{"id":"https://openalex.org/W7171028024","doi":"https://doi.org/10.1007/s10735-026-10866-4","title":"Dual modulation of intracellular Ca2+ signaling by hispidulin through endoplasmic reticulum mobilization and extracellular Ca2+ entry in human breast cancer cells","display_name":"Dual modulation of intracellular Ca2+ signaling by hispidulin through endoplasmic reticulum mobilization and extracellular Ca2+ entry in human breast cancer cells","publication_year":2026,"publication_date":"2026-07-25","ids":{"openalex":"https://openalex.org/W7171028024","doi":"https://doi.org/10.1007/s10735-026-10866-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42501117"},"language":"en","primary_location":{"id":"doi:10.1007/s10735-026-10866-4","doi":"https://doi.org/10.1007/s10735-026-10866-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10735-026-10866-4","pdf_url":null,"source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143625223","display_name":"Nai-Yu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nai-Yu Wang","raw_affiliation_strings":["Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112698873","display_name":"Chang Cl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Chung Chang","raw_affiliation_strings":["Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150916","display_name":"Chiang\u2010Ting Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141243467","display_name":"Chang Gung University of Science and Technology","ror":"https://ror.org/009knm296","country_code":"TW","type":"education","lineage":["https://openalex.org/I141243467"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chiang-Ting Chou","raw_affiliation_strings":["School of Nursing, Chang Gung University of Science and Technology Chiayi Campus, Puzi City, Chiayi County, 61363, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Chang Gung University of Science and Technology Chiayi Campus, Puzi City, Chiayi County, 61363, Taiwan","institution_ids":["https://openalex.org/I141243467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073589288","display_name":"Po\u2010Min Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Min Chang","raw_affiliation_strings":["Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036583745","display_name":"Wei\u2010Zhe Liang","orcid":"https://orcid.org/0000-0001-7131-6377","observed_orcids":["https://orcid.org/0000-0001-7131-6377"]},"institutions":[{"id":"https://openalex.org/I32303042","display_name":"Tajen University","ror":"https://ror.org/01fvf0d84","country_code":"TW","type":"education","lineage":["https://openalex.org/I32303042"]},{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wei-Zhe Liang","raw_affiliation_strings":["Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan. pseudoo67@tajen.edu.tw","Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Yanpu Township, Pingtung County, 90741, Taiwan. pseudoo67@tajen.edu.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, 813414, Taiwan. pseudoo67@tajen.edu.tw","institution_ids":["https://openalex.org/I4210152230"]},{"raw_affiliation_string":"Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Yanpu Township, Pingtung County, 90741, Taiwan. pseudoo67@tajen.edu.tw","institution_ids":["https://openalex.org/I32303042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036583745"],"corresponding_institution_ids":["https://openalex.org/I32303042","https://openalex.org/I4210152230"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"57","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hispidulin","display_name":"hispidulin","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8159999847412109},{"id":"https://openalex.org/keywords/intracellular-calcium-signaling","display_name":"intracellular calcium signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7239999771118164},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.8240000009536743},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9950000047683716},{"id":"https://openalex.org/keywords/extracellular-calcium-influx","display_name":"extracellular calcium influx","score":0.8640000224113464},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.859000027179718},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.878000020980835},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9919999837875366},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.972000002861023},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.6850000023841858},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/2-apb","display_name":"2-APB","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7505000233650208},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7483000159263611},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6987000107765198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.676800012588501},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.673799991607666},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5317999720573425},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4724000096321106},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.4675999879837036},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4537999927997589},{"id":"https://openalex.org/C2776610495","wikidata":"https://www.wikidata.org/wiki/Q18047835","display_name":"ORAI1","level":4,"score":0.4375999867916107},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4275999963283539},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.41659998893737793},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4081000089645386},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.36500000953674316},{"id":"https://openalex.org/C2777146706","wikidata":"https://www.wikidata.org/wiki/Q3981006","display_name":"Thapsigargin","level":3,"score":0.3619000017642975},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.3059000074863434},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.29120001196861267},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2696000039577484}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047309","descriptor_name":"Flavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10735-026-10866-4","doi":"https://doi.org/10.1007/s10735-026-10866-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10735-026-10866-4","pdf_url":null,"source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},{"id":"pmid:42501117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42501117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular histology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W946895768","https://openalex.org/W2023864242","https://openalex.org/W2028043136","https://openalex.org/W2028948213","https://openalex.org/W2036323932","https://openalex.org/W2053261401","https://openalex.org/W2058449890","https://openalex.org/W2067670322","https://openalex.org/W2073131935","https://openalex.org/W2141260882","https://openalex.org/W2335148571","https://openalex.org/W2401837478","https://openalex.org/W2531986144","https://openalex.org/W2580171566","https://openalex.org/W2767224068","https://openalex.org/W2790654889","https://openalex.org/W2913809058","https://openalex.org/W2944643129","https://openalex.org/W2969614841","https://openalex.org/W2982862631","https://openalex.org/W3084051281","https://openalex.org/W3087756157","https://openalex.org/W3135856321","https://openalex.org/W3178009076","https://openalex.org/W4206935580","https://openalex.org/W4362601055","https://openalex.org/W4366772805","https://openalex.org/W4382602119","https://openalex.org/W4387095493","https://openalex.org/W4388297053","https://openalex.org/W4388840406","https://openalex.org/W4389117680","https://openalex.org/W4394061195","https://openalex.org/W4413052378","https://openalex.org/W4413810605","https://openalex.org/W4416531485","https://openalex.org/W4417033831"],"related_works":["https://openalex.org/W2397578201","https://openalex.org/W2286210882","https://openalex.org/W1979871623","https://openalex.org/W2059104701","https://openalex.org/W2048870179","https://openalex.org/W1989282289","https://openalex.org/W2098191389","https://openalex.org/W2119803146","https://openalex.org/W2090304479","https://openalex.org/W1420536965"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-07-26T00:00:00"}