org/W3013533796","https://openalex.org/W3014426241","https://openalex.org/W3018788549","https://openalex.org/W3176292753","https://openalex.org/W3216406313","https://openalex.org/W4323047263","https://openalex.org/W4377011307","https://openalex.org/W4385760977","https://openalex.org/W4393001320"],"related_works":["https://openalex.org/W3115522172","https://openalex.org/W4285502680","https://openalex.org/W4388636586","https://openalex.org/W2034746193","https://openalex.org/W2519795941","https://openalex.org/W3108048193","https://openalex.org/W4317423337","https://openalex.org/W3001733215","https://openalex.org/W4287312994","https://openalex.org/W3007238739"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-07-29T00:00:00"}