{"id":"https://openalex.org/W7171386830","doi":"https://doi.org/10.1007/s00726-026-03532-2","title":"ATP13A4 sensitizes cells to polyamine-induced cytotoxicity in a SAT1-dependent manner","display_name":"ATP13A4 sensitizes cells to polyamine-induced cytotoxicity in a SAT1-dependent manner","publication_year":2026,"publication_date":"2026-07-27","ids":{"openalex":"https://openalex.org/W7171386830","doi":"https://doi.org/10.1007/s00726-026-03532-2"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-026-03532-2","doi":"https://doi.org/10.1007/s00726-026-03532-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-026-03532-2","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00726-026-03532-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125166356","display_name":"Emily Meeus","orcid":"https://orcid.org/0009-0004-9074-4296","observed_orcids":["https://orcid.org/0009-0004-9074-4296"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Emily Meeus","raw_affiliation_strings":["Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043291954","display_name":"Elke Ausloos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elke Ausloos","raw_affiliation_strings":["Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040886525","display_name":"Chris Van den Haute","orcid":"https://orcid.org/0000-0002-6650-3845","observed_orcids":["https://orcid.org/0000-0002-6650-3845"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Chris Van den Haute","raw_affiliation_strings":["Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium","Leuven Viral Vector Core, KU Leuven, Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Leuven Viral Vector Core, KU Leuven, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016643155","display_name":"Jan Eggermont","orcid":"https://orcid.org/0000-0002-8497-1159","observed_orcids":["https://orcid.org/0000-0002-8497-1159"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Eggermont","raw_affiliation_strings":["Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024492574","display_name":"Sarah van Veen","orcid":"https://orcid.org/0000-0002-7639-7847","observed_orcids":["https://orcid.org/0000-0002-7639-7847"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sarah van Veen","raw_affiliation_strings":["Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008583951","display_name":"Peter Vangheluwe","orcid":"https://orcid.org/0000-0002-7822-2944","observed_orcids":["https://orcid.org/0000-0002-7822-2944"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Peter Vangheluwe","raw_affiliation_strings":["Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Transport Systems, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008583951"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":1.9386,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.89332744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.7549999952316284},{"id":"https://openalex.org/keywords/polyamine-toxicity","display_name":"polyamine toxicity","score":0.7149999737739563},{"id":"https://openalex.org/keywords/polyamine-uptake","display_name":"polyamine uptake","score":0.7120000123977661},{"id":"https://openalex.org/keywords/sat1","display_name":"SAT1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/spermidine-spermine-n1-acetyltransferase","display_name":"spermidine/spermine N1-acetyltransferase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stress-signaling","display_name":"stress signaling","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.8539999723434448},{"id":"https://openalex.org/keywords/polyamine-transport","display_name":"polyamine transport","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.9133999943733215},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7972999811172485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6470999717712402},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6355000138282776},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6180999875068665},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.42829999327659607},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4083000123500824},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38929998874664307},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.3882000148296356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3837999999523163},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C147025567","wikidata":"https://www.wikidata.org/wiki/Q16335140","display_name":"Cellular model","level":3,"score":0.34850001335144043},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.32820001244544983},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C191141034","wikidata":"https://www.wikidata.org/wiki/Q3087369","display_name":"Cell physiology","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C78885561","wikidata":"https://www.wikidata.org/wiki/Q189055","display_name":"Cellular compartment","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00726-026-03532-2","doi":"https://doi.org/10.1007/s00726-026-03532-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-026-03532-2","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00726-026-03532-2","doi":"https://doi.org/10.1007/s00726-026-03532-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-026-03532-2","pdf_url":null,"source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.458011656999588,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Polyamines":[1],"are":[2],"essential":[3],"metabolites":[4],"whose":[5],"intracellular":[6,28],"levels":[7,168],"must":[8],"be":[9,106],"tightly":[10],"controlled,":[11],"as":[12,50],"excessive":[13,166],"accumulation":[14],"perturbs":[15],"cellular":[16,35,55,64,72,115],"homeostasis":[17],"and":[18,62,88,122,141,169],"viability.":[19],"Although":[20],"polyamine":[21,29,38,75,154,167,176],"transport":[22,32],"is":[23,179],"a":[24,51,92],"major":[25],"determinant":[26],"of":[27,54,78,86,97,137],"burden,":[30],"how":[31],"processes":[33],"influence":[34],"responses":[36],"to":[37,57,74,83,158],"excess":[39],"remains":[40],"incompletely":[41],"understood.":[42],"Here,":[43],"we":[44,66],"identify":[45],"the":[46,71,175],"P5-type":[47],"ATPase":[48],"ATP13A4":[49,69,80,99,112],"transport-dependent":[52],"regulator":[53],"sensitivity":[56,73],"polyamines.":[58],"Using":[59],"complementary":[60],"gain-":[61],"loss-of-function":[63],"models,":[65],"demonstrate":[67],"that":[68,152],"modulates":[70],"toxicity.":[76],"Expression":[77],"functional":[79],"sensitized":[81],"cells":[82,157],"polyamine-induced":[84,128],"loss":[85],"viability":[87],"cell":[89,146],"death,":[90],"whereas":[91],"transport-deficient":[93],"mutant":[94],"or":[95],"depletion":[96],"endogenous":[98],"conferred":[100],"protection.":[101],"This":[102],"effect":[103],"could":[104],"not":[105],"explained":[107],"by":[108],"extracellular":[109],"amine":[110],"oxidation.":[111],"expression":[113],"increased":[114],"dependence":[116],"on":[117,162],"spermidine/spermine":[118],"N\u00b9-acetyltransferase":[119],"1":[120],"(SAT1),":[121],"pharmacological":[123],"SAT1":[124],"inhibition":[125,143],"markedly":[126],"exacerbated":[127],"cytotoxicity.":[129],"ATP13A4-dependent":[130],"uptake":[131,155],"was":[132],"further":[133],"associated":[134],"with":[135],"activation":[136],"JNK-linked":[138],"stress":[139,171],"signaling,":[140],"JNK":[142],"partially":[144],"attenuated":[145],"death.":[147],"Collectively,":[148],"these":[149],"findings":[150],"indicate":[151],"ATP13A4-mediated":[153],"sensitizes":[156],"polyamines,":[159],"increasing":[160],"reliance":[161],"SAT1-dependent":[163],"buffering":[164,177],"against":[165],"engaging":[170],"signaling":[172],"pathways":[173],"when":[174],"capacity":[178],"exceeded.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-07-28T00:00:00"}