{"id":"https://openalex.org/W7170090637","doi":"https://doi.org/10.1016/j.exphem.2026.105485","title":"Reassessment of hematopoietic stem cell aging through metabolic uncoupling and mitochondrial resilience","display_name":"Reassessment of hematopoietic stem cell aging through metabolic uncoupling and mitochondrial resilience","publication_year":2026,"publication_date":"2026-07-22","ids":{"openalex":"https://openalex.org/W7170090637","doi":"https://doi.org/10.1016/j.exphem.2026.105485","pmid":"https://pubmed.ncbi.nlm.nih.gov/42486253"},"language":"en","primary_location":{"id":"doi:10.1016/j.exphem.2026.105485","doi":"https://doi.org/10.1016/j.exphem.2026.105485","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2026.105485","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.exphem.2026.105485","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013532357","display_name":"Chong Yang","orcid":"https://orcid.org/0000-0003-0325-3970","observed_orcids":["https://orcid.org/0000-0003-0325-3970"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]},{"id":"https://openalex.org/I4391768267","display_name":"State Key Laboratory of Experimental Hematology","ror":"https://ror.org/0093mkr06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768267"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong Yang","raw_affiliation_strings":["State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China; Tianjin Institutes of Health Science, China"],"raw_orcid":"https://orcid.org/0000-0003-0325-3970","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China; Tianjin Institutes of Health Science, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887","https://openalex.org/I4391768267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043894598","display_name":"Keiyo Takubo","orcid":"https://orcid.org/0000-0002-1736-7592","observed_orcids":["https://orcid.org/0000-0002-1736-7592"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4405256897","display_name":"Kanagawa Institute of Industrial Science and Technology","ror":"https://ror.org/04n160k30","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256897"]},{"id":"https://openalex.org/I4405286378","display_name":"National Institute of Global Health and Medicine","ror":"https://ror.org/01z463p85","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286378"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiyo Takubo","raw_affiliation_strings":["Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan; Kanagawa Institute of Industrial Science and Technology (KISTEC), Kawasaki, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1736-7592","affiliations":[{"raw_affiliation_string":"Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan; Kanagawa Institute of Industrial Science and Technology (KISTEC), Kawasaki, Kanagawa, Japan","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4405256897","https://openalex.org/I4405286378","https://openalex.org/I4405286871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054636847","display_name":"Toshio Suda","orcid":"https://orcid.org/0000-0001-7540-1771","observed_orcids":["https://orcid.org/0000-0001-7540-1771"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]},{"id":"https://openalex.org/I4391768267","display_name":"State Key Laboratory of Experimental Hematology","ror":"https://ror.org/0093mkr06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768267"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Toshio Suda","raw_affiliation_strings":["State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China; Tianjin Institutes of Health Science, China. Electronic address: sudato@keio.jp"],"raw_orcid":"https://orcid.org/0000-0001-7540-1771","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China; Tianjin Institutes of Health Science, China. Electronic address: sudato@keio.jp","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887","https://openalex.org/I4391768267"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5054636847"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887","https://openalex.org/I4391768267"],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":{"value":3250,"currency":"USD","value_usd":3250},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34234234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"161","issue":null,"first_page":"105485","last_page":"105485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-aging","display_name":"hematopoietic stem cell aging","score":0.9750000238418579},{"id":"https://openalex.org/keywords/metabolic-uncoupling","display_name":"metabolic uncoupling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hsc-heterogeneity","display_name":"HSC heterogeneity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7639999985694885},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6753000020980835},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6539000272750854},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.6335999965667725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5297999978065491},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.5034999847412109},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.43050000071525574},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.42739999294281006},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4050999879837036},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3361999988555908},{"id":"https://openalex.org/C137176749","wikidata":"https://www.wikidata.org/wiki/Q4105337","display_name":"Psychological resilience","level":2,"score":0.3352999985218048},{"id":"https://openalex.org/C2779585090","wikidata":"https://www.wikidata.org/wiki/Q3457762","display_name":"Resilience (materials science)","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.2937999963760376},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2919999957084656},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.267300009727478},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C2908780919","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Cellular Aging","level":4,"score":0.25529998540878296},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exphem.2026.105485","doi":"https://doi.org/10.1016/j.exphem.2026.105485","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2026.105485","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},{"id":"pmid:42486253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42486253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.exphem.2026.105485","doi":"https://doi.org/10.1016/j.exphem.2026.105485","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2026.105485","pdf_url":null,"source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320319612","display_name":"Japan Health Research Promotion Bureau","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322310","display_name":"Kanagawa Academy of Science and Technology","ror":"https://ror.org/04yvd9h56"},{"id":"https://openalex.org/F4320336738","display_name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1984358237","https://openalex.org/W2043163249","https://openalex.org/W2054719244","https://openalex.org/W2068141056","https://openalex.org/W2074516296","https://openalex.org/W2078707329","https://openalex.org/W2082402714","https://openalex.org/W2085387059","https://openalex.org/W2094035951","https://openalex.org/W2115852450","https://openalex.org/W2295313298","https://openalex.org/W2314047536","https://openalex.org/W2337668972","https://openalex.org/W2552591666","https://openalex.org/W2592615787","https://openalex.org/W2615913297","https://openalex.org/W2768033029","https://openalex.org/W2772722011","https://openalex.org/W2795010312","https://openalex.org/W2795993938","https://openalex.org/W2913441877","https://openalex.org/W2975986603","https://openalex.org/W3004951630","https://openalex.org/W3024084935","https://openalex.org/W3044602707","https://openalex.org/W3093539402","https://openalex.org/W3111980798","https://openalex.org/W3118649846","https://openalex.org/W3214257683","https://openalex.org/W4380854034","https://openalex.org/W4381092110","https://openalex.org/W4390930605","https://openalex.org/W4396944422","https://openalex.org/W4398147511","https://openalex.org/W4402443304","https://openalex.org/W4403659524","https://openalex.org/W4408029620","https://openalex.org/W4408200989","https://openalex.org/W4408823985","https://openalex.org/W4410621622","https://openalex.org/W4411581371","https://openalex.org/W4411829751","https://openalex.org/W4411846088","https://openalex.org/W4411913262","https://openalex.org/W4413035455","https://openalex.org/W4413495251","https://openalex.org/W4415404465","https://openalex.org/W7135183368"],"related_works":["https://openalex.org/W7168129518","https://openalex.org/W3206773738","https://openalex.org/W4387167422","https://openalex.org/W4383653044","https://openalex.org/W2137077194","https://openalex.org/W2951867685","https://openalex.org/W4415612491","https://openalex.org/W4403234319","https://openalex.org/W7166784160","https://openalex.org/W7048022876"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1,13],"cell":[2,14],"(HSC)":[3],"aging":[4,45,74],"is":[5,37,75],"often":[6],"described":[7],"as":[8,61,63],"a":[9,42],"gradual":[10],"loss":[11],"of":[12,81],"fitness":[15],"that":[16,34,72],"culminates":[17],"in":[18,100],"impaired":[19],"blood":[20],"production,":[21],"immune":[22],"dysfunction,":[23],"and":[24,54,86],"increased":[25],"susceptibility":[26],"to":[27,47],"hematologic":[28],"disease.":[29],"However,":[30],"recent":[31,94],"work":[32],"suggests":[33],"this":[35,68],"view":[36],"too":[38],"simple.":[39],"Rather":[40],"than":[41],"uniform":[43],"decline,":[44],"appears":[46],"remodel":[48],"the":[49,79,101],"HSC":[50,73],"compartment":[51],"into":[52],"metabolically":[53],"functionally":[55],"distinct":[56],"states,":[57],"including":[58],"maladaptive":[59],"trajectories":[60],"well":[62],"surprisingly":[64],"resilient":[65],"subsets.":[66],"In":[67],"review,":[69],"we":[70],"argue":[71],"best":[76],"understood":[77],"through":[78],"interplay":[80],"mitochondrial":[82],"regulation,":[83],"metabolic":[84],"uncoupling,":[85],"niche-derived":[87],"stress,":[88],"with":[89],"particular":[90],"emphasis":[91],"on":[92],"how":[93],"findings":[95],"revise":[96],"several":[97],"longstanding":[98],"assumptions":[99],"field":[102],"(Box":[103],"1).":[104]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-07-23T00:00:00"}