{"id":"https://openalex.org/W7170079405","doi":"https://doi.org/10.1186/s12951-026-04830-3","title":"Pathological microenvironment-responsive nano-glycospheres restore disc homeostasis by combinatorial metabolic and genetic regulation","display_name":"Pathological microenvironment-responsive nano-glycospheres restore disc homeostasis by combinatorial metabolic and genetic regulation","publication_year":2026,"publication_date":"2026-07-22","ids":{"openalex":"https://openalex.org/W7170079405","doi":"https://doi.org/10.1186/s12951-026-04830-3"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-026-04830-3","doi":"https://doi.org/10.1186/s12951-026-04830-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-04830-3","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12951-026-04830-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136441620","display_name":"Lei Zhao","orcid":"https://orcid.org/0000-0002-3785-6211","observed_orcids":["https://orcid.org/0000-0002-3785-6211"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhao","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007091013","display_name":"Ma Wp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]},{"id":"https://openalex.org/I4210161528","display_name":"Qilu Hospital of Shandong University","ror":"https://ror.org/056ef9489","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161528"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzheng Ma","raw_affiliation_strings":["Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, People\u2019s Republic of China","Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, 250012, People\u2019s Republic of China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210161528"]},{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062460476","display_name":"Wantao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wantao Wang","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","Pain Research Center, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]},{"raw_affiliation_string":"Pain Research Center, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091902920","display_name":"Dan Zhou","orcid":"https://orcid.org/0009-0005-6925-1232","observed_orcids":["https://orcid.org/0009-0005-6925-1232"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Zhou","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023008631","display_name":"Jinghao Fan","orcid":"https://orcid.org/0009-0006-7293-8470","observed_orcids":["https://orcid.org/0009-0006-7293-8470"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinghao Fan","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112816456","display_name":"Mingkang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingkang Liu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349511","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0001-9612-6844","observed_orcids":["https://orcid.org/0000-0001-9612-6844"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101907057","display_name":"Lin Huang","orcid":"https://orcid.org/0000-0002-0611-985X","observed_orcids":["https://orcid.org/0000-0002-0611-985X"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Huang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408966","display_name":"Wei Xue","orcid":"https://orcid.org/0000-0003-0124-9433","observed_orcids":["https://orcid.org/0000-0003-0124-9433","https://orcid.org/0009-0007-1364-0858","https://orcid.org/0009-0007-4647-0170"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Wei","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070802145","display_name":"Zhaomin Zheng","orcid":"https://orcid.org/0000-0001-6232-1326","observed_orcids":["https://orcid.org/0000-0001-6232-1326"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaomin Zheng","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","Pain Research Center, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]},{"raw_affiliation_string":"Pain Research Center, Sun Yat-sen University, Guangzhou, 510080, People\u2019s Republic of China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078220885","display_name":"Hongmei Liu","orcid":"https://orcid.org/0000-0003-1064-2448","observed_orcids":["https://orcid.org/0000-0003-1064-2448"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongmei Liu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046676725","display_name":"Decheng Wu","orcid":"https://orcid.org/0000-0002-5276-8607","observed_orcids":["https://orcid.org/0000-0002-5276-8607"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Decheng Wu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-5276-8607","affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, People\u2019s Republic of China","institution_ids":["https://openalex.org/I3045169105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046676725","https://openalex.org/A5070802145","https://openalex.org/A5078220885"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I3045169105","https://openalex.org/I4210128921"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57310294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":1.0},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.9639999866485596},{"id":"https://openalex.org/keywords/phenylboronic-acid","display_name":"phenylboronic acid","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ph-sensitive-nanoparticles","display_name":"pH-responsive nanoparticles","score":0.503000020980835},{"id":"https://openalex.org/keywords/glycolysis-inhibition","display_name":"glycolysis inhibition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8519999980926514},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/discogenic-pain","display_name":"discogenic pain","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/disc-homeostasis","display_name":"disc homeostasis","score":0.6660000085830688},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.722000002861023},{"id":"https://openalex.org/keywords/lumbar-disc-degeneration","display_name":"lumbar disc degeneration","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.6858999729156494},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.6208000183105469},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6154999732971191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5550000071525574},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5486000180244446},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5297999978065491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47380000352859497},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.4634000062942505},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4309000074863434},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4043999910354614},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4027000069618225},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35580000281333923},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.3555999994277954},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3199000060558319},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29030001163482666},{"id":"https://openalex.org/C2777482401","wikidata":"https://www.wikidata.org/wiki/Q469057","display_name":"Damp","level":2,"score":0.2782000005245209},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.2660999894142151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12951-026-04830-3","doi":"https://doi.org/10.1186/s12951-026-04830-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-04830-3","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12951-026-04830-3","doi":"https://doi.org/10.1186/s12951-026-04830-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-04830-3","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2424658592","display_name":null,"funder_award_id":"KJZD20230923114612025","funder_id":"https://openalex.org/F4320336569","funder_display_name":"Shenzhen Science and Technology Innovation Program"},{"id":"https://openalex.org/G6636863035","display_name":null,"funder_award_id":"KQTD20200820113012029","funder_id":"https://openalex.org/F4320336569","funder_display_name":"Shenzhen Science and Technology Innovation Program"},{"id":"https://openalex.org/G8328764803","display_name":null,"funder_award_id":"22575114","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320336569","display_name":"Shenzhen Science and Technology Innovation Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Intervertebral":[0],"disc":[1,45,120],"degeneration":[2,121],"(IVDD)":[3],"is":[4],"fundamentally":[5],"driven":[6],"by":[7,134,188],"a":[8,34,51,108,113,149,178],"self-perpetuating":[9],"pathological":[10,67],"loop":[11],"involving":[12],"metabolic":[13,115,140],"derangement,":[14],"oxidative":[15,73],"stress,":[16],"and":[17,69,130,159],"enzymatic":[18],"hyper-activity.":[19],"Conventional":[20],"mono-therapies":[21],"often":[22],"fall":[23],"short":[24],"of":[25,66,72,79,157,166,172,186],"reversing":[26],"this":[27,95,146],"complex":[28],"microenvironmental":[29,190],"collapse.":[30],"Here,":[31],"we":[32],"developed":[33],"smart":[35],"nano-glycosphere":[36],"(siMMP13/2-DG":[37],"NPs)":[38],"designed":[39],"for":[40,153],"dual-track":[41],"intervention":[42],"to":[43],"restore":[44],"homeostasis.":[46],"This":[47],"responsive":[48],"platform":[49],"utilized":[50],"2-deoxy-D-glucose":[52],"(2-DG)":[53],"shell":[54],"crosslinked":[55],"via":[56],"reactive":[57],"oxygen-sensitive":[58],"phenylboronic":[59],"acid":[60],"moieties,":[61],"enabling":[62],"the":[63,70,76,100,105,118,123,154,164],"simultaneous":[64],"suppression":[65],"glycolysis":[68],"neutralization":[71],"stress.":[74],"Concomitantly,":[75],"precise":[77],"delivery":[78],"siMMP13":[80],"effectively":[81,98],"silenced":[82],"major":[83],"catabolic":[84,110],"enzymes,":[85],"thereby":[86],"arresting":[87],"extracellular":[88],"matrix":[89],"degradation.":[90],"Our":[91],"findings":[92],"demonstrated":[93],"that":[94],"combinatorial":[96],"approach":[97],"interrupted":[99],"lactate-driven":[101],"inflammatory":[102],"cascade,":[103],"shifting":[104],"microenvironment":[106],"from":[107],"hostile":[109],"state":[111],"toward":[112],"pro-regenerative":[114],"balance.":[116],"In":[117],"lumbar":[119],"model,":[122],"siMMP13/2-DG":[124,173],"NPs":[125,174],"significantly":[126],"preserved":[127],"structural":[128],"integrity":[129],"alleviated":[131],"discogenic":[132],"pain":[133],"dampening":[135],"neuro-inflammatory":[136],"signaling.":[137],"By":[138],"integrating":[139],"reprogramming":[141],"with":[142,175,183],"targeted":[143],"gene":[144],"silencing,":[145],"study":[147],"establishes":[148],"versatile":[150],"therapeutic":[151,180],"paradigm":[152],"precision":[155],"management":[156],"IVDD":[158,187],"offers":[160],"broader":[161],"insights":[162],"into":[163],"treatment":[165],"other":[167],"microenvironment-mediated":[168],"musculoskeletal":[169],"disorders.":[170],"Construction":[171],"2-DG":[176],"as":[177],"potential":[179],"agent":[181],"together":[182],"siMMP13,":[184],"alleviation":[185],"balancing":[189],"homeostasis":[191]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-07-23T00:00:00"}
