{"id":"https://openalex.org/W7170045005","doi":"https://doi.org/10.3390/plants15142235","title":"Lathyrane Diterpenoids: Half-Century of Chemical Insights and Therapeutic Potential","display_name":"Lathyrane Diterpenoids: Half-Century of Chemical Insights and Therapeutic Potential","publication_year":2026,"publication_date":"2026-07-22","ids":{"openalex":"https://openalex.org/W7170045005","doi":"https://doi.org/10.3390/plants15142235","pmid":"https://pubmed.ncbi.nlm.nih.gov/42514602"},"language":"en","primary_location":{"id":"doi:10.3390/plants15142235","doi":"https://doi.org/10.3390/plants15142235","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants15142235","pdf_url":"https://www.mdpi.com/2223-7747/15/14/2235/pdf?version=1784712402","source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2223-7747/15/14/2235/pdf?version=1784712402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006543977","display_name":"Diego Caprioglio","orcid":"https://orcid.org/0000-0002-3508-5230","observed_orcids":["https://orcid.org/0000-0002-3508-5230"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Caprioglio","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3508-5230","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022261599","display_name":"Daniela Imperio","orcid":"https://orcid.org/0000-0001-6810-1439","observed_orcids":["https://orcid.org/0000-0001-6810-1439"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Imperio","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6810-1439","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057768022","display_name":"Alberto Minassi","orcid":"https://orcid.org/0000-0002-3640-2912","observed_orcids":["https://orcid.org/0000-0002-3640-2912"]},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Minassi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3640-2912","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49348088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"14","first_page":"2235","last_page":"2235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12530","display_name":"Bioactive Natural Diterpenoids Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/euphorbia","display_name":"Euphorbia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tricyclic-diterpenoids","display_name":"tricyclic diterpenoids","score":0.7739999890327454},{"id":"https://openalex.org/keywords/transannular-reactions","display_name":"transannular reactions","score":0.9070000052452087},{"id":"https://openalex.org/keywords/conformational-rigidity","display_name":"conformational rigidity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/polycyclic-natural-products","display_name":"polycyclic natural products","score":0.6919999718666077},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.675000011920929},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7889999747276306},{"id":"https://openalex.org/keywords/structural-diversity","display_name":"structural diversity","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5418000221252441},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3855000138282776},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C2992918937","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Biological organism","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27970001101493835},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C2989255885","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Molecular conformation","level":3,"score":0.2468000054359436},{"id":"https://openalex.org/C155759531","wikidata":"https://www.wikidata.org/wiki/Q7625050","display_name":"Structural rigidity","level":2,"score":0.23109999299049377},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.22840000689029694},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.22709999978542328}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/plants15142235","doi":"https://doi.org/10.3390/plants15142235","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants15142235","pdf_url":"https://www.mdpi.com/2223-7747/15/14/2235/pdf?version=1784712402","source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202606.0888.v1","doi":"https://doi.org/10.20944/preprints202606.0888.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202606.0888.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42514602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42514602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1d0fca583de04a9cbbccacee0b19ba1b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1d0fca583de04a9cbbccacee0b19ba1b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plants, Vol 15, Iss 14, p 2235 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13416206","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13416206/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plants (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/plants15142235","doi":"https://doi.org/10.3390/plants15142235","is_oa":true,"landing_page_url":"https://doi.org/10.3390/plants15142235","pdf_url":"https://www.mdpi.com/2223-7747/15/14/2235/pdf?version=1784712402","source":{"id":"https://openalex.org/S4210230202","display_name":"Plants","issn_l":"2223-7747","issn":["2223-7747"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plants","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7170045005.pdf","grobid_xml":"https://content.openalex.org/works/W7170045005.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W236207258","https://openalex.org/W1577962949","https://openalex.org/W1925945301","https://openalex.org/W1965694039","https://openalex.org/W1968931590","https://openalex.org/W1972669757","https://openalex.org/W1978613056","https://openalex.org/W1979080169","https://openalex.org/W1987712837","https://openalex.org/W1998583060","https://openalex.org/W2001811676","https://openalex.org/W2003480377","https://openalex.org/W2006434892","https://openalex.org/W2017832121","https://openalex.org/W2048309867","https://openalex.org/W2050293242","https://openalex.org/W2053422654","https://openalex.org/W2056456390","https://openalex.org/W2059931176","https://openalex.org/W2061270171","https://openalex.org/W2068502779","https://openalex.org/W2079260398","https://openalex.org/W2120593668","https://openalex.org/W2141606094","https://openalex.org/W2346819596","https://openalex.org/W2415015951","https://openalex.org/W2417626376","https://openalex.org/W2588051376","https://openalex.org/W2605691987","https://openalex.org/W2605734449","https://openalex.org/W2801853739","https://openalex.org/W2804699234","https://openalex.org/W2912789727","https://openalex.org/W2920247639","https://openalex.org/W2950752832","https://openalex.org/W2968014120","https://openalex.org/W2973043091","https://openalex.org/W2976551934","https://openalex.org/W2996515788","https://openalex.org/W3021599444","https://openalex.org/W3082072074","https://openalex.org/W3096855418","https://openalex.org/W3118761886","https://openalex.org/W3123038882","https://openalex.org/W3161883082","https://openalex.org/W3174692384","https://openalex.org/W3195103061","https://openalex.org/W4207025626","https://openalex.org/W4255604777","https://openalex.org/W4283362631","https://openalex.org/W4283766877","https://openalex.org/W4285678564","https://openalex.org/W4293105811","https://openalex.org/W4296772545","https://openalex.org/W4309436810","https://openalex.org/W4312140347","https://openalex.org/W4317542787","https://openalex.org/W4362454795","https://openalex.org/W4375945397","https://openalex.org/W4385948357","https://openalex.org/W4386861319","https://openalex.org/W4389726850","https://openalex.org/W4391578253","https://openalex.org/W4392856748","https://openalex.org/W4394807114","https://openalex.org/W4396830626","https://openalex.org/W4399565766","https://openalex.org/W4399865183","https://openalex.org/W4407295883","https://openalex.org/W4408542855","https://openalex.org/W4408819436","https://openalex.org/W4410477703","https://openalex.org/W4411557206","https://openalex.org/W4416411707","https://openalex.org/W4417027836"],"related_works":[],"abstract_inverted_index":{"Despite":[0],"being":[1],"discovered":[2],"over":[3],"a":[4,28,48,75],"century":[5],"ago,":[6],"lathyrane":[7],"diterpenoids":[8],"have":[9,66],"only":[10],"recently":[11],"attracted":[12],"significant":[13],"attention":[14],"from":[15,62],"the":[16,52,63,93],"organic":[17],"chemistry":[18,105],"community":[19],"due":[20],"to":[21],"their":[22],"distinctive":[23],"carbon":[24],"framework,":[25],"characterized":[26],"by":[27],"5/11/3":[29],"tricyclic":[30],"system.":[31],"The":[32],"conformational":[33],"rigidity":[34],"of":[35,54,78,107,111],"these":[36],"scaffolds":[37,70],"promotes":[38],"close":[39],"spatial":[40],"proximity":[41],"between":[42],"functional":[43],"groups,":[44],"making":[45],"transannular":[46],"reactions":[47],"powerful":[49],"tool":[50],"for":[51],"construction":[53],"new":[55],"complex":[56],"polycyclic":[57],"architectures.":[58],"In":[59],"parallel,":[60],"compounds":[61],"genus":[64],"Euphorbia":[65],"emerged":[67],"as":[68],"privileged":[69],"in":[71,92],"medicinal":[72,104],"chemistry,":[73],"exhibiting":[74],"wide":[76],"range":[77],"biological":[79],"activities,":[80],"including":[81],"cytotoxic,":[82],"antiviral,":[83],"and":[84,103],"neuroprotective":[85],"effects.":[86],"This":[87],"review":[88],"summarizes":[89],"recent":[90],"advances":[91],"field,":[94],"with":[95],"particular":[96],"emphasis":[97],"on":[98],"synthetic":[99],"strategies,":[100],"structural":[101],"diversity,":[102],"aspects":[106],"this":[108],"intriguing":[109],"class":[110],"secondary":[112],"metabolites.":[113]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-07-23T00:00:00"}