{"id":"https://openalex.org/W7170046900","doi":"https://doi.org/10.3390/molecules31142544","title":"Structural Improvement of the Allosteric ALOX15 Inhibitor Octyl (N-(5-(1H-Indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate","display_name":"Structural Improvement of the Allosteric ALOX15 Inhibitor Octyl (N-(5-(1H-Indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate","publication_year":2026,"publication_date":"2026-07-22","ids":{"openalex":"https://openalex.org/W7170046900","doi":"https://doi.org/10.3390/molecules31142544","pmid":"https://pubmed.ncbi.nlm.nih.gov/42513221"},"language":"en","primary_location":{"id":"doi:10.3390/molecules31142544","doi":"https://doi.org/10.3390/molecules31142544","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31142544","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/molecules31142544","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027551698","display_name":"Viktor Gavrilyuk","orcid":"https://orcid.org/0000-0002-1811-2380","observed_orcids":["https://orcid.org/0000-0002-1811-2380"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Viktor Gavrilyuk","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1811-2380","affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vladislav Aksenov","orcid":"https://orcid.org/0009-0002-7720-061X","observed_orcids":["https://orcid.org/0009-0002-7720-061X"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladislav Aksenov","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":"https://orcid.org/0009-0002-7720-061X","affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143420773","display_name":"Kirill Petrov","orcid":"https://orcid.org/0009-0001-8239-6277","observed_orcids":["https://orcid.org/0009-0001-8239-6277"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kirill Petrov","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":"https://orcid.org/0009-0001-8239-6277","affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125155182","display_name":"Angelina V. Kurchatova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Angelina V. Kurchatova","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143416926","display_name":"Dmitriy Bortnevskij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitriy Bortnevskij","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038744613","display_name":"Alexander V. Zhuravlev","orcid":"https://orcid.org/0000-0003-1189-8285","observed_orcids":["https://orcid.org/0000-0003-1189-8285"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Zhuravlev","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085569145","display_name":"Alexey Golovanov","orcid":"https://orcid.org/0000-0002-9198-2876","observed_orcids":["https://orcid.org/0000-0002-9198-2876"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexey Golovanov","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064301762","display_name":"Hartmut K\u00fchn","orcid":"https://orcid.org/0000-0001-8142-3192","observed_orcids":["https://orcid.org/0000-0001-8142-3192"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Kuhn","raw_affiliation_strings":["Institute of Biochemistry, Charite\u2014University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Charit\u00e9platz 1, 10117 Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8142-3192","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charite\u2014University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Charit\u00e9platz 1, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I4210139777","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076747528","display_name":"Igor Ivanov","orcid":"https://orcid.org/0000-0003-0543-2067","observed_orcids":["https://orcid.org/0000-0003-0543-2067"]},"institutions":[{"id":"https://openalex.org/I4210135186","display_name":"MIREA - Russian Technological University","ror":"https://ror.org/04qrtgy16","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210135186"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Igor Ivanov","raw_affiliation_strings":["Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0543-2067","affiliations":[{"raw_affiliation_string":"Lomonosov Institute of Fine Chemical Technologies, MIREA\u2014Russian Technological University, Vernadskogo pr. 86, 119571 Moscow, Russia","institution_ids":["https://openalex.org/I4210135186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076747528"],"corresponding_institution_ids":["https://openalex.org/I4210135186"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59188776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"14","first_page":"2544","last_page":"2544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.24410000443458557,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.16429999470710754,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.984000027179718},{"id":"https://openalex.org/keywords/15-lipoxygenase","display_name":"15-lipoxygenase","score":0.722000002861023},{"id":"https://openalex.org/keywords/phenylpyrroles","display_name":"phenylpyrroles","score":0.972000002861023},{"id":"https://openalex.org/keywords/triethylene-glycol","display_name":"triethylene glycol","score":0.9049999713897705},{"id":"https://openalex.org/keywords/sulfonamides","display_name":"sulfonamides","score":0.8240000009536743},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/alox15b","display_name":"ALOX15B","score":0.8130000233650208},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.6880000233650208},{"id":"https://openalex.org/keywords/water-solubility","display_name":"water solubility","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8720999956130981},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.8130999803543091},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.6240000128746033},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48739999532699585},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.4749000072479248},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.4733999967575073},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C2775934670","wikidata":"https://www.wikidata.org/wiki/Q420630","display_name":"Triethylene glycol","level":2,"score":0.4368000030517578},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4156000018119812},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3481000065803528},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.3418000042438507},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C104264131","wikidata":"https://www.wikidata.org/wiki/Q898637","display_name":"Isopropyl","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.25099998712539673}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules31142544","doi":"https://doi.org/10.3390/molecules31142544","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31142544","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:42513221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42513221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b49ad1b1ec694be4b80805abd1bec7bc","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b49ad1b1ec694be4b80805abd1bec7bc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 31, Iss 14, p 2544 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13415832","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13415832/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/molecules31142544","doi":"https://doi.org/10.3390/molecules31142544","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules31142544","pdf_url":null,"source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5816400647163391,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1966895001","https://openalex.org/W2028364979","https://openalex.org/W2031882974","https://openalex.org/W2034829797","https://openalex.org/W2037208645","https://openalex.org/W2064565919","https://openalex.org/W2083552277","https://openalex.org/W2086143831","https://openalex.org/W2127287358","https://openalex.org/W2128279921","https://openalex.org/W2149303684","https://openalex.org/W2172238206","https://openalex.org/W2215257582","https://openalex.org/W2550324626","https://openalex.org/W2997667531","https://openalex.org/W3006341053","https://openalex.org/W3010570560","https://openalex.org/W3048368879","https://openalex.org/W3140773363","https://openalex.org/W3187494908","https://openalex.org/W4206903354","https://openalex.org/W4309267666","https://openalex.org/W4384526077","https://openalex.org/W4404223859","https://openalex.org/W4412827602","https://openalex.org/W4414068326","https://openalex.org/W7127941035","https://openalex.org/W7136914574"],"related_works":[],"abstract_inverted_index":{"-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate":[0],"has":[1],"previously":[2],"been":[3],"characterized":[4],"as":[5],"substrate-specific":[6],"inhibitor":[7,146,170],"of":[8,14,26,36,45,53,70,80,102,117,137,153,158,168],"the":[9,23,37,49,54,71,81,100,103,112,122,135,138,145,156,159,165,169],"linoleic":[10],"acid":[11],"oxygenase":[12],"activity":[13],"mammalian":[15],"ALOX15":[16,87],"orthologs.":[17],"Here":[18],"we":[19],"aimed":[20],"at":[21],"optimizing":[22],"inhibitory":[24,78,93],"properties":[25],"this":[27,60],"compound":[28,56,139],"by":[29,40,58,63,74,90,129,148,162],"three":[30],"different":[31],"chemical":[32],"modifications:":[33],"(i)":[34],"replacement":[35,69,101,128,157],"indole":[38,105],"core":[39,106],"a":[41,64,75,108,118,130],"phenylpyrrole;":[42],"(ii)":[43],"introduction":[44,116],"hydrophilic":[46,119],"residues":[47],"into":[48,121],"aliphatic":[50,123],"hydrocarbon":[51,124],"chain":[52,125],"lead":[55],"or":[57,126],"replacing":[59],"building":[61],"block":[62],"triethylene":[65,131],"glycol":[66,132],"moiety;":[67],"(iii)":[68],"sulfamoylcarbamate":[72,160],"group":[73,120],"sulfonamide.":[76],"The":[77,115,176],"potencies":[79],"modified":[82],"compounds":[83,178],"for":[84,171,182,197],"pure":[85],"rabbit":[86,172,185],"were":[88,179,194],"quantified":[89],"in":[91,111,140],"vitro":[92],"assays,":[94],"and":[95,173,184,193],"our":[96],"data":[97],"indicate":[98],"that":[99],"rigid":[104],"induced":[107],"partial":[109],"loss":[110],"inhibitor's":[113],"potency.":[114],"its":[127],"moiety":[133,161],"improved":[134,164],"solubility":[136],"aqueous":[141],"solution,":[142],"but":[143,187],"reduced":[144],"potency":[147],"more":[149],"than":[150],"one":[151],"order":[152],"magnitude.":[154],"Finally,":[155],"sulfonamide":[163],"substrate":[166],"selectivity":[167],"human":[174,183,191],"ALOX15.":[175],"new":[177],"highly":[180],"potent":[181],"ALOX15,":[186],"did":[188],"not":[189],"inhibit":[190],"ALOX15B":[192],"less":[195],"effective":[196],"mouse":[198],"Alox15":[199],"(ortholog":[200],"specificity).":[201]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-07-23T00:00:00"}