{"id":"https://openalex.org/W7171385536","doi":"https://doi.org/10.3389/fimmu.2026.1886839","title":"Development of an 8-valent Salmonella and Shigella MAPS vaccine","display_name":"Development of an 8-valent Salmonella and Shigella MAPS vaccine","publication_year":2026,"publication_date":"2026-07-27","ids":{"openalex":"https://openalex.org/W7171385536","doi":"https://doi.org/10.3389/fimmu.2026.1886839","pmid":"https://pubmed.ncbi.nlm.nih.gov/42577318","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13454105"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1886839","doi":"https://doi.org/10.3389/fimmu.2026.1886839","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1886839","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1886839/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1886839/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076915115","display_name":"Emily M. Boerth","orcid":"https://orcid.org/0009-0002-4011-2923","observed_orcids":["https://orcid.org/0009-0002-4011-2923"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily M. Boerth","raw_affiliation_strings":["Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107617016","display_name":"Becky Roffler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Becky Roffler","raw_affiliation_strings":["Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099519534","display_name":"Zoe Hancock","orcid":"https://orcid.org/0000-0002-7056-2880","observed_orcids":["https://orcid.org/0000-0002-7056-2880"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoe Hancock","raw_affiliation_strings":["Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital"],"raw_orcid":"https://orcid.org/0000-0002-7056-2880","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033212775","display_name":"Joyce Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Gong","raw_affiliation_strings":["Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138711051","display_name":"Calman A. MacLennan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Calman A. MacLennan","raw_affiliation_strings":["Department of Immunology and Immunotherapy Birmingham England University of Birmingham","Oxfordshire Calman MacLennan Consulting Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Immunotherapy Birmingham England University of Birmingham","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Oxfordshire Calman MacLennan Consulting Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139206871","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0003-2590-8595","observed_orcids":["https://orcid.org/0000-0003-2590-8595"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066130020","display_name":"Ying\u2010Jie Lu","orcid":"https://orcid.org/0000-0003-1805-3955","observed_orcids":["https://orcid.org/0000-0003-1805-3955"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Jie Lu","raw_affiliation_strings":["Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital"],"raw_orcid":"https://orcid.org/0009-0002-4011-2923","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases Boston MA 02115 Boston Children's Hospital","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46690431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1886839","last_page":"1886839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.2085999995470047,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.17149999737739563,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-enterica-serovar-typhi","display_name":"Salmonella typhi","score":0.6019999980926514},{"id":"https://openalex.org/keywords/shigella","display_name":"Shigella","score":0.722000002861023},{"id":"https://openalex.org/keywords/aluminum-phosphate-adjuvant","display_name":"aluminum phosphate adjuvant","score":0.7480000257492065},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.5640000104904175},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/opsonophagocytosis","display_name":"opsonophagocytosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/serotype-specific-antibodies","display_name":"serotype-specific antibodies","score":0.4009999930858612},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.8406000137329102},{"id":"https://openalex.org/C2776986154","wikidata":"https://www.wikidata.org/wiki/Q131029","display_name":"Shigella","level":4,"score":0.7563999891281128},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6565999984741211},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5856000185012817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5388000011444092},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5120999813079834},{"id":"https://openalex.org/C2780924562","wikidata":"https://www.wikidata.org/wiki/Q190527","display_name":"Alum","level":2,"score":0.4609000086784363},{"id":"https://openalex.org/C2994552716","wikidata":"https://www.wikidata.org/wiki/Q21600865","display_name":"Salmonella typhi","level":4,"score":0.45320001244544983},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4514000117778778},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4147000014781952},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.41190001368522644},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.400299996137619},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.3644999861717224},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.3386000096797943},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.32690000534057617},{"id":"https://openalex.org/C2779546430","wikidata":"https://www.wikidata.org/wiki/Q327298","display_name":"Shigellosis","level":5,"score":0.3240000009536743},{"id":"https://openalex.org/C2780610775","wikidata":"https://www.wikidata.org/wiki/Q265094","display_name":"Shigella dysenteriae","level":4,"score":0.3181999921798706},{"id":"https://openalex.org/C2778782520","wikidata":"https://www.wikidata.org/wiki/Q326648","display_name":"Salmonella infection","level":4,"score":0.3158999979496002},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3086000084877014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29280000925064087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2750999927520752}],"mesh":[{"descriptor_ui":"D000087506","descriptor_name":"Vaccine Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000534","descriptor_name":"Alum Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004405","descriptor_name":"Dysentery, Bacillary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004405","descriptor_name":"Dysentery, Bacillary","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012480","descriptor_name":"Salmonella Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012480","descriptor_name":"Salmonella Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012760","descriptor_name":"Shigella","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D022281","descriptor_name":"Shigella Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D022562","descriptor_name":"Salmonella Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2026.1886839","doi":"https://doi.org/10.3389/fimmu.2026.1886839","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1886839","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1886839/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"doi:10.12688/verixiv.3333.1","doi":"https://doi.org/10.12688/verixiv.3333.1","is_oa":false,"landing_page_url":"https://doi.org/10.12688/verixiv.3333.1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13454105","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13454105/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13454105/pdf/fimmu-17-1886839.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42577318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42577318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:75cb3b2ddddc490195f70dd01f7fd318","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/75cb3b2ddddc490195f70dd01f7fd318","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1886839","doi":"https://doi.org/10.3389/fimmu.2026.1886839","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1886839","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1886839/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5365999937057495}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1782550901","display_name":"Children's Hospital Boston - to develop a 4-valent Shigella vaccine using Multi-Antigen Presentation System technology to a stage where it would be ready for production for a h...","funder_award_id":"INV-037586","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7171385536.pdf","grobid_xml":"https://content.openalex.org/works/W7171385536.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1553542225","https://openalex.org/W1577458838","https://openalex.org/W1972776583","https://openalex.org/W2032783993","https://openalex.org/W2045853263","https://openalex.org/W2049532298","https://openalex.org/W2056508934","https://openalex.org/W2066520169","https://openalex.org/W2071475038","https://openalex.org/W2090449499","https://openalex.org/W2103802234","https://openalex.org/W2110822396","https://openalex.org/W2114053580","https://openalex.org/W2120727179","https://openalex.org/W2127859752","https://openalex.org/W2169551048","https://openalex.org/W2771874921","https://openalex.org/W2808149260","https://openalex.org/W2886859874","https://openalex.org/W2893080428","https://openalex.org/W2896927639","https://openalex.org/W4200590191","https://openalex.org/W4213121097","https://openalex.org/W4214834648","https://openalex.org/W4220864393","https://openalex.org/W4223998874","https://openalex.org/W4244785433","https://openalex.org/W4281618833","https://openalex.org/W4282934330","https://openalex.org/W4293224667","https://openalex.org/W4306694248","https://openalex.org/W4307018272","https://openalex.org/W4313472452","https://openalex.org/W4319332756","https://openalex.org/W4379229423","https://openalex.org/W4384819234","https://openalex.org/W4387728743","https://openalex.org/W4388075293","https://openalex.org/W4390582570","https://openalex.org/W4391235493","https://openalex.org/W4392059826","https://openalex.org/W4393998995","https://openalex.org/W4394824799","https://openalex.org/W4402826703","https://openalex.org/W4403289025","https://openalex.org/W4403532028","https://openalex.org/W4405535290","https://openalex.org/W4407391543","https://openalex.org/W4408938359","https://openalex.org/W4413937992","https://openalex.org/W4414723147","https://openalex.org/W4414930796","https://openalex.org/W4416733839","https://openalex.org/W7125646436","https://openalex.org/W7133554906"],"related_works":["https://openalex.org/W4402826703","https://openalex.org/W7155167935","https://openalex.org/W2560777220","https://openalex.org/W6920727793","https://openalex.org/W4388075293","https://openalex.org/W7125922953","https://openalex.org/W4409332669","https://openalex.org/W3157588003","https://openalex.org/W2511034190","https://openalex.org/W4417296172"],"abstract_inverted_index":{"Introduction":[0],"Salmonella":[1,24,34,54,65],"and":[2,32,35,55,66,81,83,96,147,158],"Shigella":[3,36,56,67],"infections":[4],"are":[5,39],"two":[6,50,113],"of":[7,11,64,92,111,119,122,150],"the":[8,62,90,101,112,120,123,148],"leading":[9],"causes":[10],"global":[12],"diarrheal":[13],"deaths":[14],"in":[15,42,69,133],"children":[16],"younger":[17],"than":[18],"5":[19],"years.":[20],"Licensed":[21],"vaccines":[22,52,68],"against":[23,53,79,143],"Typhi":[25],"have":[26,47],"been":[27],"shown":[28],"to":[29,75,88,109],"be":[30],"effective,":[31],"other":[33],"vaccine":[37,104,144],"candidates":[38],"being":[40],"evaluated":[41,132],"clinical":[43],"trials.":[44],"Methods":[45],"We":[46,98],"previously":[48],"described":[49],"4-valent":[51,114],"strains":[57],"separately.":[58],"Here,":[59],"we":[60],"tested":[61],"combination":[63],"animal":[70],"models.":[71],"ELISA":[72],"was":[73],"used":[74,87],"determine":[76,89],"antibody":[77,141,156],"titers":[78],"antigens,":[80],"bactericidal":[82,159],"opsonophagocytic":[84],"assays":[85],"were":[86,131],"function":[91],"these":[93],"antibodies.":[94],"Results":[95],"discussion":[97],"found":[99],"that":[100,138],"8-valent":[102],"Salmonella/Shigella":[103],"induced":[105],"immune":[106],"responses":[107],"similar":[108],"those":[110],"counterparts.":[115],"The":[116,135],"immunological":[117],"benefits":[118],"addition":[121,149],"adjuvant":[124],"aluminum":[125],"phosphate":[126],"(alum),":[127],"R848/Alum,":[128],"or":[129,152],"AddaS03":[130,153],"rabbits.":[134],"results":[136],"demonstrated":[137],"alum":[139],"augments":[140],"production":[142,157],"protein":[145],"components,":[146],"R848/Alum":[151],"significantly":[154],"enhanced":[155],"activity":[160],"for":[161],"some":[162],"serotypes.":[163]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-07-28T00:00:00"}
